DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Parker G et al. Omega-3 fatty acids and mood disorders. 2006 Am J Psychiatry pmid:16741195
Gladyshev MI et al. [Influence of different methods of cooking of hunchback salmon on contents of polyunsaturatedfatty acids]. 2006 Vopr Pitan pmid:16739608
Friedman AN et al. Fish consumption and omega-3 fatty acid status and determinants in long-term hemodialysis. 2006 Am. J. Kidney Dis. pmid:16731302
Li D et al. Omega 6 to omega 3 fatty acid imbalance early in life leads to persistent reductions in DHA levels in glycerophospholipids in rat hypothalamus even after long-term omega 3 fatty acid repletion. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16716580
Mairesse G et al. Effects of geographic source, rearing system, and season on the nutritional quality of wild and farmed Perca fluviatilis. 2006 Lipids pmid:16711596
Mantovani G et al. A phase II study with antioxidants, both in the diet and supplemented, pharmaconutritional support, progestagen, and anti-cyclooxygenase-2 showing efficacy and safety in patients with cancer-related anorexia/cachexia and oxidative stress. 2006 Cancer Epidemiol. Biomarkers Prev. pmid:16702388
Coti Bertrand P et al. Maternal dietary (n-3) fatty acid deficiency alters neurogenesis in the embryonic rat brain. 2006 J. Nutr. pmid:16702323
Mjøs SA Prediction of equivalent chain lengths from two-dimensional fatty acid retention indices. 2006 J Chromatogr A pmid:16701676
Kishida E et al. Docosahexaenoic acid enrichment can reduce L929 cell necrosis induced by tumor necrosis factor. 2006 Biochim. Biophys. Acta pmid:16698313
Camuesco D et al. Intestinal anti-inflammatory activity of combined quercitrin and dietary olive oil supplemented with fish oil, rich in EPA and DHA (n-3) polyunsaturated fatty acids, in rats with DSS-induced colitis. 2006 Clin Nutr pmid:16698151
Gorjão R et al. Effect of docosahexaenoic acid-rich fish oil supplementation on human leukocyte function. 2006 Clin Nutr pmid:16697494
Turner N et al. Scaling of Na+,K+-ATPase molecular activity and membrane fatty acid composition in mammalian and avian hearts. 2006 May-Jun Physiol. Biochem. Zool. pmid:16691518
Igarashi M et al. Low liver conversion rate of alpha-linolenic to docosahexaenoic acid in awake rats on a high-docosahexaenoate-containing diet. 2006 J. Lipid Res. pmid:16687661
Waterhouse KE et al. Within and between breed differences in freezing tolerance and plasma membrane fatty acid composition of boar sperm. 2006 Reproduction pmid:16672353
Alnajjar A et al. Effect of n-3 and n-6 polyunsaturated fatty acids on lymphocyte proliferation, interleukin production and phospholipid fatty acids composition in type 2 diabetic and healthy subjects in Jordan people. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16650969
Coetzee M et al. Effects of arachidonic acid, docosahexaenoic acid, prostaglandin E(2) and parathyroid hormone on osteoprotegerin and RANKL secretion by MC3T3-E1 osteoblast-like cells. 2007 J. Nutr. Biochem. pmid:16650751
Narayanan NK et al. Docosahexaenoic acid in combination with celecoxib modulates HSP70 and p53 proteins in prostate cancer cells. 2006 Int. J. Cancer pmid:16646082
Azevedo-Martins AK et al. Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells. 2006 Toxicol In Vitro pmid:16644178
King VR et al. Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat. 2006 J. Neurosci. pmid:16641248
Hirunpanich V and Sato H Docosahexaenoic acid (DHA) inhibits saquinavir metabolism in-vitro and enhances its bioavailability in rats. 2006 J. Pharm. Pharmacol. pmid:16640834
Wright K et al. Formula supplemented with docosahexaenoic acid (DHA) and arachidonic acid (ARA): a critical review of the research. 2006 J Spec Pediatr Nurs pmid:16635189
Wurtman RJ et al. Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally. 2006 Brain Res. pmid:16631143
Burja AM et al. Isolation and characterization of polyunsaturated fatty acid producing Thraustochytrium species: screening of strains and optimization of omega-3 production. 2006 Appl. Microbiol. Biotechnol. pmid:16625394
Berger A et al. How dietary arachidonic- and docosahexaenoic- acid rich oils differentially affect the murine hepatic transcriptome. 2006 Lipids Health Dis pmid:16623957
Catalá A An overview of lipid peroxidation with emphasis in outer segments of photoreceptors and the chemiluminescence assay. 2006 Int. J. Biochem. Cell Biol. pmid:16621670
Xue H et al. Eicosapentaenoic acid and docosahexaenoic acid modulate mitogen-activated protein kinase activity in endothelium. 2006 Vascul. Pharmacol. pmid:16616699
O'Keefe JH et al. Effects of omega-3 fatty acids on resting heart rate, heart rate recovery after exercise, and heart rate variability in men with healed myocardial infarctions and depressed ejection fractions. 2006 Am. J. Cardiol. pmid:16616012
Truksa M et al. Metabolic engineering of plants to produce very long-chain polyunsaturated fatty acids. 2006 Transgenic Res. pmid:16604455
Aldámiz-Echevarría L et al. Effect of docosahexaenoic acid administration on plasma lipid profile and metabolic parameters of children with methylmalonic acidaemia. 2006 J. Inherit. Metab. Dis. pmid:16601869
Kawai Y et al. Formation of Nepsilon-(succinyl)lysine in vivo: a novel marker for docosahexaenoic acid-derived protein modification. 2006 J. Lipid Res. pmid:16582421
Bazan NG Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors. 2006 Trends Neurosci. pmid:16580739
Knudsen VK et al. Fish oil in various doses or flax oil in pregnancy and timing of spontaneous delivery: a randomised controlled trial. 2006 BJOG pmid:16579802
Geppert J et al. Microalgal docosahexaenoic acid decreases plasma triacylglycerol in normolipidaemic vegetarians: a randomised trial. 2006 Br. J. Nutr. pmid:16571158
German OL et al. Ceramide is a mediator of apoptosis in retina photoreceptors. 2006 Invest. Ophthalmol. Vis. Sci. pmid:16565407
Wang Y et al. Synthesis and preliminary antitumor activity evaluation of a DHA and doxorubicin conjugate. 2006 Bioorg. Med. Chem. Lett. pmid:16563756
Unagul P et al. Coconut water as a medium additive for the production of docosahexaenoic acid (C22:6 n3) by Schizochytrium mangrovei Sk-02. 2007 Bioresour. Technol. pmid:16563749
Bhattacharya A et al. Different ratios of eicosapentaenoic and docosahexaenoic omega-3 fatty acids in commercial fish oils differentially alter pro-inflammatory cytokines in peritoneal macrophages from C57BL/6 female mice. 2007 J. Nutr. Biochem. pmid:16563716
Strokin M et al. Neuroprotection of rat hippocampal slices exposed to oxygen-glucose deprivation by enrichment with docosahexaenoic acid and by inhibition of hydrolysis of docosahexaenoic acid-containing phospholipids by calcium independent phospholipase A2. 2006 Neuroscience pmid:16563639
Li D et al. A significant inverse relationship between concentrations of plasma homocysteine and phospholipid docosahexaenoic acid in healthy male subjects. 2006 Lipids pmid:16555476
Lyberg AM and Adlercreutz P Monitoring monohydroperoxides in docosahexaenoic acid using high-performance liquid chromatography. 2006 Lipids pmid:16555474
Wang WP et al. Agmatine protects against cell damage induced by NMDA and glutamate in cultured hippocampal neurons. 2006 Brain Res. pmid:16546145
Fer M et al. Determination of polyunsaturated fatty acid monoepoxides by high performance liquid chromatography-mass spectrometry. 2006 J Chromatogr A pmid:16545829
Li Q et al. Effect of docosahexaenoic acid on interleukin-2 receptor signaling pathway in lipid rafts. 2006 Sci. China, C, Life Sci. pmid:16544577
Straarup EM et al. The stereospecific triacylglycerol structures and Fatty Acid profiles of human milk and infant formulas. 2006 J. Pediatr. Gastroenterol. Nutr. pmid:16540799
Hoffman DR et al. Docosahexaenoic acid in red blood cells of term infants receiving two levels of long-chain polyunsaturated fatty acids. 2006 J. Pediatr. Gastroenterol. Nutr. pmid:16540798
Pall H et al. Decreased peroxisome proliferator activated receptor alpha is associated with bile duct injury in cystic fibrosis transmembrane conductance regulator-/- mice. 2006 J. Pediatr. Gastroenterol. Nutr. pmid:16540796
Tian Q et al. Peroxisome proliferator-activated receptor alpha agonist, clofibrate, has profound influence on myocardial fatty acid composition. 2006 Chem. Biol. Interact. pmid:16540100
Cerolini S et al. Effect of docosahexaenoic acid and alpha-tocopherol enrichment in chicken sperm on semen quality, sperm lipid composition and susceptibility to peroxidation. 2006 Theriogenology pmid:16530814
Kawakita E et al. Docosahexaenoic acid promotes neurogenesis in vitro and in vivo. 2006 Neuroscience pmid:16527422
Shi Y and Pestka JJ Attenuation of mycotoxin-induced IgA nephropathy by eicosapentaenoic acid in the mouse: dose response and relation to IL-6 expression. 2006 J. Nutr. Biochem. pmid:16524712
Qiu C et al. Erythrocyte omega-3 and omega-6 polyunsaturated fatty acids and preeclampsia risk in Peruvian women. 2006 Arch. Gynecol. Obstet. pmid:16520922
Usami M et al. Phospholipid fatty acid composition and diamine oxidase activity of intestinal mucosa from rats treated with irinotecan hydrochloride (CPT-11) under vegetable oil-enriched diets: comparison between perilla oil and corn oil. 2006 Mar-Apr JPEN J Parenter Enteral Nutr pmid:16517957
Shoji H et al. Effect of docosahexaenoic acid and eicosapentaenoic acid supplementation on oxidative stress levels during pregnancy. 2006 Free Radic. Res. pmid:16517502
Li CC et al. n-6 and n-3 polyunsaturated fatty acids down-regulate cytochrome P-450 2B1 gene expression induced by phenobarbital in primary rat hepatocytes. 2006 J. Nutr. Biochem. pmid:16517146
Scambi C et al. Can 5-methyltetrahydrofolate modify the phospholipid fatty acid pattern in cystic fibrosis pediatric patients? 2006 J. Cyst. Fibros. pmid:16516563
Abedin M et al. N-3 fatty acids inhibit vascular calcification via the p38-mitogen-activated protein kinase and peroxisome proliferator-activated receptor-gamma pathways. 2006 Circ. Res. pmid:16514067
Sanders TA et al. Influence of an algal triacylglycerol containing docosahexaenoic acid (22 : 6n-3) and docosapentaenoic acid (22 : 5n-6) on cardiovascular risk factors in healthy men and women. 2006 Br. J. Nutr. pmid:16512939
Chiu LC et al. Cytostatic and cytotoxic effects of cyclooxygenase inhibitors and their synergy with docosahexaenoic acid on the growth of human skin melanoma A-375 cells. 2005 Biomed. Pharmacother. pmid:16507396
Jumpsen JA et al. Fatty acids in blood and intestine following docosahexaenoic acid supplementation in adults with cystic fibrosis. 2006 J. Cyst. Fibros. pmid:16507353
Heinemann KM and Bauer JE Docosahexaenoic acid and neurologic development in animals. 2006 J. Am. Vet. Med. Assoc. pmid:16506930
Ko WC et al. Efficient hydrolysis of tuna oil by a surfactant-coated lipase in a two-phase system. 2006 J. Agric. Food Chem. pmid:16506843
Chattipakorn N et al. Effects of n-3 polyunsaturated fatty acid on upper limit of vulnerability shocks. 2006 Int. J. Cardiol. pmid:16503251
da Silva TL et al. Effect of n-dodecane on Crypthecodinium cohnii fermentations and DHA production. 2006 J. Ind. Microbiol. Biotechnol. pmid:16501933
Parker GB et al. Low levels of docosahexaenoic acid identified in acute coronary syndrome patients with depression. 2006 Psychiatry Res pmid:16499974
Ramaprasad TR et al. Spray-dried milk supplemented with alpha-linolenic acid or eicosapentaenoic acid and docosahexaenoic acid decreases HMG Co A reductase activity and increases biliary secretion of lipids in rats. 2006 Steroids pmid:16499938
Levant B et al. Reduced brain DHA content after a single reproductive cycle in female rats fed a diet deficient in N-3 polyunsaturated fatty acids. 2006 Biol. Psychiatry pmid:16499882
López-Alarcón M et al. [The effect of docosahexaenoic acid on the loss of appetite in pediatric patients with pneumonia]. 2006 Jan-Feb Rev Med Inst Mex Seguro Soc pmid:16497254
Perveen Z et al. Isolation and characterization of a novel thraustochytrid-like microorganism that efficiently produces docosahexaenoic acid. 2006 Biotechnol. Lett. pmid:16489498
Arachchige PG et al. Dietary sesamin and docosahexaenoic and eicosapentaenoic acids synergistically increase the gene expression of enzymes involved in hepatic peroxisomal fatty acid oxidation in rats. 2006 Metab. Clin. Exp. pmid:16483883
Bauch A et al. Dietary intake and sources of long-chain n-3 PUFAs in German adults. 2006 Eur J Clin Nutr pmid:16482078
Goyens PL and Mensink RP Effects of alpha-linolenic acid versus those of EPA/DHA on cardiovascular risk markers in healthy elderly subjects. 2006 Eur J Clin Nutr pmid:16482073
Mamalakis G et al. Depression and adipose and serum cholesteryl ester polyunsaturated fatty acids in the survivors of the seven countries study population of Crete. 2006 Eur J Clin Nutr pmid:16482070
Park YS et al. Prolyl endopeptidase inhibitory activity of unsaturated fatty acids. 2006 J. Agric. Food Chem. pmid:16478242
Hossain Z et al. Docosahexaenoic acid and eicosapentaenoic acid-enriched phosphatidylcholine liposomes enhance the permeability, transportation and uptake of phospholipids in Caco-2 cells. 2006 Mol. Cell. Biochem. pmid:16477371
Mori TA and Woodman RJ The independent effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors in humans. 2006 Curr Opin Clin Nutr Metab Care pmid:16477172
Hubbard AF et al. Association of adipose and red blood cell lipids with severity of dominant Stargardt macular dystrophy (STGD3) secondary to an ELOVL4 mutation. 2006 Arch. Ophthalmol. pmid:16476896
Pfrommer CA et al. Docosahexaenoic acid induces ciap1 mRNA and protects human endothelial cells from stress-induced apoptosis. 2006 Am. J. Physiol. Heart Circ. Physiol. pmid:16473961
Sekine S et al. Dietary docosahexaenoic acid-induced generation of liver lipid peroxides is not suppressed further by elevated levels of glutathione in ODS rats. 2006 Nutrition pmid:16472975
Seo J et al. Docosahexaenoic acid selectively inhibits plasma membrane targeting of lipidated proteins. 2006 FASEB J. pmid:16469846
Delarue J et al. Interaction of fish oil and a glucocorticoid on metabolic responses to an oral glucose load in healthy human subjects. 2006 Br. J. Nutr. pmid:16469141
Glomset JA Role of docosahexaenoic acid in neuronal plasma membranes. 2006 Sci. STKE pmid:16467193
Gough NR Focus issue: signaling lipids. 2006 Sci. STKE pmid:16467192
Mamalakis G et al. Depression and long chain n-3 fatty acids in adipose tissue in adults from Crete. 2006 Eur J Clin Nutr pmid:16465199
Poulos A et al. Effect of 22-32 carbon n-3 polyunsaturated fatty acids on superoxide production in human neutrophils: synergism of docosahexaenoic acid with f-met-leu-phe and phorbol ester. 1991 Immunology pmid:1646160
Perez MA et al. Dietary docosahexaenoic acid alters pregnant rat reproductive tissue prostaglandin and matrix metalloproteinase production. 2006 J. Nutr. Biochem. pmid:16457997
Julien C et al. Postmortem brain fatty acid profile of levodopa-treated Parkinson disease patients and parkinsonian monkeys. 2006 Neurochem. Int. pmid:16442670
Williams CM and Burdge G Long-chain n-3 PUFA: plant v. marine sources. 2006 Proc Nutr Soc pmid:16441943
Tapia-Salazar M et al. Effect of DHA supplementation on digestible starch utilization by rainbow trout. 2006 Br. J. Nutr. pmid:16441919
Arab K et al. Docosahexaenoic acid enhances the antioxidant response of human fibroblasts by upregulating gamma-glutamyl-cysteinyl ligase and glutathione reductase. 2006 Br. J. Nutr. pmid:16441913
Mayes C et al. Variation in [U-13C] alpha linolenic acid absorption, beta-oxidation and conversion to docosahexaenoic acid in the pre-term infant fed a DHA-enriched formula. 2006 Pediatr. Res. pmid:16439591
Burdge GC et al. Docosahexaenoic acid is selectively enriched in plasma phospholipids during pregnancy in Trinidadian women--results of a pilot study. 2006 Jan-Feb Reprod. Nutr. Dev. pmid:16438916
Samadi P et al. Docosahexaenoic acid reduces levodopa-induced dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine monkeys. 2006 Ann. Neurol. pmid:16437566
Haugaard SB et al. Dietary intervention increases n-3 long-chain polyunsaturated fatty acids in skeletal muscle membrane phospholipids of obese subjects. Implications for insulin sensitivity. 2006 Clin. Endocrinol. (Oxf) pmid:16430716
Christensen JH et al. Prostate tissue and leukocyte levels of n-3 polyunsaturated fatty acids in men with benign prostate hyperplasia or prostate cancer. 2006 BJU Int. pmid:16430627
Hashimoto M et al. Docosahexaenoic acid-induced amelioration on impairment of memory learning in amyloid beta-infused rats relates to the decreases of amyloid beta and cholesterol levels in detergent-insoluble membrane fractions. 2005 Biochim. Biophys. Acta pmid:16427803
Tsuzuki T et al. Conjugated docosahexaenoic acid inhibits lipid accumulation in rats. 2006 J. Nutr. Biochem. pmid:16426831
Serhan CN et al. Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes. 2006 J. Immunol. pmid:16424216
Jia Q et al. Docosahexaenoic acid consumption inhibits deoxynivalenol-induced CREB/ATF1 activation and IL-6 gene transcription in mouse macrophages. 2006 J. Nutr. pmid:16424113
Alexander JW et al. Can immunonutrients reduce rejection rates in African Americans? 2005 Exp Clin Transplant pmid:16417441
Ren H et al. Primary open-angle glaucoma patients have reduced levels of blood docosahexaenoic and eicosapentaenoic acids. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16410047