DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Berge RK et al. In contrast with docosahexaenoic acid, eicosapentaenoic acid and hypolipidaemic derivatives decrease hepatic synthesis and secretion of triacylglycerol by decreased diacylglycerol acyltransferase activity and stimulation of fatty acid oxidation. 1999 Biochem. J. pmid:10493929
Gee JM et al. Consumption of fish oil leads to prompt incorporation of eicosapentaenoic acid into colonic mucosa of patients prior to surgery for colorectal cancer, but has no detectable effect on epithelial cytokinetics. 1999 J. Nutr. pmid:10498759
Cunnane SC et al. Docosahexaenoate requirement and infant development. 1999 Nutrition pmid:10501301
Clandinin MT et al. Assessment of feeding different amounts of arachidonic and docosahexaenoic acids in preterm infant formulas on the fatty acid content of lipoprotein lipids. 1999 Acta Paediatr. pmid:10503691
Jørgensen MH et al. The role of long-chain polyunsaturated fatty acids in neonatal nutrition. 1999 Acta Paediatr. pmid:10503696
Lemaitre-Delaunay D et al. Blood compartmental metabolism of docosahexaenoic acid (DHA) in humans after ingestion of a single dose of [(13)C]DHA in phosphatidylcholine. 1999 J. Lipid Res. pmid:10508206
Morris SA et al. Developmental sensitivity of the piglet brain to docosahexanoic acid. 1999 Pediatr. Res. pmid:10509359
Pakala R et al. Eicosapentaenoic acid and docosahexaenoic acid block serotonin-induced smooth muscle cell proliferation. 1999 Arterioscler. Thromb. Vasc. Biol. pmid:10521359
Nguyen KA et al. The PPAR activator docosahexaenoic acid prevents acetaminophen hepatotoxicity in male CD-1 mice. 1999 J. Toxicol. Environ. Health Part A pmid:10522648
Véricel E et al. The influence of low intake of n-3 fatty acids on platelets in elderly people. 1999 Atherosclerosis pmid:10525140
Conquer JA et al. Fatty acid analysis of blood serum, seminal plasma, and spermatozoa of normozoospermic vs. asthenozoospermic males. 1999 Lipids pmid:10529089
Desvergne B and Wahli W Peroxisome proliferator-activated receptors: nuclear control of metabolism. 1999 Endocr. Rev. pmid:10529898
Ku K et al. Beneficial effects of omega-3 fatty acid treatment on the recovery of cardiac function after cold storage of hyperlipidemic rats. 1999 Metab. Clin. Exp. pmid:10535379
Rose DP and Connolly JM Antiangiogenicity of docosahexaenoic acid and its role in the suppression of breast cancer cell growth in nude mice. 1999 Int. J. Oncol. pmid:10536186
Xiao Y and Li X Polyunsaturated fatty acids modify mouse hippocampal neuronal excitability during excitotoxic or convulsant stimulation. 1999 Brain Res. pmid:10536218
Franklin ST et al. Dietary marine algae (Schizochytrium sp.) increases concentrations of conjugated linoleic, docosahexaenoic and transvaccenic acids in milk of dairy cows. 1999 J. Nutr. pmid:10539783
Zaouali-Ajina M et al. Dietary docosahexaenoic acid-enriched phospholipids normalize urinary melatonin excretion in adult (n-3) polyunsaturated fatty acid-deficient rats. 1999 J. Nutr. pmid:10539787
de la Presa Owens S and Innis SM Docosahexaenoic and arachidonic acid prevent a decrease in dopaminergic and serotoninergic neurotransmitters in frontal cortex caused by a linoleic and alpha-linolenic acid deficient diet in formula-fed piglets. 1999 J. Nutr. pmid:10539789
Huang C and Li S Calorimetric and molecular mechanics studies of the thermotropic phase behavior of membrane phospholipids. 1999 Biochim. Biophys. Acta pmid:10548720
Senanayake SP and Shahidi F Enzyme-assisted acidolysis of borage (Borago officinalis L.) and evening primrose (Oenothera biennis L.) oils: incorporation of omega-3 polyunsaturated fatty acids. 1999 J. Agric. Food Chem. pmid:10552616
Bakker EC et al. Early nutrition, essential fatty acid status and visual acuity of term infants at 7 months of age. 1999 Eur J Clin Nutr pmid:10557000
Elmore JS et al. Effect of the polyunsaturated fatty acid composition of beef muscle on the profile of aroma volatiles. 1999 J. Agric. Food Chem. pmid:10564028
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Agostoni C et al. Long-chain polyunsaturated fatty acids in human milk. 1999 Acta Paediatr Suppl pmid:10569226
Freedman SD et al. A membrane lipid imbalance plays a role in the phenotypic expression of cystic fibrosis in cftr(-/-) mice. 1999 Proc. Natl. Acad. Sci. U.S.A. pmid:10570187
Madsen L et al. Eicosapentaenoic and docosahexaenoic acid affect mitochondrial and peroxisomal fatty acid oxidation in relation to substrate preference. 1999 Lipids pmid:10574660
Yoshida H et al. Effect of dietary seal and fish oils on triacylglycerol metabolism in rats. 1999 J. Nutr. Sci. Vitaminol. pmid:10575632
Bisogno T et al. Biosynthesis and inactivation of N-arachidonoylethanolamine (anandamide) and N-docosahexaenoylethanolamine in bovine retina. 1999 Arch. Biochem. Biophys. pmid:10577359
Jørgensen MH et al. Does human milk DHA level affect functional outcome in infants? 1999 J Hum Lact pmid:10578769
Samples BL et al. Polyunsaturated fatty acids enhance the heat induced stress response in rainbow trout (Oncorhynchus mykiss) leukocytes. 1999 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:10582313
Norrish AE et al. Prostate cancer risk and consumption of fish oils: a dietary biomarker-based case-control study. 1999 Br. J. Cancer pmid:10584888
Conquer JA et al. Effect of supplementation with dietary seal oil on selected cardiovascular risk factors and hemostatic variables in healthy male subjects. 1999 Thromb. Res. pmid:10588467
Levy R and Herzberg GR Hydrolysis of long-chain, n-3 fatty acid enriched chylomicrons by cardiac lipoprotein lipase. 1999 Can. J. Physiol. Pharmacol. pmid:10588486
Senkal M et al. Outcome and cost-effectiveness of perioperative enteral immunonutrition in patients undergoing elective upper gastrointestinal tract surgery: a prospective randomized study. 1999 Arch Surg pmid:10593328
LeVine SM et al. Microchemical analysis of retina layers in pigmented and albino rats by Fourier transform infrared microspectroscopy. 1999 Biochim. Biophys. Acta pmid:10594378
Kageyama K et al. Cytotoxicity of docosahexaenoic acid and eicosapentaenoic acid in tumor cells and the dependence on binding to serum proteins and incorporation into intracellular lipids. 2000 Jan-Feb Oncol. Rep. pmid:10601596
Miyazaki M et al. Dietary docosahexaenoic acid ameliorates, but rapeseed oil and safflower oil accelerate renal injury in stroke-prone spontaneously hypertensive rats as compared with soybean oil, which is associated with expression for renal transforming growth factor-beta, fibronectin and renin. 2000 Biochim. Biophys. Acta pmid:10601699
Retterstøl K et al. The pathway from arachidonic to docosapentaenoic acid (20:4n-6 to 22:5n-6) and from eicosapentaenoic to docosahexaenoic acid (20:5n-3 to 22:6n-3) studied in testicular cells from immature rats. 2000 Biochim. Biophys. Acta pmid:10601701
Nitsan Z et al. Enrichment of poultry products with omega3 fatty acids by dietary supplementation with the alga Nannochloropsis and mantur oil. 1999 J. Agric. Food Chem. pmid:10606584
McGahon BM et al. Age-related changes in synaptic function: analysis of the effect of dietary supplementation with omega-3 fatty acids. 1999 Neuroscience pmid:10613520
Ghebremeskel K et al. Maternal diet high in fat reduces docosahexaenoic acid in liver lipids of newborn and sucking rat pups. 1999 Br. J. Nutr. pmid:10615212
Makrides M et al. A critical appraisal of the role of dietary long-chain polyunsaturated fatty acids on neural indices of term infants: a randomized, controlled trial. 2000 Pediatrics pmid:10617701
Tolley EA and Carlson SE Considerations of statistical power in infant studies of visual acuity development and docosahexaenoic acid status. 2000 Am. J. Clin. Nutr. pmid:10617938
Connor SL et al. Cheek cell phospholipids in human infants: a marker of docosahexaenoic and arachidonic acids in the diet, plasma, and red blood cells. 2000 Am. J. Clin. Nutr. pmid:10617942
Connor WE Importance of n-3 fatty acids in health and disease. 2000 Am. J. Clin. Nutr. pmid:10617967
Innis SM Essential fatty acids in infant nutrition: lessons and limitations from animal studies in relation to studies on infant fatty acid requirements. 2000 Am. J. Clin. Nutr. pmid:10617978
Neuringer M Infant vision and retinal function in studies of dietary long-chain polyunsaturated fatty acids: methods, results, and implications. 2000 Am. J. Clin. Nutr. pmid:10617981
Carlson SE Behavioral methods used in the study of long-chain polyunsaturated fatty acid nutrition in primate infants. 2000 Am. J. Clin. Nutr. pmid:10617982
Crawford M Placental delivery of arachidonic and docosahexaenoic acids: implications for the lipid nutrition of preterm infants. 2000 Am. J. Clin. Nutr. pmid:10617983
Al MD et al. Long-chain polyunsaturated fatty acids, pregnancy, and pregnancy outcome. 2000 Am. J. Clin. Nutr. pmid:10617984
Jensen CL et al. Effect of docosahexaenoic acid supplementation of lactating women on the fatty acid composition of breast milk lipids and maternal and infant plasma phospholipids. 2000 Am. J. Clin. Nutr. pmid:10617985
Makrides M and Gibson RA Long-chain polyunsaturated fatty acid requirements during pregnancy and lactation. 2000 Am. J. Clin. Nutr. pmid:10617987
Auestad N and Innis SM Dietary n-3 fatty acid restriction during gestation in rats: neuronal cell body and growth-cone fatty acids. 2000 Am. J. Clin. Nutr. pmid:10617988
Dutta-Roy AK Transport mechanisms for long-chain polyunsaturated fatty acids in the human placenta. 2000 Am. J. Clin. Nutr. pmid:10617989
Stordy BJ Dark adaptation, motor skills, docosahexaenoic acid, and dyslexia. 2000 Am. J. Clin. Nutr. pmid:10617990
Burgess JR et al. Long-chain polyunsaturated fatty acids in children with attention-deficit hyperactivity disorder. 2000 Am. J. Clin. Nutr. pmid:10617991
James MJ et al. Dietary polyunsaturated fatty acids and inflammatory mediator production. 2000 Am. J. Clin. Nutr. pmid:10617994
Kremer JM n-3 fatty acid supplements in rheumatoid arthritis. 2000 Am. J. Clin. Nutr. pmid:10617995
Hughes DA and Pinder AC n-3 polyunsaturated fatty acids inhibit the antigen-presenting function of human monocytes. 2000 Am. J. Clin. Nutr. pmid:10617997
Ziboh VA et al. Metabolism of polyunsaturated fatty acids by skin epidermal enzymes: generation of antiinflammatory and antiproliferative metabolites. 2000 Am. J. Clin. Nutr. pmid:10617998
Donadio JV Use of fish oil to treat patients with immunoglobulin a nephropathy. 2000 Am. J. Clin. Nutr. pmid:10618000
Martínez M et al. Therapeutic effects of docosahexaenoic acid ethyl ester in patients with generalized peroxisomal disorders. 2000 Am. J. Clin. Nutr. pmid:10618001
Gibson RA Long-chain polyunsaturated fatty acids and infant development. 1999 Lancet pmid:10622289
Lucas A et al. Efficacy and safety of long-chain polyunsaturated fatty acid supplementation of infant-formula milk: a randomised trial. 1999 Lancet pmid:10622297
Connolly JM et al. Effects of reduced dietary linoleic acid intake, alone or combined with an algal source of docosahexaenoic acid, on MDA-MB-231 breast cancer cell growth and apoptosis in nude mice. 1999 Nutr Cancer pmid:10624705
Diep QN et al. Endothelin-1 attenuates omega3 fatty acid-induced apoptosis by inhibition of caspase 3. 2000 Hypertension pmid:10642312
Greener M Fatty acid imbalance might lead to novel treatments for CF. 2000 Mol Med Today pmid:10652475
Hashimoto M et al. Effects of eicosapentaenoic acid and docosahexaenoic acid on plasma membrane fluidity of aortic endothelial cells. 1999 Lipids pmid:10652989
Devlin AM and Innis SM Dietary phospholipid alters biliary lipid composition in formula-fed piglets. 1999 Lipids pmid:10652991
Polette A et al. Synthesis of acetyl,docosahexaenoyl-glycerophosphocholine and its characterization using nuclear magnetic resonance. 1999 Lipids pmid:10652994
Janssen A et al. Docosahexaenoic acid deficit is not a major pathogenic factor in peroxisome-deficient mice. 2000 Lab. Invest. pmid:10653000
Lapillonne A et al. Erythrocyte fatty acid composition in term infants fed human milk or a formula enriched with a low eicosapentanoic acid fish oil for 4 months. 2000 Jan-Feb Eur. J. Pediatr. pmid:10653329
Cunnane S Modelling human infant requirements for long-chain polyunsaturated fatty acids. 1999 Br. J. Nutr. pmid:10655962
Wensing AG et al. Effects of dietary n-3 polyunsaturated fatty acids from plant and marine origin on platelet aggregation in healthy elderly subjects. 1999 Br. J. Nutr. pmid:10655965
Cunnane SC and Francescutti V Fatty acid profiles of maternal adipose tissue in relation to infant development. 1999 Br. J. Nutr. pmid:10655972
Ollero M et al. Variation of docosahexaenoic acid content in subsets of human spermatozoa at different stages of maturation: implications for sperm lipoperoxidative damage. 2000 Mol. Reprod. Dev. pmid:10657052
Calabresi L et al. Omacor in familial combined hyperlipidemia: effects on lipids and low density lipoprotein subclasses. 2000 Atherosclerosis pmid:10657575
Shikano M et al. Inhibition of protein tyrosine kinase activity by 1a-docosahexaenoyl mitomycin C. 1999 Ann. N. Y. Acad. Sci. pmid:10667236
Moore SA et al. Regulation of cerebrovascular cyclooxygenase-2 by pro- and anti-inflammatory cytokines. 1999 Adv. Exp. Med. Biol. pmid:10667320
Morrow JD et al. Formation of novel isoprostane-like compounds from docosahexaenoic acid. 1999 Adv. Exp. Med. Biol. pmid:10667351
Stillwell W et al. Detection of lipid domains in docasahexaenoic acid-rich bilayers by acyl chain-specific FRET probes. 2000 Chem. Phys. Lipids pmid:10669305
Engler MM et al. The effects of a diet rich in docosahexaenoic acid on organ and vascular fatty acid composition in spontaneously hypertensive rats. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10670690
Larqué E et al. Dietary trans fatty acids affect docosahexaenoic acid concentrations in plasma and liver but not brain of pregnant and fetal rats. 2000 Pediatr. Res. pmid:10674359
Calviello G et al. n-3 PUFA dietary supplementation inhibits proliferation and store-operated calcium influx in thymoma cells growing in Balb/c mice. 2000 J. Lipid Res. pmid:10681400
Bonin A and Khan NA Regulation of calcium signalling by docosahexaenoic acid in human T-cells. Implication of CRAC channels. 2000 J. Lipid Res. pmid:10681412
Infante JP and Huszagh VA Secondary carnitine deficiency and impaired docosahexaenoic (22:6n-3) acid synthesis: a common denominator in the pathophysiology of diseases of oxidative phosphorylation and beta-oxidation. 2000 FEBS Lett. pmid:10683429
Sawazaki S et al. The effect of docosahexaenoic acid on plasma catecholamine concentrations and glucose tolerance during long-lasting psychological stress: a double-blind placebo-controlled study. 1999 J. Nutr. Sci. Vitaminol. pmid:10683816
Arterburn LM et al. A combined subchronic (90-day) toxicity and neurotoxicity study of a single-cell source of docosahexaenoic acid triglyceride (DHASCO oil). 2000 Food Chem. Toxicol. pmid:10685012
Watanabe T and Kuroda Y The effect of a newly developed ointment containing eicosapentaenoic acid and docosahexaenoic acid in the treatment of atopic dermatitis. 1999 J. Med. Invest. pmid:10687312
Zuijdgeest-van Leeuwen SD et al. Incorporation and washout of orally administered n-3 fatty acid ethyl esters in different plasma lipid fractions. 1999 Br. J. Nutr. pmid:10690163
Reich EE et al. Formation of novel D-ring and E-ring isoprostane-like compounds (D4/E4-neuroprostanes) in vivo from docosahexaenoic acid. 2000 Biochemistry pmid:10694406
Ghebremeskel K et al. Arachidonic and docosahexaenoic acids are strongly associated in maternal and neonatal blood. 2000 Eur J Clin Nutr pmid:10694772
Tomobe YI et al. Dietary docosahexaenoic acid suppresses inflammation and immunoresponses in contact hypersensitivity reaction in mice. 2000 Lipids pmid:10695925
Baur LA et al. Relationships between the fatty acid composition of muscle and erythrocyte membrane phospholipid in young children and the effect of type of infant feeding. 2000 Lipids pmid:10695927
Cunnane SC et al. Breast-fed infants achieve a higher rate of brain and whole body docosahexaenoate accumulation than formula-fed infants not consuming dietary docosahexaenoate. 2000 Lipids pmid:10695931
Negretti N et al. Inhibition of sarcoplasmic reticulum function by polyunsaturated fatty acids in intact, isolated myocytes from rat ventricular muscle. 2000 J. Physiol. (Lond.) pmid:10699081
Volker DH et al. The eicosapentaenoic to docosahexaenoic acid ratio of diets affects the pathogenesis of arthritis in Lew/SSN rats. 2000 J. Nutr. pmid:10702585
Wang L et al. Comparison of the fatty acid composition of total lipids and phospholipids in breast milk from Japanese women. 2000 Pediatr Int pmid:10703228
Yamashita K et al. Sesamin and alpha-tocopherol synergistically suppress lipid-peroxide in rats fed a high docosahexaenoic acid diet. 2000 Biofactors pmid:10705949
Berge RK et al. Hypolipidemic 3-thia fatty acids. Fatty acid oxidation and ketogenesis in rat liver under proliferation of mitochondria and peroxisomes. 1999 Adv. Exp. Med. Biol. pmid:10709636