| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Pain | D010146 | 64 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Suzuki A et al. | Enhanced colonic and rectal absorption of insulin using a multiple emulsion containing eicosapentaenoic acid and docosahexaenoic acid. | 1998 | J Pharm Sci | pmid:9758676 |
| Crabtree JT et al. | Differential distribution and metabolism of arachidonic acid and docosahexaenoic acid by human placental choriocarcinoma (BeWo) cells. | 1998 | Mol. Cell. Biochem. | pmid:9746226 |
| Decsi T et al. | Effects of dietary long-chain polyunsaturated fatty acids on plasma amino acids and indices of protein metabolism in infants: results from a randomized clinical trial. | 1998 | Ann. Nutr. Metab. | pmid:9745105 |
| Prisco D et al. | Effect of medium-term supplementation with a moderate dose of n-3 polyunsaturated fatty acids on blood pressure in mild hypertensive patients. | 1998 | Thromb. Res. | pmid:9733153 |
| Waldron MK et al. | Role of long-chain polyunsaturated n-3 fatty acids in the development of the nervous system of dogs and cats. | 1998 | J. Am. Vet. Med. Assoc. | pmid:9731252 |
| Kimura S et al. | Docosahexaenoic acid inhibits blood viscosity in stroke-prone spontaneously hypertensive rats. | 1998 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:9730013 |
| Birbes H et al. | Protein kinase C inhibitors stimulate arachidonic and docosahexaenoic acids release from uterine stromal cells through a Ca2+-independent pathway. | 1998 | FEBS Lett. | pmid:9720928 |
| Watkins SM et al. | Docosahexaenoic acid accumulates in cardiolipin and enhances HT-29 cell oxidant production. | 1998 | J. Lipid Res. | pmid:9717717 |
| Hibbeln JR et al. | A replication study of violent and nonviolent subjects: cerebrospinal fluid metabolites of serotonin and dopamine are predicted by plasma essential fatty acids. | 1998 | Biol. Psychiatry | pmid:9715355 |
| Hibbeln JR et al. | Essential fatty acids predict metabolites of serotonin and dopamine in cerebrospinal fluid among healthy control subjects, and early- and late-onset alcoholics. | 1998 | Biol. Psychiatry | pmid:9715354 |
| Hawkins RA et al. | Apoptotic death of pancreatic cancer cells induced by polyunsaturated fatty acids varies with double bond number and involves an oxidative mechanism. | 1998 | J. Pathol. | pmid:9713361 |
| Petroni A et al. | The beta-oxidation of arachidonic acid and the synthesis of docosahexaenoic acid are selectively and consistently altered in skin fibroblasts from three Zellweger patients versus X-adrenoleukodystrophy, Alzheimer and control subjects. | 1998 | Neurosci. Lett. | pmid:9708853 |
| Oudot F et al. | Polyunsaturated fatty acids influence prostanoid synthesis in vascular endothelial cells under hypoxia and reoxygenation. | 1998 | Int J Vitam Nutr Res | pmid:9706502 |
| Shikano M et al. | 1a-docosahexaenoyl mitomycin C: a novel inhibitor of protein tyrosine kinase. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9704018 |
| Birch EE et al. | Visual acuity and the essentiality of docosahexaenoic acid and arachidonic acid in the diet of term infants. | 1998 | Pediatr. Res. | pmid:9702915 |
| Campbell FM et al. | Placental membrane fatty acid-binding protein preferentially binds arachidonic and docosahexaenoic acids. | 1998 | Life Sci. | pmid:9698032 |
| Bell JG et al. | Growth, mortality, tissue histopathology and fatty acid compositions, eicosanoid production and response to stress, in juvenile turbot fed diets rich in gamma-linolenic acid in combination with eicosapentaenoic acid or docosahexaenoic acid. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9690713 |
| Ohinata H et al. | Effect of dietary docosahexaenoic acid on in vitro thermogenesis and fatty acid compositions of brown adipose tissue. | 1998 | Jpn. J. Physiol. | pmid:9689148 |
| Jarocka-Cyrta E et al. | Early dietary experience influences ontogeny of intestine in response to dietary lipid changes in later life. | 1998 | Am. J. Physiol. | pmid:9688652 |
| Hamazaki T et al. | Docosahexaenoic acid does not affect aggression of normal volunteers under nonstressful conditions. A randomized, placebo-controlled, double-blind study. | 1998 | Lipids | pmid:9688168 |
| de la Presa-Owens S et al. | Addition of triglycerides with arachidonic acid or docosahexaenoic acid to infant formula has tissue- and lipid class-specific effects on fatty acids and hepatic desaturase activities in formula-fed piglets. | 1998 | J. Nutr. | pmid:9687559 |
| Clandinin MT et al. | Docosahexaenoic acid increases thyroid-stimulating hormone concentration in male and adrenal corticotrophic hormone concentration in female weanling rats. | 1998 | J. Nutr. | pmid:9687541 |
| Infante JP and Huszagh VA | Analysis of the putative role of 24-carbon polyunsaturated fatty acids in the biosynthesis of docosapentaenoic (22:5n-6) and docosahexaenoic (22:6n-3) acids. | 1998 | FEBS Lett. | pmid:9684854 |
| Connor WE et al. | Uneven distribution of desmosterol and docosahexaenoic acid in the heads and tails of monkey sperm. | 1998 | J. Lipid Res. | pmid:9684743 |
| Nasa Y et al. | Long-term supplementation with eicosapentaenoic acid salvages cardiomyocytes from hypoxia/reoxygenation-induced injury in rats fed with fish-oil-deprived diet. | 1998 | Jpn. J. Pharmacol. | pmid:9681570 |
| Guarini P et al. | Effects of dietary fish oil and soy phosphatidylcholine on neutrophil fatty acid composition, superoxide release, and adhesion. | 1998 | Inflammation | pmid:9675609 |
| Martinez M and Vazquez E | MRI evidence that docosahexaenoic acid ethyl ester improves myelination in generalized peroxisomal disorders. | 1998 | Neurology | pmid:9674774 |
| Hagve TA et al. | Membrane fluidity and fatty acid metabolism in kidney cells from rats fed purified eicosapentaenoic acid or purified docosahexaenoic acid. | 1998 | Scand. J. Clin. Lab. Invest. | pmid:9670342 |
| Grimsgaard S et al. | Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on hemodynamics in humans. | 1998 | Am. J. Clin. Nutr. | pmid:9665096 |
| Hansen RA et al. | Duration of effects of dietary fish oil supplementation on serum eicosapentaenoic acid and docosahexaenoic acid concentrations in dogs. | 1998 | Am. J. Vet. Res. | pmid:9659553 |
| Young C et al. | Cancellation of low-frequency stimulation-induced long-term depression by docosahexaenoic acid in the rat hippocampus. | 1998 | Neurosci. Lett. | pmid:9655627 |
| Kelley DS et al. | Dietary docosahexaenoic acid and immunocompetence in young healthy men. | 1998 | Lipids | pmid:9655370 |
| Jolly CA et al. | Effect of dietary n-3 fatty acids on interleukin-2 and interleukin-2 receptor alpha expression in activated murine lymphocytes. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9654402 |
| Monia ZA et al. | Docosahexaenoic acid reduces both cyclic nucleotide and melatonin synthesis in rat pinealocytes. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9653768 |
| Edwards R et al. | Depletion of docosahexaenoic acid in red blood cell membranes of depressive patients. | 1998 | Biochem. Soc. Trans. | pmid:9649817 |
| Burdge GC | The role of docosahexaenoic acid in brain development and fetal alcohol syndrome. | 1998 | Biochem. Soc. Trans. | pmid:9649756 |
| Wright T et al. | Docosahexaenoic acid-enriched milk. | 1998 | World Rev Nutr Diet | pmid:9648512 |
| Kyle DJ and Arterburn LM | Single cell oil sources of docosahexaenoic acid: clinical studies. | 1998 | World Rev Nutr Diet | pmid:9648509 |
| Abril R and Barclay W | Production of docosahexaenoic acid-enriched poultry eggs and meat using an algae-based feed ingredient. | 1998 | World Rev Nutr Diet | pmid:9648506 |
| Barclay W et al. | Production of docosahexaenoic acid from microalgae and its benefits for use in animal feeds. | 1998 | World Rev Nutr Diet | pmid:9648505 |
| Hoffman DR and Birch DG | Omega 3 fatty acid status in patients with retinitis pigmentosa. | 1998 | World Rev Nutr Diet | pmid:9648504 |
| Leaf A and Kang JX | Omega 3 fatty acids and cardiovascular disease. | 1998 | World Rev Nutr Diet | pmid:9648502 |
| He Q et al. | Reduction of 4-hydroxynonenal and 4-hydroxyhexenal by retinal aldose reductase. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9647760 |
| Kimura S et al. | Ameliorative effects of docosahexaenoic acid on serum lipid changes in stroke-prone spontaneously hypertensive rats. | 1998 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:9644719 |
| Hibbeln JR | Fish consumption and major depression. | 1998 | Lancet | pmid:9643729 |
| Cadroy Y et al. | Arachidonic acid enhances the tissue factor expression of mononuclear cells by the cyclo-oxygenase-1 pathway: beneficial effect of n-3 fatty acids. | 1998 | J. Immunol. | pmid:9637532 |
| Williams EE et al. | Docosahexaenoic acid (DHA) alters the structure and composition of membranous vesicles exfoliated from the surface of a murine leukemia cell line. | 1998 | Biochim. Biophys. Acta | pmid:9630720 |
| Henderson RJ et al. | Effects of docosahexaenoic (22:6n-3), tetracosapentaenoic (24:5n-3) and tetracosahexaenoic (24:6n-3) acids on the desaturation and elongation of n-3 polyunsaturated fatty acids in trout liver microsomes. | 1998 | Biochim. Biophys. Acta | pmid:9630696 |
| Peterson LD et al. | Low levels of eicosapentaenoic and docosahexaenoic acids mimic the effects of fish oil upon rat lymphocytes. | 1998 | Life Sci. | pmid:9627080 |
| Bojesen IN and Bojesen E | Nature of the elements transporting long-chain fatty acids through the red cell membrane. | 1998 | J. Membr. Biol. | pmid:9625774 |