| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Pain | D010146 | 64 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid:29293497 | ||||
| pmid:29302056 | ||||
| pmid:29305860 | ||||
| pmid:29307174 | ||||
| Reddy TS et al. | Change in content, incorporation and lipoxygenation of docosahexaenoic acid in retina and retinal pigment epithelium in canine ceroid lipofuscinosis. | 1985 | Neurosci. Lett. | pmid:2931631 |
| Cunnane SC et al. | Magnesium deficiency in the rat increases tissue levels of docosahexaenoic acid. | 1985 | J. Nutr. | pmid:2932544 |
| Reynolds JW | Enteral and parenteral nutrition of low birth weight infants. | 1985 | Bol Asoc Med P R | pmid:2933046 |
| pmid:29331380 | ||||
| Mabe H et al. | [Effect of calcium entry blocker, nimodipine, on the cerebral function and metabolic recovery following experimental cerebral ischemia]. | 1985 | No To Shinkei | pmid:2934079 |
| pmid:29345914 | ||||
| Dietary fish oil increases omega-3 long-chain polyunsaturated fatty acids in human milk. | 1985 | Nutr. Rev. | pmid:2934649 | |
| Sugiura T et al. | Transacylation of 1-O-alkyl-SN-glycero-3-phosphocholine (lyso platelet-activating factor) and 1-O-alkenyl-SN-glycero-3-phosphoethanolamine with docosahexaenoic acid (22:6 omega 3). | 1985 | Biochem. Biophys. Res. Commun. | pmid:2935146 |
| Hagve TA and Christophersen BO | Evidence for peroxisomal retroconversion of adrenic acid (22:4(n-6)) and docosahexaenoic acids (22:6(n-3)) in isolated liver cells. | 1986 | Biochim. Biophys. Acta | pmid:2935195 |
| Masuzawa Y et al. | Selective acylation of alkyllysophospholipids by docosahexaenoic acid in Ehrlich ascites cells. | 1986 | Biochim. Biophys. Acta | pmid:2936397 |
| Huterer S and Wherrett JR | Incorporation of polyunsaturated fatty acids into bis(monoacylglycero)phosphate and other lipids of macrophages and of fibroblasts from control and Niemann-Pick patients. | 1986 | Biochim. Biophys. Acta | pmid:2937457 |
| Organisciak DT et al. | Rod outer segment lipids in vitamin A-adequate and -deficient rats. | 1986 | Exp. Eye Res. | pmid:2937648 |
| pmid:29392935 | ||||
| pmid:29394279 | ||||
| pmid:29407798 | ||||
| Maddaiah VT and Clejan S | Growth hormone and liver mitochondria: time course of effects on respiration and fatty acid composition in hypophysectomized rats. | 1986 | Endocrinology | pmid:2941269 |
| Tou JS | Acylation of docosahexaenoic acid into phospholipids by intact human neutrophils. | 1986 | Lipids | pmid:2941637 |
| Yergey JA et al. | High-performance liquid chromatography/thermospray mass spectrometry of eicosanoids and novel oxygenated metabolites of docosahexaenoic acid. | 1986 | Anal. Chem. | pmid:2942056 |
| Guisto NM et al. | Active labeling of phosphatidylcholines by [1-14C]docosahexaenoate in isolated photoreceptor membranes. | 1986 | Biochim. Biophys. Acta | pmid:2942188 |
| Applegate KR and Glomset JA | Computer-based modeling of the conformation and packing properties of docosahexaenoic acid. | 1986 | J. Lipid Res. | pmid:2943846 |
| Weiner MA | Cholesterol in foods rich in omega-3 fatty acids. | 1986 | N. Engl. J. Med. | pmid:2943996 |
| pmid:29462158 | ||||
| German JB and Kinsella JE | Hydroperoxide metabolism in trout gill tissue: effect of glutathione on lipoxygenase products generated from arachidonic acid and docosahexaenoic acid. | 1986 | Biochim. Biophys. Acta | pmid:2946321 |
| Carlson SE et al. | Docosahexaenoic acid status of preterm infants at birth and following feeding with human milk or formula. | 1986 | Am. J. Clin. Nutr. | pmid:2947455 |
| Meduri R et al. | [Effects of zinc and docosahexenoic acid on the corneal and cerebral lesions of rabbits infected with herpesvirus]. | 1986 | Bull Mem Soc Fr Ophtalmol | pmid:2947654 |
| Scorolli L et al. | [Changes induced by zinc and docosahexenoic acid in acute NaIO3 poisoning]. | 1986 | Bull Mem Soc Fr Ophtalmol | pmid:2947655 |
| Hong CY et al. | Effect of phosphatidylcholine, lysophosphatidylcholine, arachidonic acid and docosahexaenoic acid on the motility of human sperm. | 1986 | Int. J. Androl. | pmid:2947864 |
| Bazan NG et al. | Decreased content of docosahexaenoate and arachidonate in plasma phospholipids in Usher's syndrome. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2948509 |
| Hadjiagapiou C and Spector AA | Docosahexaenoic acid metabolism and effect on prostacyclin production in endothelial cells. | 1987 | Arch. Biochem. Biophys. | pmid:2949698 |
| Scott BL et al. | Docosahexaenoate metabolism and fatty-acid composition in developing retinas of normal and rd mutant mice. | 1987 | Exp. Eye Res. | pmid:2951268 |
| Anderson RE et al. | Abnormal plasma levels of polyunsaturated fatty acid in autosomal dominant retinitis pigmentosa. | 1987 | Exp. Eye Res. | pmid:2951269 |
| Ojima A et al. | Selective transacylation of 1-O-alkylglycerophosphoethanolamine by docosahexaenoate and arachidonate in rat brain microsomes. | 1987 | J. Neurochem. | pmid:2951496 |
| Claeys M et al. | Diacylglycerols interfere in normal phase HPLC analysis of lipoxygenase products of docosahexaenoic or arachidonic acids. | 1986 | Prostaglandins | pmid:2951768 |
| pmid:29536298 | ||||
| Carlson SE et al. | Effect of fish oil supplementation on the n-3 fatty acid content of red blood cell membranes in preterm infants. | 1987 | Pediatr. Res. | pmid:2954026 |
| Rotstein NP et al. | Effects of aging on the composition and metabolism of docosahexaenoate-containing lipids of retina. | 1987 | Lipids | pmid:2955190 |
| Infante JP | Docosahexaenoate-containing phospholipids in sarcoplasmic reticulum and retinal photoreceptors. A proposal for a role in Ca2+-ATPase calcium transport. | 1987 | Mol. Cell. Biochem. | pmid:2955214 |
| Mitsuhashi N and Kato J | Modulation of steroid hormone receptors in the brain--inhibitory effect of fatty acids on the binding between cytosol progestin receptors in the rat cortex and R5020. | 1987 | Psychoneuroendocrinology | pmid:2955444 |
| Rotstein NP and Aveldaño MI | Labeling of lipids of retina subcellular fractions by [1-14C]eicosatetraenoate (20:4(n-6)) docosapentaenoate (22:5(n-3)) and docosahexaenoate (22:6(n-3)). | 1987 | Biochim. Biophys. Acta | pmid:2958089 |
| Rotstein NP and Aveldaño MI | Labeling of phosphatidylcholines of retina subcellular fractions by [1-14C]eicosatetraenoate (20:4(n-6)), docosapentaenoate (22:5(n-3)) and docosahexaenoate (22:6(n-3)). | 1987 | Biochim. Biophys. Acta | pmid:2958090 |
| Virkkunen ME et al. | Plasma phospholipid essential fatty acids and prostaglandins in alcoholic, habitually violent, and impulsive offenders. | 1987 | Biol. Psychiatry | pmid:2958095 |
| Frank H et al. | Fatty acids in liver microsomal lipids of rats exposed to hypoxia, tetrachloromethane, or both. | 1987 | Biochim. Biophys. Acta | pmid:2959325 |
| del Nido PJ et al. | Evidence of myocardial free radical injury during elective repair of tetralogy of Fallot. | 1987 | Circulation | pmid:2959398 |
| Codde JP et al. | Effects of fish oil "Max EPA" on blood pressures and prostanoid metabolism of spontaneously hypertensive rats during salt loading. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960180 |
| Kobayashi S et al. | Changes of hemorrheological properties by highly purified DHA in normal subjects. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960200 |
| Organisciak DT et al. | Aspects of the ascorbate protective mechanism in retinal light damage of rats with normal and reduced ROS docosahexaenoic acid. | 1987 | Prog. Clin. Biol. Res. | pmid:2960984 |
| Specker BL et al. | Differences in fatty acid composition of human milk in vegetarian and nonvegetarian women: long-term effect of diet. | 1987 Sep-Oct | J. Pediatr. Gastroenterol. Nutr. | pmid:2961862 |
| Croset M et al. | Inhibition by lipoxygenase products of TXA2-like responses of platelets and vascular smooth muscle. 14-Hydroxy from 22:6n-3 is more potent than 12-HETE. | 1988 | Biochem. Pharmacol. | pmid:2965590 |
| Weissmann G et al. | Stimulus-response coupling in marine sponge cell aggregation: lipid metabolism and the function of exogenously added arachidonic and docosahexaenoic acids. | 1988 | Biochim. Biophys. Acta | pmid:2968121 |
| Ansari KA and Shoeman D | Rapid separation of free fatty acids from neutral lipids in brain extracts. | 1988 | J. Chromatogr. | pmid:2969915 |
| Hruby K | [Is retinitis pigmentosa absolutely incurable?]. | 1988 | Klin Monbl Augenheilkd | pmid:2969995 |
| Tesoriere L et al. | Modulation by docosahexaenoic acid of the epinephrine-stimulated adenylate cyclase activity of the bovine retina. | 1988 | J. Neurochem. | pmid:2970525 |
| Shingu T et al. | Discovery of novel brain lipoxygenase products formed from docosahexaenoic acid (22:6w3). | 1988 | Adv Alcohol Subst Abuse | pmid:2975919 |
| Louie K et al. | Docosahexaenoate-containing molecular species of glycerophospholipids from frog retinal rod outer segments show different rates of biosynthesis and turnover. | 1988 | Biochemistry | pmid:2976602 |
| Masuzawa Y | [The mysteries of docosahexaenoic acid--possible functions of C22 polyenoic fatty acids]. | 1988 | Seikagaku | pmid:2976795 |
| Takahashi R et al. | Plasma, platelet, and aorta fatty acids composition in response to dietary n-6 and n-3 fats supplementation in a rat model of non-insulin-dependent diabetes. | 1988 | J. Nutr. Sci. Vitaminol. | pmid:2976815 |
| Karanian JW et al. | Smooth muscle effects of hydroxylated docosahexaenoates produced from human platelet. | 1988 | Biomed. Biochim. Acta | pmid:2977725 |
| Lee TH et al. | Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. | 1985 | N. Engl. J. Med. | pmid:2985986 |
| Singer P et al. | Influence on serum lipids, lipoproteins and blood pressure of mackerel and herring diet in patients with type IV and V hyperlipoproteinemia. | 1985 | Atherosclerosis | pmid:2992534 |
| Barcelli U et al. | Enhancing effect of dietary supplementation with omega-3 fatty acids on plasma fibrinolysis in normal subjects. | 1985 | Thromb. Res. | pmid:2996169 |
| von Schacky C et al. | Long-term effects of dietary marine omega-3 fatty acids upon plasma and cellular lipids, platelet function, and eicosanoid formation in humans. | 1985 | J. Clin. Invest. | pmid:2997286 |
| Singer P et al. | Blood pressure- and lipid-lowering effect of mackerel and herring diet in patients with mild essential hypertension. | 1985 | Atherosclerosis | pmid:3000395 |
| German JB et al. | Lipoxygenase in trout gill tissue acting on arachidonic, eicosapentaenoic and docosahexaenoic acids. | 1986 | Biochim. Biophys. Acta | pmid:3000452 |
| von Schacky C and Weber PC | Metabolism and effects on platelet function of the purified eicosapentaenoic and docosahexaenoic acids in humans. | 1985 | J. Clin. Invest. | pmid:3001149 |
| Lee TH et al. | Enhancement of plasma levels of biologically active leukotriene B compounds during anaphylaxis in guinea pigs pretreated by indomethacin or by a fish oil-enriched diet. | 1986 | J. Immunol. | pmid:3005414 |
| Haines AP et al. | Effects of a fish oil supplement on platelet function, haemostatic variables and albuminuria in insulin-dependent diabetics. | 1986 | Thromb. Res. | pmid:3020732 |
| Croset M and Lagarde M | In vitro incorporation and metabolism of icosapentaenoic and docosahexaenoic acids in human platelets--effect on aggregation. | 1986 | Thromb. Haemost. | pmid:3022414 |
| Ziboh VA et al. | Effects of dietary supplementation of fish oil on neutrophil and epidermal fatty acids. Modulation of clinical course of psoriatic subjects. | 1986 | Arch Dermatol | pmid:3022655 |
| Fish oil for the heart. | 1987 | Med Lett Drugs Ther | pmid:3025574 | |
| Singer P et al. | Long-term effect of mackerel diet on blood pressure, serum lipids and thromboxane formation in patients with mild essential hypertension. | 1986 | Atherosclerosis | pmid:3026412 |
| Koletzko B | Omega-3 fatty acid requirement. | 1987 | Am. J. Clin. Nutr. | pmid:3039827 |
| Maxepa--Eskimos, fish oils and ischaemic heart disease. | 1988 | Drug Ther Bull | pmid:3053081 | |
| Miller JP et al. | Triglyceride lowering effect of MaxEPA fish lipid concentrate: a multicentre placebo controlled double blind study. | 1988 | Clin. Chim. Acta | pmid:3071435 |
| Norris PG et al. | Effect of dietary supplementation with fish oil on systolic blood pressure in mild essential hypertension. | 1986 | Br Med J (Clin Res Ed) | pmid:3089408 |
| Mehta J et al. | Reduction in plasminogen activator inhibitor-1 (PAI-1) with omega-3 polyunsaturated fatty acid (PUFA) intake. | 1988 | Am. Heart J. | pmid:3142242 |
| Parks JE and Hammerstedt RH | Development changes occurring in the lipids of ram epididymal spermatozoa plasma membrane. | 1985 | Biol. Reprod. | pmid:3158356 |
| Rebello T and Watts DC | Gastrocnemius muscle lipids in relation to diet in two mouse mutants, 129Re-dy and A2G-adr, with abnormal muscle function. | 1985 | J. Neurochem. | pmid:3158720 |
| Ferretti A et al. | Occurrence of prostaglandin E3 in human urine as a result of marine oil ingestion: gas chromatographic-mass spectrometric evidence. | 1988 | Biochim. Biophys. Acta | pmid:3162687 |
| Schmidt EB et al. | The effect of fish oil on lipids, coagulation and fibrinolysis in patients with angina pectoris. | 1988 | Artery | pmid:3178506 |
| Zucker ML et al. | Effects of dietary fish oil on platelet function and plasma lipids in hyperlipoproteinemic and normal subjects. | 1988 | Atherosclerosis | pmid:3178928 |
| Mehta JL et al. | Dietary supplementation with omega-3 polyunsaturated fatty acids in patients with stable coronary heart disease. Effects on indices of platelet and neutrophil function and exercise performance. | 1988 | Am. J. Med. | pmid:3276185 |
| Glauber H et al. | Adverse metabolic effect of omega-3 fatty acids in non-insulin-dependent diabetes mellitus. | 1988 | Ann. Intern. Med. | pmid:3282462 |
| Cahill PD et al. | Inhibition of vein graft intimal thickening by eicosapentanoic acid: reduced thromboxane production without change in lipoprotein levels or low-density lipoprotein receptor density. | 1988 | J. Vasc. Surg. | pmid:3336117 |
| Vandongen R et al. | Hypercholesterolaemic effect of fish oil in insulin-dependent diabetic patients. | 1988 | Med. J. Aust. | pmid:3340028 |
| Arm JP et al. | Effect of dietary supplementation with fish oil lipids on mild asthma. | 1988 | Thorax | pmid:3353893 |
| Picado C et al. | Effects of a fish oil enriched diet on aspirin intolerant asthmatic patients: a pilot study. | 1988 | Thorax | pmid:3353894 |
| Demke DM et al. | Effects of a fish oil concentrate in patients with hypercholesterolemia. | 1988 | Atherosclerosis | pmid:3355619 |
| Whittle JC | Dietary supplementation with omega-3 polyunsaturated fatty acids in patients with stable coronary heart disease. | 1988 | Am. J. Med. | pmid:3376983 |
| Gibney MJ and Bolton-Smith C | The effect of a dietary supplement of n-3 polyunsaturated fat on platelet lipid composition, platelet function and platelet plasma membrane fluidity in healthy volunteers. | 1988 | Br. J. Nutr. | pmid:3408705 |
| Cendrowski W | Multiple sclerosis and MaxEPA. | 1986 | Br J Clin Pract | pmid:3542002 |
| Codde JP et al. | The effect of dietary fish oil and salt on blood pressure and eicosanoid metabolism of spontaneously hypertensive rats. | 1987 | J. Hypertens. | pmid:3611764 |
| Sanders TA | Re: Fish oil feeding results in enhancement of cholesterol-induced atherosclerosis in rabbits. | 1987 | Atherosclerosis | pmid:3675708 |
| Chamberlain JG and Belton C | Effects of long term consumption of fish oil (Maxepa) on serum lipids and arterial ultrastructure in Japanese quail (Coturnix coturnix japonica). | 1987 | Atherosclerosis | pmid:3689486 |
| Maurice PD et al. | The effects of dietary supplementation with fish oil in patients with psoriasis. | 1987 | Br. J. Dermatol. | pmid:3689678 |
| Croft KD et al. | The effect of dietary fish oil on platelet metabolism of 14C arachidonic acid. | 1986 | Thromb. Res. | pmid:3705024 |
| Rylance PB et al. | Fish oil modifies lipids and reduces platelet aggregability in haemodialysis patients. | 1986 | Nephron | pmid:3724927 |