DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Okada M et al. The chronic administration of docosahexaenoic acid reduces the spatial cognitive deficit following transient forebrain ischemia in rats. 1996 Neuroscience pmid:8834389
Frøyland L et al. Chronic administration of eicosapentaenoic acid and docosahexaenoic acid as ethyl esters reduced plasma cholesterol and changed the fatty acid composition in rat blood and organs. 1996 Lipids pmid:8835405
Brossard N et al. Retroconversion and metabolism of [13C]22:6n-3 in humans and rats after intake of a single dose of [13C]22:6n-3-triacylglycerols. 1996 Am. J. Clin. Nutr. pmid:8839503
Leaf A et al. Long chain polyunsaturated fatty acids and visual function in preterm infants. 1996 Early Hum. Dev. pmid:8842638
Organisciak DT et al. Retinal light damage in rats with altered levels of rod outer segment docosahexaenoate. 1996 Invest. Ophthalmol. Vis. Sci. pmid:8843911
Karmali RA Historical perspective and potential use of n-3 fatty acids in therapy of cancer cachexia. 1996 Nutrition pmid:8850210
Reithmann C et al. Exposure to the n-3 polyunsaturated fatty acid docosahexaenoic acid impairs alpha 1-adrenoceptor-mediated contractile responses and inositol phosphate formation in rat cardiomyocytes. 1996 Naunyn Schmiedebergs Arch. Pharmacol. pmid:8857587
Baskaya MK et al. Enhanced accumulation of free fatty acids in experimental focal cerebral ischemia. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8860103
Saito M et al. An assessment of docosahexaenoic acid (DHA) intake with special reference to lipid metabolism in rats. 1996 J. Nutr. Sci. Vitaminol. pmid:8866256
Hamano H et al. Docosahexaenoic acid reduces GABA response in substantia nigra neuron of rat. 1996 J. Neurophysiol. pmid:8867135
Liu W et al. Docosahexaenoic acid ethyl ester and its ultraviolet degradation products showed DNA-breaking activity in vitro and cytotoxic effects on the HSC-4 cell line. 1995 Kobe J Med Sci pmid:8869009
Stillwell W et al. Cholesterol versus alpha-tocopherol: effects on properties of bilayers made from heteroacid phosphatidylcholines. 1996 Biochemistry pmid:8873602
Oski FA Making the public and pediatric community aware of the importance of fatty acids in infant nutrition. 1996 Nutrition pmid:8875527
Berkenboom G et al. Effect of dietary supplementation with fish oil on cyclosporine A-induced vascular toxicity. 1996 Cardiovasc Drugs Ther pmid:8877082
Schjøtt J et al. Effects of eicosapentaenoic acid and docosahexaenoic acid diet supplement on tolerance to the cardiotoxicity of epirubicin and to ischaemia reperfusion in the isolated rat heart. 1996 Pharmacol. Toxicol. pmid:8878248
Hughes DA and Pinder AC Influence of n-3 polyunsaturated fatty acids (PUFA) on the antigen-presenting function of human monocytes. 1996 Biochem. Soc. Trans. pmid:8878933
Alessandri JM et al. Polyunsaturated fatty acids status in blood, heart, liver, intestine, retina and brain of newborn piglets fed either sow milk or a milk replacer diet. 1996 Reprod. Nutr. Dev. pmid:8881596
Lambert MS et al. Modification of the fatty acid composition of dietary oils and fats on incorporation into chylomicrons and chylomicron remnants. 1996 Br. J. Nutr. pmid:8881715
Dahlan W et al. Fish meal lecithin as alternative precursor of docosahexaenoate and choline. 1996 Biomed. Environ. Sci. pmid:8886341
Horrobin DF Schizophrenia as a membrane lipid disorder which is expressed throughout the body. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8888116
Glen AI et al. Membrane fatty acids, niacin flushing and clinical parameters. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8888117
Peet M et al. Essential fatty acid deficiency in erythrocyte membranes from chronic schizophrenic patients, and the clinical effects of dietary supplementation. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8888126
Abbate R et al. n-3 PUFA supplementation, monocyte PCA expression and interleukin-6 production. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8888356
Luukkainen P et al. Impact of solid food on plasma arachidonic and docosahexaenoic acid status of term infants at 8 months of age. 1996 J. Pediatr. Gastroenterol. Nutr. pmid:8890071
Farkas K et al. Developmental changes in the levels of molecular species of triacylglycerol that contain docosahexaenoic acid in adipose tissue of the chick embryo. 1996 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:8896327
Ohno T et al. Fatty acid profiles of phospholipids in brown adipose tissue from rats during cold acclimation and repetitive intermittent immobilization: with special reference to docosahexaenoic acid. 1996 Jpn. J. Physiol. pmid:8899494
Farkas K et al. Changes in the size and docosahexaenoic acid content of adipocytes during chick embryo development. 1996 Lipids pmid:8900461
Vreugdenhil M et al. Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons. 1996 Proc. Natl. Acad. Sci. U.S.A. pmid:8901621
Yamada K et al. Effects of fatty acids on accumulation and secretion of histamine in RBL-2H3 cells and leukotriene release from peritoneal exudate cells isolated from Wistar rats. 1996 J. Nutr. Sci. Vitaminol. pmid:8906631
Chambon M et al. Influence of orthotopic liver transplantation on docosehexaenoic acid deficiency in cholestatic children. 1996 Transplant. Proc. pmid:8908096
Retterstøl K et al. The metabolism of 22:5(-6) and of docosahexaenoic acid [22:6(-3)] compared in rat hepatocytes. 1996 Biochim. Biophys. Acta pmid:8908151
Crosby AJ et al. Modulation of glutathione peroxidase activity in human vascular endothelial cells by fatty acids and the cytokine interleukin-1 beta. 1996 Biochim. Biophys. Acta pmid:8908152
Woods J et al. Is docosahexaenoic acid necessary in infant formula? Evaluation of high linolenate diets in the neonatal rat. 1996 Pediatr. Res. pmid:8910933
Marignani PA and Sebaldt RJ The formation of diradylglycerol molecular species in murine peritoneal macrophages varies dose-dependently with dietary purified eicosapentaenoic and docosahexaenoic ethyl esters. 1996 J. Nutr. pmid:8914943
Hamazaki T et al. Docosahexaenoic acid-rich fish oil does not affect serum lipid concentrations of normolipidemic young adults. 1996 J. Nutr. pmid:8914949
Raederstorff D et al. Anti-inflammatory properties of docosahexaenoic and eicosapentaenoic acids in phorbol-ester-induced mouse ear inflammation. 1996 Int. Arch. Allergy Immunol. pmid:8917124
Zerouga M et al. Phospholipid class as a determinant in docosahexaenoic acid's effect on tumor cell viability. 1996 Sep-Oct Anticancer Res. pmid:8917399
Carballeira NM et al. Phospholipid fatty acid composition of gorgonians of the genus Pseudopterogorgia: identification of tetracosapolyenoic acids. 1996 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:8925444
Santos FF et al. Alterations in rabbit retina lipid metabolism induced by detachment. Decreased incorporation of [3H]DHA into phospholipids. 1995-1996 Int Ophthalmol pmid:8926126
Agren JJ et al. Fish diet, fish oil and docosahexaenoic acid rich oil lower fasting and postprandial plasma lipid levels. 1996 Eur J Clin Nutr pmid:8933125
Santos GA and Silversides FG Utilization of the sex-linked gene for imperfect albinism (S*ALS). 1. Effect of early weight loss on chick metabolism. 1996 Poult. Sci. pmid:8933584
De Craemer D et al. Dietary docosahexaenoic acid has little effect on peroxisomes in healthy mice. 1996 Lipids pmid:8934448
Krämer HJ et al. Fish oil fatty acids and human platelets: dose-dependent decrease in dienoic and increase in trienoic thromboxane generation. 1996 Biochem. Pharmacol. pmid:8937428
Poling JS et al. Docosahexaenoic acid block of neuronal voltage-gated K+ channels: subunit selective antagonism by zinc. 1996 Neuropharmacology pmid:8938727
Suzuki Y et al. Trial of docosahexaenoic acid supplementation on a Japanese patient with a peroxisome biogenesis defect. 1996 Acta Paediatr Jpn pmid:8942014
Katoku Y et al. Effect of the cholesterol content of a formula on the lipid compositions of plasma lipoproteins and red blood cell membranes in early infancy. 1996 Am. J. Clin. Nutr. pmid:8942411
Reinboth JJ et al. Light elicits the release of docosahexaenoic acid from membrane phospholipids in the rat retina in vitro. 1996 Exp. Eye Res. pmid:8943700
Awad AB et al. The effect of unsaturated fatty acids on membrane composition and signal transduction in HT-29 human colon cancer cells. 1996 Cancer Lett. pmid:8950205
Ohira T et al. Improvement by eicosanoids in cancer cachexia induced by LLC-IL6 transplantation. 1996 J. Cancer Res. Clin. Oncol. pmid:8954167
Garratt JC et al. Blockade of two voltage-dependent potassium channels, mKv1.1 and mKv1.2, by docosahexaenoic acid. 1996 Eur. J. Pharmacol. pmid:8957264
Foreman-van Drongelen MM et al. Influence of feeding artificial-formula milks containing docosahexaenoic and arachidonic acids on the postnatal long-chain polyunsaturated fatty acid status of healthy preterm infants. 1996 Br. J. Nutr. pmid:8958000
Futamura Y Toxicity of amiodarone on mouse pulmonary endothelial cells cultured with or without alveolar macrophages. 1996 J Toxicol Sci pmid:8959650
Brossard N et al. Metabolic fate of an oral tracer dose of [13C]docosahexaenoic acid triglycerides in the rat. 1996 Am. J. Physiol. pmid:8967415
Khalfoun B et al. Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human lymphocyte-endothelial cell adhesion. 1996 Transplantation pmid:8970622
Martin DD et al. The fatty acid composition of human gliomas differs from that found in nonmalignant brain tissue. 1996 Lipids pmid:8972462
Fritsche KL and Cassity NA Metabolism of [3H]arachidonic acid by n-3 polyunsaturated fatty acid-enriched piglet alveolar macrophages. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8981628
Pregnolato P et al. Effect of diets containing different amounts of precursor and derivative fatty acids on serum TXB2. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8981629
Taugbøl O et al. An experimental study on transcutaneous absorption of ethylesters of eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3) in pigs. 1996 Acta Vet. Scand. pmid:8996873
Liutova LV et al. [Effect of docanol on the status of hemostasis and fibrinolysis systems, as well as lipid spectrum in patients with ischemic heart disease depending on the initial level of fibrinolytic activity]. 1996 Jan-Mar Vopr. Med. Khim. pmid:8999661
Herber SM and Van Elswyk ME Dietary marine algae promotes efficient deposition of n-3 fatty acids for the production of enriched shell eggs. 1996 Poult. Sci. pmid:9000275
Conquer JA and Holub BJ Supplementation with an algae source of docosahexaenoic acid increases (n-3) fatty acid status and alters selected risk factors for heart disease in vegetarian subjects. 1996 J. Nutr. pmid:9001371
Tamura M and Suzuki H Effects of docosahexaenoic acid and sardine oil diets on the ultrastructure of jejunal absorptive cells in adult mice. 1996 Ann. Nutr. Metab. pmid:9001686
Sheaff Greiner RC et al. Linoleate, alpha-linolenate, and docosahexaenoate recycling into saturated and monounsaturated fatty acids is a major pathway in pregnant or lactating adults and fetal or infant rhesus monkeys. 1996 J. Lipid Res. pmid:9017518
Noguchi M et al. Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA. 1997 Br. J. Cancer pmid:9020478
Badalamenti S et al. Lack of renal effects of fish oil administration in patients with advanced cirrhosis and impaired glomerular filtration. 1997 Hepatology pmid:9021940
Sauerwald TU et al. Intermediates in endogenous synthesis of C22:6 omega 3 and C20:4 omega 6 by term and preterm infants. 1997 Pediatr. Res. pmid:9029636
Delton-Vandenbroucke I et al. Polyunsaturated fatty acid metabolism in retinal and cerebral microvascular endothelial cells. 1997 J. Lipid Res. pmid:9034209
Kresiun VI et al. [The membrane-protective action of a new preparation of n-3 polyenic acids in the adrenaline-damaged myocardium]. 1996 Mar-Apr Lik. Sprava pmid:9035880
Wainwright PE et al. Arachidonic acid offsets the effects on mouse brain and behavior of a diet with a low (n-6):(n-3) ratio and very high levels of docosahexaenoic acid. 1997 J. Nutr. pmid:9040564
Iigo M et al. Inhibitory effects of docosahexaenoic acid on colon carcinoma 26 metastasis to the lung. 1997 Br. J. Cancer pmid:9043019
Dacremont G and Vincent G Assay of plasmalogens and polyunsaturated fatty acids (PUFA) in erythrocytes and fibroblasts. 1995 J. Inherit. Metab. Dis. pmid:9053558
Orth M and Luley C Diagnostic pitfalls during therapy for extreme hypertriglyceridaemia. 1997 Eur J Clin Chem Clin Biochem pmid:9056751
Infante JP and Huszagh VA On the molecular etiology of decreased arachidonic (20:4n-6), docosapentaenoic (22:5n-6) and docosahexaenoic (22:6n-3) acids in Zellweger syndrome and other peroxisomal disorders. 1997 Mol. Cell. Biochem. pmid:9062899
Yamane M and Abe A Properties of the omega-hydroxylation system of docosahexaenoic or arachidonic acid in brain or liver homogenate of rat. 1995 Neurosci. Lett. pmid:9064612
Kelso KA et al. Lipid and antioxidant changes in spermatozoa and seminal plasma throughout the reproductive period of bulls. 1997 J. Reprod. Fertil. pmid:9068407
Horimoto N et al. Arachidonic acid activation of potassium channels in rat visual cortex neurons. 1997 Neuroscience pmid:9070743
Kimura S et al. Dietary docosahexaenoic acid (22: 6n-3) prevents the development of hypertension in SHRSP. 1995 Clin Exp Pharmacol Physiol Suppl pmid:9072405
Atkinson TG et al. Incorporation of long-chain n-3 fatty acids in tissues and enhanced bone marrow cellularity with docosahexaenoic acid feeding in post-weanling Fischer 344 rats. 1997 Lipids pmid:9076666
Conquer JA and Holub BJ Dietary docosahexaenoic acid as a source of eicosapentaenoic acid in vegetarians and omnivores. 1997 Lipids pmid:9076673
Bouglé D et al. Relationships between red blood cell vitamin E and polyunsaturated fatty acid in the premature infant. 1996 Ann. Nutr. Metab. pmid:9087310
Mohan IK and Das UN Oxidant stress, anti-oxidants and essential fatty acids in systemic lupus erythematosus. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9089797
Rodriguez de Turco EB et al. Post-Golgi vesicles cotransport docosahexaenoyl-phospholipids and rhodopsin during frog photoreceptor membrane biogenesis. 1997 J. Biol. Chem. pmid:9099692
McKeone BJ et al. Alterations in serum phosphatidylcholine fatty acyl species by eicosapentaenoic and docosahexaenoic ethyl esters in patients with severe hypertriglyceridemia. 1997 J. Lipid Res. pmid:9101424
Mandell IB et al. Effects of fish meal in beef cattle diets on growth performance, carcass characteristics, and fatty acid composition of longissimus muscle. 1997 J. Anim. Sci. pmid:9110201
Ndiaye J and Hayashi S Effect of docosahexaenoic acid on lipoprotein synthesis and secretion by cultured eel hepatocytes. 1996 Cell Struct. Funct. pmid:9118236
Kikugawa K et al. beta-Carotene effectively scavenges toxic nitrogen oxides: nitrogen dioxide and peroxynitrous acid. 1997 FEBS Lett. pmid:9119059
Khalfoun B et al. In vitro effects of docosahexaenoic and eicosapentaenoic acids in association with cyclosporine A on human lymphocyte proliferation. 1997 Feb-Mar Transplant. Proc. pmid:9123309
Heird WC et al. Docosahexaenoic acid and the development and function of the infant retina. 1997 Curr. Opin. Lipidol. pmid:9127705
Tamura M and Suzuki H Effect of docosahexaenoic acid and linoleic acid diets on the ultrastructure of liver cells in adult mice. 1997 Int J Vitam Nutr Res pmid:9129257
Harris WS n-3 fatty acids and serum lipoproteins: human studies. 1997 Am. J. Clin. Nutr. pmid:9129504
Oski FA What we eat may determine who we can be. 1997 Nutrition pmid:9131682
Gordon N Nutrition and cognitive function. 1997 Brain Dev. pmid:9134186
Andreassen AK et al. Hypertension prophylaxis with omega-3 fatty acids in heart transplant recipients. 1997 J. Am. Coll. Cardiol. pmid:9137231
Buzzi M et al. Biosynthesis of docosahexaenoic acid in trout hepatocytes proceeds via 24-carbon intermediates. 1997 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:9159889
Green P et al. Replenishment of docosahexaenoic acid in n-3 fatty acid-deficient fetal rats by intraamniotic ethyl-docosahexaenoate administration. 1997 J. Neurosci. Res. pmid:9160249
Benassayag C et al. High polyunsaturated fatty acid, thromboxane A2, and alpha-fetoprotein concentrations at the human feto-maternal interface. 1997 J. Lipid Res. pmid:9162747
Jumpsen J et al. Small changes of dietary (n-6) and (n-3)/fatty acid content ration alter phosphatidylethanolamine and phosphatidylcholine fatty acid composition during development of neuronal and glial cells in rats. 1997 J. Nutr. pmid:9164993
Stillwell W et al. Effect of docosahexaenoic acid on mouse mitochondrial membrane properties. 1997 Lipids pmid:9168456
Bell JG et al. The effect of dietary lipid on polyunsaturated fatty acid metabolism in Atlantic salmon (Salmo salar) undergoing parr-smolt transformation. 1997 Lipids pmid:9168458
Allard JP et al. Lipid peroxidation during n-3 fatty acid and vitamin E supplementation in humans. 1997 Lipids pmid:9168460