DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with DHA

Download all related citations
Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Croasdell A et al. Resolvin D1 Dampens Pulmonary Inflammation and Promotes Clearance of Nontypeable Haemophilus influenzae. 2016 J. Immunol. pmid:26843331
Berrueta L et al. Stretching Impacts Inflammation Resolution in Connective Tissue. 2016 J. Cell. Physiol. pmid:26588184
Wang ZQ et al. Docosahexaenoic Acid Attenuates Doxorubicin-induced Cytotoxicity and Inflammation by Suppressing NF-κB/iNOS/NO Signaling Pathway Activation in H9C2 Cardiac Cells. 2016 J. Cardiovasc. Pharmacol. pmid:26657886
Georgieva R et al. Phospholipase A2-Induced Remodeling Processes on Liquid-Ordered/Liquid-Disordered Membranes Containing Docosahexaenoic or Oleic Acid: A Comparison Study. 2016 Langmuir pmid:26794691
Croasdell A et al. Resolvin D2 decreases TLR4 expression to mediate resolution in human monocytes. 2016 FASEB J. pmid:27256622
Arnardottir H et al. Human milk proresolving mediators stimulate resolution of acute inflammation. 2016 Mucosal Immunol pmid:26462421
Park HG et al. Metabolic fate of docosahexaenoic acid (DHA; 22:6n-3) in human cells: direct retroconversion of DHA to eicosapentaenoic acid (20:5n-3) dominates over elongation to tetracosahexaenoic acid (24:6n-3). 2016 FEBS Lett. pmid:27543786
Nagai T et al. Circulating Omega-6, But Not Omega-3 Polyunsaturated Fatty Acids, Are Associated with Clinical Outcomes in Patients with Acute Decompensated Heart Failure. 2016 PLoS ONE pmid:27824904
Li R et al. Maresin 1 Mitigates Inflammatory Response and Protects Mice from Sepsis. 2016 Mediators Inflamm. pmid:28042205
Suzuki-Kemuriyama N et al. Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice. 2016 PLoS ONE pmid:27333187
Fialkow J Omega-3 Fatty Acid Formulations in Cardiovascular Disease: Dietary Supplements are Not Substitutes for Prescription Products. 2016 Am J Cardiovasc Drugs pmid:27138439
Wong BH et al. Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development. 2016 J. Biol. Chem. pmid:27008858
Pinçon A et al. Human apolipoprotein E allele and docosahexaenoic acid intake modulate peripheral cholesterol homeostasis in mice. 2016 J. Nutr. Biochem. pmid:27239755
Dagorn F et al. Exploitable Lipids and Fatty Acids in the Invasive Oyster Crassostrea gigas on the French Atlantic Coast. 2016 Mar Drugs pmid:27231919
Tian Y et al. Bioconversion of Docosapentaenoic Acid in Human Cell Lines, Caco-2, HepG2, and THP-1. 2016 J Oleo Sci pmid:27829615
Snodgrass RG et al. Docosahexaenoic acid and palmitic acid reciprocally modulate monocyte activation in part through endoplasmic reticulum stress. 2016 J. Nutr. Biochem. pmid:27142735
Seeger DR and Murphy EJ Mouse Strain Impacts Fatty Acid Uptake and Trafficking in Liver, Heart, and Brain: A Comparison of C57BL/6 and Swiss Webster Mice. 2016 Lipids pmid:26797754
Qin X et al. Brown but not white adipose cells synthesize omega-3 docosahexaenoic acid in culture. 2016 Prostaglandins Leukot. Essent. Fatty Acids pmid:26802938
Cerf ME and Herrera E High Fat Diet Administration during Specific Periods of Pregnancy Alters Maternal Fatty Acid Profiles in the Near-Term Rat. 2016 Nutrients pmid:26742067
Andersen MK et al. Identification of Novel Genetic Determinants of Erythrocyte Membrane Fatty Acid Composition among Greenlanders. 2016 PLoS Genet. pmid:27341449
Benabdoune H et al. The role of resolvin D1 in the regulation of inflammatory and catabolic mediators in osteoarthritis. 2016 Inflamm. Res. pmid:27056390
Abeywardena MY et al. Rise in DPA Following SDA-Rich Dietary Echium Oil Less Effective in Affording Anti-Arrhythmic Actions Compared to High DHA Levels Achieved with Fish Oil in Sprague-Dawley Rats. 2016 Nutrients pmid:26742064
Sui YH et al. Dietary saturated fatty acid and polyunsaturated fatty acid oppositely affect hepatic NOD-like receptor protein 3 inflammasome through regulating nuclear factor-kappa B activation. 2016 World J. Gastroenterol. pmid:26937141
Tran DQ et al. Induction of Gnrh mRNA expression by the ω-3 polyunsaturated fatty acid docosahexaenoic acid and the saturated fatty acid palmitate in a GnRH-synthesizing neuronal cell model, mHypoA-GnRH/GFP. 2016 Mol. Cell. Endocrinol. pmid:26923440
Devassy JG et al. Omega-3 Polyunsaturated Fatty Acids and Oxylipins in Neuroinflammation and Management of Alzheimer Disease. 2016 Adv Nutr pmid:27633106
Nuez-Ortín WG et al. Preliminary Validation of a High Docosahexaenoic Acid (DHA) and -Linolenic Acid (ALA) Dietary Oil Blend: Tissue Fatty Acid Composition and Liver Proteome Response in Atlantic Salmon (Salmo salar) Smolts. 2016 PLoS ONE pmid:27556399
Moriyama R et al. Long-chain unsaturated fatty acids reduce the transcriptional activity of the rat follicle-stimulating hormone β-subunit gene. 2016 J. Reprod. Dev. pmid:26853521
Luo B et al. Resolvin D1 Programs Inflammation Resolution by Increasing TGF-β Expression Induced by Dying Cell Clearance in Experimental Autoimmune Neuritis. 2016 J. Neurosci. pmid:27629711
Zhao Q et al. Resolvin D1 Alleviates the Lung Ischemia Reperfusion Injury via Complement, Immunoglobulin, TLR4, and Inflammatory Factors in Rats. 2016 Inflammation pmid:27145782
Barden A et al. n-3 Fatty Acid Supplementation and Leukocyte Telomere Length in Patients with Chronic Kidney Disease. 2016 Nutrients pmid:27007392
Zhao Q et al. Resolvin D1 mitigates energy metabolism disorder after ischemia-reperfusion of the rat lung. 2016 J Transl Med pmid:27009328
Midtbø LK et al. Intake of farmed Atlantic salmon fed soybean oil increases hepatic levels of arachidonic acid-derived oxylipins and ceramides in mice. 2015 J. Nutr. Biochem. pmid:25776459
Shomonov-Wagner L et al. Alpha linolenic acid in maternal diet halts the lipid disarray due to saturated fatty acids in the liver of mice offspring at weaning. 2015 Lipids Health Dis pmid:25889505
Prieto P et al. Activation of autophagy in macrophages by pro-resolving lipid mediators. 2015 Autophagy pmid:26506892
Wu A et al. Curcumin boosts DHA in the brain: Implications for the prevention of anxiety disorders. 2015 Biochim. Biophys. Acta pmid:25550171
Lehmann C et al. Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein. 2015 FASEB J. pmid:26289316
Taylan A et al. S1000A12, Chitotriosidase, and Resolvin D1 as Potential Biomarkers of Familial Mediterranean Fever. 2015 J. Korean Med. Sci. pmid:26339162
Cox R et al. Resolvins Decrease Oxidative Stress Mediated Macrophage and Epithelial Cell Interaction through Decreased Cytokine Secretion. 2015 PLoS ONE pmid:26317859
Croasdell A et al. Resolvins attenuate inflammation and promote resolution in cigarette smoke-exposed human macrophages. 2015 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:26301452
Rossi S et al. Interplay between Intravitreal RvD1 and Local Endogenous Sirtuin-1 in the Protection from Endotoxin-Induced Uveitis in Rats. 2015 Mediators Inflamm. pmid:26180376
de Oliveira JR et al. AT-RvD1 modulates CCL-2 and CXCL-8 production and NF-κB, STAT-6, SOCS1, and SOCS3 expression on bronchial epithelial cells stimulated with IL-4. 2015 Biomed Res Int pmid:26075216
Kain V et al. Resolvin D1 activates the inflammation resolving response at splenic and ventricular site following myocardial infarction leading to improved ventricular function. 2015 J. Mol. Cell. Cardiol. pmid:25870158
Qin Y et al. Fish Oil Supplements Lower Serum Lipids and Glucose in Correlation with a Reduction in Plasma Fibroblast Growth Factor 21 and Prostaglandin E2 in Nonalcoholic Fatty Liver Disease Associated with Hyperlipidemia: A Randomized Clinical Trial. 2015 PLoS ONE pmid:26226139
Orr SK et al. Proresolving actions of a new resolvin D1 analog mimetic qualifies as an immunoresolvent. 2015 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:25770181
Dalli J et al. Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways. 2015 FASEB J. pmid:25713027
Rossi S et al. Protection from endotoxic uveitis by intravitreal Resolvin D1: involvement of lymphocytes, miRNAs, ubiquitin-proteasome, and M1/M2 macrophages. 2015 Mediators Inflamm. pmid:25684860
Lastrucci C et al. Molecular and cellular profiles of the resolution phase in a damage-associated molecular pattern (DAMP)-mediated peritonitis model and revelation of leukocyte persistence in peritoneal tissues. 2015 FASEB J. pmid:25609430
Pierdomenico AM et al. MicroRNA-181b regulates ALX/FPR2 receptor expression and proresolution signaling in human macrophages. 2015 J. Biol. Chem. pmid:25505240
Saito H et al. Variation of Lipids and Fatty Acids of the Japanese Freshwater Eel, Anguilla japonica, during Spawning Migration. 2015 J Oleo Sci pmid:26028326
Cespedes E et al. Adipose tissue n-3 fatty acids and metabolic syndrome. 2015 Eur J Clin Nutr pmid:25097001
Ting HC et al. Polyunsaturated fatty acids incorporation into cardiolipin in H9c2 cardiac myoblast. 2015 J. Nutr. Biochem. pmid:25866137
Valenzuela R et al. Modification of Docosahexaenoic Acid Composition of Milk from Nursing Women Who Received Alpha Linolenic Acid from Chia Oil during Gestation and Nursing. 2015 Nutrients pmid:26247968
Wang H et al. 4-Hydroxy-7-oxo-5-heptenoic Acid (HOHA) Lactone is a Biologically Active Precursor for the Generation of 2-(ω-Carboxyethyl)pyrrole (CEP) Derivatives of Proteins and Ethanolamine Phospholipids. 2015 Chem. Res. Toxicol. pmid:25793308
Akagi D et al. Systemic delivery of proresolving lipid mediators resolvin D2 and maresin 1 attenuates intimal hyperplasia in mice. 2015 FASEB J. pmid:25777995
Aursnes M et al. Synthesis of the 16S,17S-Epoxyprotectin Intermediate in the Biosynthesis of Protectins by Human Macrophages. 2015 J. Nat. Prod. pmid:26580578
Keim SA and Branum AM Dietary intake of polyunsaturated fatty acids and fish among US children 12-60 months of age. 2015 Matern Child Nutr pmid:24034437
Calandria JM et al. The Docosanoid Neuroprotectin D1 Induces TH-Positive Neuronal Survival in a Cellular Model of Parkinson's Disease. 2015 Cell. Mol. Neurobiol. pmid:26047923
Musto AE et al. Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin d1. 2015 PLoS ONE pmid:25617763
Dorninger F et al. Homeostasis of phospholipids - The level of phosphatidylethanolamine tightly adapts to changes in ethanolamine plasmalogens. 2015 Biochim. Biophys. Acta pmid:25463479
Suo R et al. Generation of Tetracosahexaenoic Acid in Benthic Marine Organisms. 2015 J Oleo Sci pmid:26136172
Kanan Y et al. Neuroprotectin D1 is synthesized in the cone photoreceptor cell line 661W and elicits protection against light-induced stress. 2015 Cell. Mol. Neurobiol. pmid:25212825
Barden AE et al. Specialized proresolving lipid mediators in humans with the metabolic syndrome after n-3 fatty acids and aspirin. 2015 Am. J. Clin. Nutr. pmid:26561623
Park CK Maresin 1 Inhibits TRPV1 in Temporomandibular Joint-Related Trigeminal Nociceptive Neurons and TMJ Inflammation-Induced Synaptic Plasticity in the Trigeminal Nucleus. 2015 Mediators Inflamm. pmid:26617436
Nordgren TM et al. Maresin-1 reduces airway inflammation associated with acute and repetitive exposures to organic dust. 2015 Transl Res pmid:25655838
Kotani K et al. Enzymatic preparation of human milk fat substitutes and their oxidation stability. 2015 J Oleo Sci pmid:25757431
Krishnamoorthy N et al. Cutting edge: maresin-1 engages regulatory T cells to limit type 2 innate lymphoid cell activation and promote resolution of lung inflammation. 2015 J. Immunol. pmid:25539814
Askari M et al. Tissue fatty acid composition and secretory phospholipase-A2 activity in oral squamous cell carcinoma. 2015 Clin Transl Oncol pmid:25351172
Fischer T [Pharmacological therapy of age-related macular degeneration based on etiopathogenesis]. 2015 Orv Hetil pmid:26548469
Amminger GP et al. Predictors of treatment response in young people at ultra-high risk for psychosis who received long-chain omega-3 fatty acids. 2015 Transl Psychiatry pmid:25585167
Jones PJ et al. High-oleic canola oil consumption enriches LDL particle cholesteryl oleate content and reduces LDL proteoglycan binding in humans. 2015 Atherosclerosis pmid:25528432
Nury T et al. Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7β-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of α-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3). 2015 Steroids pmid:25683890
Norris SE et al. Human prefrontal cortex phospholipids containing docosahexaenoic acid increase during normal adult aging, whereas those containing arachidonic acid decrease. 2015 Neurobiol. Aging pmid:25676385
Talvas J et al. Immunonutrition stimulates immune functions and antioxidant defense capacities of leukocytes in radiochemotherapy-treated head & neck and esophageal cancer patients: A double-blind randomized clinical trial. 2015 Clin Nutr pmid:25575640
Filipcikova R et al. Lycopene improves the distorted ratio between AA/DHA in the seminal plasma of infertile males and increases the likelihood of successful pregnancy. 2015 Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub pmid:23446211
Li R et al. Enzymatic Synthesis of Refined Olive Oil-Based Structured Lipid Containing Omega -3 and -6 Fatty Acids for Potential Application in Infant Formula. 2015 J. Food Sci. pmid:26408984
Wendell SG et al. 15-Hydroxyprostaglandin dehydrogenase generation of electrophilic lipid signaling mediators from hydroxy ω-3 fatty acids. 2015 J. Biol. Chem. pmid:25586183
Maciejewska D et al. Fatty acid changes help to better understand regression of nonalcoholic fatty liver disease. 2015 World J. Gastroenterol. pmid:25574105
Chen CT et al. Plasma non-esterified docosahexaenoic acid is the major pool supplying the brain. 2015 Sci Rep pmid:26511533
Linhartova P and Sampels S Combined incubation of cadmium, docosahexaenoic and eicosapentaenoic acid results in increased uptake of cadmium and elevated docosapentaenoic acid content in hepatocytes in vitro. 2015 Lipids Health Dis pmid:26627047
Holen E et al. Combining eicosapentaenoic acid, decosahexaenoic acid and arachidonic acid, using a fully crossed design, affect gene expression and eicosanoid secretion in salmon head kidney cells in vitro. 2015 Fish Shellfish Immunol. pmid:26003739
Park HG et al. The fatty acid desaturase 2 (FADS2) gene product catalyzes Δ4 desaturation to yield n-3 docosahexaenoic acid and n-6 docosapentaenoic acid in human cells. 2015 FASEB J. pmid:26065859
Lim JY et al. Biological Roles of Resolvins and Related Substances in the Resolution of Pain. 2015 Biomed Res Int pmid:26339646
Schwager J et al. ω-3 PUFAs and Resveratrol Differently Modulate Acute and Chronic Inflammatory Processes. 2015 Biomed Res Int pmid:26301248
Harrison JL et al. Resolvins AT-D1 and E1 differentially impact functional outcome, post-traumatic sleep, and microglial activation following diffuse brain injury in the mouse. 2015 Brain Behav. Immun. pmid:25585137
Katakura M et al. Chronic Arachidonic Acid Administration Decreases Docosahexaenoic Acid- and Eicosapentaenoic Acid-Derived Metabolites in Kidneys of Aged Rats. 2015 PLoS ONE pmid:26485038
Brigandi SA et al. Autistic children exhibit decreased levels of essential Fatty acids in red blood cells. 2015 Int J Mol Sci pmid:25946342
Chew EY et al. Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical Trial. 2015 JAMA pmid:26305649
Ross AB et al. Herring and Beef Meals Lead to Differences in Plasma 2-Aminoadipic Acid, β-Alanine, 4-Hydroxyproline, Cetoleic Acid, and Docosahexaenoic Acid Concentrations in Overweight Men. 2015 J. Nutr. pmid:26400963
Ossani GP et al. Short-term menhaden oil rich diet changes renal lipid profile in acute kidney injury. 2015 J Oleo Sci pmid:25948137
Zgorzynska E et al. Docosahexaenoic acid attenuates oxidative stress and protects human gingival fibroblasts against cytotoxicity induced by hydrogen peroxide and butyric acid. 2015 Arch. Oral Biol. pmid:25455128
Honda KL et al. Docosahexaenoic acid differentially affects TNFα and IL-6 expression in LPS-stimulated RAW 264.7 murine macrophages. 2015 Prostaglandins Leukot. Essent. Fatty Acids pmid:25921297
Yang S et al. Effect of thermal processing on astaxanthin and astaxanthin esters in pacific white shrimp Litopenaeus vannamei. 2015 J Oleo Sci pmid:25757428
Cotogni P et al. The Omega-3 Fatty Acid Docosahexaenoic Acid Modulates Inflammatory Mediator Release in Human Alveolar Cells Exposed to Bronchoalveolar Lavage Fluid of ARDS Patients. 2015 Biomed Res Int pmid:26301250
Dodington DW et al. Higher Intakes of Fruits and Vegetables, β-Carotene, Vitamin C, α-Tocopherol, EPA, and DHA Are Positively Associated with Periodontal Healing after Nonsurgical Periodontal Therapy in Nonsmokers but Not in Smokers. 2015 J. Nutr. pmid:26423734
Bobiński R and Mikulska M The ins and outs of maternal-fetal fatty acid metabolism. 2015 Acta Biochim. Pol. pmid:26345097
Hieda K et al. Pharmacological effect of functional foods with a hypotensive action. 2015 Nippon Yakurigaku Zasshi pmid:26165340
Mason JK et al. α-linolenic acid and docosahexaenoic acid, alone and combined with trastuzumab, reduce HER2-overexpressing breast cancer cell growth but differentially regulate HER2 signaling pathways. 2015 Lipids Health Dis pmid:26282560
Esmaeili V et al. Dietary fatty acids affect semen quality: a review. 2015 Andrology pmid:25951427
Domenichiello AF et al. Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain? 2015 Prog. Lipid Res. pmid:25920364
Kawakami Y et al. Flaxseed oil intake reduces serum small dense low-density lipoprotein concentrations in Japanese men: a randomized, double blind, crossover study. 2015 Nutr J pmid:25896182