DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Schiavone A et al. Breast meat traits of Muscovy ducks fed on a microalga (Crypthecodinium cohnii) meal supplemented diet. 2007 Br. Poult. Sci. pmid:17952729
Sakamoto T et al. Oral supplementation with docosahexaenoic acid and uridine-5'-monophosphate increases dendritic spine density in adult gerbil hippocampus. 2007 Brain Res. pmid:17950710
Schaefer MB et al. Fatty acids differentially influence phosphatidylinositol 3-kinase signal transduction in endothelial cells: impact on adhesion and apoptosis. 2008 Atherosclerosis pmid:17950294
Chen S and Li KW Mass spectrometric identification of molecular species of phosphatidylcholine and lysophosphatidylcholine extracted from shark liver. 2007 J. Agric. Food Chem. pmid:17949052
Pazirandeh S et al. Supplementation of arachidonic acid plus docosahexaenoic acid in cirrhotic patients awaiting liver transplantation: a preliminary study. 2007 Nov-Dec JPEN J Parenter Enteral Nutr pmid:17947609
Salvati S et al. Eicosapentaenoic acid stimulates the expression of myelin proteins in rat brain. 2008 J. Neurosci. Res. pmid:17941053
Blum R et al. Genotoxicity and subchronic toxicity studies of DHA-rich oil in rats. 2007 Regul. Toxicol. Pharmacol. pmid:17933446
Rahman MM et al. Docosahexaenoic acid is more potent inhibitor of osteoclast differentiation in RAW 264.7 cells than eicosapentaenoic acid. 2008 J. Cell. Physiol. pmid:17929247
Little SJ et al. Docosahexaenoic acid-induced changes in phospholipids in cortex of young and aged rats: a lipidomic analysis. 2007 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:17928211
Cerchietti LC et al. Effects of eicosapentaenoic and docosahexaenoic n-3 fatty acids from fish oil and preferential Cox-2 inhibition on systemic syndromes in patients with advanced lung cancer. 2007 Nutr Cancer pmid:17927497
Song WL et al. Neurofurans, novel indices of oxidant stress derived from docosahexaenoic acid. 2008 J. Biol. Chem. pmid:17921521
Hoffman D et al. Soy-based infant formula supplemented with DHA and ARA supports growth and increases circulating levels of these fatty acids in infants. 2008 Lipids pmid:17912568
Alessandri JM et al. Estradiol favors the formation of eicosapentaenoic acid (20:5n-3) and n-3 docosapentaenoic acid (22:5n-3) from alpha-linolenic acid (18:3n-3) in SH-SY5Y neuroblastoma cells. 2008 Lipids pmid:17912567
Yagil C and Yagil Y Peroxisome proliferator-activated receptor alpha: friend or foe? 2007 Hypertension pmid:17909117
Chen S and Subbaiah PV Phospholipid and fatty acid specificity of endothelial lipase: potential role of the enzyme in the delivery of docosahexaenoic acid (DHA) to tissues. 2007 Biochim. Biophys. Acta pmid:17905648
Mollard RC and Weiler HA Bone resorption varies as a function of time of day and quantity of dietary long chain polyunsaturated fatty acids. 2008 J. Nutr. Biochem. pmid:17904343
Li CC et al. DHA down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes by attenuating CAR translocation. 2007 Toxicol. Appl. Pharmacol. pmid:17904175
Colombo C Liver disease in cystic fibrosis. 2007 Curr Opin Pulm Med pmid:17901760
Watkins PA and Hamilton JA Roundtable discussion of session 4: fatty acids and lipids in brain disorders. 2007 J. Mol. Neurosci. pmid:17901556
Watkins PA and Hamilton JA Roundtable discussion of session 2: lipoproteins and polyunsaturated fatty acids. 2007 J. Mol. Neurosci. pmid:17901549
Polozova A and Salem N Role of liver and plasma lipoproteins in selective transport of n-3 fatty acids to tissues: a comparative study of 14C-DHA and 3H-oleic acid tracers. 2007 J. Mol. Neurosci. pmid:17901547
Huang WL et al. A combination of intravenous and dietary docosahexaenoic acid significantly improves outcome after spinal cord injury. 2007 Brain pmid:17901087
Buydens-Branchey L and Branchey M Long-chain n-3 polyunsaturated fatty acids decrease feelings of anger in substance abusers. 2008 Psychiatry Res pmid:17900705
Ando Y and Nozaki M Lipid profile of mysid Neomysis intermedia and its changes by feeding DHA-rich marine lipids. 2007 J Oleo Sci pmid:17898515
Barre DE The role of consumption of alpha-linolenic, eicosapentaenoic and docosahexaenoic acids in human metabolic syndrome and type 2 diabetes--a mini-review. 2007 J Oleo Sci pmid:17898498
Takenaka A et al. Unsaturated phosphatidylethanolamine as effective synergist in combination with alpha-tocopherol. 2007 J Oleo Sci pmid:17898457
Pignier C et al. Direct protective effects of poly-unsaturated fatty acids, DHA and EPA, against activation of cardiac late sodium current: a mechanism for ischemia selectivity. 2007 Basic Res. Cardiol. pmid:17891522
Andersson C et al. Alterations in immune response and PPAR/LXR regulation in cystic fibrosis macrophages. 2008 J. Cyst. Fibros. pmid:17889625
Huang LS et al. Oxygenation of 1-docosahexaenoyl lysophosphatidylcholine by lipoxygenases; conjugated hydroperoxydiene and dihydroxytriene derivatives. 2007 Lipids pmid:17879105
Aires V et al. Docosahexaenoic acid induces increases in [Ca2+]i via inositol 1,4,5-triphosphate production and activates protein kinase C gamma and -delta via phosphatidylserine binding site: implication in apoptosis in U937 cells. 2007 Mol. Pharmacol. pmid:17878267
Shah AP et al. Cardiovascular and endothelial effects of fish oil supplementation in healthy volunteers. 2007 J. Cardiovasc. Pharmacol. Ther. pmid:17875948
Wright SA et al. A randomised interventional trial of omega-3-polyunsaturated fatty acids on endothelial function and disease activity in systemic lupus erythematosus. 2008 Ann. Rheum. Dis. pmid:17875549
Block RC et al. EPA and DHA in blood cell membranes from acute coronary syndrome patients and controls. 2008 Atherosclerosis pmid:17875307
Wittwer J and Hersberger M The two faces of the 15-lipoxygenase in atherosclerosis. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17869078
Yang DY et al. Detrimental effects of post-treatment with fatty acids on brain injury in ischemic rats. 2007 Neurotoxicology pmid:17854901
Davidson MH et al. Efficacy and tolerability of adding prescription omega-3 fatty acids 4 g/d to simvastatin 40 mg/d in hypertriglyceridemic patients: an 8-week, randomized, double-blind, placebo-controlled study. 2007 Clin Ther pmid:17825687
Shah M et al. Lipid, glycemic, and insulin responses to meals rich in saturated, cis-monounsaturated, and polyunsaturated (n-3 and n-6) fatty acids in subjects with type 2 diabetes. 2007 Diabetes Care pmid:17804680
Puri BK et al. A 31-phosphorus neurospectroscopy study of omega-3 long-chain polyunsaturated fatty acid intervention with eicosapentaenoic acid and docosahexaenoic acid in patients with chronic refractory epilepsy. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17761409
Kaur P et al. Role of docosahexaenoic acid in modulating methylmercury-induced neurotoxicity. 2007 Toxicol. Sci. pmid:17728287
Wallström P et al. A prospective study on dietary fat and incidence of prostate cancer (Malmö, Sweden). 2007 Cancer Causes Control pmid:17726648
Hooijmans CR et al. Changes in cerebral blood volume and amyloid pathology in aged Alzheimer APP/PS1 mice on a docosahexaenoic acid (DHA) diet or cholesterol enriched Typical Western Diet (TWD). 2007 Neurobiol. Dis. pmid:17720508
Himmelfarb J et al. Gamma-tocopherol and docosahexaenoic acid decrease inflammation in dialysis patients. 2007 J Ren Nutr pmid:17720098
Bueno AA et al. Effects of different fatty acids and dietary lipids on adiponectin gene expression in 3T3-L1 cells and C57BL/6J mice adipose tissue. 2008 Pflugers Arch. pmid:17717684
Kolar SS et al. Synergy between docosahexaenoic acid and butyrate elicits p53-independent apoptosis via mitochondrial Ca(2+) accumulation in colonocytes. 2007 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:17717041
Igarashi M et al. Dietary n-3 PUFA deprivation for 15 weeks upregulates elongase and desaturase expression in rat liver but not brain. 2007 J. Lipid Res. pmid:17715424
Sahlin C et al. Docosahexaenoic acid stimulates non-amyloidogenic APP processing resulting in reduced Abeta levels in cellular models of Alzheimer's disease. 2007 Eur. J. Neurosci. pmid:17714184
Arterburn LM et al. Bioequivalence of Docosahexaenoic acid from different algal oils in capsules and in a DHA-fortified food. 2007 Lipids pmid:17713804
Mitmesser SH and Jensen CL Roles of long-chain polyunsaturated fatty acids in the term infant: developmental benefits. 2007 Jul-Aug Neonatal Netw pmid:17710956
Huang MC et al. Differential tissue dose responses of (n-3) and (n-6) PUFA in neonatal piglets fed docosahexaenoate and arachidonoate. 2007 J. Nutr. pmid:17709441
Besson N et al. Selective incorporation of docosahexaenoic acid into lysobisphosphatidic acid in cultured THP-1 macrophages. 2006 Lipids pmid:17707985
Calder PC Dietary arachidonic acid: harmful, harmless or helpful? 2007 Br. J. Nutr. pmid:17705889
Stark KD et al. Artificial rearing with docosahexaenoic acid and n-6 docosapentaenoic acid alters rat tissue fatty acid composition. 2007 J. Lipid Res. pmid:17703057
Abély M [Treatment of airway inflammation in cystic fibrosis]. 2007 Arch Pediatr pmid:17702549
Ylönen SK et al. The Pro12Ala polymorphism of the PPAR-gamma2 gene affects associations of fish intake and marine n-3 fatty acids with glucose metabolism. 2008 Eur J Clin Nutr pmid:17700648
Hogg RJ et al. Efficacy of omega-3 fatty acids in children and adults with IgA nephropathy is dosage- and size-dependent. 2006 Clin J Am Soc Nephrol pmid:17699343
Donadio JV et al. Is body size a biomarker for optimizing dosing of omega-3 polyunsaturated fatty acids in the treatment of patients with IgA nephropathy? 2006 Clin J Am Soc Nephrol pmid:17699310
Castañeda-Gutiérrez E et al. Effect of supplementation with calcium salts of fish oil on n-3 fatty acids in milk fat. 2007 J. Dairy Sci. pmid:17699033
Gronowitz E et al. Docosahexaenoic acid is associated with endosteal circumference in long bones in young males with cystic fibrosis. 2008 Br. J. Nutr. pmid:17697399
Ganuza E and Izquierdo MS Lipid accumulation in Schizochytrium G13/2S produced in continuous culture. 2007 Appl. Microbiol. Biotechnol. pmid:17694304
Brockman HL et al. Structural determinants of the packing and electrostatic behavior of unsaturated phosphoglycerides. 2007 Biophys. J. pmid:17693462
Burdge GC et al. The effect of altering the 20:5n-3 and 22:6n-3 content of a meal on the postprandial incorporation of n-3 polyunsaturated fatty acids into plasma triacylglycerol and non-esterified fatty acids in humans. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17693069
Tsuzuki T et al. Anti-angiogenic effects of conjugated docosahexaenoic acid in vitro and in vivo. 2007 Biosci. Biotechnol. Biochem. pmid:17690464
Koletzko B et al. Dietary fat intakes for pregnant and lactating women. 2007 Br. J. Nutr. pmid:17688705
Haubner L et al. The effects of maternal dietary docosahexaenoic acid intake on rat pup myelin and the auditory startle response. 2007 Dev. Neurosci. pmid:17684314
Kelley DS et al. Docosahexaenoic acid supplementation improves fasting and postprandial lipid profiles in hypertriglyceridemic men. 2007 Am. J. Clin. Nutr. pmid:17684201
Cansev M and Wurtman RJ Chronic administration of docosahexaenoic acid or eicosapentaenoic acid, but not arachidonic acid, alone or in combination with uridine, increases brain phosphatide and synaptic protein levels in gerbils. 2007 Neuroscience pmid:17683870
Florent-Béchard S et al. Towards a nutritional approach for prevention of Alzheimer's disease: biochemical and cellular aspects. 2007 J. Neurol. Sci. pmid:17681547
Bulbul M et al. Effect of docosahexaenoic acid on macrophage functions of rats. 2007 Immunobiology pmid:17678716
Geppert J et al. Co-supplementation of healthy women with fish oil and evening primrose oil increases plasma docosahexaenoic acid, gamma-linolenic acid and dihomo-gamma-linolenic acid levels without reducing arachidonic acid concentrations. 2008 Br. J. Nutr. pmid:17678567
Mukherjee PK et al. Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:17670936
Mukherjee PK et al. Photoreceptor outer segment phagocytosis attenuates oxidative stress-induced apoptosis with concomitant neuroprotectin D1 synthesis. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:17670935
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Li Q et al. Docosahexaenoic acid affects endothelial nitric oxide synthase in caveolae. 2007 Arch. Biochem. Biophys. pmid:17662956
Okuyama H et al. In vivo conversion of triacylglycerol to docosahexaenoic acid-containing phospholipids in a thraustochytrid-like microorganism, strain 12B. 2007 Biotechnol. Lett. pmid:17660943
Dullemeijer C et al. Erythrocyte folate and plasma DHA in the FACIT study. 2007 Lancet pmid:17658386
Galli C et al. Eicosapentaenoic acid for prevention of major coronary events. 2007 Lancet pmid:17658383
Kim YJ and Chung HY Antioxidative and anti-inflammatory actions of docosahexaenoic acid and eicosapentaenoic acid in renal epithelial cells and macrophages. 2007 J Med Food pmid:17651056
Omega-3 might ease depression, enhance mind & memory. There's a growing body of evidence that DHA benefits gray matter, but it's not a cure-all, say researchers. 2007 Duke Med Health News pmid:17649598
Prescription fish oil. 2007 Harv Health Lett pmid:17642082
Kato T et al. Docosahexaenoic acid (DHA), a primary tumor suppressive omega-3 fatty acid, inhibits growth of colorectal cancer independent of p53 mutational status. 2007 Nutr Cancer pmid:17640164
Duraisamy Y et al. Differential incorporation of docosahexaenoic acid into distinct cholesterol-rich membrane raft domains. 2007 Biochem. Biophys. Res. Commun. pmid:17631858
Sorgi PJ et al. Effects of an open-label pilot study with high-dose EPA/DHA concentrates on plasma phospholipids and behavior in children with attention deficit hyperactivity disorder. 2007 Nutr J pmid:17629918
Saifullah A et al. Oral fish oil supplementation raises blood omega-3 levels and lowers C-reactive protein in haemodialysis patients--a pilot study. 2007 Nephrol. Dial. Transplant. pmid:17623719
Plourde M and Cunnane SC Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements. 2007 Appl Physiol Nutr Metab pmid:17622276
de Lima TM et al. Docosahexaenoic acid enhances the toxic effect of imatinib on Bcr-Abl expressing HL-60 cells. 2007 Toxicol In Vitro pmid:17604596
Fagali N and Catalá A The effect of melatonin and structural analogues on the lipid peroxidation of triglycerides enriched in omega-3 polyunsaturated fatty acids. 2007 Life Sci. pmid:17603083
Del Turco S et al. Parallel decrease of tissue factor surface exposure and increase of tissue factor microparticle release by the n-3 fatty acid docosahexaenoate in endothelial cells. 2007 Thromb. Haemost. pmid:17598015
Lauretani F et al. Omega-6 and omega-3 fatty acids predict accelerated decline of peripheral nerve function in older persons. 2007 Eur. J. Neurol. pmid:17594339
Gorjão R et al. Regulation of interleukin-2 signaling by fatty acids in human lymphocytes. 2007 J. Lipid Res. pmid:17592174
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Miller MR et al. Replacement of fish oil with thraustochytrid Schizochytrium sp. L oil in Atlantic salmon parr (Salmo salar L) diets. 2007 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:17588797
Leonardi F et al. Docosahexaenoic acid supplementation induces dose and time dependent oxidative changes in C6 glioma cells. 2007 Free Radic. Res. pmid:17577735
Rupp H et al. Microdetermination of fatty acids by gas chromatography and cardiovascular risk stratification by the "EPA+DHA level". 2006 Herz pmid:17575804
Hardman WE Dietary canola oil suppressed growth of implanted MDA-MB 231 human breast tumors in nude mice. 2007 Nutr Cancer pmid:17571951
Schwab JM et al. Resolvin E1 and protectin D1 activate inflammation-resolution programmes. 2007 Nature pmid:17568749
Aspenström-Fagerlund B et al. Oleic acid and docosahexaenoic acid cause an increase in the paracellular absorption of hydrophilic compounds in an experimental model of human absorptive enterocytes. 2007 Toxicology pmid:17560003
Judge MP et al. Maternal consumption of a docosahexaenoic acid-containing functional food during pregnancy: benefit for infant performance on problem-solving but not on recognition memory tasks at age 9 mo. 2007 Am. J. Clin. Nutr. pmid:17556695