| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Pain | D010146 | 64 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Mayol V et al. | Cholesterol and omega-3 fatty acids inhibit Na, K-ATPase activity in human endothelial cells. | 1999 | Atherosclerosis | pmid:10030384 |
| Sergiel JP et al. | Individual effects of dietary EPA and DHA on the functioning of the isolated working rat heart. | 1998 Jul-Aug | Can. J. Physiol. Pharmacol. | pmid:10030453 |
| Hossain MS et al. | Antioxidative effects of docosahexaenoic acid in the cerebrum versus cerebellum and brainstem of aged hypercholesterolemic rats. | 1999 | J. Neurochem. | pmid:10037485 |
| Gerbi A and Maixent JM | Fatty acid-induced modulation of ouabain responsiveness of rat Na, K-ATPase isoforms. | 1999 | J. Membr. Biol. | pmid:10051686 |
| Adan Y et al. | Effects of docosahexaenoic and eicosapentaenoic acid on lipid metabolism, eicosanoid production, platelet aggregation and atherosclerosis in hypercholesterolemic rats. | 1999 | Biosci. Biotechnol. Biochem. | pmid:10052130 |
| Hung P et al. | Dietary effect of EPA-rich and DHA-rich fish oils on the immune function of Sprague-Dawley rats. | 1999 | Biosci. Biotechnol. Biochem. | pmid:10052133 |
| Gaposchkin DP and Zoeller RA | Plasmalogen status influences docosahexaenoic acid levels in a macrophage cell line. Insights using ether lipid-deficient variants. | 1999 | J. Lipid Res. | pmid:10064738 |
| Andriamampandry MD et al. | Antithrombotic effects of (n-3) polyunsaturated fatty acids in rat models of arterial and venous thrombosis. | 1999 | Thromb. Res. | pmid:10065894 |
| Chen D and Auborn K | Fish oil constituent docosahexa-enoic acid selectively inhibits growth of human papillomavirus immortalized keratinocytes. | 1999 | Carcinogenesis | pmid:10069461 |
| Burns RA et al. | Evaluation of single-cell sources of docosahexaenoic acid and arachidonic acid: 3-month rat oral safety study with an in utero phase. | 1999 | Food Chem. Toxicol. | pmid:10069479 |
| Hill DJ et al. | Effect of prostanoids and their precursors on the aggregation of rainbow trout thrombocytes. | 1999 | Am. J. Physiol. | pmid:10070125 |
| Ikemoto A et al. | Effects of docosahexaenoic and arachidonic acids on the synthesis and distribution of aminophospholipids during neuronal differentiation of PC12 cells. | 1999 | Arch. Biochem. Biophys. | pmid:10087166 |
| Böhles H et al. | Maternal plasma homocysteine, placenta status and docosahexaenoic acid concentration in erythrocyte phospholipids of the newborn. | 1999 | Eur. J. Pediatr. | pmid:10094448 |
| Rice KE et al. | Hydrolysis of menhaden oil by a Candida cylindracea lipase immobilized in a hollow-fiber reactor. | 1999 | Biotechnol. Bioeng. | pmid:10099579 |
| Xiang M et al. | Composition of long chain polyunsaturated fatty acids in human milk and growth of young infants in rural areas of northern China. | 1999 | Acta Paediatr. | pmid:10102142 |
| Ackman RG | Docosahexaenoic acid in the infant and its mother. | 1999 | Lipids | pmid:10102238 |
| Innis SM et al. | Neonatal polyunsaturated fatty acid metabolism. | 1999 | Lipids | pmid:10102240 |
| Carlson SE and Neuringer M | Polyunsaturated fatty acid status and neurodevelopment: a summary and critical analysis of the literature. | 1999 | Lipids | pmid:10102243 |
| Wu GS and Rao NA | Activation of NADPH oxidase by docosahexaenoic acid hydroperoxide and its inhibition by a novel retinal pigment epithelial protein. | 1999 | Invest. Ophthalmol. Vis. Sci. | pmid:10102279 |
| BondÃa-MartÃnez E et al. | Fatty acid composition of plasma and erythrocytes in term infants fed human milk and formulae with and without docosahexaenoic and arachidonic acids from egg yolk lecithin. | 1998 | Early Hum. Dev. | pmid:10102659 |
| Adan Y et al. | Concentration of serum lipids and aortic lesion size in female and male apo E-deficient mice fed docosahexaenoic acid. | 1999 | Biosci. Biotechnol. Biochem. | pmid:10192911 |
| Bougnoux P et al. | Cytotoxic drugs efficacy correlates with adipose tissue docosahexaenoic acid level in locally advanced breast carcinoma. | 1999 | Br. J. Cancer | pmid:10206290 |
| Williams EE et al. | Docosahexaenoic acid (DHA) alters the phospholipid molecular species composition of membranous vesicles exfoliated from the surface of a murine leukemia cell line. | 1999 | Biochim. Biophys. Acta | pmid:10209223 |
| Spaide RF et al. | Characterization of peroxidized lipids in Bruch's membrane. | 1999 | Retina (Philadelphia, Pa.) | pmid:10213241 |
| Chang MC et al. | Dynamics of docosahexaenoic acid metabolism in the central nervous system: lack of effect of chronic lithium treatment. | 1999 | Neurochem. Res. | pmid:10215514 |
| Wainwright PE et al. | Water maze performance is unaffected in artificially reared rats fed diets supplemented with arachidonic acid and docosahexaenoic acid. | 1999 | J. Nutr. | pmid:10222403 |
| Green P et al. | Developmental changes in rat brain membrane lipids and fatty acids. The preferential prenatal accumulation of docosahexaenoic acid. | 1999 | J. Lipid Res. | pmid:10224166 |
| Rudra PK and Krokan HE | Acrolein cytotoxicity and glutathione depletion in n-3 fatty acid sensitive- and resistant human tumor cells. | 1999 Jan-Feb | Anticancer Res. | pmid:10226583 |
| Billman GE et al. | Prevention of sudden cardiac death by dietary pure omega-3 polyunsaturated fatty acids in dogs. | 1999 | Circulation | pmid:10318669 |
| Watanabe A et al. | Low plasma levels of docosahexaenoic acid in patients with liver cirrhosis and its correction with a polyunsaturated fatty acid-enriched soft oil capsule. | 1999 | Nutrition | pmid:10319360 |
| Engler MM et al. | Docosahexaenoic acid is an antihypertensive nutrient that affects aldosterone production in SHR. | 1999 | Proc. Soc. Exp. Biol. Med. | pmid:10320629 |
| Haggarty P et al. | Effect of maternal polyunsaturated fatty acid concentration on transport by the human placenta. | 1999 | Biol. Neonate | pmid:10325438 |
| Nourooz-Zadeh J and Pereira P | Age-related accumulation of free polyunsaturated fatty acids in human retina. | 1999 | Ophthalmic Res. | pmid:10325542 |
| Pakala R et al. | Serotonin-induced endothelial cell proliferation is blocked by omega-3 fatty acids. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10328332 |
| Jeyarajah DR et al. | Docosahexaenoic acid, a component of fish oil, inhibits nitric oxide production in vitro. | 1999 | J. Surg. Res. | pmid:10329109 |
| Hun CS et al. | Increased uncoupling protein2 mRNA in white adipose tissue, and decrease in leptin, visceral fat, blood glucose, and cholesterol in KK-Ay mice fed with eicosapentaenoic and docosahexaenoic acids in addition to linolenic acid. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10334920 |
| Masuda R et al. | Incorporation of dietary docosahexaenoic acid into the central nervous system of the yellowtail Seriola quinqueradiata. | 1999 | Brain Behav. Evol. | pmid:10343083 |
| Roberts LJ et al. | Novel eicosanoids. Isoprostanes and related compounds. | 1999 | Methods Mol. Biol. | pmid:10343322 |
| Shahar E et al. | Docosahexaenoic acid and smoking-related chronic obstructive pulmonary disease. The Atherosclerosis Risk in Communities Study Investigators. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10351918 |
| Marckmann P | Footprint of fish: docosahexaenoic acid (DHA) in adipose tissue. | 1999 | Nutrition | pmid:10355858 |
| Kotkat HM et al. | Effect of dietary fish oil (active EPA-30) on liver phospholipids in young and aged rats. | 1999 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:10356759 |
| Barichello JM et al. | Enhanced rectal absorption of insulin-loaded Pluronic F-127 gels containing unsaturated fatty acids. | 1999 | Int J Pharm | pmid:10361163 |
| Bowen RA et al. | Does increasing dietary linolenic acid content increase the docosahexaenoic acid content of phospholipids in neuronal cells of neonatal rats? | 1999 | Pediatr. Res. | pmid:10367771 |
| Higgins S et al. | Effects of oleic acid, docosahexaenoic acid and eicosapentaenoic acid on background and genotoxin-induced frequencies of SCEs in Indian muntjac fibroblasts. | 1999 | Mutagenesis | pmid:10375002 |
| Flock S et al. | Syntheses of some polyunsaturated sulfur- and oxygen-containing fatty acids related to eicosapentaenoic and docosahexaenoic acids. | 1999 | Acta Chem. Scand. | pmid:10377950 |
| Smit EN et al. | Low erythrocyte docosahexaenoic acid in malnourished, often breast-fed, Pakistani infants: a matter of concern? | 1999 | Eur. J. Pediatr. | pmid:10378406 |
| Yeh YY et al. | Dietary supplementation with arachidonic and docosahexaenoic acids has no effect on pulmonary surfactant in artificially reared infant rats. | 1999 | Lipids | pmid:10380120 |
| Harding CO et al. | Docosahexaenoic acid and retinal function in children with long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency. | 1999 | J. Inherit. Metab. Dis. | pmid:10384386 |
| Wijendran V et al. | Maternal plasma phospholipid polyunsaturated fatty acids in pregnancy with and without gestational diabetes mellitus: relations with maternal factors. | 1999 | Am. J. Clin. Nutr. | pmid:10393139 |