DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with DHA

Download all related citations
Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Tikhonenko M et al. N-3 polyunsaturated Fatty acids prevent diabetic retinopathy by inhibition of retinal vascular damage and enhanced endothelial progenitor cell reparative function. 2013 PLoS ONE pmid:23383097
Mirza M et al. Progressive retinal degeneration and glial activation in the CLN6 (nclf) mouse model of neuronal ceroid lipofuscinosis: a beneficial effect of DHA and curcumin supplementation. 2013 PLoS ONE pmid:24124525
Umhau JC et al. Brain docosahexaenoic acid [DHA] incorporation and blood flow are increased in chronic alcoholics: a positron emission tomography study corrected for cerebral atrophy. 2013 PLoS ONE pmid:24098376
Renganathan K et al. CEP biomarkers as potential tools for monitoring therapeutics. 2013 PLoS ONE pmid:24098476
Hsiao HM et al. A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation. 2013 PLoS ONE pmid:23484005
Nagai T et al. Circulating Omega-6, But Not Omega-3 Polyunsaturated Fatty Acids, Are Associated with Clinical Outcomes in Patients with Acute Decompensated Heart Failure. 2016 PLoS ONE pmid:27824904
Suzuki-Kemuriyama N et al. Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice. 2016 PLoS ONE pmid:27333187
Correia M et al. Crosstalk between Helicobacter pylori and gastric epithelial cells is impaired by docosahexaenoic acid. 2013 PLoS ONE pmid:23577140
Bonilla DL et al. Incorporation of a dietary omega 3 fatty acid impairs murine macrophage responses to Mycobacterium tuberculosis. 2010 PLoS ONE pmid:20526363
Zhang X et al. Resolvin D1 protects podocytes in adriamycin-induced nephropathy through modulation of 14-3-3β acetylation. 2013 PLoS ONE pmid:23840712
Haas-Stapleton EJ et al. Candida albicans modulates host defense by biosynthesizing the pro-resolving mediator resolvin E1. 2007 PLoS ONE pmid:18091990
Markhus MW et al. Low omega-3 index in pregnancy is a possible biological risk factor for postpartum depression. 2013 PLoS ONE pmid:23844041
Bhatia HS et al. Omega-3 fatty acid deficiency during brain maturation reduces neuronal and behavioral plasticity in adulthood. 2011 PLoS ONE pmid:22163304
Singh A et al. Gene-metabolite expression in blood can discriminate allergen-induced isolated early from dual asthmatic responses. 2013 PLoS ONE pmid:23844124
Arsenault D et al. DHA improves cognition and prevents dysfunction of entorhinal cortex neurons in 3xTg-AD mice. 2011 PLoS ONE pmid:21383850
Brouwer IA et al. Effect of alpha linolenic acid supplementation on serum prostate specific antigen (PSA): results from the alpha omega trial. 2013 PLoS ONE pmid:24349086
Motter AL and Ahern GP TRPA1 is a polyunsaturated fatty acid sensor in mammals. 2012 PLoS ONE pmid:22723860
Astarita G et al. Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease. 2010 PLoS ONE pmid:20838618
Jeckel KM et al. Docosahexaenoic acid supplementation does not improve Western diet-induced cardiomyopathy in rats. 2012 PLoS ONE pmid:23300587
Candelario J et al. PTH1 receptor is involved in mediating cellular response to long-chain polyunsaturated fatty acids. 2012 PLoS ONE pmid:23300710
Ishikado A et al. 4-Hydroxy hexenal derived from docosahexaenoic acid protects endothelial cells via Nrf2 activation. 2013 PLoS ONE pmid:23936010
Nuez-Ortín WG et al. Preliminary Validation of a High Docosahexaenoic Acid (DHA) and -Linolenic Acid (ALA) Dietary Oil Blend: Tissue Fatty Acid Composition and Liver Proteome Response in Atlantic Salmon (Salmo salar) Smolts. 2016 PLoS ONE pmid:27556399
Sublimi Saponetti M et al. Aggregation of Aß(25-35) on DOPC and DOPC/DHA bilayers: an atomic force microscopy study. 2014 PLoS ONE pmid:25551704
Alsharari ZD et al. Serum Fatty Acids, Desaturase Activities and Abdominal Obesity - A Population-Based Study of 60-Year Old Men and Women. 2017 PLoS ONE pmid:28125662
Gladine C et al. Lipid profiling following intake of the omega 3 fatty acid DHA identifies the peroxidized metabolites F4-neuroprostanes as the best predictors of atherosclerosis prevention. 2014 PLoS ONE pmid:24558496
Park J et al. Reciprocal modulation of surface expression of annexin A2 in a human umbilical vein endothelial cell-derived cell line by eicosapentaenoic acid and docosahexaenoic acid. 2014 PLoS ONE pmid:24465474
Xiao G et al. Eicosapentaenoic acid enhances heat stress-impaired intestinal epithelial barrier function in Caco-2 cells. 2013 PLoS ONE pmid:24066055
Vedin I et al. Effects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD study. 2012 PLoS ONE pmid:22545106
Gronroos NN et al. Fish, fish-derived n-3 fatty acids, and risk of incident atrial fibrillation in the Atherosclerosis Risk in Communities (ARIC) study. 2012 PLoS ONE pmid:22570739
Lachance C et al. Fenretinide corrects the imbalance between omega-6 to omega-3 polyunsaturated fatty acids and inhibits macrophage inflammatory mediators via the ERK pathway. 2013 PLoS ONE pmid:24069363
Labrousse VF et al. Short-term long chain omega3 diet protects from neuroinflammatory processes and memory impairment in aged mice. 2012 PLoS ONE pmid:22662127
Mansara PP et al. Differential Ratios of Omega Fatty Acids (AA/EPA+DHA) Modulate Growth, Lipid Peroxidation and Expression of Tumor Regulatory MARBPs in Breast Cancer Cell Lines MCF7 and MDA-MB-231. 2015 PLoS ONE pmid:26325577
Lopez HL Nutritional interventions to prevent and treat osteoarthritis. Part I: focus on fatty acids and macronutrients. 2012 PM R pmid:22632694
Luczaj W and Skrzydlewska E [The present-day look at lipid peroxidation]. 2006 Postepy Biochem. pmid:17078507
Duda MK [Polyunsaturated fatty acids omega-3 as modulators of intracellular signaling pathways]. 2012 Postepy Biochem. pmid:23214138
Walczewska A et al. [The role of docosahexaenoic acid in neuronal function]. 2011 Postepy Hig Med Dosw (Online) pmid:21677356
Crandell JR et al. Lipid effects of switching from prescription EPA+DHA (omega-3-acid ethyl esters) to prescription EPA only (icosapent ethyl) in dyslipidemic patients. 2016 Postgrad Med pmid:27684412
Leaf DA Omega-3 fatty acids and coronary artery disease. More than a fish tale. 1989 Postgrad Med pmid:2542914
Sadovsky R and Kris-Etherton P Prescription omega-3-acid ethyl esters for the treatment of very high triglycerides. 2009 Postgrad Med pmid:19641280
Harris WS et al. Omega-3 fatty acids and cardiovascular disease: new developments and applications. 2013 Postgrad Med pmid:24200766
Du M et al. Effects of dietary conjugated linoleic acid and linoleic:linolenic acid ratio on polyunsaturated fatty acid status in laying hens. 2000 Poult. Sci. pmid:11194037
Pappas AC et al. Maternal organo-selenium compounds and polyunsaturated fatty acids affect progeny performance and levels of selenium and docosahexaenoic acid in the chick tissues. 2006 Poult. Sci. pmid:16977847
Meluzzi A et al. Effects of dietary vitamin E on the quality of table eggs enriched with n-3 long-chain fatty acids. 2000 Poult. Sci. pmid:10780651
Carrillo-Domínguez S et al. Cholesterol and n-3 and n-6 fatty acid content in eggs from laying hens fed with red crab meal (Pleuroncodes planipes). 2005 Poult. Sci. pmid:15685957
Ko YH et al. Cloning and expression of Tsaiya duck liver fatty acid binding protein. 2004 Poult. Sci. pmid:15554058
Grobas S et al. Influence of source and percentage of fat added to diet on performance and fatty acid composition of egg yolks of two strains of laying hens. 2001 Poult. Sci. pmid:11495470
Cherian G and Sim J Preferential accumulation of n-3 fatty acids in the brain of chicks from eggs enriched with n-3 fatty acids. 1992 Poult. Sci. pmid:1454683
Ding ST and Lilburn MS Changes in fatty acid profiles in different lipid classes during late development of turkey embryos from two genetic lines. 1997 Poult. Sci. pmid:9181615
Santos GA and Silversides FG Utilization of the sex-linked gene for imperfect albinism (S*ALS). 1. Effect of early weight loss on chick metabolism. 1996 Poult. Sci. pmid:8933584
Herber SM and Van Elswyk ME Dietary marine algae promotes efficient deposition of n-3 fatty acids for the production of enriched shell eggs. 1996 Poult. Sci. pmid:9000275
Surai PF and Sparks NH Tissue-specific fatty acid and alpha-tocopherol profiles in male chickens depending on dietary tuna oil and vitamin E provision. 2000 Poult. Sci. pmid:10947182
Koppenol A et al. Effect of the ratio of dietary n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid on broiler breeder performance, egg quality, and yolk fatty acid composition at different breeder ages. 2014 Poult. Sci. pmid:24604849
Bou R et al. Effect of dietary fat sources and zinc and selenium supplements on the composition and consumer acceptability of chicken meat. 2005 Poult. Sci. pmid:16050130
López-Ferrer S et al. n-3 enrichment of chicken meat. 1. Use of very long-chain fatty acids in chicken diets and their influence on meat quality: fish oil. 2001 Poult. Sci. pmid:11441841
Wang YW et al. Maternal dietary N-3 fatty acids alter the spleen fatty acid composition and bovine serum albumin-induced wing web swelling in broilers. 2002 Poult. Sci. pmid:12455601
Cherian G et al. Dietary conjugated linoleic acid with fish oil alters yolk n-3 and trans fatty acid content and volatile compounds in raw, cooked, and irradiated eggs. 2002 Poult. Sci. pmid:12412926
Allen PC and Danforth HD Effects of dietary supplementation with n-3 fatty acid ethyl esters on coccidiosis in chickens. 1998 Poult. Sci. pmid:9835336
Gao YC and Charter EA Nutritionally important fatty acids in hen egg yolks from different sources. 2000 Poult. Sci. pmid:10875777
Szabó A et al. Differential utilization of hepatic and myocardial fatty acids during forced molt of laying hens. 2005 Poult. Sci. pmid:15685949
Houston L Dietary change in arthritis. 1994 Practitioner pmid:8208662
Mourek J Metabolic syndrome (does it have a common denominator?). 2008 Prague Med Rep pmid:19548590
Muramatsu T et al. Higher dietary intake of alpha-linolenic acid is associated with lower insulin resistance in middle-aged Japanese. 2010 May-Jun Prev Med pmid:20211645
Gomez-Pinilla F The combined effects of exercise and foods in preventing neurological and cognitive disorders. 2011 Prev Med pmid:21281667
Mori TA Dietary n-3 PUFA and CVD: a review of the evidence. 2014 Proc Nutr Soc pmid:24119287
von Schacky C n-3 PUFA in CVD: influence of cytokine polymorphism. 2007 Proc Nutr Soc pmid:17466099
Sijben JW and Calder PC Differential immunomodulation with long-chain n-3 PUFA in health and chronic disease. 2007 Proc Nutr Soc pmid:17466105
Hennebelle M et al. Ageing and apoE change DHA homeostasis: relevance to age-related cognitive decline. 2014 Proc Nutr Soc pmid:24103099
Anil E The impact of EPA and DHA on blood lipids and lipoprotein metabolism: influence of apoE genotype. 2007 Proc Nutr Soc pmid:17343773
Morris MC Nutritional determinants of cognitive aging and dementia. 2012 Proc Nutr Soc pmid:22067138
Ian Givens D and Gibbs RA Current intakes of EPA and DHA in European populations and the potential of animal-derived foods to increase them. 2008 Proc Nutr Soc pmid:18498671
Childs CE et al. Gender differences in the n-3 fatty acid content of tissues. 2008 Proc Nutr Soc pmid:18234128
Calder PC Dietary modification of inflammation with lipids. 2002 Proc Nutr Soc pmid:12296294
Yaqoob P Fatty acids and the immune system: from basic science to clinical applications. 2004 Proc Nutr Soc pmid:15070442
Wainwright PE Dietary essential fatty acids and brain function: a developmental perspective on mechanisms. 2002 Proc Nutr Soc pmid:12002796
Spite M Deciphering the role of n-3 polyunsaturated fatty acid-derived lipid mediators in health and disease. 2013 Proc Nutr Soc pmid:23991833
Cottin SC et al. The differential effects of EPA and DHA on cardiovascular risk factors. 2011 Proc Nutr Soc pmid:21349231
Williams CM and Burdge G Long-chain n-3 PUFA: plant v. marine sources. 2006 Proc Nutr Soc pmid:16441943
Gibbs RA et al. Postgraduate Symposium: Long-chain n-3 PUFA: intakes in the UK and the potential of a chicken meat prototype to increase them. 2010 Proc Nutr Soc pmid:19954567
Calder PC Long-chain fatty acids and inflammation. 2012 Proc Nutr Soc pmid:22369781
Kelley DS and Adkins Y Similarities and differences between the effects of EPA and DHA on markers of atherosclerosis in human subjects. 2012 Proc Nutr Soc pmid:22369859
Vreugdenhil M et al. Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons. 1996 Proc. Natl. Acad. Sci. U.S.A. pmid:8901621
Salem N et al. Arachidonic and docosahexaenoic acids are biosynthesized from their 18-carbon precursors in human infants. 1996 Proc. Natl. Acad. Sci. U.S.A. pmid:8552667
He C et al. Improved spatial learning performance of fat-1 mice is associated with enhanced neurogenesis and neuritogenesis by docosahexaenoic acid. 2009 Proc. Natl. Acad. Sci. U.S.A. pmid:19549874
Mukherjee PK et al. Photoreceptor outer segment phagocytosis attenuates oxidative stress-induced apoptosis with concomitant neuroprotectin D1 synthesis. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:17670935
Mukherjee PK et al. Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:17670936
Pepe S et al. Omega 3 polyunsaturated fatty acid modulates dihydropyridine effects on L-type Ca2+ channels, cytosolic Ca2+, and contraction in adult rat cardiac myocytes. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:7522322
Scott BL and Bazan NG Membrane docosahexaenoate is supplied to the developing brain and retina by the liver. 1989 Proc. Natl. Acad. Sci. U.S.A. pmid:2523075
Norris PC and Dennis EA Omega-3 fatty acids cause dramatic changes in TLR4 and purinergic eicosanoid signaling. 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:22586114
Zhang G et al. Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23553837
Kang JX and Leaf A Effects of long-chain polyunsaturated fatty acids on the contraction of neonatal rat cardiac myocytes. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:7937911
Massaro M et al. The omega-3 fatty acid docosahexaenoate attenuates endothelial cyclooxygenase-2 induction through both NADP(H) oxidase and PKC epsilon inhibition. 2006 Proc. Natl. Acad. Sci. U.S.A. pmid:17018645
Krishnamoorthy S et al. Resolvin D1 binds human phagocytes with evidence for proresolving receptors. 2010 Proc. Natl. Acad. Sci. U.S.A. pmid:20080636
Mukherjee PK et al. Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15152078
Berger A et al. Anandamide and diet: inclusion of dietary arachidonate and docosahexaenoate leads to increased brain levels of the corresponding N-acylethanolamines in piglets. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11353819
Corey EJ et al. Docosahexaenoic acid is a strong inhibitor of prostaglandin but not leukotriene biosynthesis. 1983 Proc. Natl. Acad. Sci. U.S.A. pmid:6304720
Fredman G et al. Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:25246560
Harris WS et al. Docosahexaenoic acid ethyl esters ineffective? 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23671065
Kitajka K et al. The role of n-3 polyunsaturated fatty acids in brain: modulation of rat brain gene expression by dietary n-3 fatty acids. 2002 Proc. Natl. Acad. Sci. U.S.A. pmid:11880617
Fontes-Villalba M et al. African hominin stable isotopic data do not necessarily indicate grass consumption. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:24062471
Honoré E et al. External blockade of the major cardiac delayed-rectifier K+ channel (Kv1.5) by polyunsaturated fatty acids. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:8127910