| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Pain | D010146 | 64 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Liu Q et al. | Dietary n-6:n-3 ratio and Vitamin E improve motility characteristics in association with membrane properties of boar spermatozoa. | 2017 Mar-Apr | Asian J. Androl. | pmid:26763547 |
| Manni A et al. | Stearoyl-CoA desaturase-1, a novel target of omega-3 fatty acids for reducing breast cancer risk in obese postmenopausal women. | 2017 | Eur J Clin Nutr | pmid:28145413 |
| Burak C et al. | Effects of the flavonol quercetin and α-linolenic acid on n-3 PUFA status in metabolically healthy men and women: a randomised, double-blinded, placebo-controlled, crossover trial. | 2017 | Br. J. Nutr. | pmid:28366181 |
| Pascoal LB et al. | Resolvin RvD2 reduces hypothalamic inflammation and rescues mice from diet-induced obesity. | 2017 | J Neuroinflammation | pmid:28086928 |
| Sugasini D and Subbaiah PV | Rate of acyl migration in lysophosphatidylcholine (LPC) is dependent upon the nature of the acyl group. Greater stability of sn-2 docosahexaenoyl LPC compared to the more saturated LPC species. | 2017 | PLoS ONE | pmid:29117232 |
| Tsuchiya T et al. | Involvement of Resveratrol and ω-3 Polyunsaturated Fatty Acids on Sirtuin 1 Gene Expression in THP1 Cells. | 2017 | Am. J. Med. Sci. | pmid:29078847 |
| Asatryan A and Bazan NG | Molecular mechanisms of signaling via the docosanoid neuroprotectin D1 for cellular homeostasis and neuroprotection. | 2017 | J. Biol. Chem. | pmid:28615451 |
| Nakamoto K et al. | Dysfunctional GPR40/FFAR1 signaling exacerbates pain behavior in mice. | 2017 | PLoS ONE | pmid:28723961 |
| Villalpando DM et al. | Dietary docosahexaenoic acid supplementation prevents the formation of cholesterol oxidation products in arteries from orchidectomized rats. | 2017 | PLoS ONE | pmid:28968462 |
| Tang S et al. | Maresin 1 Mitigates High Glucose-Induced Mouse Glomerular Mesangial Cell Injury by Inhibiting Inflammation and Fibrosis. | 2017 | Mediators Inflamm. | pmid:28182085 |
| Wang Y et al. | N-Docosahexaenoyl Dopamine, an Endocannabinoid-like Conjugate of Dopamine and the n-3 Fatty Acid Docosahexaenoic Acid, Attenuates Lipopolysaccharide-Induced Activation of Microglia and Macrophages via COX-2. | 2017 | ACS Chem Neurosci | pmid:28292183 |
| Chouinard-Watkins R et al. | Phospholipid class-specific brain enrichment in response to lysophosphatidylcholine docosahexaenoic acid infusion. | 2017 | Biochim. Biophys. Acta | pmid:28760485 |
| Debbabi M et al. | Comparison of the effects of major fatty acids present in the Mediterranean diet (oleic acid, docosahexaenoic acid) and in hydrogenated oils (elaidic acid) on 7-ketocholesterol-induced oxiapoptophagy in microglial BV-2 cells. | 2017 | Chem. Phys. Lipids | pmid:28408132 |
| Stylos E et al. | Tailoring naringenin conjugates with amplified and triple antiplatelet activity profile: Rational design, synthesis, human plasma stability and in vitro evaluation. | 2017 | Biochim Biophys Acta Gen Subj | pmid:28844979 |
| Maoka T et al. | Carotenoids of Red, Brown, and Black Specimens of Plectropomus leopardus, the Coral Trout (Suziara in Japanese). | 2017 | J Oleo Sci | pmid:28515376 |
| Di Nunzio M et al. | Is cytotoxicity a determinant of the different in vitro and in vivo effects of bioactives? | 2017 | BMC Complement Altern Med | pmid:28882181 |
| Lee Y et al. | Analysis of endogenous lipids during intestinal wound healing. | 2017 | PLoS ONE | pmid:28800645 |
| Tylichová Z et al. | Activation of autophagy and PPARγ protect colon cancer cells against apoptosis induced by interactive effects of butyrate and DHA in a cell type-dependent manner: The role of cell differentiation. | 2017 | J. Nutr. Biochem. | pmid:27840291 |
| Yilmaz JL et al. | Determination of Substrate Preferences for Desaturases and Elongases for Production of Docosahexaenoic Acid from Oleic Acid in Engineered Canola. | 2017 | Lipids | pmid:28197856 |
| Hofmanová J et al. | Dietary fatty acids specifically modulate phospholipid pattern in colon cells with distinct differentiation capacities. | 2017 | Eur J Nutr | pmid:26983609 |
| Wang Y et al. | Docosahexaenoyl serotonin emerges as most potent inhibitor of IL-17 and CCL-20 released by blood mononuclear cells from a series of N-acyl serotonins identified in human intestinal tissue. | 2017 | Biochim. Biophys. Acta | pmid:28526351 |
| Lefort N et al. | Dietary Buglossoides Arvensis Oil Increases Circulating n-3 Polyunsaturated Fatty Acids in a Dose-Dependent Manner and Enhances Lipopolysaccharide-Stimulated Whole Blood Interleukin-10-A Randomized Placebo-Controlled Trial. | 2017 | Nutrients | pmid:28287415 |
| Zarrouk A et al. | Attenuation of 7-ketocholesterol-induced overproduction of reactive oxygen species, apoptosis, and autophagy by dimethyl fumarate on 158N murine oligodendrocytes. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:26921765 |
| Senftleber NK et al. | Marine Oil Supplements for Arthritis Pain: A Systematic Review and Meta-Analysis of Randomized Trials. | 2017 | Nutrients | pmid:28067815 |
| Alsharari ZD et al. | Serum Fatty Acids, Desaturase Activities and Abdominal Obesity - A Population-Based Study of 60-Year Old Men and Women. | 2017 | PLoS ONE | pmid:28125662 |
| Muralikumar S et al. | Probing the intermolecular interactions of PPARγ-LBD with polyunsaturated fatty acids and their anti-inflammatory metabolites to infer most potential binding moieties. | 2017 | Lipids Health Dis | pmid:28109294 |
| Lippestad M et al. | Resolvin D1 Increases Mucin Secretion in Cultured Rat Conjunctival Goblet Cells via Multiple Signaling Pathways. | 2017 | Invest. Ophthalmol. Vis. Sci. | pmid:28892824 |
| Marin R et al. | Anomalies occurring in lipid profiles and protein distribution in frontal cortex lipid rafts in dementia with Lewy bodies disclose neurochemical traits partially shared by Alzheimer's and Parkinson's diseases. | 2017 | Neurobiol. Aging | pmid:27768960 |
| Mottola G et al. | Aspirin-triggered resolvin D1 attenuates PDGF-induced vascular smooth muscle cell migration via the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) pathway. | 2017 | PLoS ONE | pmid:28362840 |
| Souza CO et al. | Milk protein-based formulas containing different oils affect fatty acids balance in term infants: A randomized blinded crossover clinical trial. | 2017 | Lipids Health Dis | pmid:28410612 |
| Nury T et al. | 7-Ketocholesterol is increased in the plasma of X-ALD patients and induces peroxisomal modifications in microglial cells: Potential roles of 7-ketocholesterol in the pathophysiology of X-ALD. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27041118 |
| Eickmeier O et al. | Pro-resolving lipid mediator Resolvin D1 serves as a marker of lung disease in cystic fibrosis. | 2017 | PLoS ONE | pmid:28158236 |
| Quartu M et al. | Involvement of the endocannabinoid system in the physiological response to transient common carotid artery occlusion and reperfusion. | 2017 | Lipids Health Dis | pmid:28103941 |
| Zhang K et al. | Regulation of the Docosapentaenoic Acid/Docosahexaenoic Acid Ratio (DPA/DHA Ratio) in Schizochytrium limacinum B4D1. | 2017 | Appl. Biochem. Biotechnol. | pmid:27832512 |
| Visentin S et al. | Red blood cell membrane fatty acid composition in infants fed formulas with different lipid profiles. | 2016 | Early Hum. Dev. | pmid:27391868 |
| Viola JR et al. | Resolving Lipid Mediators Maresin 1 and Resolvin D2 Prevent Atheroprogression in Mice. | 2016 | Circ. Res. | pmid:27531933 |
| Zhang MJ et al. | Resolvin D2 Enhances Postischemic Revascularization While Resolving Inflammation. | 2016 | Circulation | pmid:27507404 |
| Lu Y et al. | Impedance spectroscopy analysis of human odorant binding proteins immobilized on nanopore arrays for biochemical detection. | 2016 | Biosens Bioelectron | pmid:26710343 |
| Lam SM et al. | Biological relevance of fatty acyl heterogeneity to the neural membrane dynamics of rhesus macaques during normative aging. | 2016 | Oncotarget | pmid:27517158 |
| Gold DR et al. | Lung VITAL: Rationale, design, and baseline characteristics of an ancillary study evaluating the effects of vitamin D and/or marine omega-3 fatty acid supplements on acute exacerbations of chronic respiratory disease, asthma control, pneumonia and lung function in adults. | 2016 | Contemp Clin Trials | pmid:26784651 |
| Bassuk SS et al. | Baseline characteristics of participants in the VITamin D and OmegA-3 TriaL (VITAL). | 2016 | Contemp Clin Trials | pmid:26767629 |
| Gao J et al. | Neuroprotective effects of docosahexaenoic acid on hippocampal cell death and learning and memory impairments in a valproic acid-induced rat autism model. | 2016 | Int. J. Dev. Neurosci. | pmid:26639559 |
| Moeinzadeh F et al. | Effects of Omega-3 Fatty Acid Supplementation on Serum Biomarkers, Inflammatory Agents, and Quality of Life of Patients on Hemodialysis. | 2016 | Iran J Kidney Dis | pmid:27903997 |
| Zhao Z et al. | The Association of Fatty Acid Levels and Gleason Grade among Men Undergoing Radical Prostatectomy. | 2016 | PLoS ONE | pmid:27880795 |
| Heskey CE et al. | Adipose tissue α-linolenic acid is inversely associated with insulin resistance in adults. | 2016 | Am. J. Clin. Nutr. | pmid:26912497 |
| Cinelli G et al. | Influence of Maternal Obesity and Gestational Weight Gain on Maternal and Foetal Lipid Profile. | 2016 | Nutrients | pmid:27314385 |
| Revuelta M et al. | Antioxidant Treatments Recover the Alteration of Auditory-Evoked Potentials and Reduce Morphological Damage in the Inferior Colliculus after Perinatal Asphyxia in Rat. | 2016 | Brain Pathol. | pmid:25990815 |
| Kuda O et al. | Docosahexaenoic Acid-Derived Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) With Anti-inflammatory Properties. | 2016 | Diabetes | pmid:27313314 |
| Kim KH et al. | Resolvin D1 prevents smoking-induced emphysema and promotes lung tissue regeneration. | 2016 | Int J Chron Obstruct Pulmon Dis | pmid:27313451 |
| Gharekhani A et al. | Potential Effects of Omega-3 Fatty Acids on Insulin Resistance and Lipid Profile in Maintenance Hemodialysis Patients: a Randomized Placebo-Controlled Trial. | 2016 | Iran J Kidney Dis | pmid:27721230 |