DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Landmark K et al. Effects of fish oil, nifedipine and their combination on blood pressure and lipids in primary hypertension. 1993 J Hum Hypertens pmid:8450517
Oskarsson HJ et al. Dietary fish oil supplementation reduces myocardial infarct size in a canine model of ischemia and reperfusion. 1993 J. Am. Coll. Cardiol. pmid:8459088
Ikeda I et al. Lymphatic transport of eicosapentaenoic and docosahexaenoic acids as triglyceride, ethyl ester and free acid, and their effect on cholesterol transport in rats. 1993 Life Sci. pmid:8464336
Baybutt RC et al. The effects of dietary fish oil on alveolar type II cell fatty acids and lung surfactant phospholipids. 1993 Lipids pmid:8464346
Shikano M et al. Effect of docosahexaenoic acid on the generation of platelet-activating factor by eosinophilic leukemia cells, Eol-1. 1993 J. Immunol. pmid:8468486
Lin DS et al. Unique lipids of primate spermatozoa: desmosterol and docosahexaenoic acid. 1993 J. Lipid Res. pmid:8468532
Tatò F et al. Effects of fish oil concentrate on lipoproteins and apolipoproteins in familial combined hyperlipidemia. 1993 Clin Investig pmid:8471818
Wang H et al. N-3 fatty acids stimulate intracellular degradation of apoprotein B in rat hepatocytes. 1993 J. Clin. Invest. pmid:8473489
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Makrides M et al. Erythrocyte docosahexaenoic acid correlates with the visual response of healthy, term infants. 1993 Pediatr. Res. pmid:8479826
Thien FC et al. Dietary fish oil effects on seasonal hay fever and asthma in pollen-sensitive subjects. 1993 Am. Rev. Respir. Dis. pmid:8484622
Greenfield SM et al. A randomized controlled study of evening primrose oil and fish oil in ulcerative colitis. 1993 Aliment. Pharmacol. Ther. pmid:8485269
Püttmann M et al. Fast HPLC determination of serum free fatty acids in the picomole range. 1993 Clin. Chem. pmid:8485873
Cunnane SC et al. Detection of [U-13C]eicosapentaenoic acid in rat liver lipids using 13C nuclear magnetic resonance spectroscopy. 1993 Lipids pmid:8487618
Yasugi T et al. The influence of docosahexaenoic acid loading on stroke-prone spontaneously hypertensive rats. 1993 Ann. N. Y. Acad. Sci. pmid:8489157
Hinds A and Sanders TA The effect of increasing levels of dietary fish oil rich in eicosapentaenoic and docosahexaenoic acids on lymphocyte phospholipid fatty acid composition and cell-mediated immunity in the mouse. 1993 Br. J. Nutr. pmid:8489998
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Deslypere JP et al. Stability of n-3 fatty acids in human fat tissue aspirates during storage. 1993 Am. J. Clin. Nutr. pmid:8503357
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Takahashi M et al. Reduction in formation and growth of 1,2-dimethylhydrazine-induced aberrant crypt foci in rat colon by docosahexaenoic acid. 1993 Cancer Res. pmid:8504420
Gamen S et al. mtDNA-depleted U937 cells are sensitive to TNF and Fas-mediated cytotoxicity. 1995 FEBS Lett. pmid:8521957
Hayashi M et al. The effects of long-term treatment with eicosapentaenoic acid and docosahexaenoic acid on hypoxia/rexoygenation injury of isolated cardiac cells in adult rats. 1995 J. Mol. Cell. Cardiol. pmid:8523462
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van Houwelingen AC et al. Essential fatty acid status in neonates after fish-oil supplementation during late pregnancy. 1995 Br. J. Nutr. pmid:8541278
Ikeda I et al. Digestion and lymphatic transport of eicosapentaenoic and docosahexaenoic acids given in the form of triacylglycerol, free acid and ethyl ester in rats. 1995 Biochim. Biophys. Acta pmid:8541338
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Appel MJ and Woutersen RA Dietary fish oil (MaxEPA) enhances pancreatic carcinogenesis in azaserine-treated rats. 1996 Br. J. Cancer pmid:8554980
Pepe S and McLennan PL Dietary fish oil confers direct antiarrhythmic properties on the myocardium of rats. 1996 J. Nutr. pmid:8558320
Girón MD et al. The short-term effect of dietary fats on the brain fatty acid composition in rats. 1995 Arch. Physiol. Biochem. pmid:8574769
Nakamura T et al. Serum fatty acid composition in normal Japanese and its relationship with dietary fish and vegetable oil contents and blood lipid levels. 1995 Ann. Nutr. Metab. pmid:8585694
Achtani C et al. Effect of MaxEPA (fish oil) on lipoproteins and its receptors in hypercholesterolemic rabbits. 1995 Biochem. Mol. Biol. Int. pmid:8595389
Grynberg A et al. Effect of docosahexaenoic acid and eicosapentaenoic acid in the phospholipids of rat heart muscle cells on adrenoceptor responsiveness and mechanism. 1995 J. Mol. Cell. Cardiol. pmid:8596201
Christensen JH et al. Effect of fish oil on heart rate variability in survivors of myocardial infarction: a double blind randomised controlled trial. 1996 BMJ pmid:8597736
Hughes DA et al. (n-3) Polyunsaturated fatty acids modulate the expression of functionally associated molecules on human monocytes in vitro. 1996 J. Nutr. pmid:8598544
Khalfoun B et al. Docosahexaenoic and eicosapentaenoic acids inhibit human lymphoproliferative responses in vitro but not the expression of T cell surface activation markers. 1996 Scand. J. Immunol. pmid:8602457
Hamazaki T et al. The effect of docosahexaenoic acid on aggression in young adults. A placebo-controlled double-blind study. 1996 J. Clin. Invest. pmid:8613538
Shashoua VE and Hesse GW N-docosahexaenoyl, 3 hydroxytyramine: a dopaminergic compound that penetrates the blood-brain barrier and suppresses appetite. 1996 Life Sci. pmid:8614292
Carlson SE et al. Effect of long-chain n-3 fatty acid supplementation on visual acuity and growth of preterm infants with and without bronchopulmonary dysplasia. 1996 Am. J. Clin. Nutr. pmid:8615350
Pageaux JF et al. Biogenesis and metabolic fate of docosahexaenoic and arachidonic acids in rat uterine stromal cells in culture. 1996 Arch. Biochem. Biophys. pmid:8615684
Serhiienko OO [The experimental and clinical aspects of eicosapentaenoic amd docosahexaenoic acids (a review of the literature and the author's own data)]. 1995 May-Jun Lik. Sprava pmid:8630815
Engler MB and Engler MM Influence of aging on the relaxant responses to omega-3 fatty acids in Fischer 344 rat aorta. 1996 Gerontology pmid:8641598
Khair-El-Din T et al. Transcription of the murine iNOS gene is inhibited by docosahexaenoic acid, a major constituent of fetal and neonatal sera as well as fish oils. 1996 J. Exp. Med. pmid:8642266
Prisco D et al. Effect of n-3 polyunsaturated fatty acid intake on phospholipid fatty acid composition in plasma and erythrocytes. 1996 Am. J. Clin. Nutr. pmid:8644688
Makrides M et al. Is dietary docosahexaenoic acid essential for term infants? 1996 Lipids pmid:8649228
Weisinger HS et al. The effect of docosahexaenoic acid on the electroretinogram of the guinea pig. 1996 Lipids pmid:8649236
Carlson SE and Werkman SH A randomized trial of visual attention of preterm infants fed docosahexaenoic acid until two months. 1996 Lipids pmid:8649239
Werkman SH and Carlson SE A randomized trial of visual attention of preterm infants fed docosahexaenoic acid until nine months. 1996 Lipids pmid:8649241
Jørgensen MH et al. Visual acuity and erythrocyte docosahexaenoic acid status in breast-fed and formula-fed term infants during the first four months of life. 1996 Lipids pmid:8649242
Balestrieri GP et al. Fish oil supplementation in patients with heterozygous familial hypercholesterolemia. 1996 Recenti Prog Med pmid:8650428
Beijers RJ and Schaafsma A Long-chain polyunsaturated fatty acid content in Dutch preterm breast milk; differences in the concentrations of docosahexaenoic acid and arachidonic acid due to length of gestation. 1996 Early Hum. Dev. pmid:8654314
Moore SA et al. Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid. 1995 J. Lipid Res. pmid:8656081
Luthria DL et al. Regulation of the biosynthesis of 4,7,10,13,16,19-docosahexaenoic acid. 1996 J. Biol. Chem. pmid:8663162
Marzo I et al. Biosynthesis of docosahexaenoic acid in human cells: evidence that two different delta 6-desaturase activities may exist. 1996 Biochim. Biophys. Acta pmid:8664338
Innis SM et al. Feeding formula without arachidonic acid and docosahexaenoic acid has no effect on preferential looking acuity or recognition memory in healthy full-term infants at 9 mo of age. 1996 Am. J. Clin. Nutr. pmid:8669412
Rotstein NP et al. Active synthesis of C24:5, n-3 fatty acid in retina. 1996 Biochem. J. pmid:8670163
Lagarde M [Biosynthesis and functions of eicosanoids. Recent data]. 1995 C. R. Seances Soc. Biol. Fil. pmid:8673630
Tamura M and Suzuki H Effect of docosahexaenoic acid and sardine oil diets on the ultrastructure of hepatocytes in adult mice. 1995 J. Nutr. Sci. Vitaminol. pmid:8676220
Yamane M et al. Subcellular localization of docosahexaenoic acid and arachidonic acid omega-hydroxylation activity in the brain, liver and colonic adenocarcinoma. 1996 J Chromatogr A pmid:8680600
Innis SM and Hansen JW Plasma fatty acid responses, metabolic effects, and safety of microalgal and fungal oils rich in arachidonic and docosahexaenoic acids in healthy adults. 1996 Am. J. Clin. Nutr. pmid:8694015
Lim BO et al. Effects of n-3 polyunsaturated fatty acids and lectins on immunoglobulin production by spleen lymphocytes of Sprague-Dawley rats. 1996 Biosci. Biotechnol. Biochem. pmid:8695902
Chen Y et al. Docosahexaenoic acid modulates the interactions of the interphotoreceptor retinoid-binding protein with 11-cis-retinal. 1996 J. Biol. Chem. pmid:8702792
Hammes HP et al. Acceleration of experimental diabetic retinopathy in the rat by omega-3 fatty acids. 1996 Diabetologia pmid:8721768
Carlson SE et al. Visual acuity and fatty acid status of term infants fed human milk and formulas with and without docosahexaenoate and arachidonate from egg yolk lecithin. 1996 Pediatr. Res. pmid:8726246
De Caterina R and Libby P Control of endothelial leukocyte adhesion molecules by fatty acids. 1996 Lipids pmid:8729095
Croset M et al. In vivo compartmental metabolism of 13C-docosahexaenoic acid, studied by gas chromatography-combustion isotope ratio mass spectrometry. 1996 Lipids pmid:8729104
Martinez M Docosahexaenoic acid therapy in docosahexaenoic acid-deficient patients with disorders of peroxisomal biogenesis. 1996 Lipids pmid:8729110
Gibson RA et al. Effect of dietary docosahexaenoic acid on brain composition and neural function in term infants. 1996 Lipids pmid:8729115
Connor WE et al. Increased docosahexaenoic acid levels in human newborn infants by administration of sardines and fish oil during pregnancy. 1996 Lipids pmid:8729116
Green P and Yavin E Natural and accelerated docosahexaenoic acid accumulation in the prenatal rat brain. 1996 Lipids pmid:8729125
Cerolini S et al. Preferential mobilisation of docosahexaenoic acid from adipose tissue triacylglycerol of the chick embryo. 1996 Biochem. Soc. Trans. pmid:8736823
Boehm G et al. Docosahexaenoic and arachidonic acid content of serum and red blood cell membrane phospholipids of preterm infants fed breast milk, standard formula or formula supplemented with n-3 and n-6 long-chain polyunsaturated fatty acids. 1996 Eur. J. Pediatr. pmid:8741041
McLennan P et al. The cardiovascular protective role of docosahexaenoic acid. 1996 Eur. J. Pharmacol. pmid:8741170
Sasaki H et al. [Immunosuppressive effect of intravenously injected docosahexaenoic acid on single lung allotransplantation in the rat]. 1996 Nihon Kyobu Geka Gakkai Zasshi pmid:8741552
Degrace P et al. Intestinal lymph absorption of butter, corn oil, cod liver oil, menhaden oil, and eicosapentaenoic and docosahexaenoic acid ethyl esters in rats. 1996 Lipids pmid:8743053
Yamada Y et al. Effect of eicosapentaenoic acid and docosahexaenoic acid on diabetic osteopenia. 1995 Diabetes Res. Clin. Pract. pmid:8745204
Boswell K et al. Preclinical evaluation of single-cell oils that are highly enriched with arachidonic acid and docosahexaenoic acid. 1996 Food Chem. Toxicol. pmid:8761351
Weisinger HS et al. Effect of dietary n-3 deficiency on the electroretinogram in the guinea pig. 1996 Ann. Nutr. Metab. pmid:8773733
Maccoll AJ et al. Erythrocyte morphology and filterability in rats fed on diets containing different fats and oils. 1996 Br. J. Nutr. pmid:8774223
Rotstein NP et al. Docosahexaenoic acid is required for the survival of rat retinal photoreceptors in vitro. 1996 J. Neurochem. pmid:8780010
Lecomte M et al. Docosahexaenoic acid is a major n-3 polyunsaturated fatty acid in bovine retinal microvessels. 1996 J. Neurochem. pmid:8780049
Palozza P et al. n-3 fatty acids induce oxidative modifications in human erythrocytes depending on dose and duration of dietary supplementation. 1996 Am. J. Clin. Nutr. pmid:8780337
Minami M and Noguchi M Effects of low-dose eicosapentaenoic acid, docosahexaenoic acid and dietary fat on the incidence, growth and cell kinetics of mammary carcinomas in rats. 1996 Sep-Oct Oncology pmid:8784475
Willumsen N et al. Eicosapentaenoic acid, but not docosahexaenoic acid, increases mitochondrial fatty acid oxidation and upregulates 2,4-dienoyl-CoA reductase gene expression in rats. 1996 Lipids pmid:8784738
Innis SM et al. Blood lipid docosahexaenoic and arachidonic acid in term gestation infants fed formulas with high docosahexaenoic acid, low eicosapentaenoic acid fish oil. 1996 Lipids pmid:8784742
Dembitsky VM and Rezanka T Unusually high levels of eicosatetraenoic, eicosapentaenoic, and docosahexaenoic fatty acids in Palestinian freshwater sponges. 1996 Lipids pmid:8784746
Mitjavila MT et al. Effect of degree of unsaturation in dietary fatty acids on arachidonic acid mobilization by peritoneal macrophages. 1996 Lipids pmid:8784749
Simonelli F et al. Evaluation of fatty acids in membrane phospholipids of erythrocytes in retinitis pigmentosa patients. 1996 Ophthalmic Res. pmid:8792359
Carnielli VP et al. The very low birth weight premature infant is capable of synthesizing arachidonic and docosahexaenoic acids from linoleic and linolenic acids. 1996 Pediatr. Res. pmid:8798265
Xu LZ et al. Ligand specificity of brain lipid-binding protein. 1996 J. Biol. Chem. pmid:8798739
Fernández-Bañares F et al. Changes of the mucosal n3 and n6 fatty acid status occur early in the colorectal adenoma-carcinoma sequence. 1996 Gut pmid:8801207
Huang MC and Craig-Schmidt MC Arachidonate and docosahexaenoate added to infant formula influence fatty acid composition and subsequent eicosanoid production in neonatal pigs. 1996 J. Nutr. pmid:8814208
Pöschl JM et al. Dietary docosahexaenoic acid improves red blood cell deformability in rats. 1996 Thromb. Res. pmid:8822144
Bayorh MA et al. Effects of MaxEPA on salt-induced hypertension: relationship to [3H]nitrobenzylthioinosine binding sites. 1996 Clin. Exp. Hypertens. pmid:8822232
Polette A et al. N-3 fatty acid-induced lipid peroxidation in human platelets is prevented by catechins. 1996 Thromb. Haemost. pmid:8822591
Ku K et al. The effects of omega-3 polyunsaturated (correction of polyunsatulated) fatty acids on the recovery of cardiac function following cold preservation and reperfusion in hyperlipidemic rats. 1996 Transplantation pmid:8824469
Khair-el-Din TA et al. Inhibition of macrophage nitric-oxide production and Ia-expression by docosahexaenoic acid, a constituent of fetal and neonatal serum. 1996 Am. J. Reprod. Immunol. pmid:8831896