| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Pain | D010146 | 64 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Raederstorff D et al. | Anti-inflammatory properties of docosahexaenoic and eicosapentaenoic acids in phorbol-ester-induced mouse ear inflammation. | 1996 | Int. Arch. Allergy Immunol. | pmid:8917124 |
| Hamazaki T et al. | Docosahexaenoic acid-rich fish oil does not affect serum lipid concentrations of normolipidemic young adults. | 1996 | J. Nutr. | pmid:8914949 |
| Marignani PA and Sebaldt RJ | The formation of diradylglycerol molecular species in murine peritoneal macrophages varies dose-dependently with dietary purified eicosapentaenoic and docosahexaenoic ethyl esters. | 1996 | J. Nutr. | pmid:8914943 |
| Woods J et al. | Is docosahexaenoic acid necessary in infant formula? Evaluation of high linolenate diets in the neonatal rat. | 1996 | Pediatr. Res. | pmid:8910933 |
| Crosby AJ et al. | Modulation of glutathione peroxidase activity in human vascular endothelial cells by fatty acids and the cytokine interleukin-1 beta. | 1996 | Biochim. Biophys. Acta | pmid:8908152 |
| Retterstøl K et al. | The metabolism of 22:5(-6) and of docosahexaenoic acid [22:6(-3)] compared in rat hepatocytes. | 1996 | Biochim. Biophys. Acta | pmid:8908151 |
| Chambon M et al. | Influence of orthotopic liver transplantation on docosehexaenoic acid deficiency in cholestatic children. | 1996 | Transplant. Proc. | pmid:8908096 |
| Yamada K et al. | Effects of fatty acids on accumulation and secretion of histamine in RBL-2H3 cells and leukotriene release from peritoneal exudate cells isolated from Wistar rats. | 1996 | J. Nutr. Sci. Vitaminol. | pmid:8906631 |
| Vreugdenhil M et al. | Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8901621 |
| Farkas K et al. | Changes in the size and docosahexaenoic acid content of adipocytes during chick embryo development. | 1996 | Lipids | pmid:8900461 |
| Ohno T et al. | Fatty acid profiles of phospholipids in brown adipose tissue from rats during cold acclimation and repetitive intermittent immobilization: with special reference to docosahexaenoic acid. | 1996 | Jpn. J. Physiol. | pmid:8899494 |
| Farkas K et al. | Developmental changes in the levels of molecular species of triacylglycerol that contain docosahexaenoic acid in adipose tissue of the chick embryo. | 1996 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:8896327 |
| Luukkainen P et al. | Impact of solid food on plasma arachidonic and docosahexaenoic acid status of term infants at 8 months of age. | 1996 | J. Pediatr. Gastroenterol. Nutr. | pmid:8890071 |
| Abbate R et al. | n-3 PUFA supplementation, monocyte PCA expression and interleukin-6 production. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888356 |
| Peet M et al. | Essential fatty acid deficiency in erythrocyte membranes from chronic schizophrenic patients, and the clinical effects of dietary supplementation. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888126 |
| Glen AI et al. | Membrane fatty acids, niacin flushing and clinical parameters. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888117 |
| Horrobin DF | Schizophrenia as a membrane lipid disorder which is expressed throughout the body. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888116 |
| Dahlan W et al. | Fish meal lecithin as alternative precursor of docosahexaenoate and choline. | 1996 | Biomed. Environ. Sci. | pmid:8886341 |
| Lambert MS et al. | Modification of the fatty acid composition of dietary oils and fats on incorporation into chylomicrons and chylomicron remnants. | 1996 | Br. J. Nutr. | pmid:8881715 |
| Alessandri JM et al. | Polyunsaturated fatty acids status in blood, heart, liver, intestine, retina and brain of newborn piglets fed either sow milk or a milk replacer diet. | 1996 | Reprod. Nutr. Dev. | pmid:8881596 |
| Hughes DA and Pinder AC | Influence of n-3 polyunsaturated fatty acids (PUFA) on the antigen-presenting function of human monocytes. | 1996 | Biochem. Soc. Trans. | pmid:8878933 |
| Schjøtt J et al. | Effects of eicosapentaenoic acid and docosahexaenoic acid diet supplement on tolerance to the cardiotoxicity of epirubicin and to ischaemia reperfusion in the isolated rat heart. | 1996 | Pharmacol. Toxicol. | pmid:8878248 |
| Berkenboom G et al. | Effect of dietary supplementation with fish oil on cyclosporine A-induced vascular toxicity. | 1996 | Cardiovasc Drugs Ther | pmid:8877082 |
| Oski FA | Making the public and pediatric community aware of the importance of fatty acids in infant nutrition. | 1996 | Nutrition | pmid:8875527 |
| Stillwell W et al. | Cholesterol versus alpha-tocopherol: effects on properties of bilayers made from heteroacid phosphatidylcholines. | 1996 | Biochemistry | pmid:8873602 |
| Liu W et al. | Docosahexaenoic acid ethyl ester and its ultraviolet degradation products showed DNA-breaking activity in vitro and cytotoxic effects on the HSC-4 cell line. | 1995 | Kobe J Med Sci | pmid:8869009 |
| Hamano H et al. | Docosahexaenoic acid reduces GABA response in substantia nigra neuron of rat. | 1996 | J. Neurophysiol. | pmid:8867135 |
| Saito M et al. | An assessment of docosahexaenoic acid (DHA) intake with special reference to lipid metabolism in rats. | 1996 | J. Nutr. Sci. Vitaminol. | pmid:8866256 |
| Baskaya MK et al. | Enhanced accumulation of free fatty acids in experimental focal cerebral ischemia. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8860103 |
| Reithmann C et al. | Exposure to the n-3 polyunsaturated fatty acid docosahexaenoic acid impairs alpha 1-adrenoceptor-mediated contractile responses and inositol phosphate formation in rat cardiomyocytes. | 1996 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:8857587 |
| Karmali RA | Historical perspective and potential use of n-3 fatty acids in therapy of cancer cachexia. | 1996 | Nutrition | pmid:8850210 |
| Organisciak DT et al. | Retinal light damage in rats with altered levels of rod outer segment docosahexaenoate. | 1996 | Invest. Ophthalmol. Vis. Sci. | pmid:8843911 |
| Leaf A et al. | Long chain polyunsaturated fatty acids and visual function in preterm infants. | 1996 | Early Hum. Dev. | pmid:8842638 |
| Brossard N et al. | Retroconversion and metabolism of [13C]22:6n-3 in humans and rats after intake of a single dose of [13C]22:6n-3-triacylglycerols. | 1996 | Am. J. Clin. Nutr. | pmid:8839503 |
| Frøyland L et al. | Chronic administration of eicosapentaenoic acid and docosahexaenoic acid as ethyl esters reduced plasma cholesterol and changed the fatty acid composition in rat blood and organs. | 1996 | Lipids | pmid:8835405 |
| Okada M et al. | The chronic administration of docosahexaenoic acid reduces the spatial cognitive deficit following transient forebrain ischemia in rats. | 1996 | Neuroscience | pmid:8834389 |
| Khair-el-Din TA et al. | Inhibition of macrophage nitric-oxide production and Ia-expression by docosahexaenoic acid, a constituent of fetal and neonatal serum. | 1996 | Am. J. Reprod. Immunol. | pmid:8831896 |
| Ku K et al. | The effects of omega-3 polyunsaturated (correction of polyunsatulated) fatty acids on the recovery of cardiac function following cold preservation and reperfusion in hyperlipidemic rats. | 1996 | Transplantation | pmid:8824469 |
| Polette A et al. | N-3 fatty acid-induced lipid peroxidation in human platelets is prevented by catechins. | 1996 | Thromb. Haemost. | pmid:8822591 |
| Bayorh MA et al. | Effects of MaxEPA on salt-induced hypertension: relationship to [3H]nitrobenzylthioinosine binding sites. | 1996 | Clin. Exp. Hypertens. | pmid:8822232 |
| Pöschl JM et al. | Dietary docosahexaenoic acid improves red blood cell deformability in rats. | 1996 | Thromb. Res. | pmid:8822144 |
| Huang MC and Craig-Schmidt MC | Arachidonate and docosahexaenoate added to infant formula influence fatty acid composition and subsequent eicosanoid production in neonatal pigs. | 1996 | J. Nutr. | pmid:8814208 |
| Fernández-Bañares F et al. | Changes of the mucosal n3 and n6 fatty acid status occur early in the colorectal adenoma-carcinoma sequence. | 1996 | Gut | pmid:8801207 |
| Xu LZ et al. | Ligand specificity of brain lipid-binding protein. | 1996 | J. Biol. Chem. | pmid:8798739 |
| Carnielli VP et al. | The very low birth weight premature infant is capable of synthesizing arachidonic and docosahexaenoic acids from linoleic and linolenic acids. | 1996 | Pediatr. Res. | pmid:8798265 |
| Simonelli F et al. | Evaluation of fatty acids in membrane phospholipids of erythrocytes in retinitis pigmentosa patients. | 1996 | Ophthalmic Res. | pmid:8792359 |
| Mitjavila MT et al. | Effect of degree of unsaturation in dietary fatty acids on arachidonic acid mobilization by peritoneal macrophages. | 1996 | Lipids | pmid:8784749 |
| Dembitsky VM and Rezanka T | Unusually high levels of eicosatetraenoic, eicosapentaenoic, and docosahexaenoic fatty acids in Palestinian freshwater sponges. | 1996 | Lipids | pmid:8784746 |
| Innis SM et al. | Blood lipid docosahexaenoic and arachidonic acid in term gestation infants fed formulas with high docosahexaenoic acid, low eicosapentaenoic acid fish oil. | 1996 | Lipids | pmid:8784742 |
| Willumsen N et al. | Eicosapentaenoic acid, but not docosahexaenoic acid, increases mitochondrial fatty acid oxidation and upregulates 2,4-dienoyl-CoA reductase gene expression in rats. | 1996 | Lipids | pmid:8784738 |