| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Pain | D010146 | 64 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kraffe E et al. | Evidence of a tetradocosahexaenoic cardiolipin in some marine bivalves. | 2002 | Lipids | pmid:12056594 |
| Patten GS et al. | Restoration of depressed prostanoid-induced ileal contraction in spontaneously hypertensive rats by dietary fish oil. | 2005 | Lipids | pmid:15825832 |
| Butovich IA et al. | Novel oxylipins formed from docosahexaenoic acid by potato lipoxygenase--10(S)-hydroxydocosahexaenoic acid and 10,20-dihydroxydocosahexaenoic acid. | 2005 | Lipids | pmid:15957250 |
| Hashimoto M et al. | Effects of eicosapentaenoic acid and docosahexaenoic acid on plasma membrane fluidity of aortic endothelial cells. | 1999 | Lipids | pmid:10652989 |
| Devlin AM and Innis SM | Dietary phospholipid alters biliary lipid composition in formula-fed piglets. | 1999 | Lipids | pmid:10652991 |
| Polette A et al. | Synthesis of acetyl,docosahexaenoyl-glycerophosphocholine and its characterization using nuclear magnetic resonance. | 1999 | Lipids | pmid:10652994 |
| Sullivan JC et al. | Modeling the primary oxidation in commercial fish oil preparations. | 2011 | Lipids | pmid:21104333 |
| Lu FS et al. | Oxidative stability of marine phospholipids in the liposomal form and their applications. | 2011 | Lipids | pmid:21088919 |
| Arterburn LM et al. | Bioequivalence of Docosahexaenoic acid from different algal oils in capsules and in a DHA-fortified food. | 2007 | Lipids | pmid:17713804 |
| Paschoal VA et al. | Eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid differentially modulate rat neutrophil function in vitro. | 2013 | Lipids | pmid:23086551 |
| Ackman RG | The absorption of fish oils and concentrates. | 1992 | Lipids | pmid:1491603 |
| Betancor MB et al. | Vitamin C enhances vitamin E status and reduces oxidative stress indicators in sea bass larvae fed high DHA microdiets. | 2012 | Lipids | pmid:23086553 |
| Innis SM | n-3 fatty acid requirements of the newborn. | 1992 | Lipids | pmid:1491606 |
| Birbes H et al. | Inhibition of Ca2+-independent phospholipase A2 affects arachidonate-, not docosahexaenoate-, phospholipid remodeling in U(III) cells. | 1999 | Lipids | pmid:10419092 |
| Aukema HM et al. | Abnormal lipid and fatty acid compositions of kidneys from mice with polycystic kidney disease. | 1992 | Lipids | pmid:1385849 |
| McLennan PL and Raederstorff D | Diabetes puts myocardial n-3 fatty acid status at risk in the absence of supplementation in the rat. | 1999 | Lipids | pmid:10419102 |
| Takahata K et al. | Protection from chemotherapy-induced alopecia by docosahexaenoic acid. | 1999 | Lipids | pmid:10419109 |
| Finstad HS et al. | Proliferation and types of killing of leukemia cell lines by very long chain polyunsaturated fatty acids. | 1999 | Lipids | pmid:10419110 |
| Bougnoux P et al. | Cytotoxic drug efficacy correlates with adipose tissue docosahexaenoic acid level in locally advanced breast carcinoma. | 1999 | Lipids | pmid:10419111 |
| Calviello G et al. | Effects of eicosapentaenoic and docosahexaenoic acids dietary supplementation on cell proliferation and apoptosis in rat colonic mucosa. | 1999 | Lipids | pmid:10419112 |
| Rotstein NP et al. | Essentiality of docosahexaenoic acid in retina photoreceptor cell development. | 1999 | Lipids | pmid:10419114 |
| Gilbert M et al. | Opposite regulation of prostaglandin H synthase isoforms by eicosapentaenoic and docosahexaenoic acids. | 1999 | Lipids | pmid:10419156 |
| Løchsen T et al. | Effects of fish oil and n-3 fatty acids on the regulation of delta9-fatty acid desaturase mRNA and -activity in rat liver. | 1999 | Lipids | pmid:10419157 |
| Jensen CL et al. | Effects of maternal docosahexaenoic acid supplementation on visual function and growth of breast-fed term infants. | 1999 | Lipids | pmid:10419159 |
| Otto SJ et al. | The postpartum docosahexaenoic acid status of lactating and nonlactating mothers. | 1999 | Lipids | pmid:10419160 |
| van Houwelingen AC et al. | The female docosahexaenoic acid status related to the number of completed pregnancies. | 1999 | Lipids | pmid:10419161 |
| Borod E et al. | Effects of third trimester consumption of eggs high in docosahexaenoic acid on docosahexaenoic acid status and pregnancy. | 1999 | Lipids | pmid:10419162 |
| Anderson RE et al. | A hypothesis to explain the reduced blood levels of docosahexaenoic acid in inherited retinal degenerations caused by mutations in genes encoding retina-specific proteins. | 1999 | Lipids | pmid:10419164 |
| Greiner RS et al. | Rats with low levels of brain docosahexaenoic acid show impaired performance in olfactory-based and spatial learning tasks. | 1999 | Lipids | pmid:10419165 |
| Dewailly E et al. | Fish consumption and blood lipids in three ethnic groups of Québec (Canada). | 2003 | Lipids | pmid:12848280 |
| Smuts CM et al. | High-DHA eggs: feasibility as a means to enhance circulating DHA in mother and infant. | 2003 | Lipids | pmid:12848286 |
| Patten GS et al. | Dietary fish oil dose-response effects on ileal phospholipid fatty acids and contractility. | 2005 | Lipids | pmid:16329465 |
| Visioli F et al. | Dietary intake of fish vs. formulations leads to higher plasma concentrations of n-3 fatty acids. | 2003 | Lipids | pmid:12848287 |
| Saito H et al. | High docosahexaenoic acid levels in both neutral and polar lipids of a highly migratory fish: Thunnus tonggol (Bleeker). | 2005 | Lipids | pmid:16329467 |
| Cleland LG et al. | A biomarker of n-3 compliance in patients taking fish oil for rheumatoid arthritis. | 2003 | Lipids | pmid:12848288 |
| Lyberg AM et al. | Monitoring the oxidation of docosahexaenoic acid in lipids. | 2005 | Lipids | pmid:16329470 |
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| Mitchell DC et al. | Enhancement of G protein-coupled signaling by DHA phospholipids. | 2003 | Lipids | pmid:12848291 |
| Gawrisch K et al. | The structure of DHA in phospholipid membranes. | 2003 | Lipids | pmid:12848292 |
| Lagarde M et al. | Pathophysiologic role of redox status in blood platelet activation. Influence of docosahexaenoic acid. | 2003 | Lipids | pmid:12848295 |
| Tanaka T et al. | Oral supplementation with dihomo-γ-linolenic acid (DGLA)-enriched oil increases serum DGLA content in healthy adults. | 2012 | Lipids | pmid:22411689 |
| Frøyland L et al. | Chronic administration of eicosapentaenoic acid and docosahexaenoic acid as ethyl esters reduced plasma cholesterol and changed the fatty acid composition in rat blood and organs. | 1996 | Lipids | pmid:8835405 |
| Saito H and Hashimoto J | Characteristics of the fatty acid composition of a deep-sea vent gastropod, Ifremeria nautilei. | 2010 | Lipids | pmid:20549377 |
| Yeh YY et al. | Dietary supplementation with arachidonic and docosahexaenoic acids has no effect on pulmonary surfactant in artificially reared infant rats. | 1999 | Lipids | pmid:10380120 |
| Calviello G et al. | Cell proliferation, differentiation, and apoptosis are modified by n-3 polyunsaturated fatty acids in normal colonic mucosa. | 1999 | Lipids | pmid:10405974 |
| Boeynaems JM et al. | Iodination of docosahexaenoic acid by lactoperoxidase and thyroid gland in vitro: formation of an lodolactone. | 1981 | Lipids | pmid:6153054 |
| Trattner S et al. | Sesamin supplementation increases white muscle docosahexaenoic acid (DHA) levels in rainbow trout (Oncorhynchus mykiss) fed high alpha-linolenic acid (ALA) containing vegetable oil: metabolic actions. | 2008 | Lipids | pmid:18781351 |
| Trattner S et al. | Sesamin increases alpha-linolenic acid conversion to docosahexaenoic acid in atlantic salmon (Salmo salar L.) hepatocytes: role of altered gene expression. | 2008 | Lipids | pmid:18784949 |
| Vandal M et al. | Plasma omega-3 fatty acid response to a fish oil supplement in the healthy elderly. | 2008 | Lipids | pmid:18795357 |
| Hamazaki T et al. | Docosahexaenoic acid does not affect aggression of normal volunteers under nonstressful conditions. A randomized, placebo-controlled, double-blind study. | 1998 | Lipids | pmid:9688168 |
| Hawkes JS et al. | Transforming growth factor beta in human milk does not change in response to modest intakes of docosahexaenoic acid. | 2001 | Lipids | pmid:11768164 |
| Huang LS et al. | Lysophosphatidylcholine containing docosahexaenoic acid at the sn-1 position is anti-inflammatory. | 2010 | Lipids | pmid:20165929 |
| Talahalli RR et al. | Lower efficacy in the utilization of dietary ALA as compared to preformed EPA + DHA on long chain n-3 PUFA levels in rats. | 2010 | Lipids | pmid:20734237 |
| De Craemer D et al. | Dietary docosahexaenoic acid has little effect on peroxisomes in healthy mice. | 1996 | Lipids | pmid:8934448 |
| Bonatto SJ et al. | Fish oil supplementation improves neutrophil function during cancer chemotherapy. | 2012 | Lipids | pmid:22160495 |
| Ratledge C et al. | Production of docosahexaenoic acid by Crypthecodinium cohnii grown in a pH-auxostat culture with acetic acid as principal carbon source. | 2001 | Lipids | pmid:11795857 |
| Bharadwaj AS et al. | Dietary source of stearidonic acid promotes higher muscle DHA concentrations than linolenic acid in hybrid striped bass. | 2010 | Lipids | pmid:20049582 |
| Chen S and Subbaiah PV | Regioisomers of phosphatidylcholine containing DHA and their potential to deliver DHA to the brain: role of phospholipase specificities. | 2013 | Lipids | pmid:23604781 |
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| Ando Y et al. | Reinvestigation of positional distribution of fatty acids in docosahexaenoic acid-rich fish oil triacyl-sn-glycerols. | 2000 | Lipids | pmid:10907794 |
| Park Y and Harris W | EPA, but not DHA, decreases mean platelet volume in normal subjects. | 2002 | Lipids | pmid:12530552 |
| Nøding R et al. | Effects of polyunsaturated fatty acids and their n-6 hydroperoxides on growth of five malignant cell lines and the significance of culture media. | 1998 | Lipids | pmid:9560803 |
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| Hirano R et al. | Regulation by long-chain fatty acids of the expression of cholesteryl ester transfer protein in HepG2 cells. | 2001 | Lipids | pmid:11383693 |
| Nichols PD et al. | Occurrence of high levels of tetracosahexaenoic acid in the jellyfish Aurelia sp. | 2003 | Lipids | pmid:14733367 |
| Tou JS | Acylation of docosahexaenoic acid into phospholipids by intact human neutrophils. | 1986 | Lipids | pmid:2941637 |
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| Martin LJ et al. | Effect of 4,7,10,13,16,19-docosahexaenoic acid on triglyceride accumulation and secretion in rat hepatocytes in culture. | 1991 | Lipids | pmid:1832732 |
| Verlengia R et al. | Effects of EPA and DHA on proliferation, cytokine production, and gene expression in Raji cells. | 2004 | Lipids | pmid:15669761 |
| Hixson SM et al. | Changes in tissue lipid and fatty acid composition of farmed rainbow trout in response to dietary camelina oil as a replacement of fish oil. | 2014 | Lipids | pmid:24264359 |
| Anderson RE and Penn JS | Environmental light and heredity are associated with adaptive changes in retinal DHA levels that affect retinal function. | 2004 | Lipids | pmid:15726827 |
| Serhan CN et al. | Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers. | 2004 | Lipids | pmid:15726828 |
| Mayzaud P et al. | Polar and neutral lipid composition in the pelagic tunicate Pyrosoma atlanticum. | 2007 | Lipids | pmid:17541797 |
| Willumsen N et al. | Eicosapentaenoic acid, but not docosahexaenoic acid, increases mitochondrial fatty acid oxidation and upregulates 2,4-dienoyl-CoA reductase gene expression in rats. | 1996 | Lipids | pmid:8784738 |
| Innis SM et al. | Blood lipid docosahexaenoic and arachidonic acid in term gestation infants fed formulas with high docosahexaenoic acid, low eicosapentaenoic acid fish oil. | 1996 | Lipids | pmid:8784742 |
| Dembitsky VM and Rezanka T | Unusually high levels of eicosatetraenoic, eicosapentaenoic, and docosahexaenoic fatty acids in Palestinian freshwater sponges. | 1996 | Lipids | pmid:8784746 |
| Mitjavila MT et al. | Effect of degree of unsaturation in dietary fatty acids on arachidonic acid mobilization by peritoneal macrophages. | 1996 | Lipids | pmid:8784749 |
| Madsen L et al. | Eicosapentaenoic and docosahexaenoic acid affect mitochondrial and peroxisomal fatty acid oxidation in relation to substrate preference. | 1999 | Lipids | pmid:10574660 |
| Hodge J et al. | Differential utilization of eicosapentaenoic acid and docosahexaenoic acid in human plasma. | 1993 | Lipids | pmid:8355578 |
| Stillwell W et al. | Docosahexaenoic acid increases permeability of lipid vesicles and tumor cells. | 1993 | Lipids | pmid:8441334 |
| Bitsanis D et al. | Gestational diabetes mellitus enhances arachidonic and docosahexaenoic acids in placental phospholipids. | 2006 | Lipids | pmid:16808147 |