| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Pain | D010146 | 64 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Berge K et al. | Poorly oxidizable fatty acid analogues inhibit the proliferation of cancer cells in culture. | 1999 | Adv. Exp. Med. Biol. | pmid:10709646 |
| Madsen L et al. | EPA and DHA possess different metabolic properties. | 1999 | Adv. Exp. Med. Biol. | pmid:10709658 |
| Yasuda S et al. | Dietary docosahexaenoic acid enhances ferric nitrilotriacetate-induced oxidative damage in mice but not when additional alpha-tocopherol is supplemented. | 1999 | Free Radic. Res. | pmid:10711790 |
| Hansen J et al. | Dietary supplementation with highly purified eicosapentaenoic acid and docosahexaenoic acid does not influence PAI-1 activity. | 2000 | Thromb. Res. | pmid:10713313 |
| Hempenius RA et al. | Evaluation of a subchronic (13-week) oral toxicity study, preceded by an in utero exposure phase, with arachidonic acid oil derived from Mortierella alpina in rats. | 2000 Feb-Mar | Food Chem. Toxicol. | pmid:10717353 |
| Grande JP et al. | Suppressive effects of fish oil on mesangial cell proliferation in vitro and in vivo. | 2000 | Kidney Int. | pmid:10720955 |
| Fidler N et al. | Oxidation of an oil rich in docosahexaenoic acid compared to linoleic acid in lactating women. | 1999 | Ann. Nutr. Metab. | pmid:10725767 |
| Thakkar RR et al. | Docosahexaenoic acid reverses cyclosporin A-induced changes in membrane structure and function. | 2000 | Biochim. Biophys. Acta | pmid:10742598 |
| Surai PF et al. | Designer egg evaluation in a controlled trial. | 2000 | Eur J Clin Nutr | pmid:10745280 |
| Brooks SL et al. | Mothers, infants, and DHA. Implications for nursing practice. | 2000 Mar-Apr | MCN Am J Matern Child Nurs | pmid:10748583 |
| Puri BK et al. | Eicosapentaenoic acid treatment in schizophrenia associated with symptom remission, normalisation of blood fatty acids, reduced neuronal membrane phospholipid turnover and structural brain changes. | 2000 Jan-Feb | Int. J. Clin. Pract. | pmid:10750263 |
| Igarashi M and Miyazawa T | Do conjugated eicosapentaenoic acid and conjugated docosahexaenoic acid induce apoptosis via lipid peroxidation in cultured human tumor cells? | 2000 | Biochem. Biophys. Res. Commun. | pmid:10753678 |
| Sametz W et al. | Influence of polyunsaturated fatty acids on vasoconstrictions induced by 8-iso-PGF(2alpha) and 8-iso-PGE(2). | 2000 | Pharmacology | pmid:10754452 |
| Birch EE et al. | A randomized controlled trial of early dietary supply of long-chain polyunsaturated fatty acids and mental development in term infants. | 2000 | Dev Med Child Neurol | pmid:10755457 |
| Gross EA et al. | G239T mutation in Repeat 1 of human IRBP: possible implications for more than one binding site in a single repeat. | 2000 | Mol. Vis. | pmid:10756181 |
| Conquer JA et al. | Effect of DHA supplementation on DHA status and sperm motility in asthenozoospermic males. | 2000 | Lipids | pmid:10757545 |
| Gaposchkin DP et al. | Incorporation of polyunsaturated fatty acids into CT-26, a transplantable murine colonic adenocarcinoma. | 2000 | Lipids | pmid:10757549 |
| Kim HY and Hamilton J | Accumulation of docosahexaenoic acid in phosphatidylserine is selectively inhibited by chronic ethanol exposure in C-6 glioma cells. | 2000 | Lipids | pmid:10757550 |
| Ogilvie GK et al. | Effect of fish oil, arginine, and doxorubicin chemotherapy on remission and survival time for dogs with lymphoma: a double-blind, randomized placebo-controlled study. | 2000 | Cancer | pmid:10760770 |
| Xi S et al. | Suppression of proto-oncogene (AP-1) in a model of skin epidermal hyperproliferation is reversed by topical application of 13-hydroxyoctadecadienoic acid and 15-hydroxyeicosatrienoic acid. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10765974 |
| Onuki Y et al. | In vivo effects of highly purified docosahexaenoic acid on rectal insulin absorption. | 2000 | Int J Pharm | pmid:10767564 |
| Sasaki T et al. | Dietary docosahexaenoic acid can alter the surface expression of CD4 and CD8 on T cells in peripheral blood. | 2000 | J. Agric. Food Chem. | pmid:10775347 |
| MartÃnez M et al. | [Treatment of generalized peroxisomal disorders with docosahexaenoic acid ethyl ether]. | 1999 | Rev Neurol | pmid:10778491 |
| Meluzzi A et al. | Effects of dietary vitamin E on the quality of table eggs enriched with n-3 long-chain fatty acids. | 2000 | Poult. Sci. | pmid:10780651 |
| Greatrex JC et al. | Scotopic sensitivity in dyslexia and requirements for DHA supplementation. | 2000 | Lancet | pmid:10791530 |
| Bechoua S et al. | Protective effect of docosahexaenoic acid against hydrogen peroxide-induced oxidative stress in human lymphocytes. | 1999 | Biochem. Pharmacol. | pmid:10796072 |
| Mori TA et al. | Purified eicosapentaenoic and docosahexaenoic acids have differential effects on serum lipids and lipoproteins, LDL particle size, glucose, and insulin in mildly hyperlipidemic men. | 2000 | Am. J. Clin. Nutr. | pmid:10799369 |
| Smit EN et al. | Fish oil supplementation improves docosahexaenoic acid status of malnourished infants. | 2000 | Arch. Dis. Child. | pmid:10799425 |
| Tsukada H et al. | Docosahexaenoic acid (DHA) improves the age-related impairment of the coupling mechanism between neuronal activation and functional cerebral blood flow response: a PET study in conscious monkeys. | 2000 | Brain Res. | pmid:10799683 |
| Itokazu N et al. | Bidirectional actions of docosahexaenoic acid on hippocampal neurotransmissions in vivo. | 2000 | Brain Res. | pmid:10799687 |
| Yano M et al. | Docosahexaenoic acid and vitamin E can reduce human monocytic U937 cell apoptosis induced by tumor necrosis factor. | 2000 | J. Nutr. | pmid:10801904 |
| Amamoto T et al. | [Relationship between hippocampal arachidonic acid content and induction of LTP in aged rats]. | 1999 | Nihon Shinkei Seishin Yakurigaku Zasshi | pmid:10803212 |
| Valk EE and Hornstra G | Relationship between vitamin E requirement and polyunsaturated fatty acid intake in man: a review. | 2000 | Int J Vitam Nutr Res | pmid:10804454 |
| Min Y et al. | Pregnancy reduces arachidonic and docosahexaenoic in plasma triacylglycerols of Korean women. | 2000 | Int J Vitam Nutr Res | pmid:10804459 |
| Weber P and Raederstorff D | Triglyceride-lowering effect of omega-3 LC-polyunsaturated fatty acids--a review. | 2000 | Nutr Metab Cardiovasc Dis | pmid:10812585 |
| Goustard-Langelier B et al. | Phospholipid incorporation and metabolic conversion of n-3 polyunsaturated fatty acids in the Y79 retinoblastoma cell line. | 2000 | J. Neurosci. Res. | pmid:10820439 |
| Farkas T et al. | Docosahexaenoic acid-containing phospholipid molecular species in brains of vertebrates. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10823917 |
| Lim SY and Suzuki H | Intakes of dietary docosahexaenoic acid ethyl ester and egg phosphatidylcholine improve maze-learning ability in young and old mice. | 2000 | J. Nutr. | pmid:10827221 |
| Huster D et al. | Strength of Ca(2+) binding to retinal lipid membranes: consequences for lipid organization. | 2000 | Biophys. J. | pmid:10827979 |
| Smit EN et al. | Breast milk docosahexaenoic acid (DHA) correlates with DHA status of malnourished infants. | 2000 | Arch. Dis. Child. | pmid:10833187 |
| Jahangiri A et al. | Termination of asynchronous contractile activity in rat atrial myocytes by n-3 polyunsaturated fatty acids. | 2000 | Mol. Cell. Biochem. | pmid:10839192 |
| Watanabe S et al. | Dietary docosahexaenoic acid but not eicosapentaenoic acid suppresses lipopolysaccharide-induced interleukin-1 beta mRNA induction in mouse spleen leukocytes. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10841036 |
| Marx N et al. | Peroxisome proliferator-activated receptor-gamma activators inhibit IFN-gamma-induced expression of the T cell-active CXC chemokines IP-10, Mig, and I-TAC in human endothelial cells. | 2000 | J. Immunol. | pmid:10843708 |
| Kielar ML et al. | Docosahexaenoic acid decreases IRF-1 mRNA and thus inhibits activation of both the IRF-E and NFkappa d response elements of the iNOS promoter. | 2000 | Transplantation | pmid:10852612 |
| Giusto NM et al. | Lipid metabolism in vertebrate retinal rod outer segments. | 2000 | Prog. Lipid Res. | pmid:10856601 |
| Morris S et al. | Utilization of docosahexaenoic acid from intravenous egg yolk phospholipid. | 2000 | Lipids | pmid:10858022 |
| Kosugi Y et al. | Esterification of polyunsaturated fatty acids by various forms of immobilized lipase from Rhizomucor miehei. | 2000 | Lipids | pmid:10858032 |
| Torres IC et al. | Study of the effects of dietary fish intake on serum lipids and lipoproteins in two populations with different dietary habits. | 2000 | Br. J. Nutr. | pmid:10858695 |
| Kubo K et al. | Preferential incorporation of docosahexaenoic acid into nonphosphorus lipids and phosphatidylethanolamine protects rats from dietary DHA-stimulated lipid peroxidation. | 2000 | J. Nutr. | pmid:10867046 |
| Decsi T and Koletzko B | Effects of protein-energy malnutrition and human immunodeficiency virus-1 infection on essential fatty acid metabolism in children. | 2000 | Nutrition | pmid:10869902 |