| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Pain | D010146 | 64 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yeh YY et al. | Modification of milk formula to enhance accretion of long-chain n-6 and n-3 polyunsaturated fatty acids in artificially reared infant rats. | 1998 | Lipids | pmid:9625599 |
| Almallah YZ et al. | Distal procto-colitis, natural cytotoxicity, and essential fatty acids. | 1998 | Am. J. Gastroenterol. | pmid:9625132 |
| Lu CY et al. | Docosahexaenoic acid, a constituent of fetal and neonatal serum, inhibits nitric oxide production by murine macrophages stimulated by IFN gamma plus LPS, or by IFN gamma plus Listeria monocytogenes. | 1998 | J. Reprod. Immunol. | pmid:9616876 |
| Ikeda I et al. | Effects of dietary alpha-linolenic, eicosapentaenoic and docosahexaenoic acids on hepatic lipogenesis and beta-oxidation in rats. | 1998 | Biosci. Biotechnol. Biochem. | pmid:9614698 |
| Christensen MM et al. | Dietary structured triacylglycerols containing docosahexaenoic acid given from birth affect visual and auditory performance and tissue fatty acid profiles of rats. | 1998 | J. Nutr. | pmid:9614162 |
| Kikuchi S et al. | Modulation of eosinophil chemotactic activities to leukotriene B4 by n-3 polyunsaturated fatty acids. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9610849 |
| Glozman S et al. | Intraamniotic ethyl docosahexaenoate administration protects fetal rat brain from ischemic stress. | 1998 | J. Neurochem. | pmid:9603213 |
| Roberts LJ et al. | Formation of isoprostane-like compounds (neuroprostanes) in vivo from docosahexaenoic acid. | 1998 | J. Biol. Chem. | pmid:9593698 |
| Hossain MS et al. | Influence of docosahexaenoic acid on cerebral lipid peroxide level in aged rats with and without hypercholesterolemia. | 1998 | Neurosci. Lett. | pmid:9593513 |
| Tashiro T et al. | Effects of a newly developed fat emulsion containing eicosapentaenoic acid and docosahexaenoic acid on fatty acid profiles in rats. | 1998 | Nutrition | pmid:9591310 |
| Habán P et al. | [The effect of n-3 fatty acid administration on selected indicators of cardiovascular disease risk in patients with type 2 diabetes mellitus]. | 1998 | Bratisl Lek Listy | pmid:9588078 |
| Hirafuji M et al. | Effect of docosahexaenoic acid on smooth muscle cell functions. | 1998 | Life Sci. | pmid:9585158 |
| Green P and Yavin E | Mechanisms of docosahexaenoic acid accretion in the fetal brain. | 1998 | J. Neurosci. Res. | pmid:9579403 |
| Zerouga M et al. | Can docosahexaenoic acid inhibit metastasis by decreasing deformability of the tumor cell plasma membrane? | 1997 | Cancer Lett. | pmid:9570367 |
| Horie T et al. | Docosahexaenoic acid exhibits a potent protection of small intestine from methotrexate-induced damage in mice. | 1998 | Life Sci. | pmid:9566775 |
| Nøding R et al. | Effects of polyunsaturated fatty acids and their n-6 hydroperoxides on growth of five malignant cell lines and the significance of culture media. | 1998 | Lipids | pmid:9560803 |
| Nabekura J et al. | Functional modulation of human recombinant gamma-aminobutyric acid type A receptor by docosahexaenoic acid. | 1998 | J. Biol. Chem. | pmid:9556589 |
| Bechoua S et al. | Docosahexaenoic acid lowers phosphatidate level in human activated lymphocytes despite phospholipase D activation. | 1998 | J. Lipid Res. | pmid:9555950 |
| Kishida E et al. | Distinctive inhibitory activity of docosahexaenoic acid against sphingosine-induced apoptosis. | 1998 | Biochim. Biophys. Acta | pmid:9555103 |
| Timmer-Bosscha H et al. | Differential effects of all-trans-retinoic acid, docosahexaenoic acid, and hexadecylphosphocholine on cisplatin-induced cytotoxicity and apoptosis in a cisplantin-sensitive and resistant human embryonal carcinoma cell line. | 1998 | Cancer Chemother. Pharmacol. | pmid:9554591 |
| Hørby Jørgensen M et al. | Effect of formula supplemented with docosahexaenoic acid and gamma-linolenic acid on fatty acid status and visual acuity in term infants. | 1998 | J. Pediatr. Gastroenterol. Nutr. | pmid:9552137 |
| Madsen L et al. | Docosahexaenoic and eicosapentaenoic acids are differently metabolized in rat liver during mitochondria and peroxisome proliferation. | 1998 | J. Lipid Res. | pmid:9548590 |
| Sebaldt RJ and Marignani P | Diradylglycerol formation is altered by n-3 highly unsaturated fatty acids, with differences between eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids. | 1997 | Adv. Exp. Med. Biol. | pmid:9547650 |
| Rousseau D et al. | Is a dietary n-3 fatty acid supplement able to influence the cardiac effect of the psychological stress? | 1998 | Mol. Cell. Biochem. | pmid:9546620 |
| Voskuyl RA et al. | Anticonvulsant effect of polyunsaturated fatty acids in rats, using the cortical stimulation model. | 1998 | Eur. J. Pharmacol. | pmid:9543232 |
| Starkopf J et al. | Lipid peroxidation, arachidonic acid and products of the lipoxygenase pathway in ischaemic preconditioning of rat heart. | 1998 | Cardiovasc. Res. | pmid:9539859 |
| Wolk A et al. | Effect of additional questions about fat on the validity of fat estimates from a food frequency questionnaire. Study Group of MRS SWEA. | 1998 | Eur J Clin Nutr | pmid:9537304 |
| Rhodes LE and White SI | Dietary fish oil as a photoprotective agent in hydroa vacciniforme. | 1998 | Br. J. Dermatol. | pmid:9536243 |
| Paulsen JE et al. | A fish oil-derived concentrate enriched in eicosapentaenoic and docosahexaenoic acid as ethyl esters inhibits the formation and growth of aberrant crypt foci in rat colon. | 1998 | Pharmacol. Toxicol. | pmid:9527643 |
| Urano S et al. | Aging and oxidative stress in neurodegeneration. | 1998 | Biofactors | pmid:9523034 |
| Ramanadham S et al. | Electrospray ionization mass spectrometric analyses of phospholipids from rat and human pancreatic islets and subcellular membranes: comparison to other tissues and implications for membrane fusion in insulin exocytosis. | 1998 | Biochemistry | pmid:9521776 |
| Ward PE et al. | Niacin skin flush in schizophrenia: a preliminary report. | 1998 | Schizophr. Res. | pmid:9516668 |
| Larsen LN et al. | Alpha- and beta- alkyl-substituted eicosapentaenoic acids: incorporation into phospholipids and effects on prostaglandin H synthase and 5-lipoxygenase. | 1998 | Biochem. Pharmacol. | pmid:9514074 |
| Osmundsen H et al. | Effects of dietary treatment of rats with eicosapentaenoic acid or docosahexaenoic acid on hepatic lipid metabolism. | 1998 | Biochem. J. | pmid:9512474 |
| Conquer JA and Holub BJ | Effect of supplementation with different doses of DHA on the levels of circulating DHA as non-esterified fatty acid in subjects of Asian Indian background. | 1998 | J. Lipid Res. | pmid:9507989 |
| Peterson LD et al. | Eicosapentaenoic and docosahexaenoic acids alter rat spleen leukocyte fatty acid composition and prostaglandin E2 production but have different effects on lymphocyte functions and cell-mediated immunity. | 1998 | Lipids | pmid:9507239 |
| Hansen JB et al. | Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on fatty acid absorption, incorporation into serum phospholipids and postprandial triglyceridemia. | 1998 | Lipids | pmid:9507234 |
| Morita N and Shirai J | Effects of microcapsulated docosahexaenoic acid preparation on properties of dough and bread. | 1997 | J. Nutr. Sci. Vitaminol. | pmid:9505244 |
| Woltil HA et al. | Long-chain polyunsaturated fatty acid status and early growth of low birth weight infants. | 1998 | Eur. J. Pediatr. | pmid:9504790 |
| Hirafuji M et al. | [Specific modulation of vascular smooth muscle cell functions by docosahexaenoic acid]. | 1997 | Nippon Yakurigaku Zasshi | pmid:9503427 |
| Alessandri JM et al. | Docosahexaenoic acid concentrations in retinal phospholipids of piglets fed an infant formula enriched with long-chain polyunsaturated fatty acids: effects of egg phospholipids and fish oils with different ratios of eicosapentaenoic acid to docosahexaenoic acid. | 1998 | Am. J. Clin. Nutr. | pmid:9497179 |
| Calviello G et al. | Dietary supplementation with eicosapentaenoic and docosahexaenoic acid inhibits growth of Morris hepatocarcinoma 3924A in rats: effects on proliferation and apoptosis. | 1998 | Int. J. Cancer | pmid:9495237 |
| Ramesh G and Das UN | Effect of cis-unsaturated fatty acids on Meth-A ascitic tumour cells in vitro and in vivo. | 1998 | Cancer Lett. | pmid:9489490 |
| Nieuwenhuys CM and Hornstra G | The effects of purified eicosapentaenoic and docosahexaenoic acids on arterial thrombosis tendency and platelet function in rats. | 1998 | Biochim. Biophys. Acta | pmid:9487152 |
| Prasad MR et al. | Regional membrane phospholipid alterations in Alzheimer's disease. | 1998 | Neurochem. Res. | pmid:9482271 |
| Das UN et al. | Can tumour cell drug resistance be reversed by essential fatty acids and their metabolites? | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9482165 |
| Mani I et al. | Upregulation of nuclear PKC and MAP-kinase during hyperproliferation of guinea pig epidermis: modulation by 13-(S)-hydroxyoctadecadienoic acid (13-HODE). | 1998 | Cell. Signal. | pmid:9481490 |
| Germain E et al. | Enhancement of doxorubicin cytotoxicity by polyunsaturated fatty acids in the human breast tumor cell line MDA-MB-231: relationship to lipid peroxidation. | 1998 | Int. J. Cancer | pmid:9466659 |
| Yamane M et al. | Docosahexaenoic/arachidonic acid omega-hydroxylation system and differentiation in the human colonic adenocarcinoma cell line, Caco-2. | 1998 | Cancer Lett. | pmid:9464491 |
| Zheng Z et al. | Effect of ganglioside GM1 on ethanol-induced changes in the incorporation of free fatty acids into membrane phospholipids in mouse brain. | 1997 Nov-Dec | Alcohol Alcohol. | pmid:9463723 |