DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with DHA

Download all related citations
Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Yazawa K [Importance of "health foods", EPA and DHA, for preventive medicine]. 2004 Rinsho Byori pmid:15137325
Cardoso C et al. Methylmercury risks and EPA + DHA benefits associated with seafood consumption in Europe. 2010 Risk Anal. pmid:20604879
Buznikov GA et al. [Cholinergic regulation of the sea urchin embryonic and larval development]. 2001 Ross Fiziol Zh Im I M Sechenova pmid:11822358
Chetty N et al. Fatty acid composition of some South African fresh-water fish. 1989 S. Afr. Med. J. pmid:2552593
Carvajal O and Angulo O Effect of n-3 polyunsaturated fatty acids on the lipidic profile of healthy Mexican volunteers. 1997 May-Jun Salud Publica Mex pmid:9304226
Hexeberg S et al. Docosahexaenoic acid induces lipid accumulation in myocardial cells of rats. 1994 Scand. J. Clin. Lab. Invest. pmid:7709170
Hagve TA et al. Membrane fluidity and fatty acid metabolism in kidney cells from rats fed purified eicosapentaenoic acid or purified docosahexaenoic acid. 1998 Scand. J. Clin. Lab. Invest. pmid:9670342
Eritsland J et al. Long-term effects of n-3 fatty acids on serum lipids and glycaemic control. 1994 Scand. J. Clin. Lab. Invest. pmid:7939369
Foulon T et al. Effects of fish oil fatty acids on plasma lipids and lipoproteins and oxidant-antioxidant imbalance in healthy subjects. 1999 Scand. J. Clin. Lab. Invest. pmid:10463462
Schjøtt J et al. Infusion of EPA and DHA lipid emulsions: effects on heart lipids and tolerance to ischaemia-reperfusion in the isolated rat heart. 1993 Scand. J. Clin. Lab. Invest. pmid:8140399
Hagve TA et al. The decrease in osmotic fragility of erythrocytes during supplementation with n-3 fatty acids is a transient phenomenon. 1991 Scand. J. Clin. Lab. Invest. pmid:1835122
Solakivi T et al. Serum fatty acid profile in subjects with irritable bowel syndrome. 2011 Scand. J. Gastroenterol. pmid:21073373
Andersson L et al. Hydrolysis of phosphatidylethanolamine by human pancreatic phospholipase A2. Effect of bile salts. 1994 Scand. J. Gastroenterol. pmid:8171289
Khalfoun B et al. Docosahexaenoic and eicosapentaenoic acids inhibit human lymphoproliferative responses in vitro but not the expression of T cell surface activation markers. 1996 Scand. J. Immunol. pmid:8602457
Thusgaard M et al. Effect of fish oil (n-3 polyunsaturated fatty acids) on plasma lipids, lipoproteins and inflammatory markers in HIV-infected patients treated with antiretroviral therapy: a randomized, double-blind, placebo-controlled study. 2009 Scand. J. Infect. Dis. pmid:19685375
Westberg G and Tarkowski A Effect of MaxEPA in patients with SLE. A double-blind, crossover study. 1990 Scand. J. Rheumatol. pmid:2186476
Medema S et al. Levels of Red Blood Cell Fatty Acids in Patients With Psychosis, Their Unaffected Siblings, and Healthy Controls. 2016 Schizophr Bull pmid:26385764
McNamara RK et al. Abnormalities in the fatty acid composition of the postmortem orbitofrontal cortex of schizophrenic patients: gender differences and partial normalization with antipsychotic medications. 2007 Schizophr. Res. pmid:17236749
Kale A et al. Opposite changes in predominantly docosahexaenoic acid (DHA) in cerebrospinal fluid and red blood cells from never-medicated first-episode psychotic patients. 2008 Schizophr. Res. pmid:17997280
Peet M et al. Two double-blind placebo-controlled pilot studies of eicosapentaenoic acid in the treatment of schizophrenia. 2001 Schizophr. Res. pmid:11356585
Ward PE et al. Niacin skin flush in schizophrenia: a preliminary report. 1998 Schizophr. Res. pmid:9516668
McNamara RK Omega-3 fatty acid deficiency: a preventable risk factor for schizophrenia? 2011 Schizophr. Res. pmid:21276713
Harper KN et al. Maternal serum docosahexaenoic acid and schizophrenia spectrum disorders in adult offspring. 2011 Schizophr. Res. pmid:21324652
McNamara RK et al. Chronic risperidone treatment preferentially increases rat erythrocyte and prefrontal cortex omega-3 fatty acid composition: evidence for augmented biosynthesis. 2009 Schizophr. Res. pmid:18993032
Schmitt Y and Schneider H [Effect of the administration of highly-unsaturated fatty acids on the parameters of lipoprotein metabolism and rheology of patients under chronic hemodialysis treatment]. 1991 Schweiz Med Wochenschr pmid:1836897
Chen CT et al. Plasma non-esterified docosahexaenoic acid is the major pool supplying the brain. 2015 Sci Rep pmid:26511533
Dalli J et al. Novel n-3 immunoresolvents: structures and actions. 2013 Sci Rep pmid:23736886
Sharma S et al. High-fat diet transition reduces brain DHA levels associated with altered brain plasticity and behaviour. 2012 Sci Rep pmid:22666534
Wang CS et al. ALX/FPR2 Modulates Anti-Inflammatory Responses in Mouse Submandibular Gland. 2016 Sci Rep pmid:27064029
Sapieha P et al. 5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of ω-3 polyunsaturated fatty acids. 2011 Sci Transl Med pmid:21307302
Li Q et al. Effect of docosahexaenoic acid on interleukin-2 receptor signaling pathway in lipid rafts. 2006 Sci. China, C, Life Sci. pmid:16544577
Glomset JA Role of docosahexaenoic acid in neuronal plasma membranes. 2006 Sci. STKE pmid:16467193
Gough NR Focus issue: signaling lipids. 2006 Sci. STKE pmid:16467192
Fernández-González R et al. Decontamination solutions for polychlorinated biphenyls (PCBs) in raw fish oils from environmentally contaminated sea fishes. 2014 Sci. Total Environ. pmid:24095964
de Urquiza AM et al. Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain. 2000 Science pmid:11118147
Seki H et al. Resolvins as regulators of the immune system. 2010 ScientificWorldJournal pmid:20454764
Börgeson E and Godson C Molecular circuits of resolution in renal disease. 2010 ScientificWorldJournal pmid:20623097
Carlo T and Levy BD Molecular circuits of resolution in airway inflammation. 2010 ScientificWorldJournal pmid:20623098
Morris T et al. New perspectives on aspirin and the endogenous control of acute inflammatory resolution. 2006 ScientificWorldJournal pmid:16951898
Zhang Q and Ma Y [Determination of EPA and DHA in marine microalgaes by GC]. 2004 Se Pu pmid:15807130
Lu J et al. [Analysis of fatty acids in tissues of Penaeus vannamei cultured in sea- and fresh-waters by ultrasonic extraction-capillary gas chromatography]. 2005 Se Pu pmid:16013568
Arita M and Isobe Y [Structure and function of anti-inflammatory lipid mediators derived from omega-3 polyunsaturated fatty acids]. 2008 Seikagaku pmid:19086412
Masuzawa Y [The mysteries of docosahexaenoic acid--possible functions of C22 polyenoic fatty acids]. 1988 Seikagaku pmid:2976795
Ozawa H [Omega-3 polyunsaturated fatty acids and mental disorders]. 2009 Seishin Shinkeigaku Zasshi pmid:20344875
Ozawa H [Mood disorders and omega 3 polyunsaturated fatty acids]. 2009 Seishin Shinkeigaku Zasshi pmid:20344877
Nakagome K et al. [Clinical application of omega 3 polyunsaturated fatty acids in psychiatry]. 2009 Seishin Shinkeigaku Zasshi pmid:20344878
Hamazaki T et al. [Emotion and omega 3 polyunsaturated fatty acids]. 2009 Seishin Shinkeigaku Zasshi pmid:20344879
Matsuoka Y and Nishi D [Possible use of omega 3 polyunsaturated fatty acids for prevention of PTSD]. 2009 Seishin Shinkeigaku Zasshi pmid:20344880
Yoshikawa T [Schizophrenia and omega 3 polyunsaturated fatty acids]. 2009 Seishin Shinkeigaku Zasshi pmid:20344881
Yui K et al. [Effects of arachidonic acids on social behavior in patients with autism spectrum disorders]. 2009 Seishin Shinkeigaku Zasshi pmid:20217968
Lee HN et al. Resolution of inflammation as a novel chemopreventive strategy. 2013 Semin Immunopathol pmid:23370700
Carlson SE Docosahexaenoic acid and arachidonic acid in infant development. 2001 Semin Neonatol pmid:11988033
Tam VC Lipidomic profiling of bioactive lipids by mass spectrometry during microbial infections. 2013 Semin. Immunol. pmid:24084369
Goodnight SH Effects of dietary fish oil and omega-3 fatty acids on platelets and blood vessels. 1988 Semin. Thromb. Hemost. pmid:2845585
McEwen BJ et al. Effects of omega-3 polyunsaturated fatty acids on platelet function in healthy subjects and subjects with cardiovascular disease. 2013 Semin. Thromb. Hemost. pmid:23329646
Liu YJ [Biological activity and mechanism of action of eicosapentaenic acid and docosahexaenoic acid from fish oil]. 1987 Sheng Li Ke Xue Jin Zhan pmid:2823380
Feng Y et al. [Progress in metabolic mechanism of docosahexenoic acid production by fermentation]. 2010 Sheng Wu Gong Cheng Xue Bao pmid:21141112
Qian J et al. [Technology investigation of extracting fish oil by enzymolysising ocean wild fish]. 2008 Sheng Wu Gong Cheng Xue Bao pmid:18807986
Li HX and Yang GS [Effects of docosahexaenoic acid on rat adipocytes proliferation and differentiation]. 2005 Sheng Wu Gong Cheng Xue Bao pmid:16285532
Wang Y et al. Maresin 1 Inhibits Epithelial-to-Mesenchymal Transition in Vitro and Attenuates Bleomycin Induced Lung Fibrosis in Vivo. 2015 Shock pmid:26196843
Mohajeri S and Newman SA Review of evidence for dietary influences on atopic dermatitis. 2014 Jul-Aug Skin Therapy Lett. pmid:25188523
Gajewski BJ et al. Predicting accrual in clinical trials with Bayesian posterior predictive distributions. 2008 Stat Med pmid:17979152
Tian H et al. 14S,21R-dihydroxy-docosahexaenoic acid treatment enhances mesenchymal stem cell amelioration of renal ischemia/reperfusion injury. 2012 Stem Cells Dev. pmid:21846180
Nury T et al. Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7β-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of α-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3). 2015 Steroids pmid:25683890
Ramaprasad TR et al. Spray-dried milk supplemented with alpha-linolenic acid or eicosapentaenoic acid and docosahexaenoic acid decreases HMG Co A reductase activity and increases biliary secretion of lipids in rats. 2006 Steroids pmid:16499938
Green D et al. A double-blind, placebo-controlled trial of fish oil concentrate (MaxEpa) in stroke patients. 1985 Jul-Aug Stroke pmid:3895595
Sekikawa A et al. Differential association of docosahexaenoic and eicosapentaenoic acids with carotid intima-media thickness. 2011 Stroke pmid:21757663
Belayev L et al. Docosahexaenoic acid complexed to albumin elicits high-grade ischemic neuroprotection. 2005 Stroke pmid:15569878
Belayev L et al. Robust docosahexaenoic acid-mediated neuroprotection in a rat model of transient, focal cerebral ischemia. 2009 Stroke pmid:19542051
Lalancette-Hébert M et al. Accumulation of dietary docosahexaenoic acid in the brain attenuates acute immune response and development of postischemic neuronal damage. 2011 Stroke pmid:21852616
Imre SG et al. Increased proportion of docosahexanoic acid and high lipid peroxidation capacity in erythrocytes of stroke patients. 1994 Stroke pmid:7974583
Liu X et al. Amide-type adduct of dopamine - plausible cause of Parkinson diseases. 2014 Subcell. Biochem. pmid:24374917
Nakamura M et al. Optimal dose of preoperative enteral immunonutrition for patients with esophageal cancer. 2009 Surg. Today pmid:19784723
Young C et al. Docosahexaenoic acid inhibits synaptic transmission and epileptiform activity in the rat hippocampus. 2000 Synapse pmid:10881029
Hsu K Long-chain polyunsaturated fatty acids as anti-HIV supplementation during breastfeeding. 2009 Taiwan J Obstet Gynecol pmid:19346195
Arita M and Serhan CN [Novel chemical mediators in the resolution of inflammation]. 2007 Tanpakushitsu Kakusan Koso pmid:17419455
Maldjian A et al. Changes in sperm quality and lipid composition during cryopreservation of boar semen. 2005 Theriogenology pmid:15626408
Mitre R et al. Oral intake of shark liver oil modifies lipid composition and improves motility and velocity of boar sperm. 2004 Theriogenology pmid:15451263
Cerolini S et al. Effect of docosahexaenoic acid and alpha-tocopherol enrichment in chicken sperm on semen quality, sperm lipid composition and susceptibility to peroxidation. 2006 Theriogenology pmid:16530814
Brinsko SP et al. Effect of feeding a DHA-enriched nutriceutical on the quality of fresh, cooled and frozen stallion semen. 2005 Theriogenology pmid:15725455
Gholami H et al. Effect of feeding a docosahexaenoic acid-enriched nutriceutical on the quality of fresh and frozen-thawed semen in Holstein bulls. 2010 Theriogenology pmid:20708237
Gliozzi TM et al. Quality and lipid composition of spermatozoa in rabbits fed DHA and vitamin E rich diets. 2009 Theriogenology pmid:19121864
Am-in N et al. Lipid profiles of sperm and seminal plasma from boars having normal or low sperm motility. 2011 Theriogenology pmid:21167582
Arm JP et al. Effect of dietary supplementation with fish oil lipids on mild asthma. 1988 Thorax pmid:3353893
Picado C et al. Effects of a fish oil enriched diet on aspirin intolerant asthmatic patients: a pilot study. 1988 Thorax pmid:3353894
Croset M and Lagarde M In vitro incorporation and metabolism of icosapentaenoic and docosahexaenoic acids in human platelets--effect on aggregation. 1986 Thromb. Haemost. pmid:3022414
Polette A et al. N-3 fatty acid-induced lipid peroxidation in human platelets is prevented by catechins. 1996 Thromb. Haemost. pmid:8822591
Larson MK et al. Effects of omega-3 acid ethyl esters and aspirin, alone and in combination, on platelet function in healthy subjects. 2008 Thromb. Haemost. pmid:18841286
Véricel E et al. Moderate oral supplementation with docosahexaenoic acid improves platelet function and oxidative stress in type 2 diabetic patients. 2015 Thromb. Haemost. pmid:25832443
Del Turco S et al. Parallel decrease of tissue factor surface exposure and increase of tissue factor microparticle release by the n-3 fatty acid docosahexaenoate in endothelial cells. 2007 Thromb. Haemost. pmid:17598015
Haines AP et al. Effects of a fish oil supplement on platelet function, haemostatic variables and albuminuria in insulin-dependent diabetics. 1986 Thromb. Res. pmid:3020732
Croft KD et al. The effect of dietary fish oil on platelet metabolism of 14C arachidonic acid. 1986 Thromb. Res. pmid:3705024
Vreeken J et al. Transient aggregation resistance of human blood platelets in fresh plasma. II. Physiological relevance: influence of fish oil. 1989 Thromb. Res. pmid:2551059
Prisco D et al. Effect of medium-term supplementation with a moderate dose of n-3 polyunsaturated fatty acids on blood pressure in mild hypertensive patients. 1998 Thromb. Res. pmid:9733153
Umemura K et al. Effect of dietary docosahexaenoic acid in the rat middle cerebral artery thrombosis model. 1995 Thromb. Res. pmid:7660354
Pöschl JM et al. Dietary docosahexaenoic acid improves red blood cell deformability in rats. 1996 Thromb. Res. pmid:8822144
Gaudette DC and Holub BJ Effect of albumin-bound DHA on phosphoinositide phosphorylation in collagen stimulated human platelets. 1990 Thromb. Res. pmid:2162088
Hansen J et al. Dietary supplementation with highly purified eicosapentaenoic acid and docosahexaenoic acid does not influence PAI-1 activity. 2000 Thromb. Res. pmid:10713313
Eritsland J et al. Effect of long-term, moderate-dose supplementation with omega-3 fatty acids on monocyte procoagulant activity and release of interleukin-6 in patients with coronary artery disease. 1995 Thromb. Res. pmid:7740525
Conquer JA et al. Effect of supplementation with dietary seal oil on selected cardiovascular risk factors and hemostatic variables in healthy male subjects. 1999 Thromb. Res. pmid:10588467