DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Innis SM Polyunsaturated fatty acids in human milk: an essential role in infant development. 2004 Adv. Exp. Med. Biol. pmid:15384565
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Bairati I et al. Double-blind, randomized, controlled trial of fish oil supplements in prevention of recurrence of stenosis after coronary angioplasty. 1992 Circulation pmid:1537131
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Seal JR and Porter NA Liquid chromatography coordination ion-spray mass spectrometry (LC-CIS-MS) of docosahexaenoate ester hydroperoxides. 2004 Anal Bioanal Chem pmid:15338093
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Baker RR and Chang HY The hydrolysis of natural phosphatidylethanolamines by phospholipase A2 from rat serum: a degree of selectivity is shown for docosahexaenoate release. 1992 Biochim. Biophys. Acta pmid:1533163
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Innis SM Plasma and red blood cell fatty acid values as indexes of essential fatty acids in the developing organs of infants fed with milk or formulas. 1992 J. Pediatr. pmid:1532829
Gordon WC et al. Retinal pigment epithelial cells play a central role in the conservation of docosahexaenoic acid by photoreceptor cells after shedding and phagocytosis. 1992 Curr. Eye Res. pmid:1532774
Van Anholt RD et al. Arachidonic acid reduces the stress response of gilthead seabream Sparus aurata L. 2004 J. Exp. Biol. pmid:15326218
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Irie M and Sakimoto M Fat characteristics of pigs fed fish oil containing eicosapentaenoic and docosahexaenoic acids. 1992 J. Anim. Sci. pmid:1532172
Nenseter MS et al. Effect of dietary supplementation with n-3 polyunsaturated fatty acids on physical properties and metabolism of low density lipoprotein in humans. 1992 Arterioscler. Thromb. pmid:1532127
Herzberg GR et al. Intestinal absorption of fish oil in rats previously adapted to diets containing fish oil or corn oil. 1992 Biochim. Biophys. Acta pmid:1531932
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Harris JI et al. Statin treatment alters serum n-3 and n-6 fatty acids in hypercholesterolemic patients. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15310527
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Hofmanová J et al. Interaction of polyunsaturated fatty acids and sodium butyrate during apoptosis in HT-29 human colon adenocarcinoma cells. 2005 Eur J Nutr pmid:15309463
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Chen JR et al. Dietary patterns and blood fatty acid composition in children with attention-deficit hyperactivity disorder in Taiwan. 2004 J. Nutr. Biochem. pmid:15302081
Sung M et al. Differential effects of dietary fatty acids on the regulation of CYP2E1 and protein kinase C in human hepatoma HepG2 cells. 2004 J Med Food pmid:15298768
Broadfield EC et al. A case-control study of dietary and erythrocyte membrane fatty acids in asthma. 2004 Clin. Exp. Allergy pmid:15298563
Narayanan BA et al. Effects of a combination of docosahexaenoic acid and 1,4-phenylene bis(methylene) selenocyanate on cyclooxygenase 2, inducible nitric oxide synthase and beta-catenin pathways in colon cancer cells. 2004 Carcinogenesis pmid:15297372
Meyer A et al. Novel fatty acid elongases and their use for the reconstitution of docosahexaenoic acid biosynthesis. 2004 J. Lipid Res. pmid:15292371
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Chiu LC et al. Docosahexaenoic acid modulates different genes in cell cycle and apoptosis to control growth of human leukemia HL-60 cells. 2004 Int. J. Oncol. pmid:15289877
Calderon F and Kim HY Docosahexaenoic acid promotes neurite growth in hippocampal neurons. 2004 J. Neurochem. pmid:15287904
Bauer JE et al. Maternal diet alpha-linolenic acid during gestation and lactation does not increase docosahexaenoic acid in canine milk. 2004 J. Nutr. pmid:15284396
Naliwaiko K et al. Effects of fish oil on the central nervous system: a new potential antidepressant? 2004 Nutr Neurosci pmid:15279495
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Haggarty P Effect of placental function on fatty acid requirements during pregnancy. 2004 Eur J Clin Nutr pmid:15266306
Mesa MD et al. Effects of oils rich in eicosapentaenoic and docosahexaenoic acids on the oxidizability and thrombogenicity of low-density lipoprotein. 2004 Atherosclerosis pmid:15262190
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AbuGhazaleh AA and Jenkins TC Short communication: docosahexaenoic acid promotes vaccenic acid accumulation in mixed ruminal cultures when incubated with linoleic acid. 2004 J. Dairy Sci. pmid:15259240
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AbuGhazaleh AA and Jenkins TC Disappearance of docosahexaenoic and eicosapentaenoic acids from cultures of mixed ruminal microorganisms. 2004 J. Dairy Sci. pmid:15202649
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Mukherjee PK et al. Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15152078
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