| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Pain | D010146 | 64 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mantzioris E et al. | Biochemical effects of a diet containing foods enriched with n-3 fatty acids. | 2000 | Am. J. Clin. Nutr. | pmid:10871559 |
| Narita K et al. | Therapeutic time window in the penumbra during permanent focal ischemia in rats: changes of free fatty acids and glycerophospholipids. | 2000 | Neurol. Res. | pmid:10874689 |
| Gao YC and Charter EA | Nutritionally important fatty acids in hen egg yolks from different sources. | 2000 | Poult. Sci. | pmid:10875777 |
| Kumar KV et al. | Oxidant stress and essential fatty acids in patients with risk and established ARDS. | 2000 | Clin. Chim. Acta | pmid:10876008 |
| Morishita M et al. | The dose-related hypoglycemic effects of insulin emulsions incorporating highly purified EPA and DHA. | 2000 | Int J Pharm | pmid:10878324 |
| de la Presa Owens S and Innis SM | Diverse, region-specific effects of addition of arachidonic and docosahexanoic acids to formula with low or adequate linoleic and alpha-linolenic acids on piglet brain monoaminergic neurotransmitters. | 2000 | Pediatr. Res. | pmid:10879811 |
| Lesage F et al. | Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors. | 2000 | J. Biol. Chem. | pmid:10880510 |
| Young C et al. | Docosahexaenoic acid inhibits synaptic transmission and epileptiform activity in the rat hippocampus. | 2000 | Synapse | pmid:10881029 |
| Kontogiannea M et al. | omega-3 fatty acids decrease endothelial adhesion of human colorectal carcinoma cells. | 2000 | J. Surg. Res. | pmid:10896822 |
| Xiao YF et al. | Coexpression with beta(1)-subunit modifies the kinetics and fatty acid block of hH1(alpha) Na(+) channels. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10899039 |
| Kim HY et al. | Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. | 2000 | J. Biol. Chem. | pmid:10903316 |
| de Turco EB et al. | Strong association of unesterified [3H]docosahexaenoic acid and [3H-docosahexaenoyl]phosphatidate to rhodopsin during in vivo labeling of frog retinal rod outer segments. | 2000 | Neurochem. Res. | pmid:10905632 |
| Martin RE et al. | Uptake and incorporation of docosahexaenoic acid (DHA) into neuronal cell body and neurite/nerve growth cone lipids: evidence of compartmental DHA metabolism in nerve growth factor-differentiated PC12 cells. | 2000 | Neurochem. Res. | pmid:10905634 |
| Ghebremeskel K et al. | Blood fatty acid composition of pregnant and nonpregnant Korean women: red cells may act as a reservoir of arachidonic acid and docosahexaenoic acid for utilization by the developing fetus. | 2000 | Lipids | pmid:10907792 |
| Ando Y et al. | Reinvestigation of positional distribution of fatty acids in docosahexaenoic acid-rich fish oil triacyl-sn-glycerols. | 2000 | Lipids | pmid:10907794 |
| Matthews KR et al. | Effect of whole linseed (Linum usitatissimum) in the diet of finishing pigs on growth performance and on the quality and fatty acid composition of various tissues. | 2000 | Br. J. Nutr. | pmid:10911772 |
| Smit EN et al. | Effect of supplementation of arachidonic acid (AA) or a combination of AA plus docosahexaenoic acid on breastmilk fatty acid composition. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10913225 |
| Mukhopadhyay S et al. | Preferential distribution of long chain polyunsaturated fatty acids in phospatidyl ethanolamine fraction of guinea pig alveolar apical membranes. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10913226 |
| Everts S and Davis JH | 1H and (13)C NMR of multilamellar dispersions of polyunsaturated (22:6) phospholipids. | 2000 | Biophys. J. | pmid:10920020 |
| Kimura S | [Antihypertensive effect of docosahexaenoic acid in stroke-prone spontaneously hypertensive rats]. | 2000 | Yakugaku Zasshi | pmid:10920715 |
| Arterburn LM et al. | A developmental safety study in rats using DHA- and ARA-rich single-cell oils. | 2000 | Food Chem. Toxicol. | pmid:10930697 |
| Healy DA et al. | Effect of low-to-moderate amounts of dietary fish oil on neutrophil lipid composition and function. | 2000 | Lipids | pmid:10941877 |
| Vanderhoof J et al. | A multicenter long-term safety and efficacy trial of preterm formula supplemented with long-chain polyunsaturated fatty acids. | 2000 | J. Pediatr. Gastroenterol. Nutr. | pmid:10941962 |
| Fritsche KL et al. | Consumption of eicosapentaenoic acid and docosahexaenoic acid impair murine interleukin-12 and interferon-gamma production in vivo. | 2000 | J. Infect. Dis. | pmid:10944484 |
| Albino AP et al. | Cell cycle arrest and apoptosis of melanoma cells by docosahexaenoic acid: association with decreased pRb phosphorylation. | 2000 | Cancer Res. | pmid:10945621 |
| Guo X and Ota Y | Incorporation of eicosapentaenoic and docosahexaenoic acids by a yeast (FO726A). | 2000 | J. Appl. Microbiol. | pmid:10945786 |
| Retterstøl K et al. | Metabolism of some radiolabeled essential fatty acids in isolated rat hepatocytes is affected by dietary ethanol. | 2000 | Alcohol | pmid:10946154 |
| Surai PF and Sparks NH | Tissue-specific fatty acid and alpha-tocopherol profiles in male chickens depending on dietary tuna oil and vitamin E provision. | 2000 | Poult. Sci. | pmid:10947182 |
| Kohno H et al. | Modifying effect of tuna orbital oil rich in docosahexaenoic acid and vitamin D3 on azoxymethane-induced colonic aberrant crypt foci in rats. | 2000 Sep-Oct | Oncol. Rep. | pmid:10948340 |
| Liu QY and Tan BK | Effects of cis-unsaturated fatty acids on doxorubicin sensitivity in P388/DOX resistant and P388 parental cell lines. | 2000 | Life Sci. | pmid:10954054 |
| Marangoni F et al. | Polyunsaturated fatty acid concentrations in human hindmilk are stable throughout 12-months of lactation and provide a sustained intake to the infant during exclusive breastfeeding: an Italian study. | 2000 | Br. J. Nutr. | pmid:10961166 |
| Higdon JV et al. | Supplementation of postmenopausal women with fish oil rich in eicosapentaenoic acid and docosahexaenoic acid is not associated with greater in vivo lipid peroxidation compared with oils rich in oleate and linoleate as assessed by plasma malondialdehyde and F(2)-isoprostanes. | 2000 | Am. J. Clin. Nutr. | pmid:10966889 |
| Wander RC and Du SH | Oxidation of plasma proteins is not increased after supplementation with eicosapentaenoic and docosahexaenoic acids. | 2000 | Am. J. Clin. Nutr. | pmid:10966891 |
| Dagnelie G et al. | Lutein improves visual function in some patients with retinal degeneration: a pilot study via the Internet. | 2000 | Optometry | pmid:10970259 |
| Fidler N et al. | Docosahexaenoic acid transfer into human milk after dietary supplementation: a randomized clinical trial. | 2000 | J. Lipid Res. | pmid:10974044 |
| Kajita M et al. | Enhanced enteral bioavailability of vancomycin using water-in-oil-in-water multiple emulsion incorporating highly purified unsaturated fatty acid. | 2000 | J Pharm Sci | pmid:10980499 |
| Mori TA et al. | Differential effects of eicosapentaenoic acid and docosahexaenoic acid on vascular reactivity of the forearm microcirculation in hyperlipidemic, overweight men. | 2000 | Circulation | pmid:10982541 |
| Hsu FF et al. | Electrospray ionization mass spectrometric analyses of changes in tissue phospholipid molecular species during the evolution of hyperlipidemia and hyperglycemia in Zucker diabetic fatty rats. | 2000 | Lipids | pmid:10984107 |
| Hamilton L et al. | n-3 fatty acid deficiency decreases phosphatidylserine accumulation selectively in neuronal tissues. | 2000 | Lipids | pmid:10984109 |
| Wijendran V et al. | Fetal erythrocyte phospholipid polyunsaturated fatty acids are altered in pregnancy complicated with gestational diabetes mellitus. | 2000 | Lipids | pmid:10984116 |
| Cunnane SC | Commentary on the workshop statement. Essentiality of and recommended dietary intakes for Omega-6 and Omega-3 fatty acids. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10991770 |
| Xi S et al. | 15-hydroxyeicosatrienoic acid (15-HETrE) suppresses epidermal hyperproliferation via the modulation of nuclear transcription factor (AP-1) and apoptosis. | 2000 | Arch. Dermatol. Res. | pmid:10994774 |
| MartÃnez-Cayuela M et al. | Metabolism of palmitic and docosahexaenoic acids in Reuber H35 hepatoma cells. | 2000 | J. Biochem. | pmid:11011136 |
| Petrik MB et al. | Highly unsaturated (n-3) fatty acids, but not alpha-linolenic, conjugated linoleic or gamma-linolenic acids, reduce tumorigenesis in Apc(Min/+) mice. | 2000 | J. Nutr. | pmid:11015469 |
| Favrelère S et al. | Age-related changes in ethanolamine glycerophospholipid fatty acid levels in rat frontal cortex and hippocampus. | 2000 Sep-Oct | Neurobiol. Aging | pmid:11016534 |
| Glozman S et al. | Docosahexaenoic acid-deficient phosphatidyl serine and high alpha-tocopherol in a fetal mouse brain over-expressing Cu/Zn-superoxide dismutase. | 2000 | Biochim. Biophys. Acta | pmid:11018466 |
| Qian SY et al. | EPR detection of lipid-derived free radicals from PUFA, LDL, and cell oxidations. | 2000 | Free Radic. Biol. Med. | pmid:11025200 |
| House S | Stages in reproduction particularly vulnerable to xenobiotic hazards and nutritional deficits. | 2000 | Nutr Health | pmid:11028931 |
| Jenski LJ et al. | Docosahexaenoic acid-containing phosphatidylcholine affects the binding of monoclonal antibodies to purified Kb reconstituted into liposomes. | 2000 | Biochim. Biophys. Acta | pmid:11030589 |
| Arterburn LM et al. | In vitro genotoxicity testing of ARASCO and DHASCO oils. | 2000 | Food Chem. Toxicol. | pmid:11038233 |