DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with DHA

Download all related citations
Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Peterson LD et al. Eicosapentaenoic and docosahexaenoic acids alter rat spleen leukocyte fatty acid composition and prostaglandin E2 production but have different effects on lymphocyte functions and cell-mediated immunity. 1998 Lipids pmid:9507239
Conquer JA and Holub BJ Effect of supplementation with different doses of DHA on the levels of circulating DHA as non-esterified fatty acid in subjects of Asian Indian background. 1998 J. Lipid Res. pmid:9507989
Osmundsen H et al. Effects of dietary treatment of rats with eicosapentaenoic acid or docosahexaenoic acid on hepatic lipid metabolism. 1998 Biochem. J. pmid:9512474
Larsen LN et al. Alpha- and beta- alkyl-substituted eicosapentaenoic acids: incorporation into phospholipids and effects on prostaglandin H synthase and 5-lipoxygenase. 1998 Biochem. Pharmacol. pmid:9514074
Ward PE et al. Niacin skin flush in schizophrenia: a preliminary report. 1998 Schizophr. Res. pmid:9516668
Ramanadham S et al. Electrospray ionization mass spectrometric analyses of phospholipids from rat and human pancreatic islets and subcellular membranes: comparison to other tissues and implications for membrane fusion in insulin exocytosis. 1998 Biochemistry pmid:9521776
Urano S et al. Aging and oxidative stress in neurodegeneration. 1998 Biofactors pmid:9523034
Paulsen JE et al. A fish oil-derived concentrate enriched in eicosapentaenoic and docosahexaenoic acid as ethyl esters inhibits the formation and growth of aberrant crypt foci in rat colon. 1998 Pharmacol. Toxicol. pmid:9527643
Rhodes LE and White SI Dietary fish oil as a photoprotective agent in hydroa vacciniforme. 1998 Br. J. Dermatol. pmid:9536243
Wolk A et al. Effect of additional questions about fat on the validity of fat estimates from a food frequency questionnaire. Study Group of MRS SWEA. 1998 Eur J Clin Nutr pmid:9537304
Starkopf J et al. Lipid peroxidation, arachidonic acid and products of the lipoxygenase pathway in ischaemic preconditioning of rat heart. 1998 Cardiovasc. Res. pmid:9539859
Voskuyl RA et al. Anticonvulsant effect of polyunsaturated fatty acids in rats, using the cortical stimulation model. 1998 Eur. J. Pharmacol. pmid:9543232
Rousseau D et al. Is a dietary n-3 fatty acid supplement able to influence the cardiac effect of the psychological stress? 1998 Mol. Cell. Biochem. pmid:9546620
Sebaldt RJ and Marignani P Diradylglycerol formation is altered by n-3 highly unsaturated fatty acids, with differences between eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids. 1997 Adv. Exp. Med. Biol. pmid:9547650
Madsen L et al. Docosahexaenoic and eicosapentaenoic acids are differently metabolized in rat liver during mitochondria and peroxisome proliferation. 1998 J. Lipid Res. pmid:9548590
Hørby Jørgensen M et al. Effect of formula supplemented with docosahexaenoic acid and gamma-linolenic acid on fatty acid status and visual acuity in term infants. 1998 J. Pediatr. Gastroenterol. Nutr. pmid:9552137
Timmer-Bosscha H et al. Differential effects of all-trans-retinoic acid, docosahexaenoic acid, and hexadecylphosphocholine on cisplatin-induced cytotoxicity and apoptosis in a cisplantin-sensitive and resistant human embryonal carcinoma cell line. 1998 Cancer Chemother. Pharmacol. pmid:9554591
Kishida E et al. Distinctive inhibitory activity of docosahexaenoic acid against sphingosine-induced apoptosis. 1998 Biochim. Biophys. Acta pmid:9555103
Bechoua S et al. Docosahexaenoic acid lowers phosphatidate level in human activated lymphocytes despite phospholipase D activation. 1998 J. Lipid Res. pmid:9555950
Nabekura J et al. Functional modulation of human recombinant gamma-aminobutyric acid type A receptor by docosahexaenoic acid. 1998 J. Biol. Chem. pmid:9556589
Nøding R et al. Effects of polyunsaturated fatty acids and their n-6 hydroperoxides on growth of five malignant cell lines and the significance of culture media. 1998 Lipids pmid:9560803
Horie T et al. Docosahexaenoic acid exhibits a potent protection of small intestine from methotrexate-induced damage in mice. 1998 Life Sci. pmid:9566775
Zerouga M et al. Can docosahexaenoic acid inhibit metastasis by decreasing deformability of the tumor cell plasma membrane? 1997 Cancer Lett. pmid:9570367
Green P and Yavin E Mechanisms of docosahexaenoic acid accretion in the fetal brain. 1998 J. Neurosci. Res. pmid:9579403
Hirafuji M et al. Effect of docosahexaenoic acid on smooth muscle cell functions. 1998 Life Sci. pmid:9585158
Habán P et al. [The effect of n-3 fatty acid administration on selected indicators of cardiovascular disease risk in patients with type 2 diabetes mellitus]. 1998 Bratisl Lek Listy pmid:9588078
Tashiro T et al. Effects of a newly developed fat emulsion containing eicosapentaenoic acid and docosahexaenoic acid on fatty acid profiles in rats. 1998 Nutrition pmid:9591310
Hossain MS et al. Influence of docosahexaenoic acid on cerebral lipid peroxide level in aged rats with and without hypercholesterolemia. 1998 Neurosci. Lett. pmid:9593513
Roberts LJ et al. Formation of isoprostane-like compounds (neuroprostanes) in vivo from docosahexaenoic acid. 1998 J. Biol. Chem. pmid:9593698
Glozman S et al. Intraamniotic ethyl docosahexaenoate administration protects fetal rat brain from ischemic stress. 1998 J. Neurochem. pmid:9603213
Kikuchi S et al. Modulation of eosinophil chemotactic activities to leukotriene B4 by n-3 polyunsaturated fatty acids. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9610849
Christensen MM et al. Dietary structured triacylglycerols containing docosahexaenoic acid given from birth affect visual and auditory performance and tissue fatty acid profiles of rats. 1998 J. Nutr. pmid:9614162
Ikeda I et al. Effects of dietary alpha-linolenic, eicosapentaenoic and docosahexaenoic acids on hepatic lipogenesis and beta-oxidation in rats. 1998 Biosci. Biotechnol. Biochem. pmid:9614698
Lu CY et al. Docosahexaenoic acid, a constituent of fetal and neonatal serum, inhibits nitric oxide production by murine macrophages stimulated by IFN gamma plus LPS, or by IFN gamma plus Listeria monocytogenes. 1998 J. Reprod. Immunol. pmid:9616876
Almallah YZ et al. Distal procto-colitis, natural cytotoxicity, and essential fatty acids. 1998 Am. J. Gastroenterol. pmid:9625132
Yeh YY et al. Modification of milk formula to enhance accretion of long-chain n-6 and n-3 polyunsaturated fatty acids in artificially reared infant rats. 1998 Lipids pmid:9625599
Bojesen IN and Bojesen E Nature of the elements transporting long-chain fatty acids through the red cell membrane. 1998 J. Membr. Biol. pmid:9625774
Peterson LD et al. Low levels of eicosapentaenoic and docosahexaenoic acids mimic the effects of fish oil upon rat lymphocytes. 1998 Life Sci. pmid:9627080
Henderson RJ et al. Effects of docosahexaenoic (22:6n-3), tetracosapentaenoic (24:5n-3) and tetracosahexaenoic (24:6n-3) acids on the desaturation and elongation of n-3 polyunsaturated fatty acids in trout liver microsomes. 1998 Biochim. Biophys. Acta pmid:9630696
Williams EE et al. Docosahexaenoic acid (DHA) alters the structure and composition of membranous vesicles exfoliated from the surface of a murine leukemia cell line. 1998 Biochim. Biophys. Acta pmid:9630720
Cadroy Y et al. Arachidonic acid enhances the tissue factor expression of mononuclear cells by the cyclo-oxygenase-1 pathway: beneficial effect of n-3 fatty acids. 1998 J. Immunol. pmid:9637532
Hibbeln JR Fish consumption and major depression. 1998 Lancet pmid:9643729
Kimura S et al. Ameliorative effects of docosahexaenoic acid on serum lipid changes in stroke-prone spontaneously hypertensive rats. 1998 Res. Commun. Mol. Pathol. Pharmacol. pmid:9644719
He Q et al. Reduction of 4-hydroxynonenal and 4-hydroxyhexenal by retinal aldose reductase. 1998 Biochem. Biophys. Res. Commun. pmid:9647760
Leaf A and Kang JX Omega 3 fatty acids and cardiovascular disease. 1998 World Rev Nutr Diet pmid:9648502
Hoffman DR and Birch DG Omega 3 fatty acid status in patients with retinitis pigmentosa. 1998 World Rev Nutr Diet pmid:9648504
Barclay W et al. Production of docosahexaenoic acid from microalgae and its benefits for use in animal feeds. 1998 World Rev Nutr Diet pmid:9648505
Abril R and Barclay W Production of docosahexaenoic acid-enriched poultry eggs and meat using an algae-based feed ingredient. 1998 World Rev Nutr Diet pmid:9648506
Kyle DJ and Arterburn LM Single cell oil sources of docosahexaenoic acid: clinical studies. 1998 World Rev Nutr Diet pmid:9648509
Wright T et al. Docosahexaenoic acid-enriched milk. 1998 World Rev Nutr Diet pmid:9648512
Burdge GC The role of docosahexaenoic acid in brain development and fetal alcohol syndrome. 1998 Biochem. Soc. Trans. pmid:9649756
Edwards R et al. Depletion of docosahexaenoic acid in red blood cell membranes of depressive patients. 1998 Biochem. Soc. Trans. pmid:9649817
Monia ZA et al. Docosahexaenoic acid reduces both cyclic nucleotide and melatonin synthesis in rat pinealocytes. 1998 Prostaglandins Other Lipid Mediat. pmid:9653768
Jolly CA et al. Effect of dietary n-3 fatty acids on interleukin-2 and interleukin-2 receptor alpha expression in activated murine lymphocytes. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9654402
Kelley DS et al. Dietary docosahexaenoic acid and immunocompetence in young healthy men. 1998 Lipids pmid:9655370
Young C et al. Cancellation of low-frequency stimulation-induced long-term depression by docosahexaenoic acid in the rat hippocampus. 1998 Neurosci. Lett. pmid:9655627
Hansen RA et al. Duration of effects of dietary fish oil supplementation on serum eicosapentaenoic acid and docosahexaenoic acid concentrations in dogs. 1998 Am. J. Vet. Res. pmid:9659553
Grimsgaard S et al. Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on hemodynamics in humans. 1998 Am. J. Clin. Nutr. pmid:9665096
Hagve TA et al. Membrane fluidity and fatty acid metabolism in kidney cells from rats fed purified eicosapentaenoic acid or purified docosahexaenoic acid. 1998 Scand. J. Clin. Lab. Invest. pmid:9670342
Martinez M and Vazquez E MRI evidence that docosahexaenoic acid ethyl ester improves myelination in generalized peroxisomal disorders. 1998 Neurology pmid:9674774
Guarini P et al. Effects of dietary fish oil and soy phosphatidylcholine on neutrophil fatty acid composition, superoxide release, and adhesion. 1998 Inflammation pmid:9675609
Nasa Y et al. Long-term supplementation with eicosapentaenoic acid salvages cardiomyocytes from hypoxia/reoxygenation-induced injury in rats fed with fish-oil-deprived diet. 1998 Jpn. J. Pharmacol. pmid:9681570
Connor WE et al. Uneven distribution of desmosterol and docosahexaenoic acid in the heads and tails of monkey sperm. 1998 J. Lipid Res. pmid:9684743
Infante JP and Huszagh VA Analysis of the putative role of 24-carbon polyunsaturated fatty acids in the biosynthesis of docosapentaenoic (22:5n-6) and docosahexaenoic (22:6n-3) acids. 1998 FEBS Lett. pmid:9684854
Clandinin MT et al. Docosahexaenoic acid increases thyroid-stimulating hormone concentration in male and adrenal corticotrophic hormone concentration in female weanling rats. 1998 J. Nutr. pmid:9687541
de la Presa-Owens S et al. Addition of triglycerides with arachidonic acid or docosahexaenoic acid to infant formula has tissue- and lipid class-specific effects on fatty acids and hepatic desaturase activities in formula-fed piglets. 1998 J. Nutr. pmid:9687559
Hamazaki T et al. Docosahexaenoic acid does not affect aggression of normal volunteers under nonstressful conditions. A randomized, placebo-controlled, double-blind study. 1998 Lipids pmid:9688168
Jarocka-Cyrta E et al. Early dietary experience influences ontogeny of intestine in response to dietary lipid changes in later life. 1998 Am. J. Physiol. pmid:9688652
Ohinata H et al. Effect of dietary docosahexaenoic acid on in vitro thermogenesis and fatty acid compositions of brown adipose tissue. 1998 Jpn. J. Physiol. pmid:9689148
Bell JG et al. Growth, mortality, tissue histopathology and fatty acid compositions, eicosanoid production and response to stress, in juvenile turbot fed diets rich in gamma-linolenic acid in combination with eicosapentaenoic acid or docosahexaenoic acid. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9690713
Campbell FM et al. Placental membrane fatty acid-binding protein preferentially binds arachidonic and docosahexaenoic acids. 1998 Life Sci. pmid:9698032
Birch EE et al. Visual acuity and the essentiality of docosahexaenoic acid and arachidonic acid in the diet of term infants. 1998 Pediatr. Res. pmid:9702915
Shikano M et al. 1a-docosahexaenoyl mitomycin C: a novel inhibitor of protein tyrosine kinase. 1998 Biochem. Biophys. Res. Commun. pmid:9704018
Oudot F et al. Polyunsaturated fatty acids influence prostanoid synthesis in vascular endothelial cells under hypoxia and reoxygenation. 1998 Int J Vitam Nutr Res pmid:9706502
Petroni A et al. The beta-oxidation of arachidonic acid and the synthesis of docosahexaenoic acid are selectively and consistently altered in skin fibroblasts from three Zellweger patients versus X-adrenoleukodystrophy, Alzheimer and control subjects. 1998 Neurosci. Lett. pmid:9708853
Hawkins RA et al. Apoptotic death of pancreatic cancer cells induced by polyunsaturated fatty acids varies with double bond number and involves an oxidative mechanism. 1998 J. Pathol. pmid:9713361
Hibbeln JR et al. Essential fatty acids predict metabolites of serotonin and dopamine in cerebrospinal fluid among healthy control subjects, and early- and late-onset alcoholics. 1998 Biol. Psychiatry pmid:9715354
Hibbeln JR et al. A replication study of violent and nonviolent subjects: cerebrospinal fluid metabolites of serotonin and dopamine are predicted by plasma essential fatty acids. 1998 Biol. Psychiatry pmid:9715355
Watkins SM et al. Docosahexaenoic acid accumulates in cardiolipin and enhances HT-29 cell oxidant production. 1998 J. Lipid Res. pmid:9717717
Birbes H et al. Protein kinase C inhibitors stimulate arachidonic and docosahexaenoic acids release from uterine stromal cells through a Ca2+-independent pathway. 1998 FEBS Lett. pmid:9720928
Kimura S et al. Docosahexaenoic acid inhibits blood viscosity in stroke-prone spontaneously hypertensive rats. 1998 Res. Commun. Mol. Pathol. Pharmacol. pmid:9730013
Waldron MK et al. Role of long-chain polyunsaturated n-3 fatty acids in the development of the nervous system of dogs and cats. 1998 J. Am. Vet. Med. Assoc. pmid:9731252
Prisco D et al. Effect of medium-term supplementation with a moderate dose of n-3 polyunsaturated fatty acids on blood pressure in mild hypertensive patients. 1998 Thromb. Res. pmid:9733153
Decsi T et al. Effects of dietary long-chain polyunsaturated fatty acids on plasma amino acids and indices of protein metabolism in infants: results from a randomized clinical trial. 1998 Ann. Nutr. Metab. pmid:9745105
Crabtree JT et al. Differential distribution and metabolism of arachidonic acid and docosahexaenoic acid by human placental choriocarcinoma (BeWo) cells. 1998 Mol. Cell. Biochem. pmid:9746226
Suzuki A et al. Enhanced colonic and rectal absorption of insulin using a multiple emulsion containing eicosapentaenoic acid and docosahexaenoic acid. 1998 J Pharm Sci pmid:9758676
Mitchell DC et al. Why is docosahexaenoic acid essential for nervous system function? 1998 Biochem. Soc. Trans. pmid:9765880
Andriamampandry M et al. Diets enriched in (n-3) fatty acids affect rat coagulation factors dependent on vitamin K. 1998 C. R. Acad. Sci. III, Sci. Vie pmid:9766191
Lii CK et al. Effect of dietary lipid on gamma-glutamyl transferase-positive foci during hepatocarcinogenesis in rats. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9774170
Macleod JC et al. The electrical and mechanical response of adult guinea pig and rat ventricular myocytes to omega3 polyunsaturated fatty acids. 1998 Eur. J. Pharmacol. pmid:9774258
Jenski LJ et al. The triggering signal dictates the effect of docosahexaenoic acid on lymphocyte function in vitro. 1998 Lipids pmid:9778134
Ikeda I et al. Effects of long-term feeding of marine oils with different positional distribution of eicosapentaenoic and docosahexaenoic acids on lipid metabolism, eicosanoid production, and platelet aggregation in hypercholesterolemic rats. 1998 Lipids pmid:9778137
Maurage C et al. Effect of two types of fish oil supplementation on plasma and erythrocyte phospholipids in formula-fed term infants. 1998 Biol. Neonate pmid:9784633
Morley R Nutrition and cognitive development. 1998 Nutrition pmid:9785354
Rodriguez A et al. Fatty acid desaturase activities and polyunsaturated fatty acid composition in human liver between the seventeenth and thirty-sixth gestational weeks. 1998 Am. J. Obstet. Gynecol. pmid:9790399
Scott DT et al. Formula supplementation with long-chain polyunsaturated fatty acids: are there developmental benefits? 1998 Pediatrics pmid:9794989
Menard CR et al. Recycling of carbon into lipids synthesized de novo is a quantitatively important pathway of alpha-[U-13C]linolenate utilization in the developing rat brain. 1998 J. Neurochem. pmid:9798942
Kubo K et al. Dietary docosahexaenoic acid dose not promote lipid peroxidation in rat tissue to the extent expected from peroxidizability index of the lipids. 1998 Biosci. Biotechnol. Biochem. pmid:9805370
Schofield M et al. Cholesterol versus cholesterol sulfate: effects on properties of phospholipid bilayers containing docosahexaenoic acid. 1998 Chem. Phys. Lipids pmid:9807808
Price SA and Tisdale MJ Mechanism of inhibition of a tumor lipid-mobilizing factor by eicosapentaenoic acid. 1998 Cancer Res. pmid:9809986