| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Pain | D010146 | 64 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Khalfoun B et al. | Docosahexaenoic and eicosapentaenoic acids inhibit the CD28-lymphocyte activation pathway in vitro. | 1998 | Transplant. Proc. | pmid:9865267 |
| Begum G et al. | ER stress and effects of DHA as an ER stress inhibitor. | 2013 | Transl Stroke Res | pmid:24323417 |
| Nordgren TM et al. | Maresin-1 reduces airway inflammation associated with acute and repetitive exposures to organic dust. | 2015 | Transl Res | pmid:25655838 |
| Le-Niculescu H et al. | Convergent functional genomic studies of ω-3 fatty acids in stress reactivity, bipolar disorder and alcoholism. | 2011 | Transl Psychiatry | pmid:22832392 |
| Amminger GP et al. | Predictors of treatment response in young people at ultra-high risk for psychosis who received long-chain omega-3 fatty acids. | 2015 | Transl Psychiatry | pmid:25585167 |
| Zhu G et al. | A modified n-3 fatty acid desaturase gene from Caenorhabditis briggsae produced high proportion of DHA and DPA in transgenic mice. | 2008 | Transgenic Res. | pmid:18322818 |
| Truksa M et al. | Metabolic engineering of plants to produce very long-chain polyunsaturated fatty acids. | 2006 | Transgenic Res. | pmid:16604455 |
| Alimuddin G et al. | Enhancement of EPA and DHA biosynthesis by over-expression of masu salmon delta6-desaturase-like gene in zebrafish. | 2005 | Transgenic Res. | pmid:16022387 |
| Mancini I et al. | Fatty acid composition of common barbel (Barbus barbus) roe and evaluation of its haemolytic and cytotoxic activities. | 2011 | Toxicon | pmid:21510968 |
| Domingo JL et al. | Benefits and risks of fish consumption Part I. A quantitative analysis of the intake of omega-3 fatty acids and chemical contaminants. | 2007 | Toxicology | pmid:17161894 |
| Aspenström-Fagerlund B et al. | Oleic acid and docosahexaenoic acid cause an increase in the paracellular absorption of hydrophilic compounds in an experimental model of human absorptive enterocytes. | 2007 | Toxicology | pmid:17560003 |
| Balaji T et al. | Localization of cyclooxygenase-2 in mice vas deferens and its effects on fertility upon suppression using nimesulide: a preferential cyclooxygenase-2 inhibitor. | 2007 | Toxicology | pmid:17382448 |
| Kaur P et al. | Role of docosahexaenoic acid in modulating methylmercury-induced neurotoxicity. | 2007 | Toxicol. Sci. | pmid:17728287 |
| Kanno S et al. | Albumin modulates docosahexaenoic acid-induced cytotoxicity in human hepatocellular carcinoma cell lines. | 2011 | Toxicol. Lett. | pmid:21108996 |
| Qadhi R et al. | Differential responses to docosahexaenoic acid in primary and immortalized cardiac cells. | 2013 | Toxicol. Lett. | pmid:23523905 |
| Samokhvalov V et al. | PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. | 2015 | Toxicol. Lett. | pmid:25300478 |
| Nikolakopoulou Z et al. | The induction of apoptosis in pre-malignant keratinocytes by omega-3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) is inhibited by albumin. | 2013 | Toxicol. Lett. | pmid:23391486 |
| Chen J et al. | Aspirin-triggered resolvin D1 down-regulates inflammatory responses and protects against endotoxin-induced acute kidney injury. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24709673 |
| Li CC et al. | DHA down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes by attenuating CAR translocation. | 2007 | Toxicol. Appl. Pharmacol. | pmid:17904175 |
| Majkova Z et al. | Omega-3 fatty acid oxidation products prevent vascular endothelial cell activation by coplanar polychlorinated biphenyls. | 2011 | Toxicol. Appl. Pharmacol. | pmid:21130106 |
| Türkez H et al. | Ameliorative effect of docosahexaenoic acid on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced histological changes, oxidative stress, and DNA damage in rat liver. | 2012 | Toxicol Ind Health | pmid:21996711 |
| de Lima TM et al. | Docosahexaenoic acid enhances the toxic effect of imatinib on Bcr-Abl expressing HL-60 cells. | 2007 | Toxicol In Vitro | pmid:17604596 |
| Azevedo-Martins AK et al. | Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells. | 2006 | Toxicol In Vitro | pmid:16644178 |
| Blum JL et al. | Profiling of fatty acids released during calcium-induced mitochondrial permeability transition in isolated rabbit kidney cortex mitochondria. | 2011 | Toxicol In Vitro | pmid:21443943 |
| Morisaki N et al. | In vivo effects of cis-5,8,11,14,17-20:5 (n-3) and cis-4,7,10,13,16,19-22:6(n-3) on serum lipoproteins, platelet aggregation, and lipid metabolism in the aorta of rats. | 1983 | Tohoku J. Exp. Med. | pmid:6322383 |
| Munakata M et al. | The nutrient formula containing eicosapentaenoic acid and docosahexaenoic acid benefits the fatty acid status of patients receiving long-term enteral nutrition. | 2009 | Tohoku J. Exp. Med. | pmid:19155604 |
| Weil A | Why I still take my daily fish oil. | 2006 | Time | pmid:16827433 |
| Landmark K and Alm CS | [Fish and omega-3 fatty acids and heart failure]. | 2012 | Tidsskr. Nor. Laegeforen. | pmid:23736195 |
| Haines AP et al. | Effects of a fish oil supplement on platelet function, haemostatic variables and albuminuria in insulin-dependent diabetics. | 1986 | Thromb. Res. | pmid:3020732 |
| Croft KD et al. | The effect of dietary fish oil on platelet metabolism of 14C arachidonic acid. | 1986 | Thromb. Res. | pmid:3705024 |
| Vreeken J et al. | Transient aggregation resistance of human blood platelets in fresh plasma. II. Physiological relevance: influence of fish oil. | 1989 | Thromb. Res. | pmid:2551059 |
| Lee KW et al. | Effects of omega-3 polyunsaturated fatty acids on plasma indices of thrombogenesis and inflammation in patients post-myocardial infarction. | 2006 | Thromb. Res. | pmid:16154181 |
| Prisco D et al. | Effect of medium-term supplementation with a moderate dose of n-3 polyunsaturated fatty acids on blood pressure in mild hypertensive patients. | 1998 | Thromb. Res. | pmid:9733153 |
| Umemura K et al. | Effect of dietary docosahexaenoic acid in the rat middle cerebral artery thrombosis model. | 1995 | Thromb. Res. | pmid:7660354 |
| Ishii H et al. | The effect of plasma on platelet function in hypercholesterolemic rabbits and the changes in fatty acid composition of the plasma. | 1984 | Thromb. Res. | pmid:6234679 |
| Pöschl JM et al. | Dietary docosahexaenoic acid improves red blood cell deformability in rats. | 1996 | Thromb. Res. | pmid:8822144 |
| Gaudette DC and Holub BJ | Effect of albumin-bound DHA on phosphoinositide phosphorylation in collagen stimulated human platelets. | 1990 | Thromb. Res. | pmid:2162088 |
| Mezzano D et al. | Cardiovascular risk factors in vegetarians. Normalization of hyperhomocysteinemia with vitamin B(12) and reduction of platelet aggregation with n-3 fatty acids. | 2000 | Thromb. Res. | pmid:11108902 |
| Andriamampandry MD et al. | Antithrombotic effects of (n-3) polyunsaturated fatty acids in rat models of arterial and venous thrombosis. | 1999 | Thromb. Res. | pmid:10065894 |
| Barcelli U et al. | Enhancing effect of dietary supplementation with omega-3 fatty acids on plasma fibrinolysis in normal subjects. | 1985 | Thromb. Res. | pmid:2996169 |
| Bruckner GG et al. | Biosynthesis of prostanoids, tissue fatty acid composition and thrombotic parameters in rats fed diets enriched with docosahexaenoic (22:6n3) or eicosapentaenoic (20:5n3) acids. | 1984 | Thromb. Res. | pmid:6330927 |
| Chen LY et al. | Reduction in human neutrophil superoxide anion generation by n-3 polyunsaturated fatty acids: role of cyclooxygenase products and endothelium-derived relaxing factor. | 1994 | Thromb. Res. | pmid:7871491 |
| Hansen J et al. | Dietary supplementation with highly purified eicosapentaenoic acid and docosahexaenoic acid does not influence PAI-1 activity. | 2000 | Thromb. Res. | pmid:10713313 |
| Eritsland J et al. | Effect of long-term, moderate-dose supplementation with omega-3 fatty acids on monocyte procoagulant activity and release of interleukin-6 in patients with coronary artery disease. | 1995 | Thromb. Res. | pmid:7740525 |
| Mundal HH et al. | The effect of N-3 fatty acids and nifedipine on platelet function in hypertensive males. | 1993 | Thromb. Res. | pmid:8303664 |
| Conquer JA et al. | Effect of supplementation with dietary seal oil on selected cardiovascular risk factors and hemostatic variables in healthy male subjects. | 1999 | Thromb. Res. | pmid:10588467 |
| Croset M and Lagarde M | In vitro incorporation and metabolism of icosapentaenoic and docosahexaenoic acids in human platelets--effect on aggregation. | 1986 | Thromb. Haemost. | pmid:3022414 |
| Polette A et al. | N-3 fatty acid-induced lipid peroxidation in human platelets is prevented by catechins. | 1996 | Thromb. Haemost. | pmid:8822591 |
| Larson MK et al. | Effects of omega-3 acid ethyl esters and aspirin, alone and in combination, on platelet function in healthy subjects. | 2008 | Thromb. Haemost. | pmid:18841286 |
| Véricel E et al. | Moderate oral supplementation with docosahexaenoic acid improves platelet function and oxidative stress in type 2 diabetic patients. | 2015 | Thromb. Haemost. | pmid:25832443 |
| Del Turco S et al. | Parallel decrease of tissue factor surface exposure and increase of tissue factor microparticle release by the n-3 fatty acid docosahexaenoate in endothelial cells. | 2007 | Thromb. Haemost. | pmid:17598015 |
| Arm JP et al. | Effect of dietary supplementation with fish oil lipids on mild asthma. | 1988 | Thorax | pmid:3353893 |
| Picado C et al. | Effects of a fish oil enriched diet on aspirin intolerant asthmatic patients: a pilot study. | 1988 | Thorax | pmid:3353894 |
| Maldjian A et al. | Changes in sperm quality and lipid composition during cryopreservation of boar semen. | 2005 | Theriogenology | pmid:15626408 |
| Mitre R et al. | Oral intake of shark liver oil modifies lipid composition and improves motility and velocity of boar sperm. | 2004 | Theriogenology | pmid:15451263 |
| Cerolini S et al. | Effect of docosahexaenoic acid and alpha-tocopherol enrichment in chicken sperm on semen quality, sperm lipid composition and susceptibility to peroxidation. | 2006 | Theriogenology | pmid:16530814 |
| Brinsko SP et al. | Effect of feeding a DHA-enriched nutriceutical on the quality of fresh, cooled and frozen stallion semen. | 2005 | Theriogenology | pmid:15725455 |
| Gholami H et al. | Effect of feeding a docosahexaenoic acid-enriched nutriceutical on the quality of fresh and frozen-thawed semen in Holstein bulls. | 2010 | Theriogenology | pmid:20708237 |
| Gliozzi TM et al. | Quality and lipid composition of spermatozoa in rabbits fed DHA and vitamin E rich diets. | 2009 | Theriogenology | pmid:19121864 |
| Am-in N et al. | Lipid profiles of sperm and seminal plasma from boars having normal or low sperm motility. | 2011 | Theriogenology | pmid:21167582 |
| Arita M and Serhan CN | [Novel chemical mediators in the resolution of inflammation]. | 2007 | Tanpakushitsu Kakusan Koso | pmid:17419455 |
| Hsu K | Long-chain polyunsaturated fatty acids as anti-HIV supplementation during breastfeeding. | 2009 | Taiwan J Obstet Gynecol | pmid:19346195 |
| Young C et al. | Docosahexaenoic acid inhibits synaptic transmission and epileptiform activity in the rat hippocampus. | 2000 | Synapse | pmid:10881029 |
| Nakamura M et al. | Optimal dose of preoperative enteral immunonutrition for patients with esophageal cancer. | 2009 | Surg. Today | pmid:19784723 |
| Liu X et al. | Amide-type adduct of dopamine - plausible cause of Parkinson diseases. | 2014 | Subcell. Biochem. | pmid:24374917 |
| Green D et al. | A double-blind, placebo-controlled trial of fish oil concentrate (MaxEpa) in stroke patients. | 1985 Jul-Aug | Stroke | pmid:3895595 |
| Sekikawa A et al. | Differential association of docosahexaenoic and eicosapentaenoic acids with carotid intima-media thickness. | 2011 | Stroke | pmid:21757663 |
| Belayev L et al. | Docosahexaenoic acid complexed to albumin elicits high-grade ischemic neuroprotection. | 2005 | Stroke | pmid:15569878 |
| Belayev L et al. | Robust docosahexaenoic acid-mediated neuroprotection in a rat model of transient, focal cerebral ischemia. | 2009 | Stroke | pmid:19542051 |
| Lalancette-Hébert M et al. | Accumulation of dietary docosahexaenoic acid in the brain attenuates acute immune response and development of postischemic neuronal damage. | 2011 | Stroke | pmid:21852616 |
| Imre SG et al. | Increased proportion of docosahexanoic acid and high lipid peroxidation capacity in erythrocytes of stroke patients. | 1994 | Stroke | pmid:7974583 |
| Nury T et al. | Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7β-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of α-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3). | 2015 | Steroids | pmid:25683890 |
| Ramaprasad TR et al. | Spray-dried milk supplemented with alpha-linolenic acid or eicosapentaenoic acid and docosahexaenoic acid decreases HMG Co A reductase activity and increases biliary secretion of lipids in rats. | 2006 | Steroids | pmid:16499938 |
| Tian H et al. | 14S,21R-dihydroxy-docosahexaenoic acid treatment enhances mesenchymal stem cell amelioration of renal ischemia/reperfusion injury. | 2012 | Stem Cells Dev. | pmid:21846180 |
| Gajewski BJ et al. | Predicting accrual in clinical trials with Bayesian posterior predictive distributions. | 2008 | Stat Med | pmid:17979152 |
| Mohajeri S and Newman SA | Review of evidence for dietary influences on atopic dermatitis. | 2014 Jul-Aug | Skin Therapy Lett. | pmid:25188523 |
| Wang Y et al. | Maresin 1 Inhibits Epithelial-to-Mesenchymal Transition in Vitro and Attenuates Bleomycin Induced Lung Fibrosis in Vivo. | 2015 | Shock | pmid:26196843 |
| Feng Y et al. | [Progress in metabolic mechanism of docosahexenoic acid production by fermentation]. | 2010 | Sheng Wu Gong Cheng Xue Bao | pmid:21141112 |
| Qian J et al. | [Technology investigation of extracting fish oil by enzymolysising ocean wild fish]. | 2008 | Sheng Wu Gong Cheng Xue Bao | pmid:18807986 |
| Li HX and Yang GS | [Effects of docosahexaenoic acid on rat adipocytes proliferation and differentiation]. | 2005 | Sheng Wu Gong Cheng Xue Bao | pmid:16285532 |
| Liu YJ | [Biological activity and mechanism of action of eicosapentaenic acid and docosahexaenoic acid from fish oil]. | 1987 | Sheng Li Ke Xue Jin Zhan | pmid:2823380 |
| Goodnight SH | Effects of dietary fish oil and omega-3 fatty acids on platelets and blood vessels. | 1988 | Semin. Thromb. Hemost. | pmid:2845585 |
| McEwen BJ et al. | Effects of omega-3 polyunsaturated fatty acids on platelet function in healthy subjects and subjects with cardiovascular disease. | 2013 | Semin. Thromb. Hemost. | pmid:23329646 |
| Tam VC | Lipidomic profiling of bioactive lipids by mass spectrometry during microbial infections. | 2013 | Semin. Immunol. | pmid:24084369 |
| Carlson SE | Docosahexaenoic acid and arachidonic acid in infant development. | 2001 | Semin Neonatol | pmid:11988033 |
| Lee HN et al. | Resolution of inflammation as a novel chemopreventive strategy. | 2013 | Semin Immunopathol | pmid:23370700 |
| Ozawa H | [Omega-3 polyunsaturated fatty acids and mental disorders]. | 2009 | Seishin Shinkeigaku Zasshi | pmid:20344875 |
| Ozawa H | [Mood disorders and omega 3 polyunsaturated fatty acids]. | 2009 | Seishin Shinkeigaku Zasshi | pmid:20344877 |
| Nakagome K et al. | [Clinical application of omega 3 polyunsaturated fatty acids in psychiatry]. | 2009 | Seishin Shinkeigaku Zasshi | pmid:20344878 |
| Hamazaki T et al. | [Emotion and omega 3 polyunsaturated fatty acids]. | 2009 | Seishin Shinkeigaku Zasshi | pmid:20344879 |
| Matsuoka Y and Nishi D | [Possible use of omega 3 polyunsaturated fatty acids for prevention of PTSD]. | 2009 | Seishin Shinkeigaku Zasshi | pmid:20344880 |
| Yoshikawa T | [Schizophrenia and omega 3 polyunsaturated fatty acids]. | 2009 | Seishin Shinkeigaku Zasshi | pmid:20344881 |
| Yui K et al. | [Effects of arachidonic acids on social behavior in patients with autism spectrum disorders]. | 2009 | Seishin Shinkeigaku Zasshi | pmid:20217968 |
| Arita M and Isobe Y | [Structure and function of anti-inflammatory lipid mediators derived from omega-3 polyunsaturated fatty acids]. | 2008 | Seikagaku | pmid:19086412 |
| Masuzawa Y | [The mysteries of docosahexaenoic acid--possible functions of C22 polyenoic fatty acids]. | 1988 | Seikagaku | pmid:2976795 |
| Zhang Q and Ma Y | [Determination of EPA and DHA in marine microalgaes by GC]. | 2004 | Se Pu | pmid:15807130 |
| Lu J et al. | [Analysis of fatty acids in tissues of Penaeus vannamei cultured in sea- and fresh-waters by ultrasonic extraction-capillary gas chromatography]. | 2005 | Se Pu | pmid:16013568 |
| Seki H et al. | Resolvins as regulators of the immune system. | 2010 | ScientificWorldJournal | pmid:20454764 |
| Börgeson E and Godson C | Molecular circuits of resolution in renal disease. | 2010 | ScientificWorldJournal | pmid:20623097 |
| Carlo T and Levy BD | Molecular circuits of resolution in airway inflammation. | 2010 | ScientificWorldJournal | pmid:20623098 |