| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Pain | D010146 | 64 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kraffe E et al. | Evidence of a tetradocosahexaenoic cardiolipin in some marine bivalves. | 2002 | Lipids | pmid:12056594 |
| Li HX et al. | Increasing DHA and EPA concentrations prolong action potential durations and reduce transient outward potassium currents in rat ventricular myocytes. | 2011 | Lipids | pmid:21140236 |
| Kraffe E et al. | Docosahexaenoic acid- and eicosapentaenoic acid-enriched cardiolipin in the Manila clam Ruditapes philippinarum. | 2005 | Lipids | pmid:16149741 |
| Grandgirard A et al. | Occurrence of geometrical isomers of eicosapentaenoic and docosahexaenoic acids in liver lipids of rats fed heated linseed oil. | 1989 | Lipids | pmid:2555649 |
| Garrido A et al. | Ingestion of high doses of fish oil increases the susceptibility of cellular membranes to the induction of oxidative stress. | 1989 | Lipids | pmid:2555651 |
| Hashimoto M et al. | Effects of eicosapentaenoic acid and docosahexaenoic acid on plasma membrane fluidity of aortic endothelial cells. | 1999 | Lipids | pmid:10652989 |
| Devlin AM and Innis SM | Dietary phospholipid alters biliary lipid composition in formula-fed piglets. | 1999 | Lipids | pmid:10652991 |
| Polette A et al. | Synthesis of acetyl,docosahexaenoyl-glycerophosphocholine and its characterization using nuclear magnetic resonance. | 1999 | Lipids | pmid:10652994 |
| Sullivan JC et al. | Modeling the primary oxidation in commercial fish oil preparations. | 2011 | Lipids | pmid:21104333 |
| Lu FS et al. | Oxidative stability of marine phospholipids in the liposomal form and their applications. | 2011 | Lipids | pmid:21088919 |
| Paschoal VA et al. | Eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid differentially modulate rat neutrophil function in vitro. | 2013 | Lipids | pmid:23086551 |
| Betancor MB et al. | Vitamin C enhances vitamin E status and reduces oxidative stress indicators in sea bass larvae fed high DHA microdiets. | 2012 | Lipids | pmid:23086553 |
| Bougnoux P et al. | Cytotoxic drug efficacy correlates with adipose tissue docosahexaenoic acid level in locally advanced breast carcinoma. | 1999 | Lipids | pmid:10419111 |
| Calviello G et al. | Effects of eicosapentaenoic and docosahexaenoic acids dietary supplementation on cell proliferation and apoptosis in rat colonic mucosa. | 1999 | Lipids | pmid:10419112 |
| Rotstein NP et al. | Essentiality of docosahexaenoic acid in retina photoreceptor cell development. | 1999 | Lipids | pmid:10419114 |
| Miller C et al. | Guinea pig epidermis generates putative anti-inflammatory metabolites from fish oil polyunsaturated fatty acids. | 1989 | Lipids | pmid:2559281 |
| Gilbert M et al. | Opposite regulation of prostaglandin H synthase isoforms by eicosapentaenoic and docosahexaenoic acids. | 1999 | Lipids | pmid:10419156 |
| Løchsen T et al. | Effects of fish oil and n-3 fatty acids on the regulation of delta9-fatty acid desaturase mRNA and -activity in rat liver. | 1999 | Lipids | pmid:10419157 |
| Jensen CL et al. | Effects of maternal docosahexaenoic acid supplementation on visual function and growth of breast-fed term infants. | 1999 | Lipids | pmid:10419159 |
| Otto SJ et al. | The postpartum docosahexaenoic acid status of lactating and nonlactating mothers. | 1999 | Lipids | pmid:10419160 |
| van Houwelingen AC et al. | The female docosahexaenoic acid status related to the number of completed pregnancies. | 1999 | Lipids | pmid:10419161 |
| Borod E et al. | Effects of third trimester consumption of eggs high in docosahexaenoic acid on docosahexaenoic acid status and pregnancy. | 1999 | Lipids | pmid:10419162 |
| Anderson RE et al. | A hypothesis to explain the reduced blood levels of docosahexaenoic acid in inherited retinal degenerations caused by mutations in genes encoding retina-specific proteins. | 1999 | Lipids | pmid:10419164 |
| Greiner RS et al. | Rats with low levels of brain docosahexaenoic acid show impaired performance in olfactory-based and spatial learning tasks. | 1999 | Lipids | pmid:10419165 |
| Kyle DJ et al. | Low serum docosahexaenoic acid is a significant risk factor for Alzheimer's dementia. | 1999 | Lipids | pmid:10419166 |
| Størvold GL et al. | Docosahexaenoic acid activates some SREBP-2 targets independent of cholesterol and ER stress in SW620 colon cancer cells. | 2009 | Lipids | pmid:19582494 |
| Glozman S et al. | Ethyl docosahexaenoic acid administration during intrauterine life enhances prostanoid production and reduces free radicals generation in the fetal rat brain. | 1999 | Lipids | pmid:10419167 |
| Koussoroplis AM et al. | From aquatic to terrestrial food webs: decrease of the docosahexaenoic acid/linoleic acid ratio. | 2008 | Lipids | pmid:18335265 |
| Kim HY and Edsall L | The role of docosahexaenoic acid (22:6n-3) in neuronal signaling. | 1999 | Lipids | pmid:10419168 |
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| Mitchell DC et al. | Enhancement of G protein-coupled signaling by DHA phospholipids. | 2003 | Lipids | pmid:12848291 |
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| Reicks M et al. | Recovery of fish oil-derived fatty acids in lymph of thoracic duct-cannulated Wistar rats. | 1990 | Lipids | pmid:2139156 |
| Boeynaems JM et al. | Iodination of docosahexaenoic acid by lactoperoxidase and thyroid gland in vitro: formation of an lodolactone. | 1981 | Lipids | pmid:6153054 |
| Gaudette DC and Holub BJ | Albumin-bound docosahexaenoic acid and collagen-induced human platelet reactivity. | 1990 | Lipids | pmid:2139712 |
| Bryan DL et al. | Modulation of respiratory syncytial virus-induced prostaglandin E2 production by n-3 long-chain polyunsaturated fatty acids in human respiratory epithelium. | 2005 | Lipids | pmid:16382572 |
| Sørensen BM et al. | Storage lipid accumulation and acyltransferase action in developing flaxseed. | 2005 | Lipids | pmid:16382576 |
| Waldron MK et al. | Plasma phospholipid fatty acid and ex vivo neutrophil responses are differentially altered in dogs fed fish- and linseed-oil containing diets at the same n-6:n-3 fatty acid ratio. | 2012 | Lipids | pmid:22252853 |
| Degrace P et al. | Intestinal lymph absorption of butter, corn oil, cod liver oil, menhaden oil, and eicosapentaenoic and docosahexaenoic acid ethyl esters in rats. | 1996 | Lipids | pmid:8743053 |
| Kimura F et al. | Supplementation of DHA-rich microalgal oil or fish oil during the suckling period in mildly n-3 fatty acid-deficient rat pups. | 2011 | Lipids | pmid:21901511 |
| Hamazaki T et al. | Docosahexaenoic acid does not affect aggression of normal volunteers under nonstressful conditions. A randomized, placebo-controlled, double-blind study. | 1998 | Lipids | pmid:9688168 |
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| Pifferi F et al. | Fatty acid composition of the brain, retina, liver and adipose tissue of the grey mouse lemur (Microcebus murinus, primate). | 2012 | Lipids | pmid:22684890 |
| Huang LS et al. | Lysophosphatidylcholine containing docosahexaenoic acid at the sn-1 position is anti-inflammatory. | 2010 | Lipids | pmid:20165929 |
| Hsu FF et al. | Electrospray ionization mass spectrometric analyses of changes in tissue phospholipid molecular species during the evolution of hyperlipidemia and hyperglycemia in Zucker diabetic fatty rats. | 2000 | Lipids | pmid:10984107 |
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| Mocellin MC et al. | Fish oil decreases C-reactive protein/albumin ratio improving nutritional prognosis and plasma fatty acid profile in colorectal cancer patients. | 2013 | Lipids | pmid:23888317 |
| Ratledge C et al. | Production of docosahexaenoic acid by Crypthecodinium cohnii grown in a pH-auxostat culture with acetic acid as principal carbon source. | 2001 | Lipids | pmid:11795857 |
| Wijendran V et al. | Fetal erythrocyte phospholipid polyunsaturated fatty acids are altered in pregnancy complicated with gestational diabetes mellitus. | 2000 | Lipids | pmid:10984116 |
| Cunnane SC et al. | Detection of [U-13C]eicosapentaenoic acid in rat liver lipids using 13C nuclear magnetic resonance spectroscopy. | 1993 | Lipids | pmid:8487618 |
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| Rotstein NP et al. | Effects of aging on the composition and metabolism of docosahexaenoate-containing lipids of retina. | 1987 | Lipids | pmid:2955190 |
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| Mitjavila MT et al. | Effect of degree of unsaturation in dietary fatty acids on arachidonic acid mobilization by peritoneal macrophages. | 1996 | Lipids | pmid:8784749 |
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| Hodge J et al. | Differential utilization of eicosapentaenoic acid and docosahexaenoic acid in human plasma. | 1993 | Lipids | pmid:8355578 |
| Stillwell W et al. | Docosahexaenoic acid increases permeability of lipid vesicles and tumor cells. | 1993 | Lipids | pmid:8441334 |
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| Bryan DL et al. | Polyunsaturated fatty acids regulate cytokine and prostaglandin E2 production by respiratory cells in response to mast cell mediators. | 2006 | Lipids | pmid:17269555 |
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