| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Pain | D010146 | 64 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hamazaki T and Hirayama S | The effect of docosahexaenoic acid-containing food administration on symptoms of attention-deficit/hyperactivity disorder-a placebo-controlled double-blind study. | 2004 | Eur J Clin Nutr | pmid:15116088 |
| Weisman D et al. | Efficacy of omega-3 fatty acid supplementation in primary and secondary prevention of coronary heart disease. | 2004 | Isr. Med. Assoc. J. | pmid:15115262 |
| Nkondjock A and Ghadirian P | Intake of specific carotenoids and essential fatty acids and breast cancer risk in Montreal, Canada. | 2004 | Am. J. Clin. Nutr. | pmid:15113726 |
| Stark KD and Holub BJ | Differential eicosapentaenoic acid elevations and altered cardiovascular disease risk factor responses after supplementation with docosahexaenoic acid in postmenopausal women receiving and not receiving hormone replacement therapy. | 2004 | Am. J. Clin. Nutr. | pmid:15113713 |
| Leu GZ et al. | Anti-HCV activities of selective polyunsaturated fatty acids. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15110784 |
| Gómez de Segura IA et al. | Protective effects of dietary enrichment with docosahexaenoic acid plus protein in 5-fluorouracil-induced intestinal injury in the rat. | 2004 | Eur J Gastroenterol Hepatol | pmid:15097041 |
| Denys A et al. | Thapsigargin-stimulated MAP kinase phosphorylation via CRAC channels and PLD activation: inhibitory action of docosahexaenoic acid. | 2004 | FEBS Lett. | pmid:15094063 |
| Sanjurjo P et al. | Supplementation with docosahexaenoic acid in the last trimester of pregnancy: maternal-fetal biochemical findings. | 2004 | J Perinat Med | pmid:15085888 |
| Speake BK et al. | Comparison of the fatty-acid compositions of prey items and yolks of Australian insectivorous scincid lizards. | 2004 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:15085383 |
| Lengqvist J et al. | Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid X receptor alpha ligand-binding domain. | 2004 | Mol. Cell Proteomics | pmid:15073272 |
| Yaqoob P | Fatty acids and the immune system: from basic science to clinical applications. | 2004 | Proc Nutr Soc | pmid:15070442 |
| Di Stasi D et al. | Early modifications of fatty acid composition in plasma phospholipids, platelets and mononucleates of healthy volunteers after low doses of n-3 polyunsaturated fatty acids. | 2004 | Eur. J. Clin. Pharmacol. | pmid:15069592 |
| Fewtrell MS et al. | Randomized, double-blind trial of long-chain polyunsaturated fatty acid supplementation with fish oil and borage oil in preterm infants. | 2004 | J. Pediatr. | pmid:15069395 |
| Blanco PG et al. | Induction of colitis in cftr-/- mice results in bile duct injury. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15064232 |
| Parinyasiri U et al. | Effect of fish oil on oxidative stress, lipid profile and renal function in IgA nephropathy. | 2004 | J Med Assoc Thai | pmid:15061297 |
| Hoffman DR et al. | A randomized, placebo-controlled clinical trial of docosahexaenoic acid supplementation for X-linked retinitis pigmentosa. | 2004 | Am. J. Ophthalmol. | pmid:15059710 |
| Murata Y et al. | Degradation of ethyl docosahexaenoate by gamma-ray irradiation and suppression of this degradation by antioxidants. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15056911 |
| Nkondjock A and Ghadirian P | Dietary carotenoids and risk of colon cancer: case-control study. | 2004 | Int. J. Cancer | pmid:15054875 |
| Sala-Vila A et al. | The source of long-chain PUFA in formula supplements does not affect the fatty acid composition of plasma lipids in full-term infants. | 2004 | J. Nutr. | pmid:15051839 |
| Marszalek JR et al. | Acyl-CoA synthetase 2 overexpression enhances fatty acid internalization and neurite outgrowth. | 2004 | J. Biol. Chem. | pmid:15051725 |
| Kew S et al. | Effects of oils rich in eicosapentaenoic and docosahexaenoic acids on immune cell composition and function in healthy humans. | 2004 | Am. J. Clin. Nutr. | pmid:15051614 |
| Theobald HE et al. | LDL cholesterol-raising effect of low-dose docosahexaenoic acid in middle-aged men and women. | 2004 | Am. J. Clin. Nutr. | pmid:15051597 |
| Shahdat H et al. | Synaptic plasma membrane-bound acetylcholinesterase activity is not affected by docosahexaenoic acid-induced decrease in membrane order. | 2004 | Life Sci. | pmid:15051424 |
| Ota Y et al. | Vitamin E supplementation increases polyunsaturated fatty acids of RBC membrane in HCV-infected patients. | 2004 | Nutrition | pmid:15043851 |
| Hogg RJ and Wyatt RJ | A randomized controlled trial of mycophenolate mofetil in patients with IgA nephropathy [ISRCTN62574616]. | 2004 | BMC Nephrol | pmid:15043759 |
| Horrocks LA and Farooqui AA | Docosahexaenoic acid in the diet: its importance in maintenance and restoration of neural membrane function. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15041028 |
| Hejazi MA and Wijffels RH | Milking of microalgae. | 2004 | Trends Biotechnol. | pmid:15038924 |
| Merendino N et al. | Induction of apoptosis in human pancreatic cancer cells by docosahexaenoic acid. | 2003 | Ann. N. Y. Acad. Sci. | pmid:15033753 |
| Gorson DM | Fish oil supplementation and ulcerative colitis. | 1992 | Ann. Intern. Med. | pmid:1503361 |
| Hsu JM et al. | The effect of dietary docosahexaenoic acid on the expression of porcine lipid metabolism-related genes. | 2004 | J. Anim. Sci. | pmid:15032424 |
| Gohlke H | [Prevention of coronary disease and sudden death by nutrition]. | 2004 | Z Kardiol | pmid:15021992 |
| Moriguchi K et al. | Suppression of N-methyl-N-nitrosourea-induced photoreceptor apoptosis in rats by docosahexaenoic acid. | 2004 Mar-Apr | Ophthalmic Res. | pmid:15017106 |
| Chiu CC et al. | Omega-3 polyunsaturated fatty acids for postpartum depression. | 2004 | Am. J. Obstet. Gynecol. | pmid:15002412 |
| Liu JD et al. | Thiol antioxidant and thiol-reducing agents attenuate 15-deoxy-delta 12,14-prostaglandin J2-induced heme oxygenase-1 expression. | 2004 | Life Sci. | pmid:14998722 |
| Jiang Y et al. | Fatty acid composition and squalene content of the marine microalga Schizochytrium mangrovei. | 2004 | J. Agric. Food Chem. | pmid:14995120 |
| Hirayama S et al. | Effect of docosahexaenoic acid-containing food administration on symptoms of attention-deficit/hyperactivity disorder - a placebo-controlled double-blind study. | 2004 | Eur J Clin Nutr | pmid:14985685 |
| Dunstan JA et al. | Effects of n-3 polyunsaturated fatty acid supplementation in pregnancy on maternal and fetal erythrocyte fatty acid composition. | 2004 | Eur J Clin Nutr | pmid:14985680 |
| Swamy MV et al. | Modulation of cyclooxygenase-2 activities by the combined action of celecoxib and decosahexaenoic acid: novel strategies for colon cancer prevention and treatment. | 2004 | Mol. Cancer Ther. | pmid:14985462 |
| Marangell LB et al. | Omega-3 fatty acids for the prevention of postpartum depression: negative data from a preliminary, open-label pilot study. | 2004 | Depress Anxiety | pmid:14978781 |
| van Heeckeren AM et al. | Nutritional effects on host response to lung infections with mucoid Pseudomonas aeruginosa in mice. | 2004 | Infect. Immun. | pmid:14977953 |
| Colas S et al. | Enhanced radiosensitivity of rat autochthonous mammary tumors by dietary docosahexaenoic acid. | 2004 | Int. J. Cancer | pmid:14961586 |
| D'Almeida A et al. | Effects of a combination of evening primrose oil (gamma linolenic acid) and fish oil (eicosapentaenoic + docahexaenoic acid) versus magnesium, and versus placebo in preventing pre-eclampsia. | 1992 | Women Health | pmid:1492408 |
| Innis SM | n-3 fatty acid requirements of the newborn. | 1992 | Lipids | pmid:1491606 |
| Ackman RG | The absorption of fish oils and concentrates. | 1992 | Lipids | pmid:1491603 |
| Baumstark MW et al. | Influence of n-3 fatty acids from fish oils on concentration of high- and low-density lipoprotein subfractions and their lipid and apolipoprotein composition. | 1992 | Clin. Biochem. | pmid:1490295 |
| Sajiki J and Takahashi K | Free fatty acids inducing mouse lethal toxicity in lipid extracts of Engraulis japonica, the Japanese anchovy. | 1992 | Lipids | pmid:1487961 |
| Mehta VR | 'Side effects of eicosapentaenoic acid and docosahexaenoic acid (maxepa)'. | 1992 | J Assoc Physicians India | pmid:1484043 |
| Grynberg A et al. | Eicosapentaenoic and docosahexaenoic acids in cultured rat ventricular myocytes and hypoxia-induced alterations of phospholipase-A activity. | 1992 | Mol. Cell. Biochem. | pmid:1480156 |
| Bordoni A et al. | Diacylglycerol fatty acid composition is related to activation of protein kinase C in cultured cardiomyocytes. | 1992 | Cardioscience | pmid:1477293 |
| Appel MJ and Woutersen RA | Effects of a diet high in fish oil (MaxEPA) on the formation of micronucleated erythrocytes in blood and on the number of atypical acinar cell foci Induced in rat pancreas by azaserine. | 2003 | Nutr Cancer | pmid:14769538 |
| Calabresi L et al. | An omega-3 polyunsaturated fatty acid concentrate increases plasma high-density lipoprotein 2 cholesterol and paraoxonase levels in patients with familial combined hyperlipidemia. | 2004 | Metab. Clin. Exp. | pmid:14767865 |
| Strandvik B | Fatty acid metabolism in cystic fibrosis. | 2004 | N. Engl. J. Med. | pmid:14762189 |
| Freedman SD et al. | Association of cystic fibrosis with abnormalities in fatty acid metabolism. | 2004 | N. Engl. J. Med. | pmid:14762183 |
| Das UN | Long-chain polyunsaturated fatty acids interact with nitric oxide, superoxide anion, and transforming growth factor-beta to prevent human essential hypertension. | 2004 | Eur J Clin Nutr | pmid:14749737 |
| Hansen HS and Olsen SF | Sleep patterns, docosahexaenoic acid, and gestational length. | 2004 | Am. J. Clin. Nutr. | pmid:14749243 |
| de Groot RH et al. | Effect of alpha-linolenic acid supplementation during pregnancy on maternal and neonatal polyunsaturated fatty acid status and pregnancy outcome. | 2004 | Am. J. Clin. Nutr. | pmid:14749231 |
| Kim HY et al. | Substrate preference in phosphatidylserine biosynthesis for docosahexaenoic acid containing species. | 2004 | Biochemistry | pmid:14744148 |
| Liu Z et al. | Determination of fatty acid levels in erythrocyte membranes of patients with chronic fatigue syndrome. | 2003 | Nutr Neurosci | pmid:14744043 |
| Auestad N et al. | Auditory brainstem evoked response in juvenile rats fed rat milk formulas with high docosahexaenoic acid. | 2003 | Nutr Neurosci | pmid:14744037 |
| Sijtsma L and de Swaaf ME | Biotechnological production and applications of the omega-3 polyunsaturated fatty acid docosahexaenoic acid. | 2004 | Appl. Microbiol. Biotechnol. | pmid:14740186 |
| MacDonald IM et al. | Effect of docosahexaenoic acid supplementation on retinal function in a patient with autosomal dominant Stargardt-like retinal dystrophy. | 2004 | Br J Ophthalmol | pmid:14736799 |
| Nichols PD et al. | Occurrence of high levels of tetracosahexaenoic acid in the jellyfish Aurelia sp. | 2003 | Lipids | pmid:14733367 |
| Huang J et al. | Grouping newly isolated docosahexaenoic acid-producing thraustochytrids based on their polyunsaturated fatty acid profiles and comparative analysis of 18S rRNA genes. | 2003 Sep-Oct | Mar. Biotechnol. | pmid:14730428 |
| Honen BN et al. | Suppression of calcium sparks in rat ventricular myocytes and direct inhibition of sheep cardiac RyR channels by EPA, DHA and oleic acid. | 2003 | J. Membr. Biol. | pmid:14724746 |
| Boroda AM et al. | [Specificity of endometrium phospholipids and their fatty acids changes in the development of hyperplasia]. | 2003 Oct-Nov | Lik. Sprava | pmid:14723136 |
| Bakken AM and Farstad M | The activities of acyl-CoA:1-acyl-lysophospholipid acyltransferase(s) in human platelets. | 1992 | Biochem. J. | pmid:1471991 |
| Milatovic D et al. | Pharmacologic suppression of neuronal oxidative damage and dendritic degeneration following direct activation of glial innate immunity in mouse cerebrum. | 2003 | J. Neurochem. | pmid:14713307 |
| Farooqui AA et al. | Plasmalogens, docosahexaenoic acid and neurological disorders. | 2003 | Adv. Exp. Med. Biol. | pmid:14713251 |
| Barbarich NC et al. | Use of nutritional supplements to increase the efficacy of fluoxetine in the treatment of anorexia nervosa. | 2004 | Int J Eat Disord | pmid:14705152 |
| Muskiet FA et al. | Is docosahexaenoic acid (DHA) essential? Lessons from DHA status regulation, our ancient diet, epidemiology and randomized controlled trials. | 2004 | J. Nutr. | pmid:14704315 |
| Spiekerkoetter U et al. | Peripheral neuropathy, episodic myoglobinuria, and respiratory failure in deficiency of the mitochondrial trifunctional protein. | 2004 | Muscle Nerve | pmid:14694500 |
| Champeil-Potokar G et al. | Astrocytes in culture require docosahexaenoic acid to restore the n-3/n-6 polyunsaturated fatty acid balance in their membrane phospholipids. | 2004 | J. Neurosci. Res. | pmid:14689452 |
| Nilsen DW and Harris WS | n-3 Fatty acids and cardiovascular disease. | 2004 | Am. J. Clin. Nutr. | pmid:14684413 |
| Blanaru JL et al. | Dose response of bone mass to dietary arachidonic acid in piglets fed cow milk-based formula. | 2004 | Am. J. Clin. Nutr. | pmid:14684410 |
| Mawatari S et al. | Absence of correlation between glycated hemoglobin and lipid composition of erythrocyte membrane in type 2 diabetic patients. | 2004 | Metab. Clin. Exp. | pmid:14681853 |
| Iribarren C et al. | Dietary intake of n-3, n-6 fatty acids and fish: relationship with hostility in young adults--the CARDIA study. | 2004 | Eur J Clin Nutr | pmid:14679363 |
| Stene LC and Joner G | Use of cod liver oil during the first year of life is associated with lower risk of childhood-onset type 1 diabetes: a large, population-based, case-control study. | 2003 | Am. J. Clin. Nutr. | pmid:14668274 |
| Pawlosky R et al. | n-3 fatty acid metabolism in women. | 2003 | Br. J. Nutr. | pmid:14667193 |
| Barbir M et al. | Maxepa versus bezafibrate in hyperlipidemic cardiac transplant recipients. | 1992 | Am. J. Cardiol. | pmid:1466329 |
| Wang X et al. | Neuroprotective effect of docosahexaenoic acid on glutamate-induced cytotoxicity in rat hippocampal cultures. | 2003 | Neuroreport | pmid:14663210 |
| Musiek ES et al. | Quantification of F-ring isoprostane-like compounds (F4-neuroprostanes) derived from docosahexaenoic acid in vivo in humans by a stable isotope dilution mass spectrometric assay. | 2004 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:14659440 |
| Lin DS et al. | Selective changes of docosahexaenoic acid-containing phospholipid molecular species in monkey testis during puberty. | 2004 | J. Lipid Res. | pmid:14657201 |
| Clandinin MT and VanAerde J | Formula supplementation and growth. | 2003 | Pediatrics | pmid:14654632 |
| Logan AC | Neurobehavioral aspects of omega-3 fatty acids: possible mechanisms and therapeutic value in major depression. | 2003 | Altern Med Rev | pmid:14653768 |
| Phillips T et al. | A dietary supplement attenuates IL-6 and CRP after eccentric exercise in untrained males. | 2003 | Med Sci Sports Exerc | pmid:14652498 |
| Kjeldsen-Kragh J et al. | Dietary omega-3 fatty acid supplementation and naproxen treatment in patients with rheumatoid arthritis. | 1992 | J. Rheumatol. | pmid:1464864 |
| Metcalf RG et al. | A practical approach to increasing intakes of n-3 polyunsaturated fatty acids: use of novel foods enriched with n-3 fats. | 2003 | Eur J Clin Nutr | pmid:14647226 |
| Shirai N and Suzuki H | Effect of dietary docosahexaenoic acid and catechins on maze behavior in mice. | 2004 | Ann. Nutr. Metab. | pmid:14646341 |
| Aires V et al. | Docosahexaenoic acid and other fatty acids induce a decrease in pHi in Jurkat T-cells. | 2003 | Br. J. Pharmacol. | pmid:14645139 |
| Sneddon AA et al. | Regulation of selenoprotein GPx4 expression and activity in human endothelial cells by fatty acids, cytokines and antioxidants. | 2003 | Atherosclerosis | pmid:14642406 |
| Kew S et al. | The effect of feeding structured triacylglycerols enriched in eicosapentaenoic or docosahexaenoic acids on murine splenocyte fatty acid composition and leucocyte phagocytosis. | 2003 | Br. J. Nutr. | pmid:14641966 |
| Kaempf-Rotzoll DE et al. | Influence of long-chain polyunsaturated fatty acid formula feeds on vitamin E status in preterm infants. | 2003 | Int J Vitam Nutr Res | pmid:14639802 |
| Maki KC et al. | Lipid responses in mildly hypertriglyceridemic men and women to consumption of docosahexaenoic acid-enriched eggs. | 2003 | Int J Vitam Nutr Res | pmid:14639800 |
| Valenzuela A et al. | Supplementation of female rats with alpha-linolenic acid or docosahexaenoic acid leads to the same omega-6/omega-3 LC-PUFA accretion in mother tissues and in fetal and newborn brains. | 2004 | Ann. Nutr. Metab. | pmid:14639043 |
| Min Y et al. | Adverse effect of obesity on red cell membrane arachidonic and docosahexaenoic acids in gestational diabetes. | 2004 | Diabetologia | pmid:14634727 |
| Seal JR and Porter NA | Liquid chromatography coordination ion-spray mass spectrometry (LC-CIS-MS) of docosahexaenoate ester hydroperoxides. | 2004 | Anal Bioanal Chem | pmid:14634702 |
| Laurin D et al. | Omega-3 fatty acids and risk of cognitive impairment and dementia. | 2003 | J. Alzheimers Dis. | pmid:14624027 |
| D'Eufemia P et al. | Fatty acid profile of oesophageal mucosa in children with gastro-oesophageal reflux disease. | 2003 | Dig Liver Dis | pmid:14620617 |
| Semenova EM and Converse CA | Comparison between oleic acid and docosahexaenoic acid binding to interphotoreceptor retinoid-binding protein. | 2003 | Vision Res. | pmid:14611942 |
| Turner N et al. | Docosahexaenoic acid (DHA) content of membranes determines molecular activity of the sodium pump: implications for disease states and metabolism. | 2003 | Naturwissenschaften | pmid:14610651 |