| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Pain | D010146 | 64 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pakala R et al. | Thromboxane A2 fails to induce proliferation of smooth muscle cells enriched with eicosapentaenoic acid and docosahexaenoic acid. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10397410 |
| Kafrawy O et al. | Docosahexaenoic acid in phosphatidylcholine mediates cytotoxicity more effectively than other omega-3 and omega-6 fatty acids. | 1998 | Cancer Lett. | pmid:10397449 |
| Andersen LF et al. | Evaluation of a food frequency questionnaire with weighed records, fatty acids, and alpha-tocopherol in adipose tissue and serum. | 1999 | Am. J. Epidemiol. | pmid:10400557 |
| Calviello G et al. | Cell proliferation, differentiation, and apoptosis are modified by n-3 polyunsaturated fatty acids in normal colonic mucosa. | 1999 | Lipids | pmid:10405974 |
| Hamazaki T et al. | Administration of docosahexaenoic acid influences behavior and plasma catecholamine levels at times of psychological stress. | 1999 | Lipids | pmid:10419086 |
| Crawford MA et al. | Evidence for the unique function of docosahexaenoic acid during the evolution of the modern hominid brain. | 1999 | Lipids | pmid:10419087 |
| Birbes H et al. | Inhibition of Ca2+-independent phospholipase A2 affects arachidonate-, not docosahexaenoate-, phospholipid remodeling in U(III) cells. | 1999 | Lipids | pmid:10419092 |
| McLennan PL and Raederstorff D | Diabetes puts myocardial n-3 fatty acid status at risk in the absence of supplementation in the rat. | 1999 | Lipids | pmid:10419102 |
| Takahata K et al. | Protection from chemotherapy-induced alopecia by docosahexaenoic acid. | 1999 | Lipids | pmid:10419109 |
| Finstad HS et al. | Proliferation and types of killing of leukemia cell lines by very long chain polyunsaturated fatty acids. | 1999 | Lipids | pmid:10419110 |
| Bougnoux P et al. | Cytotoxic drug efficacy correlates with adipose tissue docosahexaenoic acid level in locally advanced breast carcinoma. | 1999 | Lipids | pmid:10419111 |
| Calviello G et al. | Effects of eicosapentaenoic and docosahexaenoic acids dietary supplementation on cell proliferation and apoptosis in rat colonic mucosa. | 1999 | Lipids | pmid:10419112 |
| Rotstein NP et al. | Essentiality of docosahexaenoic acid in retina photoreceptor cell development. | 1999 | Lipids | pmid:10419114 |
| Gilbert M et al. | Opposite regulation of prostaglandin H synthase isoforms by eicosapentaenoic and docosahexaenoic acids. | 1999 | Lipids | pmid:10419156 |
| Løchsen T et al. | Effects of fish oil and n-3 fatty acids on the regulation of delta9-fatty acid desaturase mRNA and -activity in rat liver. | 1999 | Lipids | pmid:10419157 |
| Jensen CL et al. | Effects of maternal docosahexaenoic acid supplementation on visual function and growth of breast-fed term infants. | 1999 | Lipids | pmid:10419159 |
| Otto SJ et al. | The postpartum docosahexaenoic acid status of lactating and nonlactating mothers. | 1999 | Lipids | pmid:10419160 |
| van Houwelingen AC et al. | The female docosahexaenoic acid status related to the number of completed pregnancies. | 1999 | Lipids | pmid:10419161 |
| Borod E et al. | Effects of third trimester consumption of eggs high in docosahexaenoic acid on docosahexaenoic acid status and pregnancy. | 1999 | Lipids | pmid:10419162 |
| Anderson RE et al. | A hypothesis to explain the reduced blood levels of docosahexaenoic acid in inherited retinal degenerations caused by mutations in genes encoding retina-specific proteins. | 1999 | Lipids | pmid:10419164 |
| Greiner RS et al. | Rats with low levels of brain docosahexaenoic acid show impaired performance in olfactory-based and spatial learning tasks. | 1999 | Lipids | pmid:10419165 |
| Kyle DJ et al. | Low serum docosahexaenoic acid is a significant risk factor for Alzheimer's dementia. | 1999 | Lipids | pmid:10419166 |
| Glozman S et al. | Ethyl docosahexaenoic acid administration during intrauterine life enhances prostanoid production and reduces free radicals generation in the fetal rat brain. | 1999 | Lipids | pmid:10419167 |
| Kim HY and Edsall L | The role of docosahexaenoic acid (22:6n-3) in neuronal signaling. | 1999 | Lipids | pmid:10419168 |
| Harris WS | n-3 fatty acids and human lipoprotein metabolism: an update. | 1999 | Lipids | pmid:10419172 |
| Howe PR et al. | Equal antithrombotic and triglyceride-lowering effectiveness of eicosapentaenoic acid-rich and docosahexaenoic acid-rich fish oil supplements. | 1999 | Lipids | pmid:10419186 |
| Horrocks LA and Yeo YK | Docosahexaenoic acid-enriched foods: production and effects on blood lipids. | 1999 | Lipids | pmid:10419189 |
| Terano T et al. | Docosahexaenoic acid supplementation improves the moderately severe dementia from thrombotic cerebrovascular diseases. | 1999 | Lipids | pmid:10419198 |
| Guesnet P et al. | Blood lipid concentrations of docosahexaenoic and arachidonic acids at birth determine their relative postnatal changes in term infants fed breast milk or formula. | 1999 | Am. J. Clin. Nutr. | pmid:10426708 |
| Pakala R et al. | Serotonin fails to induce proliferation of endothelial cells preloaded with eicosapentaenoic acid and docosahexaenoic acid. | 1999 | Atherosclerosis | pmid:10428304 |
| Gamoh S et al. | Chronic administration of docosahexaenoic acid improves reference memory-related learning ability in young rats. | 1999 | Neuroscience | pmid:10430487 |
| Singleton CB et al. | Blockade by N-3 polyunsaturated fatty acid of the Kv4.3 current stably expressed in Chinese hamster ovary cells. | 1999 | Br. J. Pharmacol. | pmid:10433502 |
| Rodriguez de Turco EB et al. | Selective retinal pigment epithelial cell lipid metabolism and remodeling conserves photoreceptor docosahexaenoic acid following phagocytosis. | 1999 | J. Neurosci. Res. | pmid:10440897 |
| de Deckere EA | Possible beneficial effect of fish and fish n-3 polyunsaturated fatty acids in breast and colorectal cancer. | 1999 | Eur. J. Cancer Prev. | pmid:10443950 |
| Kelley DS et al. | Docosahexaenoic acid ingestion inhibits natural killer cell activity and production of inflammatory mediators in young healthy men. | 1999 | Lipids | pmid:10443964 |
| Hoffman DR et al. | Fatty acid profile of buccal cheek cell phospholipids as an index for dietary intake of docosahexaenoic acid in preterm infants. | 1999 | Lipids | pmid:10443966 |
| Smuts CM et al. | Smoking and alcohol use during pregnancy affects preterm infants' docosahexaenoic acid (DHA) status. | 1999 | Acta Paediatr. | pmid:10447136 |
| Matsuyama N et al. | Polyunsaturated fatty acid anilides as inhibitors of acyl-coA: cholesterol acyltransferase (ACAT). | 1999 | Bioorg. Med. Chem. Lett. | pmid:10450977 |
| Mori TA et al. | Docosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans. | 1999 | Hypertension | pmid:10454450 |
| Helge JW et al. | Regular exercise modulates muscle membrane phospholipid profile in rats. | 1999 | J. Nutr. | pmid:10460197 |
| Foulon T et al. | Effects of fish oil fatty acids on plasma lipids and lipoproteins and oxidant-antioxidant imbalance in healthy subjects. | 1999 | Scand. J. Clin. Lab. Invest. | pmid:10463462 |
| Makrides M et al. | Dietary long-chain polyunsaturated fatty acids do not influence growth of term infants: A randomized clinical trial. | 1999 | Pediatrics | pmid:10469771 |
| Gilbert M et al. | Differential effects of long chain n-3 fatty acids on the expression of PGH synthase isoforms in bovine aortic endothelial cells. | 1999 May-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10471122 |
| Risé P and Galli C | Arachidonic and docosahexaenoic acids differentially affect the expression of fatty acyl-CoA oxidase, protein kinase C and lipid peroxidation in HepG2 cells. | 1999 May-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10471123 |
| Chen H et al. | Synthesis and release of docosahexaenoic acid by the RPE cells of prcd-affected dogs. | 1999 | Invest. Ophthalmol. Vis. Sci. | pmid:10476811 |
| Galli C | Health implications of DHA. | 1999 | Pharmacol. Res. | pmid:10479461 |
| Lagarde M | Health benefits of docosahexaenoic acid (DHA) | 1999 | Pharmacol. Res. | pmid:10479462 |
| Horrocks LA and Yeo YK | Health benefits of docosahexaenoic acid (DHA) | 1999 | Pharmacol. Res. | pmid:10479465 |
| Hishinuma T et al. | Effects of long-term supplementation of eicosapentanoic and docosahexanoic acid on the 2-, 3-series prostacyclin production by endothelial cells. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10480487 |
| Barber MD et al. | The effect of an oral nutritional supplement enriched with fish oil on weight-loss in patients with pancreatic cancer. | 1999 | Br. J. Cancer | pmid:10487616 |