DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Gibson RA and Makrides M The role of long chain polyunsaturated fatty acids (LCPUFA) in neonatal nutrition. 1998 Acta Paediatr. pmid:9825965
Martínez M and Mougan I Fatty acid composition of human brain phospholipids during normal development. 1998 J. Neurochem. pmid:9832152
Allen PC and Danforth HD Effects of dietary supplementation with n-3 fatty acid ethyl esters on coccidiosis in chickens. 1998 Poult. Sci. pmid:9835336
Helland IB et al. Fatty acid composition in maternal milk and plasma during supplementation with cod liver oil. 1998 Eur J Clin Nutr pmid:9846598
Saha SK et al. Thermogenesis and fatty acid composition of brown adipose tissue in rats rendered hyperthyroid and hypothyroid-with special reference to docosahexaenoic acid. 1998 Jpn. J. Physiol. pmid:9852344
Yuan C et al. The unique lipid composition of gecko (Gekko Gekko) photoreceptor outer segment membranes. 1998 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:9854823
Rotstein NP et al. Docosahexaenoic acid promotes differentiation of developing photoreceptors in culture. 1998 Invest. Ophthalmol. Vis. Sci. pmid:9856786
Martin RE Docosahexaenoic acid decreases phospholipase A2 activity in the neurites/nerve growth cones of PC12 cells. 1998 J. Neurosci. Res. pmid:9856864
Huster D et al. Influence of docosahexaenoic acid and cholesterol on lateral lipid organization in phospholipid mixtures. 1998 Biochemistry pmid:9860844
Khalfoun B et al. Docosahexaenoic and eicosapentaenoic acids inhibit the CD28-lymphocyte activation pathway in vitro. 1998 Transplant. Proc. pmid:9865267
Cho HP et al. Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase. 1999 J. Biol. Chem. pmid:9867867
Ward GR et al. Long-chain polyunsaturated fatty acid levels in formulae influence deposition of docosahexaenoic acid and arachidonic acid in brain and red blood cells of artificially reared neonatal rats. 1998 J. Nutr. pmid:9868196
Ishihara K et al. Effect of tetracosahexaenoic acid on the content and release of histamine, and eicosanoid production in MC/9 mouse mast cell. 1998 Lipids pmid:9870906
Hansen JB et al. Lipid peroxidation of isolated chylomicrons and oxidative status in plasma after intake of highly purified eicosapentaenoic or docosahexaenoic acids. 1998 Lipids pmid:9870908
Vaagenes H et al. Low doses of eicosapentaenoic acid, docosahexaenoic acid, and hypolipidemic eicosapentaenoic acid derivatives have no effect on lipid peroxidation in plasma. 1998 Lipids pmid:9870909
Akedo I et al. Three cases with familial adenomatous polyposis diagnosed as having malignant lesions in the course of a long-term trial using docosahexanoic acid (DHA)-concentrated fish oil capsules. 1998 Jpn. J. Clin. Oncol. pmid:9879296
Bernoud N et al. Preferential transfer of 2-docosahexaenoyl-1-lysophosphatidylcholine through an in vitro blood-brain barrier over unesterified docosahexaenoic acid. 1999 J. Neurochem. pmid:9886086
Mani I et al. Evidence of nuclear PKC/MAP-kinase cascade in guinea pig model of epidermal hyperproliferation. 1999 J. Invest. Dermatol. pmid:9886262
Marzo I et al. Loss of delta6-desaturase activity leads to impaired docosahexaenoic acid synthesis in Y-79 retinoblastoma cells. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9888202
Kollman KA et al. Dietary lipids influence intestinal adaptation after massive bowel resection. 1999 J. Pediatr. Gastroenterol. Nutr. pmid:9890467
Perin N et al. Dietary lipid composition modifies intestinal morphology and nutrient transport in young rats. 1999 J. Pediatr. Gastroenterol. Nutr. pmid:9890468
Su HM et al. Bioequivalence of dietary alpha-linolenic and docosahexaenoic acids as sources of docosahexaenoate accretion in brain and associated organs of neonatal baboons. 1999 Pediatr. Res. pmid:9890614
Lin Q et al. Ligand selectivity of the peroxisome proliferator-activated receptor alpha. 1999 Biochemistry pmid:9890897
Baur LA et al. Relationships between maternal risk of insulin resistance and the child's muscle membrane fatty acid composition. 1999 Diabetes pmid:9892230
Hashimoto M et al. The hypotensive effect of docosahexaenoic acid is associated with the enhanced release of ATP from the caudal artery of aged rats. 1999 J. Nutr. pmid:9915878
Terano T et al. Eicosapentaenoic acid and docosahexaenoic acid inhibit vascular smooth muscle cell proliferation by inhibiting phosphorylation of Cdk2-cyclinE complex. 1999 Biochem. Biophys. Res. Commun. pmid:9918868
Hirafuji M et al. Effect of docosahexaenoic acid on intracellular calcium dynamics in vascular smooth muscle cells from normotensive and genetically hypertensive rats. 1998 Res. Commun. Mol. Pathol. Pharmacol. pmid:9920344
Nourooz-Zadeh J et al. F4-isoprostanes as specific marker of docosahexaenoic acid peroxidation in Alzheimer's disease. 1999 J. Neurochem. pmid:9930747
Weisinger HS et al. Effects of dietary n-3 fatty acid deficiency and repletion in the guinea pig retina. 1999 Invest. Ophthalmol. Vis. Sci. pmid:9950590
Araya Araya J et al. [Differences in percent composition of long chain polyunsaturated fatty acids in maternal-fetal erythrocytes in term and preterm infants]. 1998 Arch Latinoam Nutr pmid:9951532
Azavache V et al. [The liver as a source of essential long chain polyunsaturated fatty acids for postnatal brain development in the rat]. 1998 Arch Latinoam Nutr pmid:9951533
Cellini M et al. Fatty acid use in glaucomatous optic neuropathy treatment. 1998 Acta Ophthalmol Scand Suppl pmid:9972342
Matorras R et al. Biochemical markers of n-3 long chain polyunsaturated fatty acid intake during pregnancy. 1998 Clin Exp Obstet Gynecol pmid:9987571
Krugman S and Law P Breastfeeding and IQ. 1999 Pediatrics pmid:9988628
Sasaki T et al. Effects of dietary docosahexaenoic acid on surface molecules involved in T cell proliferation. 1999 Biochim. Biophys. Acta pmid:9989281
Alexander JW Influence of EPA and DHA intravenous fat emulsions on nitrogen retention and protein kinetics in burned rats. 1999 Nutrition pmid:9990585