DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Reardon HT et al. Dietary long-chain polyunsaturated fatty acids upregulate expression of FADS3 transcripts. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22398025
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Brenna T et al. Docosahexaenoic acid in translational medicine: the Tenth Fatty Acids and Cell Signaling meeting (FACS-10). 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23103099
Galvao TF et al. Marine n3 polyunsaturated fatty acids enhance resistance to mitochondrial permeability transition in heart failure but do not improve survival. 2013 Am. J. Physiol. Heart Circ. Physiol. pmid:23103493
Tai EK et al. An update on adding docosahexaenoic acid (DHA) and arachidonic acid (AA) to baby formula. 2013 Food Funct pmid:24150114
Hegarty B and Parker G Fish oil as a management component for mood disorders - an evolving signal. 2013 Curr Opin Psychiatry pmid:23108232
Miller BJ et al. Dietary supplements for preventing postnatal depression. 2013 Cochrane Database Syst Rev pmid:24158923
Ren LJ et al. Impact of phosphate concentration on docosahexaenoic acid production and related enzyme activities in fermentation of Schizochytrium sp. 2013 Bioprocess Biosyst Eng pmid:23108442
Jansen D et al. Effects of specific multi-nutrient enriched diets on cerebral metabolism, cognition and neuropathology in AβPPswe-PS1dE9 mice. 2013 PLoS ONE pmid:24086523
Abdelmoaty S et al. Spinal actions of lipoxin A4 and 17(R)-resolvin D1 attenuate inflammation-induced mechanical hypersensitivity and spinal TNF release. 2013 PLoS ONE pmid:24086560
Stamey Lanier J et al. Mammary uptake of fatty acids supplied by intravenous triacylglycerol infusion to lactating dairy cows. 2013 Lipids pmid:23504269
Bazan NG et al. Docosahexaenoic acid and its derivative neuroprotectin D1 display neuroprotective properties in the retina, brain and central nervous system. 2013 Nestle Nutr Inst Workshop Ser pmid:24107502
Yang YC et al. Docosahexaenoic acid inhibition of inflammation is partially via cross-talk between Nrf2/heme oxygenase 1 and IKK/NF-κB pathways. 2013 J. Nutr. Biochem. pmid:22901690
Tsuboi H et al. Associations of depressive symptoms with serum proportions of palmitic and arachidonic acids, and α-tocopherol effects among male population--a preliminary study. 2013 Clin Nutr pmid:22901744
Lindberg M et al. Long-term tracking of plasma phospholipid fatty acid concentrations and their correlation with the dietary intake of marine foods in newly diagnosed diabetic patients: results from a follow-up of the HUNT Study, Norway. 2013 Br. J. Nutr. pmid:22846205
MacLean E et al. n-3 Fatty acids inhibit transcription of human IL-13: implications for development of T helper type 2 immune responses. 2013 Br. J. Nutr. pmid:22849952
Hajjaji N and Bougnoux P Selective sensitization of tumors to chemotherapy by marine-derived lipids: a review. 2013 Cancer Treat. Rev. pmid:22850619
Lund I et al. Importance of DHA for first feeding pikeperch larvae--influence on behavioural responses. 2013 Commun. Agric. Appl. Biol. Sci. pmid:25141683
Mesa-Rodriguez A et al. Effect of increasing DHA content in new weaning diets for longfin yellowtail (Seriola rivoliana). 2013 Commun. Agric. Appl. Biol. Sci. pmid:25141689
Miyashima A et al. DHA requirement of larval Japanese flounder Paralichthys olivaceus in the rotifer feeding period. 2013 Commun. Agric. Appl. Biol. Sci. pmid:25141691
Morais S et al. Effect of Senegalese sole broodstock nutrition on early larval performance and metabolism of long-chain polyunsaturated fatty acids (DHA and EPA). 2013 Commun. Agric. Appl. Biol. Sci. pmid:25141693
Paz-Raymundo B et al. Effect of DHA on the expression of the delta6-desaturase during larval development of yellow snapper, Lutjanus argentiventris. 2013 Commun. Agric. Appl. Biol. Sci. pmid:25141709
Botelho PB et al. Effect of Echium oil compared with marine oils on lipid profile and inhibition of hepatic steatosis in LDLr knockout mice. 2013 Lipids Health Dis pmid:23510369
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Sundrani D et al. Matrix metalloproteinases-2, -3 and tissue inhibitors of metalloproteinases-1, -2 in placentas from preterm pregnancies and their association with one-carbon metabolites. 2013 Reproduction pmid:23412981
Chien KL et al. A Taiwanese food frequency questionnaire correlates with plasma docosahexaenoic acid but not with plasma eicosapentaenoic acid levels: questionnaires and plasma biomarkers. 2013 BMC Med Res Methodol pmid:23414574
Maskrey BH et al. Emerging importance of omega-3 fatty acids in the innate immune response: molecular mechanisms and lipidomic strategies for their analysis. 2013 Mol Nutr Food Res pmid:23417926
Lapillonne A et al. Lipid needs of preterm infants: updated recommendations. 2013 J. Pediatr. pmid:23445847
Del Bó C et al. Horse meat consumption affects iron status, lipid profile and fatty acid composition of red blood cells in healthy volunteers. 2013 Int J Food Sci Nutr pmid:23025273
Lim SN et al. Improved outcome after spinal cord compression injury in mice treated with docosahexaenoic acid. 2013 Exp. Neurol. pmid:23026410
Miyata J et al. Dysregulated synthesis of protectin D1 in eosinophils from patients with severe asthma. 2013 J. Allergy Clin. Immunol. pmid:23006546
Lau BY et al. Investigating the role of polyunsaturated fatty acids in bone development using animal models. 2013 Molecules pmid:24248147
Scholtz SA et al. Clinical overview of effects of dietary long-chain polyunsaturated fatty acids during the perinatal period. 2013 Nestle Nutr Inst Workshop Ser pmid:24107504
Randall KM et al. Effects of dietary supplementation of coriander oil, in canola oil diets, on the metabolism of [1-(14)C] 18:3n-3 and [1-(14)C] 18:2n-6 in rainbow trout hepatocytes. 2013 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:23867781
McNamara RK et al. Low docosahexaenoic acid status is associated with reduced indices in cortical integrity in the anterior cingulate of healthy male children: a 1H MRS Study. 2013 Nutr Neurosci pmid:23582513
Ammann EM et al. ω-3 fatty acids and domain-specific cognitive aging: secondary analyses of data from WHISCA. 2013 Neurology pmid:24068783
Berberovic E et al. Arachidonic and docosahexaenoic acid in the blood of a mother and umbilical vein in diabetic pregnant women. 2013 J. Matern. Fetal. Neonatal. Med. pmid:23480524
Lee HN et al. Resolvin D1 stimulates efferocytosis through p50/p50-mediated suppression of tumor necrosis factor-α expression. 2013 J. Cell. Sci. pmid:23788426
Araújo JR et al. Gestational diabetes mellitus decreases placental uptake of long-chain polyunsaturated fatty acids: involvement of long-chain acyl-CoA synthetase. 2013 J. Nutr. Biochem. pmid:23790250
Russell KL et al. Low brain DHA content worsens sensorimotor outcomes after TBI and decreases TBI-induced Timp1 expression in juvenile rats. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23796971
Xue Z et al. Production of omega-3 eicosapentaenoic acid by metabolic engineering of Yarrowia lipolytica. 2013 Nat. Biotechnol. pmid:23873085
Pase MP and Stough C Describing a taxonomy of cognitive processes for clinical trials assessing cognition. 2013 Am. J. Clin. Nutr. pmid:23873682
Bruins MJ et al. Plasma oxylipin profiling identifies polyunsaturated vicinal diols as responsive to arachidonic acid and docosahexaenoic acid intake in growing piglets. 2013 J. Lipid Res. pmid:23543770
Calder PC Editorial: Fat chance to enhance B cell function. 2013 J. Leukoc. Biol. pmid:23547174
Aarak KE et al. Release of EPA and DHA from salmon oil - a comparison of in vitro digestion with human and porcine gastrointestinal enzymes. 2013 Br. J. Nutr. pmid:23510480
Stonehouse W et al. DHA supplementation improved both memory and reaction time in healthy young adults: a randomized controlled trial. 2013 Am. J. Clin. Nutr. pmid:23515006
Fagan P and Wijesundera C Rapid isolation of omega-3 long-chain polyunsaturated fatty acids using monolithic high performance liquid chromatography columns. 2013 J Sep Sci pmid:23559561
Jans JJ et al. Supplementation with a powdered blend of PUFAs normalizes DHA and AA levels in patients with PKU. 2013 Mol. Genet. Metab. pmid:23562298
Rahmawaty S et al. Dietary intake and food sources of EPA, DPA and DHA in Australian children. 2013 Lipids pmid:23881381
Bruno MJ et al. Interactions of drugs and amphiphiles with membranes: modulation of lipid bilayer elastic properties by changes in acyl chain unsaturation and protonation. 2013 Faraday Discuss. pmid:23805753
Jung SB et al. Docosahexaenoic acid improves vascular function via up-regulation of SIRT1 expression in endothelial cells. 2013 Biochem. Biophys. Res. Commun. pmid:23806688
Decsi T and Boehm G trans Isomeric fatty acids are inversely related to the availability of long-chain PUFAs in the perinatal period. 2013 Am. J. Clin. Nutr. pmid:23824720
Sun YB et al. Endothelial dysfunction exacerbates renal interstitial fibrosis through enhancing fibroblast Smad3 linker phosphorylation in the mouse obstructed kidney. 2013 PLoS ONE pmid:24391884
Lundström SL et al. Lipid mediator serum profiles in asthmatics significantly shift following dietary supplementation with omega-3 fatty acids. 2013 Mol Nutr Food Res pmid:23824870
Lohner S et al. Lower n-3 long-chain polyunsaturated fatty acid values in patients with phenylketonuria: a systematic review and meta-analysis. 2013 Nutr Res pmid:23827125
Zhang X et al. Resolvin D1 reverts lipopolysaccharide-induced TJ proteins disruption and the increase of cellular permeability by regulating IκBα signaling in human vascular endothelial cells. 2013 Oxid Med Cell Longev pmid:24381712
Kelly OJ et al. Long-chain polyunsaturated fatty acids may mutually benefit both obesity and osteoporosis. 2013 Nutr Res pmid:23827126
German OL et al. Retinoid X receptor activation is essential for docosahexaenoic acid protection of retina photoreceptors. 2013 J. Lipid Res. pmid:23723389
Hiratsuka S et al. Effects of dietary sialic acid in n-3 fatty acid-deficient dams during pregnancy and lactation on the learning abilities of their pups after weaning. 2013 J. Nutr. Sci. Vitaminol. pmid:23727644
Willatts P et al. Effects of long-chain PUFA supplementation in infant formula on cognitive function in later childhood. 2013 Am. J. Clin. Nutr. pmid:23783296
Meyer BJ et al. Improvement of major depression is associated with increased erythrocyte DHA. 2013 Lipids pmid:23733443
Zawadzki M et al. Perna canaliculus lipid complex PCSO-524â„¢ demonstrated pain relief for osteoarthritis patients benchmarked against fish oil, a randomized trial, without placebo control. 2013 Mar Drugs pmid:23739042
Giroud S et al. Membrane phospholipid fatty acid composition regulates cardiac SERCA activity in a hibernator, the Syrian hamster (Mesocricetus auratus). 2013 PLoS ONE pmid:23650545
Ostapchenko VG et al. Increased prion protein processing and expression of metabotropic glutamate receptor 1 in a mouse model of Alzheimer's disease. 2013 J. Neurochem. pmid:23651058
Ramkumar HL et al. Nutrient supplementation with n3 polyunsaturated fatty acids, lutein, and zeaxanthin decrease A2E accumulation and VEGF expression in the retinas of Ccl2/Cx3cr1-deficient mice on Crb1rd8 background. 2013 J. Nutr. pmid:23677863
Nobre ME et al. Eicosapentaenoic acid and docosahexaenoic acid exert anti-inflammatory and antinociceptive effects in rodents at low doses. 2013 Nutr Res pmid:23684444
Xu ZZ et al. Neuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma. 2013 Ann. Neurol. pmid:23686636
Flock MR et al. Immunometabolic role of long-chain omega-3 fatty acids in obesity-induced inflammation. 2013 Diabetes Metab. Res. Rev. pmid:23592441
Nagachinta S and Akoh CC Synthesis of structured lipid enriched with omega fatty acids and sn-2 palmitic acid by enzymatic esterification and its incorporation in powdered infant formula. 2013 J. Agric. Food Chem. pmid:23597247
Liu Y et al. Fish oil alleviates activation of the hypothalamic-pituitary-adrenal axis associated with inhibition of TLR4 and NOD signaling pathways in weaned piglets after a lipopolysaccharide challenge. 2013 J. Nutr. pmid:24005609
Li X et al. Cyclooxygenase-2 induction in macrophages is modulated by docosahexaenoic acid via interactions with free fatty acid receptor 4 (FFA4). 2013 FASEB J. pmid:24005906
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Elsherbiny ME et al. Interaction of brain fatty acid-binding protein with the polyunsaturated fatty acid environment as a potential determinant of poor prognosis in malignant glioma. 2013 Prog. Lipid Res. pmid:23981365
Wang Y et al. DHA inhibits protein degradation more efficiently than EPA by regulating the PPARγ/NFκB pathway in C2C12 myotubes. 2013 Biomed Res Int pmid:23984342
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Betancor MB et al. Physiological pathways involved in nutritional muscle dystrophy and healing in European sea bass (Dicentrarchus labrax) larvae. 2013 Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. pmid:23202658
Latorre R and Contreras G Keeping you healthy: BK channel activation by omega-3 fatty acids. 2013 J. Gen. Physiol. pmid:24127527
Nagai T et al. Actual ratios of triacylglycerol positional isomers and enantiomers comprising saturated fatty acids and highly unsaturated fatty acids in fishes and marine mammals. 2013 J Oleo Sci pmid:24292353
Das UN Autism as a disorder of deficiency of brain-derived neurotrophic factor and altered metabolism of polyunsaturated fatty acids. 2013 Nutrition pmid:23911220
Zeilmaker MJ et al. Fish consumption during child bearing age: a quantitative risk-benefit analysis on neurodevelopment. 2013 Food Chem. Toxicol. pmid:22079313
Wu BT et al. Low fish intake is associated with low blood concentrations of vitamin D, choline and n-3 DHA in pregnant women. 2013 Br. J. Nutr. pmid:22691303
Flock MR et al. Determinants of erythrocyte omega-3 fatty acid content in response to fish oil supplementation: a dose-response randomized controlled trial. 2013 J Am Heart Assoc pmid:24252845
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Yan Y et al. Enhanced catalysis of Yarrowia lipolytica lipase LIP2 immobilized on macroporous resin and its application in enrichment of polyunsaturated fatty acids. 2013 Bioresour. Technol. pmid:23347925
Jaudszus A et al. Evaluation of suppressive and pro-resolving effects of EPA and DHA in human primary monocytes and T-helper cells. 2013 J. Lipid Res. pmid:23349208
Neuhofer A et al. Impaired local production of proresolving lipid mediators in obesity and 17-HDHA as a potential treatment for obesity-associated inflammation. 2013 Diabetes pmid:23349501
Sofi F et al. The atherosclerotic risk profile is affected differently by fish flesh with a similar EPA and DHA content but different n-6/n-3 ratio. 2013 Asia Pac J Clin Nutr pmid:23353608
McEwen BJ et al. Effects of omega-3 polyunsaturated fatty acids on platelet function in healthy subjects and subjects with cardiovascular disease. 2013 Semin. Thromb. Hemost. pmid:23329646
Turk HF et al. Inhibitory effects of omega-3 fatty acids on injury-induced epidermal growth factor receptor transactivation contribute to delayed wound healing. 2013 Am. J. Physiol., Cell Physiol. pmid:23426968
Sun SN et al. Docosahexaenoic acid (DHA) induces apoptosis in human hepatocellular carcinoma cells. 2013 Int J Clin Exp Pathol pmid:23330014
Gruszfeld D and Socha P Early nutrition and health: short- and long-term outcomes. 2013 World Rev Nutr Diet pmid:24029784
Przyrembel H and Agostoni C Growing-up milk: a necessity or marketing? 2013 World Rev Nutr Diet pmid:24029786
Lyons MR et al. Impact of sex on the heart's metabolic and functional responses to diabetic therapies. 2013 Am. J. Physiol. Heart Circ. Physiol. pmid:24043256
Uhl O et al. Changes of molecular glycerophospholipid species in plasma and red blood cells during docosahexaenoic acid supplementation. 2013 Lipids pmid:24043586
Aliche-Djoudi F et al. A role for lipid rafts in the protection afforded by docosahexaenoic acid against ethanol toxicity in primary rat hepatocytes. 2013 Food Chem. Toxicol. pmid:23907024
Thom VT et al. Regulation of ecto-5´-nucleotidase by docosahexaenoic acid in human endothelial cells. 2013 Cell. Physiol. Biochem. pmid:23988425