| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Pain | D010146 | 64 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hearn JA et al. | Marine lipid concentrate and atherosclerosis in the rabbit model. | 1989 | Atherosclerosis | pmid:2539167 |
| Ramon S et al. | The specialized proresolving mediator 17-HDHA enhances the antibody-mediated immune response against influenza virus: a new class of adjuvant? | 2014 | J. Immunol. | pmid:25392529 |
| pmid:25393480 | ||||
| pmid:25394495 | ||||
| Shimokawa H and Vanhoutte PM | Dietary omega 3 fatty acids and endothelium-dependent relaxations in porcine coronary arteries. | 1989 | Am. J. Physiol. | pmid:2539756 |
| Wales KM et al. | N-3 PUFAs protect against aortic inflammation and oxidative stress in angiotensin II-infused apolipoprotein E-/- mice. | 2014 | PLoS ONE | pmid:25398022 |
| Lands WE | n-3 fatty acids as precursors for active metabolic substances: dissonance between expected and observed events. | 1989 | J Intern Med Suppl | pmid:2539828 |
| Karmali RA | n-3 fatty acids and cancer. | 1989 | J Intern Med Suppl | pmid:2539832 |
| Fischer S | How should we measure n-3 polyunsaturated fatty acids and their metabolites in humans? | 1989 | J Intern Med Suppl | pmid:2539833 |
| Dyerberg J and Nordøy A | Prospectives on n-3 fatty acids in medical research. | 1989 | J Intern Med Suppl | pmid:2539834 |
| Rustan AC and Drevon CA | Eicosapentaenoic acid inhibits hepatic production of very low density lipoprotein. | 1989 | J Intern Med Suppl | pmid:2539835 |
| Hirai A et al. | Eicosapentaenoic acid and adult diseases in Japan: epidemiological and clinical aspects. | 1989 | J Intern Med Suppl | pmid:2539836 |
| Sanders TA et al. | Influence of n-3 fatty acids on blood lipids in normal subjects. | 1989 | J Intern Med Suppl | pmid:2539838 |
| pmid:25398731 | ||||
| Fleming JA and Kris-Etherton PM | The evidence for α-linolenic acid and cardiovascular disease benefits: Comparisons with eicosapentaenoic acid and docosahexaenoic acid. | 2014 | Adv Nutr | pmid:25398754 |
| Gilbert K et al. | Resolvin D1, a metabolite of omega-3 polyunsaturated fatty acid, decreases post-myocardial infarct depression. | 2014 | Mar Drugs | pmid:25402828 |
| Bates D et al. | A double-blind controlled trial of long chain n-3 polyunsaturated fatty acids in the treatment of multiple sclerosis. | 1989 | J. Neurol. Neurosurg. Psychiatr. | pmid:2540285 |
| pmid:25405323 | ||||
| pmid:25406967 | ||||
| Kermack AJ et al. | A randomised controlled trial of a preconceptional dietary intervention in women undergoing IVF treatment (PREPARE trial). | 2014 | BMC Womens Health | pmid:25407227 |
| pmid:25408476 | ||||
| Chatterjee A et al. | The pro-resolving lipid mediator maresin 1 (MaR1) attenuates inflammatory signaling pathways in vascular smooth muscle and endothelial cells. | 2014 | PLoS ONE | pmid:25409514 |
| pmid:25410733 | ||||
| pmid:25411039 | ||||
| pmid:25411442 | ||||
| Liu J and Ma DW | The role of n-3 polyunsaturated fatty acids in the prevention and treatment of breast cancer. | 2014 | Nutrients | pmid:25412153 |
| pmid:25413005 | ||||
| pmid:25413343 | ||||
| Kim HY and Salem N | Preparation and the structural determination of hydroperoxy derivatives of docosahexaenoic acid and other polyunsaturates by thermospray LC/MS. | 1989 | Prostaglandins | pmid:2541468 |
| pmid:25417743 | ||||
| Burns CP et al. | Effect of docosahexaenoic acid on rate of differentiation of HL-60 human leukemia. | 1989 | Cancer Res. | pmid:2541901 |
| Westberg G et al. | Effect of eicosapentaenoic acid rich menhaden oil and MaxEPA on the autoimmune disease of Mrl/l mice. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2542168 |
| Anderson GJ et al. | Rapid modulation of the n-3 docosahexaenoic acid levels in the brain and retina of the newly hatched chick. | 1989 | J. Lipid Res. | pmid:2542425 |
| pmid:25425336 | ||||
| Lucena CF et al. | Omega-3 supplementation improves pancreatic islet redox status: in vivo and in vitro studies. | 2015 | Pancreas | pmid:25426612 |
| Mori TA et al. | Dietary fish oils increase serum lipids in insulin-dependent diabetics compared with healthy controls. | 1989 | Metab. Clin. Exp. | pmid:2542722 |
| Leaf DA | Omega-3 fatty acids and coronary artery disease. More than a fish tale. | 1989 | Postgrad Med | pmid:2542914 |
| Arm JP et al. | The effects of dietary supplementation with fish oil lipids on the airways response to inhaled allergen in bronchial asthma. | 1989 | Am. Rev. Respir. Dis. | pmid:2543246 |
| Yeo YK et al. | The effect of long-term consumption of fish oil on platelet-activating factor synthesis in rat renal microsomes. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2543394 |
| pmid:25436433 | ||||
| pmid:25441967 | ||||
| pmid:25444517 | ||||
| pmid:25445227 | ||||
| pmid:25445491 | ||||
| pmid:25446979 | ||||
| Timmer-Bosscha H et al. | Influence of docosahexaenoic acid on cisplatin resistance in a human small cell lung carcinoma cell line. | 1989 | J. Natl. Cancer Inst. | pmid:2544740 |
| pmid:25448278 | ||||
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| pmid:25448610 | ||||
| pmid:25450347 | ||||
| pmid:25450447 | ||||
| pmid:25451778 | ||||
| Keelan JA | Letter to the editor: "fatty acids and placental transport: insight or in vitro artifact?". | 2014 | Am. J. Physiol., Cell Physiol. | pmid:25452382 |
| Lager S et al. | Reply to "Letter to the editor: 'fatty acids and placental transport: insight or in vitro artifact?'". | 2014 | Am. J. Physiol., Cell Physiol. | pmid:25452383 |
| pmid:25453942 | ||||
| Mueller BA et al. | Comparative effects of omega-3 fatty acids in men and women. | 1989 | Clin Pharm | pmid:2545407 |
| Zgorzynska E et al. | Docosahexaenoic acid attenuates oxidative stress and protects human gingival fibroblasts against cytotoxicity induced by hydrogen peroxide and butyric acid. | 2015 | Arch. Oral Biol. | pmid:25455128 |
| Goodnight SH | The effects of omega-3 fatty acids on thrombosis and atherogenesis. | 1989 | Hematol Pathol | pmid:2545665 |
| pmid:25457546 | ||||
| pmid:25458573 | ||||
| pmid:25458863 | ||||
| pmid:25461677 | ||||
| pmid:25461680 | ||||
| pmid:25463478 | ||||
| Dorninger F et al. | Homeostasis of phospholipids - The level of phosphatidylethanolamine tightly adapts to changes in ethanolamine plasmalogens. | 2015 | Biochim. Biophys. Acta | pmid:25463479 |
| Lee TH and Arm JP | The effects of a fish oil enriched diet on experimentally-induced and clinical asthma. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2546399 |
| Hirai A et al. | Effect of oral administration of highly purified eicosapentaenoic acid and docosahexaenoic acid on platelet function and serum lipids in hyperlipidemic patients. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2546401 |
| pmid:25466121 | ||||
| pmid:25466661 | ||||
| pmid:25468178 | ||||
| Schaffer HK | Essential fatty acids and eicosanoids in cutaneous inflammation. | 1989 | Int. J. Dermatol. | pmid:2546896 |
| pmid:25471800 | ||||
| pmid:25471811 | ||||
| pmid:25472960 | ||||
| pmid:25474717 | ||||
| pmid:25477531 | ||||
| Steiner A et al. | Effect of fish oil on blood pressure and serum lipids in hypertension and hyperlipidaemia. | 1989 | J Hypertens Suppl | pmid:2547916 |
| pmid:25479393 | ||||
| pmid:25480558 | ||||
| pmid:25481335 | ||||
| pmid:25488613 | ||||
| Thomson AB et al. | Influence of dietary fat composition on intestinal absorption in the rat. | 1989 | Lipids | pmid:2549323 |
| pmid:25494615 | ||||
| pmid:25496531 | ||||
| pmid:25497441 | ||||
| pmid:25497550 | ||||
| pmid:25500337 | ||||
| pmid:25500548 | ||||
| Somers SD et al. | Alteration of in vitro murine peritoneal macrophage function by dietary enrichment with eicosapentaenoic and docosahexaenoic acids in menhaden fish oil. | 1989 | Cell. Immunol. | pmid:2550148 |
| pmid:25503390 | ||||
| pmid:25504325 | ||||
| pmid:25504554 | ||||
| pmid:25504868 | ||||
| Pierdomenico AM et al. | MicroRNA-181b regulates ALX/FPR2 receptor expression and proresolution signaling in human macrophages. | 2015 | J. Biol. Chem. | pmid:25505240 |
| Yoshino S and Ellis EF | Stimulation of anaphylaxis in the mouse footpad by dietary fish oil fatty acids. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2550967 |
| Bégin ME et al. | Plasma fatty acid levels in patients with acquired immune deficiency syndrome and in controls. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2550969 |
| Aoki N et al. | Acute effects of unsaturated fatty acids in splanchnic artery occlusion shock. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2550971 |
| Vreeken J et al. | Transient aggregation resistance of human blood platelets in fresh plasma. II. Physiological relevance: influence of fish oil. | 1989 | Thromb. Res. | pmid:2551059 |
| pmid:25512022 | ||||
| Vacek JL et al. | Short-term effects of omega-3 fatty acids on exercise stress test parameters, angina and lipoproteins. | 1989 | Biomed. Pharmacother. | pmid:2551411 |