DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Davidson MH et al. Effects of docosahexaenoic acid on serum lipoproteins in patients with combined hyperlipidemia: a randomized, double-blind, placebo-controlled trial. 1997 J Am Coll Nutr pmid:9176830
Connor WE et al. Biochemical markers for puberty in the monkey testis: desmosterol and docosahexaenoic acid. 1997 J. Clin. Endocrinol. Metab. pmid:9177405
Shimura T et al. Docosahexanoic acid (DHA) improved glucose and lipid metabolism in KK-Ay mice with genetic non-insulin-dependent diabetes mellitus (NIDDM). 1997 Biol. Pharm. Bull. pmid:9178930
Jones CR et al. Evidence for the involvement of docosahexaenoic acid in cholinergic stimulated signal transduction at the synapse. 1997 Neurochem. Res. pmid:9178948
Ikemoto A et al. Membrane fatty acid modifications of PC12 cells by arachidonate or docosahexaenoate affect neurite outgrowth but not norepinephrine release. 1997 Neurochem. Res. pmid:9178949
Ding ST and Lilburn MS Changes in fatty acid profiles in different lipid classes during late development of turkey embryos from two genetic lines. 1997 Poult. Sci. pmid:9181615
Terano T et al. Eicosapentaenoic acid and docosahexaenoic acid inhibit DNA synthesis through inhibiting cdk2 kinase in vascular smooth muscle cells. 1997 Ann. N. Y. Acad. Sci. pmid:9186612
Innis SM and Dyer R Dietary triacylglycerols with palmitic acid (16:0) in the 2-position increase 16:0 in the 2-position of plasma and chylomicron triacylglycerols, but reduce phospholipid arachidonic and docosahexaenoic acids, and alter cholesteryl ester metabolism in formula-Fed piglets. 1997 J. Nutr. pmid:9202085
Petrukhina GN et al. [The effect of the chronic internal administration of the new Russian n-3 polyunsaturated fatty acid concentrate--epaden--on blood coagulation system indices in rabbits]. 1997 Mar-Apr Eksp Klin Farmakol pmid:9206567
Murakami T et al. Suppressive action of docosahexaenoic acid enriched-Euglena on reduction of endothelium-dependent relaxation in stroke-prone spontaneously hypertensive rats (SHRSP). 1997 J. Nutr. Sci. Vitaminol. pmid:9219094
Reynaud D and Pace-Asciak CR Docosahexaenoic acid causes accumulation of free arachidonic acid in rat pineal gland and hippocampus to form hepoxilins from both substrates. 1997 Biochim. Biophys. Acta pmid:9219915
Hempenius RA et al. Preliminary safety assessment of an arachidonic acid-enriched oil derived from Mortierella alpina: summary of toxicological data. 1997 Food Chem. Toxicol. pmid:9225015
Peng HW et al. Urine lipids in patients with a history of filariasis. 1997 Urol. Res. pmid:9228676
Panchenko VM et al. [Effects of eifitol on lipid metabolism in patients with clinically different ischemic heart diseases]. 1997 Klin Med (Mosk) pmid:9229613
Huang ZH et al. N-6 and n-3 polyunsaturated fatty acids stimulate translocation of protein kinase Calpha, -betaI, -betaII and -epsilon and enhance agonist-induced NADPH oxidase in macrophages. 1997 Biochem. J. pmid:9230140
Takahashi M et al. Suppression of azoxymethane-induced rat colon carcinoma development by a fish oil component, docosahexaenoic acid (DHA). 1997 Carcinogenesis pmid:9230276
Rotstein NP et al. Apoptosis of retinal photoreceptors during development in vitro: protective effect of docosahexaenoic acid. 1997 J. Neurochem. pmid:9231708
Schønberg SA and Skorpen F Paracetamol counteracts docosahexaenoic acid-induced growth inhibition of A-427 lung carcinoma cells and enhances tumor cell proliferation in vitro. 1997 Jul-Aug Anticancer Res. pmid:9252660
Oliveira FL et al. Triglyceride hydrolysis of soy oil vs fish oil emulsions. 1997 Jul-Aug JPEN J Parenter Enteral Nutr pmid:9252949
Vidgren HM et al. Incorporation of n-3 fatty acids into plasma lipid fractions, and erythrocyte membranes and platelets during dietary supplementation with fish, fish oil, and docosahexaenoic acid-rich oil among healthy young men. 1997 Lipids pmid:9252957
Kanazawa A et al. Increased hepatic beta-oxidation of docosahexaenoic acid, elongation of eicosapentaenoic acid, and acylation of lysophosphatidate in rats fed a docosahexaenoic acid-enriched diet. 1997 Lipids pmid:9252962
Hishinuma T et al. Microdetermination of the thromboxane B3 gas chromatography-selected-ion monitoring using [18O]thromboxane B3 as an internal standard. 1997 Prostaglandins pmid:9261859
Khalfoun B et al. Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human lymphocyte proliferation induced by allogenic cells. 1997 Transplant. Proc. pmid:9270778
Weete JD et al. Lipids and ultrastructure of Thraustochytrium sp. ATCC 26185. 1997 Lipids pmid:9270975
Freese R and Mutanen M Alpha-linolenic acid and marine long-chain n-3 fatty acids differ only slightly in their effects on hemostatic factors in healthy subjects. 1997 Am. J. Clin. Nutr. pmid:9280178
Grimsgaard S et al. Highly purified eicosapentaenoic acid and docosahexaenoic acid in humans have similar triacylglycerol-lowering effects but divergent effects on serum fatty acids. 1997 Am. J. Clin. Nutr. pmid:9280188
Suzuki H et al. Rapid incorporation of docosahexaenoic acid from dietary sources into brain microsomal, synaptosomal and mitochondrial membranes in adult mice. 1997 Int J Vitam Nutr Res pmid:9285258
Carlson SE Functional effects of increasing omega-3 fatty acid intake. 1997 J. Pediatr. pmid:9290597
Jensen CL et al. Effect of dietary linoleic/alpha-linolenic acid ratio on growth and visual function of term infants. 1997 J. Pediatr. pmid:9290604
Van Elswyk ME Comparison of n-3 fatty acid sources in laying hen rations for improvement of whole egg nutritional quality: a review. 1997 Br. J. Nutr. pmid:9292775
Brossard N et al. Human plasma albumin transports [13C]docosahexaenoic acid in two lipid forms to blood cells. 1997 J. Lipid Res. pmid:9300779
Lovegrove JA et al. Use of manufactured foods enriched with fish oils as a means of increasing long-chain n-3 polyunsaturated fatty acid intake. 1997 Br. J. Nutr. pmid:9301413
Colombo DT et al. Comparison of hexadecylphosphocholine with fish oil as an antitumor agent. 1997 J Lipid Mediat Cell Signal pmid:9302654
Carvajal O and Angulo O Effect of n-3 polyunsaturated fatty acids on the lipidic profile of healthy Mexican volunteers. 1997 May-Jun Salud Publica Mex pmid:9304226
Gibson RA et al. Effect of increasing breast milk docosahexaenoic acid on plasma and erythrocyte phospholipid fatty acids and neural indices of exclusively breast fed infants. 1997 Eur J Clin Nutr pmid:9306083
Ratnayake WM et al. Influence of dietary protein and fat on serum lipids and metabolism of essential fatty acids in rats. 1997 Br. J. Nutr. pmid:9306886
Halvorsen DS et al. The effect of highly purified eicosapentaenoic and docosahexaenoic acids on monocyte phagocytosis in man. 1997 Lipids pmid:9307933
Ikeda I et al. Effects of triolein or oleic acid on lymphatic recovery of docosahexaenoic acid given as ethyl ester and their intramolecular distribution in lymph triglyceride of rats. 1997 Lipids pmid:9307935
Watanabe K et al. Lipid and fatty acid compositions of a novel docosahexaenoic acid-producing marine bacterium. 1997 Lipids pmid:9307940
Singh RB et al. Randomized, double-blind, placebo-controlled trial of fish oil and mustard oil in patients with suspected acute myocardial infarction: the Indian experiment of infarct survival--4. 1997 Cardiovasc Drugs Ther pmid:9310278
Abran D et al. Metabolism of 4,7,10,13,16,19-docosahexaenoic acid in isolated perfused adult and newborn pig eyes. 1997 Biol. Neonate pmid:9313833
Crawford MA et al. Are deficits of arachidonic and docosahexaenoic acids responsible for the neural and vascular complications of preterm babies? 1997 Am. J. Clin. Nutr. pmid:9322584
Frøyland L et al. Mitochondrion is the principal target for nutritional and pharmacological control of triglyceride metabolism. 1997 J. Lipid Res. pmid:9323594
Yamada N et al. Changes in blood coagulation, platelet aggregation, and lipid metabolism in rats given lipids containing docosahexaenoic acid. 1997 Biosci. Biotechnol. Biochem. pmid:9339545
Scherer JM et al. Spleen cell survival and proliferation are differentially altered by docosahexaenoic acid. 1997 Cell. Immunol. pmid:9341745
Singh A and Ward OP Microbial production of docosahexaenoic acid (DHA, C22:6). 1997 Adv. Appl. Microbiol. pmid:9342829
Atkinson TG et al. DHA feeding provides host protection and prevents fibrosarcoma-induced hyperlipidemia while maintaining the tumor response to araC in Fischer 344 rats. 1997 Nutr Cancer pmid:9343830
Aguirre GD et al. Diets enriched in docosahexaenoic acid fail to correct progressive rod-cone degeneration (prcd) phenotype. 1997 Invest. Ophthalmol. Vis. Sci. pmid:9344362
Durot I et al. Influence of phospholipid long chain polyunsaturated fatty acid composition on neonatal rat cardiomyocyte function in physiological conditions and during glucose-free hypoxia-reoxygenation. 1997 Mol. Cell. Biochem. pmid:9350058
Dharmsthiti S and Ammaranond P Purification and characterization of lipase from a raw-milk yeast (Trichosporon asteroides). 1997 Biotechnol. Appl. Biochem. pmid:9357107
Calviello G et al. Low-dose eicosapentaenoic or docosahexaenoic acid administration modifies fatty acid composition and does not affect susceptibility to oxidative stress in rat erythrocytes and tissues. 1997 Lipids pmid:9358434
Herzberg GR and Skinner C Differential accumulation and release of long-chain n-3 fatty acids from liver, muscle, and adipose tissue triacylglycerols. 1997 Can. J. Physiol. Pharmacol. pmid:9360007
Boehm G et al. Docosahexaenoic and arachidonic acid absorption in preterm infants fed LCP-free or LCP-supplemented formula in comparison to infants fed fortified breast milk. 1997 Ann. Nutr. Metab. pmid:9363295
Schønberg SA et al. Evidence that changes in Se-glutathione peroxidase levels affect the sensitivity of human tumour cell lines to n-3 fatty acids. 1997 Carcinogenesis pmid:9363997
Paulsen JE et al. A fish oil derived concentrate enriched in eicosapentaenoic and docosahexaenoic acid as ethyl ester suppresses the formation and growth of intestinal polyps in the Min mouse. 1997 Carcinogenesis pmid:9363998
Takahashi M et al. Reduction in formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced aberrant crypt foci in the rat colon by docosahexaenoic acid (DHA). 1997 Carcinogenesis pmid:9364003
Mizutani M et al. Omega-3 polyunsaturated fatty acids inhibit migration of human vascular smooth muscle cells in vitro. 1997 Life Sci. pmid:9364203
Garcia MC and Kim HY Mobilization of arachidonate and docosahexaenoate by stimulation of the 5-HT2A receptor in rat C6 glioma cells. 1997 Brain Res. pmid:9369299
Goldberg EM and Zidovetzki R Effects of dipalmitoylglycerol and fatty acids on membrane structure and protein kinase C activity. 1997 Biophys. J. pmid:9370455
Raclot T et al. Site-specific regulation of gene expression by n-3 polyunsaturated fatty acids in rat white adipose tissues. 1997 J. Lipid Res. pmid:9374119
Katan MB et al. Kinetics of the incorporation of dietary fatty acids into serum cholesteryl esters, erythrocyte membranes, and adipose tissue: an 18-month controlled study. 1997 J. Lipid Res. pmid:9374124
Minami M et al. Effects of dietary docosahexaenoic acid on survival time and stroke-related behavior in stroke-prone spontaneously hypertensive rats. 1997 Gen. Pharmacol. pmid:9378247
Suzuki I et al. Inhibitory effects of oleic and docosahexaenoic acids on lung metastasis by colon-carcinoma-26 cells are associated with reduced matrix metalloproteinase-2 and -9 activities. 1997 Int. J. Cancer pmid:9389579
Kubo K et al. Changes in susceptibility of tissues to lipid peroxidation after ingestion of various levels of docosahexaenoic acid and vitamin E. 1997 Br. J. Nutr. pmid:9389890
Garcia MC et al. Effects of chronic ethanol on the mobilization of arachidonate and docosahexaenoate stimulated by the type 2A serotonin receptor agonist (+/-)-2,5-dimethoxy-4-iodoamphetamine hydrochloride in C6 glioma cells. 1997 Alcohol. Clin. Exp. Res. pmid:9394119
Clandinin MT et al. Assessment of the efficacious dose of arachidonic and docosahexaenoic acids in preterm infant formulas: fatty acid composition of erythrocyte membrane lipids. 1997 Pediatr. Res. pmid:9396564
Greiner RC et al. Brain docosahexaenoate accretion in fetal baboons: bioequivalence of dietary alpha-linolenic and docosahexaenoic acids. 1997 Pediatr. Res. pmid:9396565
Nelson GJ et al. The effect of dietary docosahexaenoic acid on platelet function, platelet fatty acid composition, and blood coagulation in humans. 1997 Lipids pmid:9397397
Nelson GJ et al. The effect of dietary docosahexaenoic acid on plasma lipoproteins and tissue fatty acid composition in humans. 1997 Lipids pmid:9397398
Minami M et al. Dietary docosahexaenoic acid increases cerebral acetylcholine levels and improves passive avoidance performance in stroke-prone spontaneously hypertensive rats. 1997 Pharmacol. Biochem. Behav. pmid:9408223
Wu X et al. Demonstration of biphasic effects of docosahexaenoic acid on apolipoprotein B secretion in HepG2 cells. 1997 Arterioscler. Thromb. Vasc. Biol. pmid:9409332
van Niel MH and Beynen AC The intake of polyunsaturated fatty acids by cats is reflected in their adipose tissue. 1997 Vet Q pmid:9413110
Anil K et al. Effect of n-3 fatty acids on VLDL production by hepatocytes is mediated through prostaglandins. 1997 Biochem. Mol. Biol. Int. pmid:9415816
Kelso KA et al. The effects of dietary supplementation with docosahexaenoic acid on the phospholipid fatty acid composition of avian spermatozoa. 1997 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:9417994
Garcia MC et al. Effect of docosahexaenoic acid on the synthesis of phosphatidylserine in rat brain in microsomes and C6 glioma cells. 1998 J. Neurochem. pmid:9422343
Achard F et al. Eicosapentaenoic and docosahexaenoic acids reduce PGH synthase 1 expression in bovine aortic endothelial cells. 1997 Biochem. Biophys. Res. Commun. pmid:9425302
Frøyland L et al. Hypotriacylglycerolemic component of fish oil. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9430383
Agren JJ et al. Hemostatic factors and platelet aggregation after a fish-enriched diet or fish oil or docosahexaenoic acid supplementation. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9430389
Yasuda S et al. Docosahexaenoic acid-rich fish oil does not enhance the elevation of serum transaminase and liver triacylglycerol induced by carbon tetrachloride in mice. 1997 Lipids pmid:9438234
Song JH et al. Oxidative stability of docosahexaenoic acid-containing oils in the form of phospholipids, triacylglycerols, and ethyl esters. 1997 Biosci. Biotechnol. Biochem. pmid:9438988
Baur LA et al. The fatty acid composition of skeletal muscle membrane phospholipid: its relationship with the type of feeding and plasma glucose levels in young children. 1998 Metab. Clin. Exp. pmid:9440487
Campan P et al. Pilot study on n-3 polyunsaturated fatty acids in the treatment of human experimental gingivitis. 1997 J. Clin. Periodontol. pmid:9442428
Nourooz-Zadeh J et al. F4-isoprostanes: a novel class of prostanoids formed during peroxidation of docosahexaenoic acid (DHA). 1998 Biochem. Biophys. Res. Commun. pmid:9446796
Ding C et al. Changes in fatty acid profile in plasma and very low density lipoprotein lipids after fish oil supplementation. 1997 Biochem. Soc. Trans. pmid:9450114
Murphy MG et al. Diets enriched in menhaden fish oil, seal oil, or shark liver oil have distinct effects on the lipid and fatty-acid composition of guinea pig heart. 1997 Mol. Cell. Biochem. pmid:9450671
Crawford MA et al. The inadequacy of the essential fatty acid content of present preterm feeds. 1998 Eur. J. Pediatr. pmid:9462903
Zheng Z et al. Effect of ganglioside GM1 on ethanol-induced changes in the incorporation of free fatty acids into membrane phospholipids in mouse brain. 1997 Nov-Dec Alcohol Alcohol. pmid:9463723
Yamane M et al. Docosahexaenoic/arachidonic acid omega-hydroxylation system and differentiation in the human colonic adenocarcinoma cell line, Caco-2. 1998 Cancer Lett. pmid:9464491
Germain E et al. Enhancement of doxorubicin cytotoxicity by polyunsaturated fatty acids in the human breast tumor cell line MDA-MB-231: relationship to lipid peroxidation. 1998 Int. J. Cancer pmid:9466659
Mani I et al. Upregulation of nuclear PKC and MAP-kinase during hyperproliferation of guinea pig epidermis: modulation by 13-(S)-hydroxyoctadecadienoic acid (13-HODE). 1998 Cell. Signal. pmid:9481490
Das UN et al. Can tumour cell drug resistance be reversed by essential fatty acids and their metabolites? 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9482165
Prasad MR et al. Regional membrane phospholipid alterations in Alzheimer's disease. 1998 Neurochem. Res. pmid:9482271
Nieuwenhuys CM and Hornstra G The effects of purified eicosapentaenoic and docosahexaenoic acids on arterial thrombosis tendency and platelet function in rats. 1998 Biochim. Biophys. Acta pmid:9487152
Ramesh G and Das UN Effect of cis-unsaturated fatty acids on Meth-A ascitic tumour cells in vitro and in vivo. 1998 Cancer Lett. pmid:9489490
Calviello G et al. Dietary supplementation with eicosapentaenoic and docosahexaenoic acid inhibits growth of Morris hepatocarcinoma 3924A in rats: effects on proliferation and apoptosis. 1998 Int. J. Cancer pmid:9495237
Alessandri JM et al. Docosahexaenoic acid concentrations in retinal phospholipids of piglets fed an infant formula enriched with long-chain polyunsaturated fatty acids: effects of egg phospholipids and fish oils with different ratios of eicosapentaenoic acid to docosahexaenoic acid. 1998 Am. J. Clin. Nutr. pmid:9497179
Hirafuji M et al. [Specific modulation of vascular smooth muscle cell functions by docosahexaenoic acid]. 1997 Nippon Yakurigaku Zasshi pmid:9503427
Woltil HA et al. Long-chain polyunsaturated fatty acid status and early growth of low birth weight infants. 1998 Eur. J. Pediatr. pmid:9504790
Morita N and Shirai J Effects of microcapsulated docosahexaenoic acid preparation on properties of dough and bread. 1997 J. Nutr. Sci. Vitaminol. pmid:9505244
Hansen JB et al. Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on fatty acid absorption, incorporation into serum phospholipids and postprandial triglyceridemia. 1998 Lipids pmid:9507234