DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Mocking RJ et al. Relationship between the hypothalamic-pituitary-adrenal-axis and fatty acid metabolism in recurrent depression. 2013 Psychoneuroendocrinology pmid:23465556
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Shaikh IA et al. Docosahexaenoic acid enhances the efficacy of docetaxel in prostate cancer cells by modulation of apoptosis: the role of genes associated with the NF-kappaB pathway. 2008 Prostate pmid:18668525
Cavazos DA et al. Docosahexaenoic acid selectively induces human prostate cancer cell sensitivity to oxidative stress through modulation of NF-κB. 2011 Prostate pmid:21360560
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Recchiuti A Resolvin D1 and its GPCRs in resolution circuits of inflammation. 2013 Prostaglandins Other Lipid Mediat. pmid:23500003
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Hishinuma T et al. Effects of long-term supplementation of eicosapentanoic and docosahexanoic acid on the 2-, 3-series prostacyclin production by endothelial cells. 1999 Prostaglandins Other Lipid Mediat. pmid:10480487
Shi H et al. VIP protects human retinal microvascular endothelial cells against high glucose-induced increases in TNF-α and enhances RvD1. 2016 Prostaglandins Other Lipid Mediat. pmid:27026343
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Williard DE et al. Comparison of 20-, 22-, and 24-carbon n-3 and n-6 polyunsaturated fatty acid utilization in differentiated rat brain astrocytes. 2002 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:12324227
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Marín MC et al. Dietary long-chain fatty acids and visual response in malnourished nursing infants. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11133176
Kruger MC and Schollum LM Is docosahexaenoic acid more effective than eicosapentaenoic acid for increasing calcium bioavailability? 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:16154334
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Decsi T et al. Polyunsaturated fatty acids in plasma and erythrocyte membrane lipids of diabetic children. 2002 Prostaglandins Leukot. Essent. Fatty Acids pmid:12401433
Graf BA et al. Age dependent incorporation of 14C-DHA into rat brain and body tissues after dosing various 14C-DHA-esters. 2010 Prostaglandins Leukot. Essent. Fatty Acids pmid:20580213
McNamara RK The emerging role of omega-3 fatty acids in psychiatry. 2006 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:16930969
Urquhart P et al. Profile of eicosanoids produced by human saphenous vein endothelial cells and the effect of dietary fatty acids. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11487303
Shinto L et al. Omega-3 fatty acid supplementation decreases matrix metalloproteinase-9 production in relapsing-remitting multiple sclerosis. 2009 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:19171471
Freeman MP Omega-3 fatty acids and perinatal depression: a review of the literature and recommendations for future research. 2006 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:16930971
Luxwolda MF et al. The relation between the omega-3 index and arachidonic acid is bell shaped: synergistic at low EPA+DHA status and antagonistic at high EPA+DHA status. 2011 Sep-Oct Prostaglandins Leukot. Essent. Fatty Acids pmid:21715149
Gousset-Dupont A et al. The effect of n-3 PUFA on eNOS activity and expression in Ea hy 926 cells. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17229561
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Mohan IK and Das UN Oxidant stress, anti-oxidants and essential fatty acids in systemic lupus erythematosus. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9089797
Kuipers RS et al. Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22115845
Chen ZY and Istfan NW Docosahexaenoic acid is a potent inducer of apoptosis in HT-29 colon cancer cells. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11090257
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Brenner RR Hormonal modulation of delta6 and delta5 desaturases: case of diabetes. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12538079
Nyuar KB et al. Regular consumption of Nile river fish could ameliorate the low milk DHA of Southern Sudanese women living in Khartoum City area. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23706881
Qiu X Biosynthesis of docosahexaenoic acid (DHA, 22:6-4, 7,10,13,16,19): two distinct pathways. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12538082
Levy BD Resolvins and protectins: natural pharmacophores for resolution biology. 2010 Apr-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:20227865
McPhee S et al. Prophylactic and therapeutic effects of Mytilus edulis fatty acids on adjuvant-induced arthritis in male Wistar rats. 2010 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:20074924
Rahman T et al. The very low density lipoprotein receptor is not necessary for maintaining brain polyunsaturated fatty acid concentrations. 2010 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:20106645
Block RC et al. The effects of EPA, DHA, and aspirin ingestion on plasma lysophospholipids and autotaxin. 2010 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:20106646
Wittwer J and Hersberger M The two faces of the 15-lipoxygenase in atherosclerosis. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17869078
Tocher DR and Dick JR Effects of essential fatty acid deficiency and supplementation with docosahexaenoic acid (DHA; 22:6n-3) on cellular fatty acid compositions and fatty acyl desaturation in a cell culture model. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11161581
Honda KL et al. Docosahexaenoic acid differentially affects TNFα and IL-6 expression in LPS-stimulated RAW 264.7 murine macrophages. 2015 Prostaglandins Leukot. Essent. Fatty Acids pmid:25921297
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Block RC et al. The effects of aspirin on platelet function and lysophosphatidic acids depend on plasma concentrations of EPA and DHA. 2015 Prostaglandins Leukot. Essent. Fatty Acids pmid:25555354
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Lokesh BR and Kinsella JE Effects of n-3 polyunsaturated fatty acids on the reacylation of arachidonic acid in peritoneal macrophages. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:7846090
Makrides M DHA supplementation during the perinatal period and neurodevelopment: Do some babies benefit more than others? 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22698951
Van Biervliet S et al. Oral DHA supplementation in DeltaF508 homozygous cystic fibrosis patients. 2008 Prostaglandins Leukot. Essent. Fatty Acids pmid:18276127
Matsumoto K et al. Inhibitory effect of docosahexaenoic acid-containing phospholipids on 5-lipoxygenase in rat basophilic leukemia cells. 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:8302921
Otto SJ et al. Increased risk of postpartum depressive symptoms is associated with slower normalization after pregnancy of the functional docosahexaenoic acid status. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12907133
Polozova A et al. Effect of docosahexaenoic acid on tissue targeting and metabolism of plasma lipoproteins. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16837179
Brouwer IA Omega-3 PUFA: good or bad for prostate cancer? 2008 Sep-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:18951003
Bryhn M et al. The bioavailability and pharmacodynamics of different concentrations of omega-3 acid ethyl esters. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16806871