DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Van Biervliet S et al. Docosahexaenoic acid trials in cystic fibrosis: a review of the rationale behind the clinical trials. 2005 J. Cyst. Fibros. pmid:15752678
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Itomura M et al. The effect of fish oil on physical aggression in schoolchildren--a randomized, double-blind, placebo-controlled trial. 2005 J. Nutr. Biochem. pmid:15741051
Aro TL et al. Fatty acids and fat-soluble vitamins in salted herring (Clupea harengus) products. 2005 J. Agric. Food Chem. pmid:15740028
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Hashimoto M et al. Chronic administration of docosahexaenoic acid ameliorates the impairment of spatial cognition learning ability in amyloid beta-infused rats. 2005 J. Nutr. pmid:15735092
Mollard RC et al. Low levels of dietary arachidonic and docosahexaenoic acids improve bone mass in neonatal piglets, but higher levels provide no benefit. 2005 J. Nutr. pmid:15735085
Serhan CN et al. Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers. 2004 Lipids pmid:15726828
Anderson RE and Penn JS Environmental light and heredity are associated with adaptive changes in retinal DHA levels that affect retinal function. 2004 Lipids pmid:15726827
Brinsko SP et al. Effect of feeding a DHA-enriched nutriceutical on the quality of fresh, cooled and frozen stallion semen. 2005 Theriogenology pmid:15725455
Kojima M et al. Serum levels of polyunsaturated fatty acids and risk of colorectal cancer: a prospective study. 2005 Am. J. Epidemiol. pmid:15718482
García-Calatayud S et al. Brain docosahexaenoic acid status and learning in young rats submitted to dietary long-chain polyunsaturated fatty acid deficiency and supplementation limited to lactation. 2005 Pediatr. Res. pmid:15718358
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Serhan CN Novel eicosanoid and docosanoid mediators: resolvins, docosatrienes, and neuroprotectins. 2005 Curr Opin Clin Nutr Metab Care pmid:15716788
Gronert K et al. A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense. 2005 J. Biol. Chem. pmid:15708862
Narayanan NK et al. A combination of docosahexaenoic acid and celecoxib prevents prostate cancer cell growth in vitro and is associated with modulation of nuclear factor-kappaB, and steroid hormone receptors. 2005 Int. J. Oncol. pmid:15703837
Geelen A et al. Effects of n-3 fatty acids from fish on premature ventricular complexes and heart rate in humans. 2005 Am. J. Clin. Nutr. pmid:15699229
Li H et al. EPA and DHA reduce LPS-induced inflammation responses in HK-2 cells: evidence for a PPAR-gamma-dependent mechanism. 2005 Kidney Int. pmid:15698426
Okuda N et al. Relation of long chain n-3 polyunsaturated fatty acid intake to serum high density lipoprotein cholesterol among Japanese men in Japan and Japanese-American men in Hawaii: the INTERLIPID study. 2005 Atherosclerosis pmid:15694947
Økland HM et al. Proximate composition, fatty acid and lipid class composition of the muscle from deep-sea teleosts and elasmobranchs. 2005 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:15694592
Beblo S et al. Effects of alcohol intake during pregnancy on docosahexaenoic acid and arachidonic acid in umbilical cord vessels of black women. 2005 Pediatrics pmid:15687427
Rajamoorthi K et al. Packing and viscoelasticity of polyunsaturated omega-3 and omega-6 lipid bilayers as seen by (2)H NMR and X-ray diffraction. 2005 J. Am. Chem. Soc. pmid:15686391
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Gerbi A et al. Dose dependent accretion of docosahexaenoic acid (DHA) in cardiac membranes of rats fed egg yolk powder enriched in DHA. 2004 Cell. Mol. Biol. (Noisy-le-grand) pmid:15672470
Mutch DM et al. An integrative metabolism approach identifies stearoyl-CoA desaturase as a target for an arachidonate-enriched diet. 2005 FASEB J. pmid:15670975
Verlengia R et al. Effects of EPA and DHA on proliferation, cytokine production, and gene expression in Raji cells. 2004 Lipids pmid:15669761
Du ZY et al. Alteration of 20:5n-3 and 22:6n-3 fat contents and liver peroxisomal activities in fenofibrate-treated rainbow trout. 2004 Lipids pmid:15669760
Sul D et al. Benzene increases the ratio of arachidonic acids to docosahexaenoic acids and inhibits the de novo synthesis of ceramide in the rat liver. 2005 Jan-Feb J Appl Toxicol pmid:15669040
Yamamoto K et al. Identification of putative metabolites of docosahexaenoic acid as potent PPARgamma agonists and antidiabetic agents. 2005 Bioorg. Med. Chem. Lett. pmid:15664804
Chiu LC et al. Docosahexaenoic acid from a cultured microalga inhibits cell growth and induces apoptosis by upregulating Bax/Bcl-2 ratio in human breast carcinoma MCF-7 cells. 2004 Ann. N. Y. Acad. Sci. pmid:15659818
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Marszalek JR et al. Long-chain acyl-CoA synthetase 6 preferentially promotes DHA metabolism. 2005 J. Biol. Chem. pmid:15655248
Storey A et al. Eicosapentaenoic acid and docosahexaenoic acid reduce UVB- and TNF-alpha-induced IL-8 secretion in keratinocytes and UVB-induced IL-8 in fibroblasts. 2005 J. Invest. Dermatol. pmid:15654981
Stark KD et al. Alcohol consumption in pregnant, black women is associated with decreased plasma and erythrocyte docosahexaenoic acid. 2005 Alcohol. Clin. Exp. Res. pmid:15654301
Milne GL et al. The cyclopentenone (A2/J2) isoprostanes--unique, highly reactive products of arachidonate peroxidation. 2005 Jan-Feb Antioxid. Redox Signal. pmid:15650409
Zemski Berry KA and Murphy RC Free radical oxidation of plasmalogen glycerophosphocholine containing esterified docosahexaenoic acid: structure determination by mass spectrometry. 2005 Jan-Feb Antioxid. Redox Signal. pmid:15650405
Hossain Z et al. Effect of polyunsaturated fatty acid-enriched phosphatidylcholine and phosphatidylserine on butyrate-induced growth inhibition, differentiation and apoptosis in Caco-2 cells. 2006 Mar-Apr Cell Biochem. Funct. pmid:15648055
Nguyen LQ et al. Feeding of spinach or sweet-potato leaves and growth performance of growing pigs kept on smallholder farms in Central Vietnam. 2004 Trop Anim Health Prod pmid:15643817
Hofmanová J et al. Polyunsaturated fatty acids sensitize human colon adenocarcinoma HT-29 cells to death receptor-mediated apoptosis. 2005 Cancer Lett. pmid:15639338
Kaul U et al. Fish oil supplements for prevention of restenosis after coronary angioplasty. 1992 Int. J. Cardiol. pmid:1563884
Hamam F and Shahidi F Production and stability of structured lipids from algal oils and capric acid. 2004 Biofactors pmid:15630303
Nagata J et al. Effects of structured lipids containing eicosapentaenoic or docosahexaenoic acid and caprylic acid on serum and liver lipid profiles in rats. 2004 Biofactors pmid:15630273
McCabe AJ et al. Docosahexaenoic acid reduces in vitro invasion of renal cell carcinoma by elevated levels of tissue inhibitor of metalloproteinase-1. 2005 J. Nutr. Biochem. pmid:15629236
Denys A et al. n-3 PUFAs modulate T-cell activation via protein kinase C-alpha and -epsilon and the NF-kappaB signaling pathway. 2005 J. Lipid Res. pmid:15627650
Maldjian A et al. Changes in sperm quality and lipid composition during cryopreservation of boar semen. 2005 Theriogenology pmid:15626408
Engler MM et al. Docosahexaenoic acid restores endothelial function in children with hyperlipidemia: results from the EARLY study. 2004 Int J Clin Pharmacol Ther pmid:15624283
Hirasawa A et al. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. 2005 Nat. Med. pmid:15619630
Sun L et al. Inhibition of osteoporosis due to restricted food intake by the fish oils DHA and EPA and perilla oil in the rat. 2004 Biosci. Biotechnol. Biochem. pmid:15618634
Verlengia R et al. Comparative effects of eicosapentaenoic acid and docosahexaenoic acid on proliferation, cytokine production, and pleiotropic gene expression in Jurkat cells. 2004 J. Nutr. Biochem. pmid:15590269
Puskás LG et al. Cholesterol and cholesterol plus DHA diet-induced gene expression and fatty acid changes in mouse eye and brain. 2004 Biochimie pmid:15589691
Dijck-Brouwer DA et al. Lower fetal status of docosahexaenoic acid, arachidonic acid and essential fatty acids is associated with less favorable neonatal neurological condition. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:15589396
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Cao DH et al. Protective effect of chronic ethyl docosahexaenoate administration on brain injury in ischemic gerbils. 2004 Pharmacol. Biochem. Behav. pmid:15582673
Rupp H et al. Risk stratification by the "EPA+DHA level" and the "EPA/AA ratio" focus on anti-inflammatory and antiarrhythmogenic effects of long-chain omega-3 fatty acids. 2004 Herz pmid:15580322
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Danbara N et al. Conjugated docosahexaenoic acid is a potent inducer of cell cycle arrest and apoptosis and inhibits growth of colo 201 human colon cancer cells. 2004 Nutr Cancer pmid:15572300
Jia Q et al. Docosahexaenoic acid attenuates mycotoxin-induced immunoglobulin a nephropathy, interleukin-6 transcription, and mitogen-activated protein kinase phosphorylation in mice. 2004 J. Nutr. pmid:15570035
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DeMar JC et al. Half-lives of docosahexaenoic acid in rat brain phospholipids are prolonged by 15 weeks of nutritional deprivation of n-3 polyunsaturated fatty acids. 2004 J. Neurochem. pmid:15569256
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Katsura K et al. Effects of hyperglycemia and hypercapnia on lipid metabolism during complete brain ischemia. 2004 Brain Res. pmid:15567345
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Furimsky A et al. Percoll gradient-centrifuged capacitated mouse sperm have increased fertilizing ability and higher contents of sulfogalactosylglycerolipid and docosahexaenoic acid-containing phosphatidylcholine compared to washed capacitated mouse sperm. 2005 Biol. Reprod. pmid:15525814
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Pacetti D et al. High-performance liquid chromatography/electrospray ionization ion-trap tandem mass spectrometric analysis and quantification of phosphatidylcholine molecular species in the serum of cystic fibrosis subjects supplemented with docosahexaenoic acid. 2004 Rapid Commun. Mass Spectrom. pmid:15386630