| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Pain | D010146 | 64 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lee KW et al. | Effects of omega-3 polyunsaturated fatty acids on plasma indices of thrombogenesis and inflammation in patients post-myocardial infarction. | 2006 | Thromb. Res. | pmid:16154181 |
| Ishii H et al. | The effect of plasma on platelet function in hypercholesterolemic rabbits and the changes in fatty acid composition of the plasma. | 1984 | Thromb. Res. | pmid:6234679 |
| Mezzano D et al. | Cardiovascular risk factors in vegetarians. Normalization of hyperhomocysteinemia with vitamin B(12) and reduction of platelet aggregation with n-3 fatty acids. | 2000 | Thromb. Res. | pmid:11108902 |
| Andriamampandry MD et al. | Antithrombotic effects of (n-3) polyunsaturated fatty acids in rat models of arterial and venous thrombosis. | 1999 | Thromb. Res. | pmid:10065894 |
| Barcelli U et al. | Enhancing effect of dietary supplementation with omega-3 fatty acids on plasma fibrinolysis in normal subjects. | 1985 | Thromb. Res. | pmid:2996169 |
| Bruckner GG et al. | Biosynthesis of prostanoids, tissue fatty acid composition and thrombotic parameters in rats fed diets enriched with docosahexaenoic (22:6n3) or eicosapentaenoic (20:5n3) acids. | 1984 | Thromb. Res. | pmid:6330927 |
| Chen LY et al. | Reduction in human neutrophil superoxide anion generation by n-3 polyunsaturated fatty acids: role of cyclooxygenase products and endothelium-derived relaxing factor. | 1994 | Thromb. Res. | pmid:7871491 |
| Mundal HH et al. | The effect of N-3 fatty acids and nifedipine on platelet function in hypertensive males. | 1993 | Thromb. Res. | pmid:8303664 |
| Landmark K and Alm CS | [Fish and omega-3 fatty acids and heart failure]. | 2012 | Tidsskr. Nor. Laegeforen. | pmid:23736195 |
| Weil A | Why I still take my daily fish oil. | 2006 | Time | pmid:16827433 |
| Morisaki N et al. | In vivo effects of cis-5,8,11,14,17-20:5 (n-3) and cis-4,7,10,13,16,19-22:6(n-3) on serum lipoproteins, platelet aggregation, and lipid metabolism in the aorta of rats. | 1983 | Tohoku J. Exp. Med. | pmid:6322383 |
| Munakata M et al. | The nutrient formula containing eicosapentaenoic acid and docosahexaenoic acid benefits the fatty acid status of patients receiving long-term enteral nutrition. | 2009 | Tohoku J. Exp. Med. | pmid:19155604 |
| de Lima TM et al. | Docosahexaenoic acid enhances the toxic effect of imatinib on Bcr-Abl expressing HL-60 cells. | 2007 | Toxicol In Vitro | pmid:17604596 |
| Azevedo-Martins AK et al. | Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells. | 2006 | Toxicol In Vitro | pmid:16644178 |
| Blum JL et al. | Profiling of fatty acids released during calcium-induced mitochondrial permeability transition in isolated rabbit kidney cortex mitochondria. | 2011 | Toxicol In Vitro | pmid:21443943 |
| Türkez H et al. | Ameliorative effect of docosahexaenoic acid on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced histological changes, oxidative stress, and DNA damage in rat liver. | 2012 | Toxicol Ind Health | pmid:21996711 |
| Chen J et al. | Aspirin-triggered resolvin D1 down-regulates inflammatory responses and protects against endotoxin-induced acute kidney injury. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24709673 |
| Li CC et al. | DHA down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes by attenuating CAR translocation. | 2007 | Toxicol. Appl. Pharmacol. | pmid:17904175 |
| Majkova Z et al. | Omega-3 fatty acid oxidation products prevent vascular endothelial cell activation by coplanar polychlorinated biphenyls. | 2011 | Toxicol. Appl. Pharmacol. | pmid:21130106 |
| Kanno S et al. | Albumin modulates docosahexaenoic acid-induced cytotoxicity in human hepatocellular carcinoma cell lines. | 2011 | Toxicol. Lett. | pmid:21108996 |
| Qadhi R et al. | Differential responses to docosahexaenoic acid in primary and immortalized cardiac cells. | 2013 | Toxicol. Lett. | pmid:23523905 |
| Samokhvalov V et al. | PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. | 2015 | Toxicol. Lett. | pmid:25300478 |
| Nikolakopoulou Z et al. | The induction of apoptosis in pre-malignant keratinocytes by omega-3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) is inhibited by albumin. | 2013 | Toxicol. Lett. | pmid:23391486 |
| Kaur P et al. | Role of docosahexaenoic acid in modulating methylmercury-induced neurotoxicity. | 2007 | Toxicol. Sci. | pmid:17728287 |
| Domingo JL et al. | Benefits and risks of fish consumption Part I. A quantitative analysis of the intake of omega-3 fatty acids and chemical contaminants. | 2007 | Toxicology | pmid:17161894 |
| Aspenström-Fagerlund B et al. | Oleic acid and docosahexaenoic acid cause an increase in the paracellular absorption of hydrophilic compounds in an experimental model of human absorptive enterocytes. | 2007 | Toxicology | pmid:17560003 |
| Balaji T et al. | Localization of cyclooxygenase-2 in mice vas deferens and its effects on fertility upon suppression using nimesulide: a preferential cyclooxygenase-2 inhibitor. | 2007 | Toxicology | pmid:17382448 |
| Mancini I et al. | Fatty acid composition of common barbel (Barbus barbus) roe and evaluation of its haemolytic and cytotoxic activities. | 2011 | Toxicon | pmid:21510968 |
| Zhu G et al. | A modified n-3 fatty acid desaturase gene from Caenorhabditis briggsae produced high proportion of DHA and DPA in transgenic mice. | 2008 | Transgenic Res. | pmid:18322818 |
| Truksa M et al. | Metabolic engineering of plants to produce very long-chain polyunsaturated fatty acids. | 2006 | Transgenic Res. | pmid:16604455 |
| Alimuddin G et al. | Enhancement of EPA and DHA biosynthesis by over-expression of masu salmon delta6-desaturase-like gene in zebrafish. | 2005 | Transgenic Res. | pmid:16022387 |
| Le-Niculescu H et al. | Convergent functional genomic studies of ω-3 fatty acids in stress reactivity, bipolar disorder and alcoholism. | 2011 | Transl Psychiatry | pmid:22832392 |
| Amminger GP et al. | Predictors of treatment response in young people at ultra-high risk for psychosis who received long-chain omega-3 fatty acids. | 2015 | Transl Psychiatry | pmid:25585167 |
| Nordgren TM et al. | Maresin-1 reduces airway inflammation associated with acute and repetitive exposures to organic dust. | 2015 | Transl Res | pmid:25655838 |
| Begum G et al. | ER stress and effects of DHA as an ER stress inhibitor. | 2013 | Transl Stroke Res | pmid:24323417 |
| Chambon M et al. | Influence of orthotopic liver transplantation on docosehexaenoic acid deficiency in cholestatic children. | 1996 | Transplant. Proc. | pmid:8908096 |
| Khalfoun B et al. | Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human lymphocyte proliferation induced by allogenic cells. | 1997 | Transplant. Proc. | pmid:9270778 |
| Khalfoun B et al. | In vitro effects of docosahexaenoic and eicosapentaenoic acids in association with cyclosporine A on human lymphocyte proliferation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123309 |
| Khalfoun B et al. | Docosahexaenoic and eicosapentaenoic acids inhibit the CD28-lymphocyte activation pathway in vitro. | 1998 | Transplant. Proc. | pmid:9865267 |
| Khalfoun B et al. | Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human lymphocyte-endothelial cell adhesion. | 1996 | Transplantation | pmid:8970622 |
| Ku K et al. | The effects of omega-3 polyunsaturated (correction of polyunsatulated) fatty acids on the recovery of cardiac function following cold preservation and reperfusion in hyperlipidemic rats. | 1996 | Transplantation | pmid:8824469 |
| Kielar ML et al. | Docosahexaenoic acid decreases IRF-1 mRNA and thus inhibits activation of both the IRF-E and NFkappa d response elements of the iNOS promoter. | 2000 | Transplantation | pmid:10852612 |
| Wallis JG et al. | Polyunsaturated fatty acid synthesis: what will they think of next? | 2002 | Trends Biochem. Sci. | pmid:12217522 |
| Hejazi MA and Wijffels RH | Milking of microalgae. | 2004 | Trends Biotechnol. | pmid:15038924 |
| Ariel A and Serhan CN | Resolvins and protectins in the termination program of acute inflammation. | 2007 | Trends Immunol. | pmid:17337246 |
| Bazan NG | Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors. | 2006 | Trends Neurosci. | pmid:16580739 |
| Ji RR et al. | Emerging roles of resolvins in the resolution of inflammation and pain. | 2011 | Trends Neurosci. | pmid:21963090 |
| Nguyen LQ et al. | Feeding of spinach or sweet-potato leaves and growth performance of growing pigs kept on smallholder farms in Central Vietnam. | 2004 | Trop Anim Health Prod | pmid:15643817 |
| Danchenko OO et al. | [Ontogenic characteristics of changes in fatty acid composition of the liver lipids as a main substrate for peroxidation in geese]. | 2003 May-Jun | Ukr Biokhim Zh (1999) | pmid:14577163 |
| Bazan NG and Scott BL | Dietary omega-3 fatty acids and accumulation of docosahexaenoic acid in rod photoreceptor cells of the retina and at synapses. | 1990 | Ups J Med Sci Suppl | pmid:2150242 |
| Engström K et al. | Effect of fish oils containing different amounts of EPA, DHA, and antioxidants on plasma and brain fatty acids and brain nitric oxide synthase activity in rats. | 2009 | Ups. J. Med. Sci. | pmid:19961266 |
| Peng HW et al. | Urine lipids in patients with a history of filariasis. | 1997 | Urol. Res. | pmid:9228676 |
| Ortiz-Alvarado O et al. | Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid in the management of hypercalciuric stone formers. | 2012 | Urology | pmid:22000931 |
| Offman E et al. | Steady-state bioavailability of prescription omega-3 on a low-fat diet is significantly improved with a free fatty acid formulation compared with an ethyl ester formulation: the ECLIPSE II study. | 2013 | Vasc Health Risk Manag | pmid:24124374 |
| von Schacky C | A review of omega-3 ethyl esters for cardiovascular prevention and treatment of increased blood triglyceride levels. | 2006 | Vasc Health Risk Manag | pmid:17326331 |
| Daud ZA et al. | Effects of protein and omega-3 supplementation, provided during regular dialysis sessions, on nutritional and inflammatory indices in hemodialysis patients. | 2012 | Vasc Health Risk Manag | pmid:22536073 |
| Xue H et al. | Eicosapentaenoic acid and docosahexaenoic acid modulate mitogen-activated protein kinase activity in endothelium. | 2006 | Vascul. Pharmacol. | pmid:16616699 |
| van Niel MH and Beynen AC | The intake of polyunsaturated fatty acids by cats is reflected in their adipose tissue. | 1997 | Vet Q | pmid:9413110 |
| Gueck T et al. | Alterations of mast cell mediator production and release by gamma-linolenic and docosahexaenoic acid. | 2004 | Vet. Dermatol. | pmid:15500483 |
| Nesbitt GH et al. | Effect of n-3 fatty acid ratio and dose on clinical manifestations, plasma fatty acids and inflammatory mediators in dogs with pruritus. | 2003 | Vet. Dermatol. | pmid:12662263 |
| Pisani LF et al. | In vitro modulatory effect of omega-3 polyunsaturated fatty acid (EPA and DHA) on phagocytosis and ROS production of goat neutrophils. | 2009 | Vet. Immunol. Immunopathol. | pmid:19395090 |
| Lecchi C et al. | In vitro modulation of caprine monocyte immune functions by ω-3 polyunsaturated fatty acids. | 2011 | Vet. J. | pmid:20889357 |
| Filburn CR and Griffin D | Canine plasma and erythrocyte response to a docosahexaenoic acid-enriched supplement: characterization and potential benefits. | 2005 | Vet. Ther. | pmid:15906268 |
| Semenova EM and Converse CA | Comparison between oleic acid and docosahexaenoic acid binding to interphotoreceptor retinoid-binding protein. | 2003 | Vision Res. | pmid:14611942 |
| Bazan NG | Metabolism of phospholipids in the retina. | 1982 | Vision Res. | pmid:6305026 |
| Ter-Karapetian VA | [The use of marine products in the prevention and treatment of vascular diseases of the heart and brain]. | 1994 | Voen Med Zh | pmid:8165800 |
| Gladyshev MI et al. | [Influence of different methods of cooking of hunchback salmon on contents of polyunsaturatedfatty acids]. | 2006 | Vopr Pitan | pmid:16739608 |
| Sergienko AA et al. | [Effects of docosahexaenoic and eicosapentaenoic acids on the state of metabolites of the prostacyclin I2--thromboxane A2 system in streptozotocin diabetes mellitus]. | 1992 Mar-Apr | Vopr Pitan | pmid:1387492 |
| Liutova LV et al. | [Effect of docanol on the status of hemostasis and fibrinolysis systems, as well as lipid spectrum in patients with ischemic heart disease depending on the initial level of fibrinolytic activity]. | 1996 Jan-Mar | Vopr. Med. Khim. | pmid:8999661 |
| Huang H and Bao S | [Studies on production of docosahexaenoic acid by Thraustochytrium aureum]. | 2002 | Wei Sheng Wu Xue Bao | pmid:12557559 |
| Wu K et al. | [Effects of phytohormones on growth and DHA production by Thraustochytrium roseum]. | 2003 | Wei Sheng Wu Xue Bao | pmid:16276880 |
| Jiang X et al. | [Cloning and expression of two elongase genes involved in the biosynthesis of docosahexaenoic acid in Thraustochytrium sp. FJN-10]. | 2008 | Wei Sheng Wu Xue Bao | pmid:18437998 |
| Meng LP et al. | [Relationship between maternal DHA intake and DHA status and development of fetus and infant]. | 2005 | Wei Sheng Yan Jiu | pmid:15952672 |
| Li H et al. | [Effect of fish oil supplementation on fatty acid composition and neurotransmitters of growing rats]. | 2000 | Wei Sheng Yan Jiu | pmid:12725043 |
| Xia Y et al. | [Effects of EPA, DHA on the secretion of NO, expression of iNOS mRNA and DNA-binding activity of NFkappaB in human monocyte]. | 2007 | Wei Sheng Yan Jiu | pmid:17953212 |
| Gong Q et al. | [Effect of pregnancy rats supplemented with docosahexaenoic acid on carnitine palmitoyl transferase-I gene expression in offspring]. | 2009 | Wei Sheng Yan Jiu | pmid:20047222 |
| McDaniel JC et al. | Effect of n-3 oral supplements on the n-6/n-3 ratio in young adults. | 2010 | West J Nurs Res | pmid:19915202 |
| Cendrowski W | [MaxEpa in multiple sclerosis]. | 1985 | Wiad. Lek. | pmid:3913158 |
| D'Almeida A et al. | Effects of a combination of evening primrose oil (gamma linolenic acid) and fish oil (eicosapentaenoic + docahexaenoic acid) versus magnesium, and versus placebo in preventing pre-eclampsia. | 1992 | Women Health | pmid:1492408 |
| Robinson JG et al. | Omega-3 fatty acids and cognitive function in women. | 2010 | Womens Health (Lond) | pmid:20088735 |
| Habbel P et al. | Docosahexaenoic acid suppresses arachidonic acid-induced proliferation of LS-174T human colon carcinoma cells. | 2009 | World J. Gastroenterol. | pmid:19266600 |
| Maciejewska D et al. | Fatty acid changes help to better understand regression of nonalcoholic fatty liver disease. | 2015 | World J. Gastroenterol. | pmid:25574105 |
| Sui YH et al. | Dietary saturated fatty acid and polyunsaturated fatty acid oppositely affect hepatic NOD-like receptor protein 3 inflammasome through regulating nuclear factor-kappa B activation. | 2016 | World J. Gastroenterol. | pmid:26937141 |
| Cheng R et al. | Cloning and functional analysis of putative malonyl-CoA:acyl-carrier protein transacylase gene from the docosahexaenoic acid-producer Schizochytrium sp. TIO1101. | 2013 | World J. Microbiol. Biotechnol. | pmid:23292648 |
| Hamazaki T et al. | Effect of docosahexaenoic acid on hostility. | 2001 | World Rev Nutr Diet | pmid:11935969 |
| Crawford MA et al. | Docosahexaenoic acid and cerebral evolution. | 2001 | World Rev Nutr Diet | pmid:11935972 |
| Suzuki H et al. | Effect of DHA oil supplementation on intelligence and visual acuity in the elderly. | 2001 | World Rev Nutr Diet | pmid:11935973 |
| Nestel P | Fish oil fatty acids beneficially modulate vascular function. | 2001 | World Rev Nutr Diet | pmid:11935976 |
| Leaf A and Kang JX | Omega 3 fatty acids and cardiovascular disease. | 1998 | World Rev Nutr Diet | pmid:9648502 |
| Hoffman DR and Birch DG | Omega 3 fatty acid status in patients with retinitis pigmentosa. | 1998 | World Rev Nutr Diet | pmid:9648504 |
| Legrand P et al. | Update of French nutritional recommendations for fatty acids. | 2011 | World Rev Nutr Diet | pmid:21865827 |
| Barclay W et al. | Production of docosahexaenoic acid from microalgae and its benefits for use in animal feeds. | 1998 | World Rev Nutr Diet | pmid:9648505 |
| Abril R and Barclay W | Production of docosahexaenoic acid-enriched poultry eggs and meat using an algae-based feed ingredient. | 1998 | World Rev Nutr Diet | pmid:9648506 |
| Kyle DJ and Arterburn LM | Single cell oil sources of docosahexaenoic acid: clinical studies. | 1998 | World Rev Nutr Diet | pmid:9648509 |
| Wright T et al. | Docosahexaenoic acid-enriched milk. | 1998 | World Rev Nutr Diet | pmid:9648512 |
| Bazan NG et al. | Docosahexaenoic acid supply to the retina and its conservation in photoreceptor cells by active retinal pigment epithelium-mediated recycling. | 1994 | World Rev Nutr Diet | pmid:7871812 |
| Anderson RE et al. | The accretion of docosahexaenoic acid in the retina. | 1994 | World Rev Nutr Diet | pmid:7871813 |
| von Houwelingen AC and Hornstra G | Trans fatty acids in early human development. | 1994 | World Rev Nutr Diet | pmid:7871822 |
| Martinez M | Polyunsaturated fatty acids in the developing human brain, red cells and plasma: influence of nutrition and peroxisomal disease. | 1994 | World Rev Nutr Diet | pmid:7871835 |
| Simopoulos AP | Omega-6/omega-3 essential fatty acids: biological effects. | 2009 | World Rev Nutr Diet | pmid:19136835 |