DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Luquain C et al. Bis(monoacylglycerol) phosphate in rat uterine stromal cells: structural characterization and specific esterification of docosahexaenoic acid. 2000 Biochem. J. pmid:11042136
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Gerber MJ et al. Profiles of a healthful diet and its relationship to biomarkers in a population sample from Mediterranean southern France. 2000 J Am Diet Assoc pmid:11043701
Hosokawa M et al. Conversion to docosahexaenoic acid-containing phosphatidylserine from squid skin lecithin by phospholipase D-mediated transphosphatidylation. 2000 J. Agric. Food Chem. pmid:11052698
Surai PF et al. Effect of long-term supplementation with arachidonic or docosahexaenoic acids on sperm production in the broiler chicken. 2000 J. Reprod. Fertil. pmid:11058441
Pakala R et al. Vascular smooth muscle cells preloaded with eicosapentaenoic acid and docosahexaenoic acid fail to respond to serotonin stimulation. 2000 Atherosclerosis pmid:11058699
Salem ML et al. N-3 polyunsaturated fatty acids accentuate B16 melanoma growth and metastasis through suppression of tumoricidal function of T cells and macrophages. 2000 Sep-Oct Anticancer Res. pmid:11062743
Sherman MP Human milk, fatty acids, and the immune response: a new glimpse. 2000 Am. J. Clin. Nutr. pmid:11063429
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Lauritizen L et al. Dietary fish and the docosahexaenoic acid (DHA) content of human milk. 2000 Adv. Exp. Med. Biol. pmid:11065103
Savino F et al. Arachidonic (AA) and docosahexaenoic (DHA) acid content in healthy infants fed with an HA milk formula supplemented with LCPUFA and in breast fed infants. 2000 Adv. Exp. Med. Biol. pmid:11065107
Decsi T et al. Low contribution of docosahexaenoic acid to the fatty acid composition of mature human milk in Hungary. 2000 Adv. Exp. Med. Biol. pmid:11065108
Lopez-Alarcon M et al. Illness-induced anorexia in the breast-fed infants. Role of IL-1beta and TNF-alpha. 2000 Adv. Exp. Med. Biol. pmid:11065112
Lim SY and Suzuki H Effect of dietary docosahexaenoic acid and phosphatidylcholine on maze behavior and fatty acid composition of plasma and brain lipids in mice. 2000 Int J Vitam Nutr Res pmid:11068705
Totland GK et al. Proliferation of mitochondria and gene expression of carnitine palmitoyltransferase and fatty acyl-CoA oxidase in rat skeletal muscle, heart and liver by hypolipidemic fatty acids. 2000 Biol. Cell pmid:11071041
Contreras MA et al. Nutritional deprivation of alpha-linolenic acid decreases but does not abolish turnover and availability of unacylated docosahexaenoic acid and docosahexaenoyl-CoA in rat brain. 2000 J. Neurochem. pmid:11080190
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Louw L and Dannhauser A Keloids in rural black South Africans. Part 2: dietary fatty acid intake and total phospholipid fatty acid profile in the blood of keloid patients. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11090250
Fokkema MR et al. Short-term supplementation of low-dose gamma-linolenic acid (GLA), alpha-linolenic acid (ALA), or GLA plus ALA does not augment LCP omega 3 status of Dutch vegans to an appreciable extent. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11090255
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Rissanen T et al. Fish oil-derived fatty acids, docosahexaenoic acid and docosapentaenoic acid, and the risk of acute coronary events: the Kuopio ischaemic heart disease risk factor study. 2000 Circulation pmid:11094031
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Ikemoto A et al. Effect of n-3 fatty acid deficiency on fatty acid composition and metabolism of aminophospholipids in rat brain synaptosomes. 2000 Lipids pmid:11104017
Decsi T et al. Fatty acid composition of human milk in Hungary. 2000 Acta Paediatr. pmid:11106060
Baldessarini RJ et al. Fatty acid derivatives of clozapine: prolonged antidopaminergic activity of docosahexaenoylclozapine in the rat. 2001 Neuropsychopharmacology pmid:11106876
Mezzano D et al. Cardiovascular risk factors in vegetarians. Normalization of hyperhomocysteinemia with vitamin B(12) and reduction of platelet aggregation with n-3 fatty acids. 2000 Thromb. Res. pmid:11108902
Song JH et al. Polyunsaturated (n-3) fatty acids susceptible to peroxidation are increased in plasma and tissue lipids of rats fed docosahexaenoic acid-containing oils. 2000 J. Nutr. pmid:11110863
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Innis SM The role of dietary n-6 and n-3 fatty acids in the developing brain. 2000 Sep-Dec Dev. Neurosci. pmid:11111165
Stockard JE et al. Effect of docosahexaenoic acid content of maternal diet on auditory brainstem conduction times in rat pups. 2000 Sep-Dec Dev. Neurosci. pmid:11111168
de Urquiza AM et al. Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain. 2000 Science pmid:11118147
Haban P et al. Supplementation with long-chain n-3 fatty acids in non-insulin-dependent diabetes mellitus (NIDDM) patients leads to the lowering of oleic acid content in serum phospholipids. 2000 Eur J Nutr pmid:11131366
Harel M et al. Modulation of arachidonate and docosahexaenoate in Morone chrysops larval tissues and the effect on growth and survival. 2000 Lipids pmid:11132186
Marín MC et al. Dietary long-chain fatty acids and visual response in malnourished nursing infants. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11133176
Sorbera LA et al. Effects of polyunsaturated fatty acids and prostaglandins on oocyte maturation in a marine teleost, the European sea bass (Dicentrarchus labrax). 2001 Biol. Reprod. pmid:11133697
Mizota A et al. Protective effects of dietary docosahexaenoic acid against kainate-induced retinal degeneration in rats. 2001 Invest. Ophthalmol. Vis. Sci. pmid:11133871
Lauritzen L et al. The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina. 2001 Jan-Mar Prog. Lipid Res. pmid:11137568
Reich EE et al. Brain regional quantification of F-ring and D-/E-ring isoprostanes and neuroprostanes in Alzheimer's disease. 2001 Am. J. Pathol. pmid:11141503
Hoffman DR et al. Impact of early dietary intake and blood lipid composition of long-chain polyunsaturated fatty acids on later visual development. 2000 J. Pediatr. Gastroenterol. Nutr. pmid:11144440
Yokoyama A et al. Effect of aerosolized docosahexaenoic acid in a mouse model of atopic asthma. 2000 Int. Arch. Allergy Immunol. pmid:11146390
Nagakura T et al. Dietary supplementation with fish oil rich in omega-3 polyunsaturated fatty acids in children with bronchial asthma. 2000 Eur. Respir. J. pmid:11153584
Cho E et al. Prospective study of dietary fat and the risk of age-related macular degeneration. 2001 Am. J. Clin. Nutr. pmid:11157315
Otto SJ et al. Changes in the maternal essential fatty acid profile during early pregnancy and the relation of the profile to diet. 2001 Am. J. Clin. Nutr. pmid:11157328
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Brand A et al. Lipid constituents in oligodendroglial cells alter susceptibility to H2O2-induced apoptotic cell death via ERK activation. 2001 J. Neurochem. pmid:11158263
Helge JW et al. Training affects muscle phospholipid fatty acid composition in humans. 2001 J. Appl. Physiol. pmid:11160068
Lim S and Suzuki H Changes in maze behavior of mice occur after sufficient accumulation of docosahexaenoic acid in brain. 2001 J. Nutr. pmid:11160553
Tocher DR and Dick JR Effects of essential fatty acid deficiency and supplementation with docosahexaenoic acid (DHA; 22:6n-3) on cellular fatty acid compositions and fatty acyl desaturation in a cell culture model. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11161581
Chen ZY and Istfan NW Docosahexaenoic acid, a major constituent of fish oil diets, prevents activation of cyclin-dependent kinases and S-phase entry by serum stimulation in HT-29 cells. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11161587
Infante JP and Huszagh VA Zellweger syndrome knockout mouse models challenge putative peroxisomal beta-oxidation involvement in docosahexaenoic acid (22:6n-3) biosynthesis. 2001 Mol. Genet. Metab. pmid:11161822
Wiesenfeld PW et al. Effect of long-chain fatty acids in the culture medium on fatty acid composition of WEHI-3 and J774A.1 cells. 2001 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:11163311
Ito Y et al. Effects of polyunsaturated fatty acids on atrophic gastritis in a Japanese population. 2001 Cancer Lett. pmid:11165751
Morita N et al. Biosynthesis of fatty acids in the docosahexaenoic acid-producing bacterium Moritella marina strain MP-1. 2000 Biochem. Soc. Trans. pmid:11171265
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Ashford A et al. Electron microscopy may reveal structure of docosahexaenoic acid-rich oil within Schizochytrium sp. 2000 Lipids pmid:11202000
al-Awadhi AM and Dunn CD Effects of fish-oil constituents and plasma lipids on fibrinolysis in vitro. 2000 Br. J. Biomed. Sci. pmid:11204855
Lance VA et al. Hyperlipidemia and reproductive failure in captive-reared alligators: vitamin E, vitamin A, plasma lipids, fatty acids, and steroid hormones. 2001 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:11207442
Frenoux JM et al. A polyunsaturated fatty acid diet lowers blood pressure and improves antioxidant status in spontaneously hypertensive rats. 2001 J. Nutr. pmid:11208936
Hung P et al. Dietary effects of eicosapentaenoic and docosahexaenoic acid esters on lipid metabolism and immune parameters in Sprague-Dawley rats. 2000 Biosci. Biotechnol. Biochem. pmid:11210121
Song JH and Miyazawa T Enhanced level of n-3 fatty acid in membrane phospholipids induces lipid peroxidation in rats fed dietary docosahexaenoic acid oil. 2001 Atherosclerosis pmid:11223421
Christophe A and Robberecht E Directed modification instead of normalization of fatty acid patterns in cystic fibrosis: an emerging concept. 2001 Curr Opin Clin Nutr Metab Care pmid:11224654
Saito M Dietary docosahexaenoic acid does not promote tissue lipid peroxide formation to the extent expected from the peroxidizability index of the lipids. 2000 Biofactors pmid:11237175
Hamazaki T et al. Anti-stress effects of DHA. 2000 Biofactors pmid:11237197
Agostoni C et al. Biochemical effects of supplemented long-chain polyunsaturated fatty acids in hyperphenylalaninemia. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11237478
Thies F et al. Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 y. 2001 Am. J. Clin. Nutr. pmid:11237929
van den Ham EC et al. Evaluation of the relation between n-3 and n-6 fatty acid status and parity in nonpregnant women from the Netherlands. 2001 Am. J. Clin. Nutr. pmid:11237941
Infante JP and Huszagh VA Impaired arachidonic (20:4n-6) and docosahexaenoic (22:6n-3) acid synthesis by phenylalanine metabolites as etiological factors in the neuropathology of phenylketonuria. 2001 Mol. Genet. Metab. pmid:11243724
Xiao YF et al. Single point mutations affect fatty acid block of human myocardial sodium channel alpha subunit Na+ channels. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11248125
Al MD et al. Relation between birth order and the maternal and neonatal docosahexaenoic acid status. 1997 Eur J Clin Nutr pmid:11248881
Gamoh S et al. Chronic administration of docosahexaenoic acid improves the performance of radial arm maze task in aged rats. 2001 Clin. Exp. Pharmacol. Physiol. pmid:11251638
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Pound EM et al. Partitioning of polyunsaturated fatty acids, which prevent cardiac arrhythmias, into phospholipid cell membranes. 2001 J. Lipid Res. pmid:11254745
Higdon JV et al. Supplementation of postmenopausal women with fish oil does not increase overall oxidation of LDL ex vivo compared to dietary oils rich in oleate and linoleate. 2001 J. Lipid Res. pmid:11254753
Moriguchi T et al. Reversal of docosahexaenoic acid deficiency in the rat brain, retina, liver, and serum. 2001 J. Lipid Res. pmid:11254754
Assies J et al. Significantly reduced docosahexaenoic and docosapentaenoic acid concentrations in erythrocyte membranes from schizophrenic patients compared with a carefully matched control group. 2001 Biol. Psychiatry pmid:11257236
Fujita S et al. Docosahexaenoic acid improves long-term potentiation attenuated by phospholipase A(2) inhibitor in rat hippocampal slices. 2001 Br. J. Pharmacol. pmid:11264234
Hayashi M et al. Uptake and accumulation of exogenous docosahexaenoic acid by Chlorella. 2001 Biosci. Biotechnol. Biochem. pmid:11272831
Rump P et al. Essential fatty acid composition of plasma phospholipids and birth weight: a study in term neonates. 2001 Am. J. Clin. Nutr. pmid:11273856
Elias SL and Innis SM Infant plasma trans, n-6, and n-3 fatty acids and conjugated linoleic acids are related to maternal plasma fatty acids, length of gestation, and birth weight and length. 2001 Am. J. Clin. Nutr. pmid:11273857
Donadio JV et al. A randomized trial of high-dose compared with low-dose omega-3 fatty acids in severe IgA nephropathy. 2001 J. Am. Soc. Nephrol. pmid:11274240
Green P et al. Ethyl docosahexaenoate-associated decrease in fetal brain lipid peroxide production is mediated by activation of prostanoid and nitric oxide pathways. 2001 Biochim. Biophys. Acta pmid:11278180
Lee JY et al. Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. 2001 J. Biol. Chem. pmid:11278967
Arrington JL et al. Docosahexaenoic acid suppresses function of the CD28 costimulatory membrane receptor in primary murine and Jurkat T cells. 2001 J. Nutr. pmid:11285317
Ikeda I et al. Reduced hepatic triglyceride secretion in rats fed docosahexaenoic acid-rich fish oil suppresses postprandial hypertriglyceridemia. 2001 J. Nutr. pmid:11285319
Collett ED et al. n-6 and n-3 polyunsaturated fatty acids differentially modulate oncogenic Ras activation in colonocytes. 2001 Am. J. Physiol., Cell Physiol. pmid:11287318
Su HM et al. Fetal baboons convert 18:3n-3 to 22:6n-3 in vivo. A stable isotope tracer study. 2001 J. Lipid Res. pmid:11290830
Schneider SM et al. Activity of the leukocyte NADPH oxidase in whole neutrophils and cell-free neutrophil preparations stimulated with long-chain polyunsaturated fatty acids. 2001 Inflammation pmid:11293662
Delton-Vandenbroucke I et al. Dual regulation of glutathione peroxidase by docosahexaenoic acid in endothelial cells depending on concentration and vascular bed origin. 2001 Free Radic. Biol. Med. pmid:11295532
Rudra PK and Krokan HE Cell-specific enhancement of doxorubicin toxicity in human tumour cells by docosahexaenoic acid. 2001 Jan-Feb Anticancer Res. pmid:11299749
Durrington PN et al. An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia. 2001 Heart pmid:11303007
Seung Kim HF et al. Inhibitory effects of omega-3 fatty acids on protein kinase C activity in vitro. 2001 Mol. Psychiatry pmid:11317232
Modeste AB et al. [Hydroa vacciniforme: dietary fish oil]. 2001 Ann Dermatol Venereol pmid:11319390
Umegaki K et al. Docosahexaenoic acid supplementation-increased oxidative damage in bone marrow DNA in aged rats and its relation to antioxidant vitamins. 2001 Free Radic. Res. pmid:11328678
Colquhoun A et al. Eicosapentaenoic acid and docosahexaenoic acid effects on tumour mitochondrial metabolism, acyl CoA metabolism and cell proliferation. 2001 Cell Biochem. Funct. pmid:11335934