| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Pain | D010146 | 64 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Brenna JT et al. | Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. | 2007 | Am. J. Clin. Nutr. | pmid:17556680 |
| Strokin M et al. | Prostaglandin synthesis in rat brain astrocytes is under the control of the n-3 docosahexaenoic acid, released by group VIB calcium-independent phospholipase A2. | 2007 | J. Neurochem. | pmid:17555549 |
| Schonfeld E et al. | Docosahexaenoic acid enhances iron uptake by modulating iron transporters and accelerates apoptotic death in PC12 cells. | 2007 | Neurochem. Res. | pmid:17551831 |
| Lucia Bergmann R et al. | Does maternal docosahexaenoic acid supplementation during pregnancy and lactation lower BMI in late infancy? | 2007 | J Perinat Med | pmid:17547539 |
| Joordens JC et al. | Preformed dietary DHA: The answer to a scientific question may in practice become translated to its opposite. | 2007 Jul-Aug | Am. J. Hum. Biol. | pmid:17546621 |
| Cunnane SC et al. | Docosahexaenoic acid and shore-based diets in hominin encephalization: a rebuttal. | 2007 Jul-Aug | Am. J. Hum. Biol. | pmid:17546620 |
| Carlson BA and Kingston JD | Docosahexaenoic acid biosynthesis and dietary contingency: Encephalization without aquatic constraint. | 2007 Jul-Aug | Am. J. Hum. Biol. | pmid:17546613 |
| Kolar SS et al. | Docosahexaenoic acid and butyrate synergistically induce colonocyte apoptosis by enhancing mitochondrial Ca2+ accumulation. | 2007 | Cancer Res. | pmid:17545640 |
| Mayzaud P et al. | Polar and neutral lipid composition in the pelagic tunicate Pyrosoma atlanticum. | 2007 | Lipids | pmid:17541797 |
| Wennberg M et al. | Fish intake, mercury, long-chain n-3 polyunsaturated fatty acids and risk of stroke in northern Sweden. | 2007 | Br. J. Nutr. | pmid:17537290 |
| Tsukui T et al. | Fucoxanthin and fucoxanthinol enhance the amount of docosahexaenoic acid in the liver of KKAy obese/diabetic mice. | 2007 | J. Agric. Food Chem. | pmid:17536824 |
| Bruno MJ et al. | Docosahexaenoic acid alters bilayer elastic properties. | 2007 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17535898 |
| Aires V et al. | Activation of TRPC6 calcium channels by diacylglycerol (DAG)-containing arachidonic acid: a comparative study with DAG-containing docosahexaenoic acid. | 2007 | Biochimie | pmid:17532549 |
| Ayalew-Pervanchon A et al. | Long-term effect of dietary {alpha}-linolenic acid or decosahexaenoic acid on incorporation of decosahexaenoic acid in membranes and its influence on rat heart in vivo. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17526653 |
| Brunton S and Collins N | Differentiating prescription omega-3-acid ethyl esters (P-OM3) from dietary-supplement omega-3 fatty acids. | 2007 | Curr Med Res Opin | pmid:17519081 |
| Blackford S et al. | Necrolytic migratory erythema without glucagonoma: the role of dietary essential fatty acids. | 1991 | Br. J. Dermatol. | pmid:1751353 |
| Thomas TR et al. | Interaction of exercise training and n-3 fatty acid supplementation on postprandial lipemia. | 2007 | Appl Physiol Nutr Metab | pmid:17510682 |
| O'Connor CI et al. | Dietary fish oil supplementation affects serum fatty acid concentrations in horses. | 2007 | J. Anim. Sci. | pmid:17504965 |
| Umhau JC | Folate and ageing. | 2007 | Lancet | pmid:17499600 |
| Bays H | Fish oil composition of Omacor and the GISSI trial. | 2007 | Am. J. Cardiol. | pmid:17493490 |
| Krauss-Etschmann S et al. | Effects of fish-oil and folate supplementation of pregnant women on maternal and fetal plasma concentrations of docosahexaenoic acid and eicosapentaenoic acid: a European randomized multicenter trial. | 2007 | Am. J. Clin. Nutr. | pmid:17490978 |
| Metcalf RG et al. | Effects of fish-oil supplementation on myocardial fatty acids in humans. | 2007 | Am. J. Clin. Nutr. | pmid:17490956 |
| Kim HY | Novel metabolism of docosahexaenoic acid in neural cells. | 2007 | J. Biol. Chem. | pmid:17488715 |
| Zand H et al. | Involvement of PPAR-gamma and p53 in DHA-induced apoptosis in Reh cells. | 2007 | Mol. Cell. Biochem. | pmid:17487454 |
| Victory R et al. | Antiadhesion effects of docosahexaenoic acid on normal human peritoneal and adhesion fibroblasts. | 2007 | Fertil. Steril. | pmid:17482172 |
| Soubias O and Gawrisch K | Docosahexaenoyl chains isomerize on the sub-nanosecond time scale. | 2007 | J. Am. Chem. Soc. | pmid:17477528 |
| Das UN | Is metabolic syndrome X a disorder of the brain with the initiation of low-grade systemic inflammatory events during the perinatal period? | 2007 | J. Nutr. Biochem. | pmid:17475465 |
| Rossary A et al. | Polyunsaturated fatty acids modulate NOX 4 anion superoxide production in human fibroblasts. | 2007 | Biochem. J. | pmid:17472580 |
| Sijben JW and Calder PC | Differential immunomodulation with long-chain n-3 PUFA in health and chronic disease. | 2007 | Proc Nutr Soc | pmid:17466105 |
| von Schacky C | n-3 PUFA in CVD: influence of cytokine polymorphism. | 2007 | Proc Nutr Soc | pmid:17466099 |
| Bonventre JV | Pathophysiology of acute kidney injury: roles of potential inhibitors of inflammation. | 2007 | Contrib Nephrol | pmid:17464114 |
| McKenney JM and Sica D | Role of prescription omega-3 fatty acids in the treatment of hypertriglyceridemia. | 2007 | Pharmacotherapy | pmid:17461707 |
| Burns T et al. | Effect of omega-3 fatty acid supplementation on the arachidonic acid:eicosapentaenoic acid ratio. | 2007 | Pharmacotherapy | pmid:17461697 |
| Stark KD et al. | Docosahexaenoic acid and n-6 docosapentaenoic acid supplementation alter rat skeletal muscle fatty acid composition. | 2007 | Lipids Health Dis | pmid:17459159 |
| Thid D et al. | DHA-induced changes of supported lipid membrane morphology. | 2007 | Langmuir | pmid:17455967 |
| Sharma AK and Rohrer B | Sustained elevation of intracellular cGMP causes oxidative stress triggering calpain-mediated apoptosis in photoreceptor degeneration. | 2007 | Curr. Eye Res. | pmid:17453946 |
| Heird WC | Omega-3 long-chain polyunsaturated fatty acids in older children. | 2007 | J. Pediatr. | pmid:17452214 |
| Fournier V et al. | Quantification of eicosapentaenoic and docosahexaenoic acid geometrical isomers formed during fish oil deodorization by gas-liquid chromatography. | 2007 | J Chromatogr A | pmid:17449039 |
| Kusumoto A et al. | Effects of arachidonate-enriched triacylglycerol supplementation on serum fatty acids and platelet aggregation in healthy male subjects with a fish diet. | 2007 | Br. J. Nutr. | pmid:17445350 |
| Green KN et al. | Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels. | 2007 | J. Neurosci. | pmid:17442823 |
| Busch B | Polyunsaturated fatty acid supplementation for ADHD? Fishy, fascinating, and far from clear. | 2007 | J Dev Behav Pediatr | pmid:17435465 |
| Ding WQ and Lind SE | Phospholipid hydroperoxide glutathione peroxidase plays a role in protecting cancer cells from docosahexaenoic acid-induced cytotoxicity. | 2007 | Mol. Cancer Ther. | pmid:17431126 |
| Kothapalli KS et al. | Differential cerebral cortex transcriptomes of baboon neonates consuming moderate and high docosahexaenoic acid formulas. | 2007 | PLoS ONE | pmid:17426818 |
| Serkov IV et al. | Effect of derivatives of docosahexaenoic acid on AMPA receptors in Purkinje neurons. | 2006 Nov-Dec | Dokl. Biol. Sci. | pmid:17425032 |
| Yano M et al. | Comprehensive analysis of the effects of ordinary nutrients on hepatitis C virus RNA replication in cell culture. | 2007 | Antimicrob. Agents Chemother. | pmid:17420205 |
| Arita M and Serhan CN | [Novel chemical mediators in the resolution of inflammation]. | 2007 | Tanpakushitsu Kakusan Koso | pmid:17419455 |
| Tanaka K et al. | Early dietary treatments with Lorenzo's oil and docosahexaenoic acid for neurological development in a case with Zellweger syndrome. | 2007 | Brain Dev. | pmid:17418516 |
| Hsieh AT et al. | The influence of moderate and high dietary long chain polyunsaturated fatty acids (LCPUFA) on baboon neonate tissue fatty acids. | 2007 | Pediatr. Res. | pmid:17413857 |
| Salem N | What is the right level of DHA in the infant diet? Commentary on article by Hsieh et al. on page 537. | 2007 | Pediatr. Res. | pmid:17413853 |
| van Gelder BM et al. | Fish consumption, n-3 fatty acids, and subsequent 5-y cognitive decline in elderly men: the Zutphen Elderly Study. | 2007 | Am. J. Clin. Nutr. | pmid:17413117 |
| Connor WE and Connor SL | The importance of fish and docosahexaenoic acid in Alzheimer disease. | 2007 | Am. J. Clin. Nutr. | pmid:17413088 |
| Payne M et al. | DHA-paclitaxel (Taxoprexin) as first-line treatment in patients with stage IIIB or IV non-small cell lung cancer: report of a phase II open-label multicenter trial. | 2006 | J Thorac Oncol | pmid:17409983 |
| Portolesi R et al. | Competition between 24:5n-3 and ALA for Delta 6 desaturase may limit the accumulation of DHA in HepG2 cell membranes. | 2007 | J. Lipid Res. | pmid:17409318 |
| Milligan LA and Bazinet RP | Is docosahexaenoic acid a red herring for the aquatic diet?--Comments by Milligan and Bazinet. | 2007 | Br. J. Nutr. | pmid:17408532 |
| Cunnane SC | Docosahexaenoic acid and human brain evolution: missing the forest for the trees--comments by Cunnane. | 2007 | Br. J. Nutr. | pmid:17408531 |
| Hwang I et al. | N-3 polyunsaturated fatty acids and atopy in Korean preschoolers. | 2007 | Lipids | pmid:17406929 |
| Harris WS et al. | Stearidonic acid increases the red blood cell and heart eicosapentaenoic acid content in dogs. | 2007 | Lipids | pmid:17406927 |
| Kebir MV et al. | Fatty acids in liver, muscle and gonad of three tropical rays including non-methylene-interrupted dienoic fatty acids. | 2007 | Lipids | pmid:17404769 |
| Portier K et al. | The effects of dietary N-3 and antioxidant supplementation on erythrocyte membrane fatty acid composition and fluidity in exercising horses. | 2006 | Equine Vet J Suppl | pmid:17402432 |
| Mozaffarian D | JELIS, fish oil, and cardiac events. | 2007 | Lancet | pmid:17398290 |
| Vancassel S et al. | Hyperactivity in the rat is associated with spontaneous low level of n-3 polyunsaturated fatty acids in the frontal cortex. | 2007 | Behav. Brain Res. | pmid:17397943 |
| Judge MP et al. | A docosahexaenoic acid-functional food during pregnancy benefits infant visual acuity at four but not six months of age. | 2007 | Lipids | pmid:17393217 |
| Meyer BJ et al. | Dose-dependent effects of docosahexaenoic acid supplementation on blood lipids in statin-treated hyperlipidaemic subjects. | 2007 | Lipids | pmid:17393216 |
| Hill AM et al. | n-3 Fatty acid supplementation and regular moderate exercise: differential effects of a combined intervention on neutrophil function. | 2007 | Br. J. Nutr. | pmid:17391558 |
| Kuipers RS et al. | Milk in the island of Chole [Tanzania] is high in lauric, myristic, arachidonic and docosahexaenoic acids, and low in linoleic acid reconstructed diet of infants born to our ancestors living in tropical coastal regions. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17383169 |
| Conklin SM et al. | Serum omega-3 fatty acids are associated with variation in mood, personality and behavior in hypercholesterolemic community volunteers. | 2007 | Psychiatry Res | pmid:17383013 |
| Balaji T et al. | Localization of cyclooxygenase-2 in mice vas deferens and its effects on fertility upon suppression using nimesulide: a preferential cyclooxygenase-2 inhibitor. | 2007 | Toxicology | pmid:17382448 |
| Fan KW et al. | Lipid characterization of mangrove thraustochytrid--Schizochytrium mangrovei. | 2007 | J. Agric. Food Chem. | pmid:17381126 |
| Theobald HE et al. | Low-dose docosahexaenoic acid lowers diastolic blood pressure in middle-aged men and women. | 2007 | J. Nutr. | pmid:17374663 |
| Innis SM | Dietary (n-3) fatty acids and brain development. | 2007 | J. Nutr. | pmid:17374644 |
| Richardson UI and Wurtman RJ | Polyunsaturated fatty acids stimulate phosphatidylcholine synthesis in PC12 cells. | 2007 | Biochim. Biophys. Acta | pmid:17350887 |
| Murphy KJ et al. | Impact of foods enriched with n-3 long-chain polyunsaturated fatty acids on erythrocyte n-3 levels and cardiovascular risk factors. | 2007 | Br. J. Nutr. | pmid:17349088 |
| Bassaganya-Riera J et al. | Arachidonic acid-and docosahexaenoic acid-enriched formulas modulate antigen-specific T cell responses to influenza virus in neonatal piglets. | 2007 | Am. J. Clin. Nutr. | pmid:17344506 |
| Anil E | The impact of EPA and DHA on blood lipids and lipoprotein metabolism: influence of apoE genotype. | 2007 | Proc Nutr Soc | pmid:17343773 |
| Maillard MH | [Resolvins: new derivates of fatty acids, polyunsaturated (omega-3) with therapeutic potential in inflammatory intestinal diseases]. | 2006 | Rev Med Suisse | pmid:17343155 |
| Jourdan ML et al. | Increased BRCA1 protein in mammary tumours of rats fed marine omega-3 fatty acids. | 2007 | Oncol. Rep. | pmid:17342305 |
| Panza F et al. | Dietary polyunsaturated fatty acid supplementation, pre-dementia syndromes, and Alzheimer's disease. | 2007 | J Am Geriatr Soc | pmid:17341255 |
| Ariel A and Serhan CN | Resolvins and protectins in the termination program of acute inflammation. | 2007 | Trends Immunol. | pmid:17337246 |
| Jakel RJ et al. | Nrf2-mediated protection against 6-hydroxydopamine. | 2007 | Brain Res. | pmid:17336276 |
| Shirai N et al. | Effect of lipids extracted from a salted herring roe food product on maze-behavior in mice. | 2006 | J. Nutr. Sci. Vitaminol. | pmid:17330509 |
| Pettersson U and Dahlqvist R | [Fish oil for prevention of thrombosis and blood lipid lowering?]. | 2007 Jan 24-30 | Lakartidningen | pmid:17328472 |
| The dish on fish. Benefits outweigh risks, according to two recent reviews. | 2007 | Harv Health Lett | pmid:17328140 | |
| Moghaddami N et al. | Novel action of n-3 polyunsaturated fatty acids: inhibition of arachidonic acid-induced increase in tumor necrosis factor receptor expression on neutrophils and a role for proteases. | 2007 | Arthritis Rheum. | pmid:17328054 |
| von Schacky C | A review of omega-3 ethyl esters for cardiovascular prevention and treatment of increased blood triglyceride levels. | 2006 | Vasc Health Risk Manag | pmid:17326331 |
| Zhang Y et al. | Neuroprotection by tamoxifen in focal cerebral ischemia is not mediated by an agonist action at estrogen receptors but is associated with antioxidant activity. | 2007 | Exp. Neurol. | pmid:17321521 |
| Decsi T et al. | Low contribution of n-3 polyunsaturated fatty acids to plasma and erythrocyte membrane lipids in diabetic young adults. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17321122 |
| Xiao Y et al. | DHA depletion in rat brain is associated with impairment on spatial learning and memory. | 2006 | Biomed. Environ. Sci. | pmid:17319274 |
| de Groot RH et al. | Exploratory study into the relation between plasma phospholipid fatty acid status and cognitive performance. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17317131 |
| Coste TC et al. | An overview of monitoring and supplementation of omega 3 fatty acids in cystic fibrosis. | 2007 | Clin. Biochem. | pmid:17316592 |
| Schley PD et al. | (n-3) PUFA alter raft lipid composition and decrease epidermal growth factor receptor levels in lipid rafts of human breast cancer cells. | 2007 | J. Nutr. | pmid:17311938 |
| López-Alarcón M et al. | Breastfeeding's protection against illness-induced anorexia is mediated partially by docosahexaenoic acid. | 2008 | Eur J Clin Nutr | pmid:17311056 |
| Koletzko B et al. | Placental transfer of long-chain polyunsaturated fatty acids (LC-PUFA). | 2007 | J Perinat Med | pmid:17302540 |
| Vibet S et al. | Differential subcellular distribution of mitoxantrone in relation to chemosensitization in two human breast cancer cell lines. | 2007 | Drug Metab. Dispos. | pmid:17296624 |
| Zhou XR et al. | Isolation and characterization of genes from the marine microalga Pavlova salina encoding three front-end desaturases involved in docosahexaenoic acid biosynthesis. | 2007 | Phytochemistry | pmid:17291553 |
| New Alzheimer's clinical trials to be undertaken by NIA nationwide consortium. | 2006 Dec-2007 Jan | Am J Alzheimers Dis Other Demen | pmid:17288014 | |
| Bazan NG | Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection. | 2007 | Curr Opin Clin Nutr Metab Care | pmid:17285000 |
| von Schacky C | Omega-3 fatty acids and cardiovascular disease. | 2007 | Curr Opin Clin Nutr Metab Care | pmid:17284999 |
| Racine RA and Deckelbaum RJ | Sources of the very-long-chain unsaturated omega-3 fatty acids: eicosapentaenoic acid and docosahexaenoic acid. | 2007 | Curr Opin Clin Nutr Metab Care | pmid:17284998 |
| Ookawa K et al. | Effect of ovary lipid of skipjack tuna on rat serum components after stress application. | 2007 | J. Vet. Med. Sci. | pmid:17283400 |
| Igarashi M et al. | Docosahexaenoic acid synthesis from alpha-linolenic acid by rat brain is unaffected by dietary n-3 PUFA deprivation. | 2007 | J. Lipid Res. | pmid:17277380 |