DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Midtbø LK et al. Intake of farmed Atlantic salmon fed soybean oil increases hepatic levels of arachidonic acid-derived oxylipins and ceramides in mice. 2015 J. Nutr. Biochem. pmid:25776459
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Akagi D et al. Systemic delivery of proresolving lipid mediators resolvin D2 and maresin 1 attenuates intimal hyperplasia in mice. 2015 FASEB J. pmid:25777995
Barden AE et al. Specialized proresolving lipid mediators in humans with the metabolic syndrome after n-3 fatty acids and aspirin. 2015 Am. J. Clin. Nutr. pmid:26561623
Lim JY et al. Biological Roles of Resolvins and Related Substances in the Resolution of Pain. 2015 Biomed Res Int pmid:26339646
Gu Z et al. Resolvin D1, resolvin D2 and maresin 1 activate the GSK3β anti-inflammatory axis in TLR4-engaged human monocytes. 2016 Innate Immun pmid:26878867
Xie W et al. ResolvinD1 reduces apoptosis and inflammation in primary human alveolar epithelial type 2 cells. 2016 Lab. Invest. pmid:26878131
Croasdell A et al. Resolvin D1 Dampens Pulmonary Inflammation and Promotes Clearance of Nontypeable Haemophilus influenzae. 2016 J. Immunol. pmid:26843331
Liu Y et al. Resolvin D1 protects against inflammation in experimental acute pancreatitis and associated lung injury. 2016 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:26702138
Abdulnour RE et al. Aspirin-triggered resolvin D1 is produced during self-resolving gram-negative bacterial pneumonia and regulates host immune responses for the resolution of lung inflammation. 2016 Mucosal Immunol pmid:26647716
Crandell JR et al. Lipid effects of switching from prescription EPA+DHA (omega-3-acid ethyl esters) to prescription EPA only (icosapent ethyl) in dyslipidemic patients. 2016 Postgrad Med pmid:27684412
Berrueta L et al. Stretching Impacts Inflammation Resolution in Connective Tissue. 2016 J. Cell. Physiol. pmid:26588184
Kim N et al. Specialized proresolving mediators (SPMs) inhibit human B-cell IgE production. 2016 Eur. J. Immunol. pmid:26474728
López-Luna P et al. Fate of orally administered radioactive fatty acids in the late-pregnant rat. 2016 Am. J. Physiol. Endocrinol. Metab. pmid:26714850
Visentin S et al. Red blood cell membrane fatty acid composition in infants fed formulas with different lipid profiles. 2016 Early Hum. Dev. pmid:27391868
Wang ZQ et al. Docosahexaenoic Acid Attenuates Doxorubicin-induced Cytotoxicity and Inflammation by Suppressing NF-κB/iNOS/NO Signaling Pathway Activation in H9C2 Cardiac Cells. 2016 J. Cardiovasc. Pharmacol. pmid:26657886
Viola JR et al. Resolving Lipid Mediators Maresin 1 and Resolvin D2 Prevent Atheroprogression in Mice. 2016 Circ. Res. pmid:27531933
Zhang MJ et al. Resolvin D2 Enhances Postischemic Revascularization While Resolving Inflammation. 2016 Circulation pmid:27507404
Georgieva R et al. Phospholipase A2-Induced Remodeling Processes on Liquid-Ordered/Liquid-Disordered Membranes Containing Docosahexaenoic or Oleic Acid: A Comparison Study. 2016 Langmuir pmid:26794691
Croasdell A et al. Resolvin D2 decreases TLR4 expression to mediate resolution in human monocytes. 2016 FASEB J. pmid:27256622
Inoue Y et al. Kidney and Liver Injuries After Major Burns in Rats Are Prevented by Resolvin D2. 2016 Crit. Care Med. pmid:26509319
Arnardottir H et al. Human milk proresolving mediators stimulate resolution of acute inflammation. 2016 Mucosal Immunol pmid:26462421
Stein K et al. A role for 12/15-lipoxygenase-derived proresolving mediators in postoperative ileus: protectin DX-regulated neutrophil extravasation. 2016 J. Leukoc. Biol. pmid:26292977
Jory J Abnormal fatty acids in Canadian children with autism. 2016 Nutrition pmid:26746679
Park HG et al. Metabolic fate of docosahexaenoic acid (DHA; 22:6n-3) in human cells: direct retroconversion of DHA to eicosapentaenoic acid (20:5n-3) dominates over elongation to tetracosahexaenoic acid (24:6n-3). 2016 FEBS Lett. pmid:27543786
McManus S et al. Differential effects of EPA versus DHA on postprandial vascular function and the plasma oxylipin profile in men. 2016 J. Lipid Res. pmid:27170732
Nagai T et al. Circulating Omega-6, But Not Omega-3 Polyunsaturated Fatty Acids, Are Associated with Clinical Outcomes in Patients with Acute Decompensated Heart Failure. 2016 PLoS ONE pmid:27824904
Graciano MF et al. Omega-3 fatty acids control productions of superoxide and nitrogen oxide and insulin content in INS-1E cells. 2016 J. Physiol. Biochem. pmid:27474043
Li R et al. Maresin 1 Mitigates Inflammatory Response and Protects Mice from Sepsis. 2016 Mediators Inflamm. pmid:28042205
Li R et al. Maresin 1, a Proresolving Lipid Mediator, Mitigates Carbon Tetrachloride-Induced Liver Injury in Mice. 2016 Oxid Med Cell Longev pmid:26881046
Hanssens L et al. The clinical benefits of long-term supplementation with omega-3 fatty acids in cystic fibrosis patients - A pilot study. 2016 Prostaglandins Leukot. Essent. Fatty Acids pmid:27154364
Lu Y et al. Impedance spectroscopy analysis of human odorant binding proteins immobilized on nanopore arrays for biochemical detection. 2016 Biosens Bioelectron pmid:26710343
Ghosh S et al. Epigenomic maintenance through dietary intervention can facilitate DNA repair process to slow down the progress of premature aging. 2016 IUBMB Life pmid:27364681
Lam SM et al. Biological relevance of fatty acyl heterogeneity to the neural membrane dynamics of rhesus macaques during normative aging. 2016 Oncotarget pmid:27517158
Subbaiah PV et al. Enhanced incorporation of dietary DHA into lymph phospholipids by altering its molecular carrier. 2016 Biochim. Biophys. Acta pmid:27178174
Suzuki-Kemuriyama N et al. Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice. 2016 PLoS ONE pmid:27333187
Kim SM et al. Role of Inflammatory Signaling in the Differential Effects of Saturated and Poly-unsaturated Fatty Acids on Peripheral Circadian Clocks. 2016 EBioMedicine pmid:27322464
Gold DR et al. Lung VITAL: Rationale, design, and baseline characteristics of an ancillary study evaluating the effects of vitamin D and/or marine omega-3 fatty acid supplements on acute exacerbations of chronic respiratory disease, asthma control, pneumonia and lung function in adults. 2016 Contemp Clin Trials pmid:26784651
Fialkow J Omega-3 Fatty Acid Formulations in Cardiovascular Disease: Dietary Supplements are Not Substitutes for Prescription Products. 2016 Am J Cardiovasc Drugs pmid:27138439
Bassuk SS et al. Baseline characteristics of participants in the VITamin D and OmegA-3 TriaL (VITAL). 2016 Contemp Clin Trials pmid:26767629
Wong BH et al. Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development. 2016 J. Biol. Chem. pmid:27008858
Allaire J et al. A randomized, crossover, head-to-head comparison of eicosapentaenoic acid and docosahexaenoic acid supplementation to reduce inflammation markers in men and women: the Comparing EPA to DHA (ComparED) Study. 2016 Am. J. Clin. Nutr. pmid:27281302
Gramer G et al. Long-chain polyunsaturated fatty acid status in children, adolescents and adults with phenylketonuria. 2016 Prostaglandins Leukot. Essent. Fatty Acids pmid:27269713
Gao J et al. Neuroprotective effects of docosahexaenoic acid on hippocampal cell death and learning and memory impairments in a valproic acid-induced rat autism model. 2016 Int. J. Dev. Neurosci. pmid:26639559
Pinçon A et al. Human apolipoprotein E allele and docosahexaenoic acid intake modulate peripheral cholesterol homeostasis in mice. 2016 J. Nutr. Biochem. pmid:27239755
Dagorn F et al. Exploitable Lipids and Fatty Acids in the Invasive Oyster Crassostrea gigas on the French Atlantic Coast. 2016 Mar Drugs pmid:27231919
Wang H et al. Potential serum biomarkers from a metabolomics study of autism. 2016 J Psychiatry Neurosci pmid:26395811
Deng X et al. iPLA2β deficiency attenuates obesity and hepatic steatosis in ob/ob mice through hepatic fatty-acyl phospholipid remodeling. 2016 Biochim. Biophys. Acta pmid:26873633
Si TL et al. Enhanced anti-inflammatory effects of DHA and quercetin in lipopolysaccharide-induced RAW264.7 macrophages by inhibiting NF-κB and MAPK activation. 2016 Mol Med Rep pmid:27176922
Tian Y et al. Bioconversion of Docosapentaenoic Acid in Human Cell Lines, Caco-2, HepG2, and THP-1. 2016 J Oleo Sci pmid:27829615
Wilding TJ et al. Chimeric Glutamate Receptor Subunits Reveal the Transmembrane Domain Is Sufficient for NMDA Receptor Pore Properties but Some Positive Allosteric Modulators Require Additional Domains. 2016 J. Neurosci. pmid:27559165
Gao J et al. Maternal DHA supplementation protects rat offspring against impairment of learning and memory following prenatal exposure to valproic acid. 2016 J. Nutr. Biochem. pmid:27469996
Snodgrass RG et al. Docosahexaenoic acid and palmitic acid reciprocally modulate monocyte activation in part through endoplasmic reticulum stress. 2016 J. Nutr. Biochem. pmid:27142735
Primdahl KG et al. Synthesis of 13(R)-Hydroxy-7Z,10Z,13R,14E,16Z,19Z Docosapentaenoic Acid (13R-HDPA) and Its Biosynthetic Conversion to the 13-Series Resolvins. 2016 J. Nat. Prod. pmid:27704804
Seeger DR and Murphy EJ Mouse Strain Impacts Fatty Acid Uptake and Trafficking in Liver, Heart, and Brain: A Comparison of C57BL/6 and Swiss Webster Mice. 2016 Lipids pmid:26797754
Yoshida S et al. Treatment with DHA/EPA ameliorates atopic dermatitis-like skin disease by blocking LTB4 production. 2016 J. Med. Invest. pmid:27644556
Qin X et al. Brown but not white adipose cells synthesize omega-3 docosahexaenoic acid in culture. 2016 Prostaglandins Leukot. Essent. Fatty Acids pmid:26802938
Jeyanathan J et al. Biohydrogenation of 22:6n-3 by Butyrivibrio proteoclasticus P18. 2016 BMC Microbiol. pmid:27283157
Goda AA et al. Astaxanthin and Docosahexaenoic Acid Reverse the Toxicity of the Maxi-K (BK) Channel Antagonist Mycotoxin Penitrem A. 2016 Mar Drugs pmid:27834847
Cerf ME and Herrera E High Fat Diet Administration during Specific Periods of Pregnancy Alters Maternal Fatty Acid Profiles in the Near-Term Rat. 2016 Nutrients pmid:26742067
Andersen MK et al. Identification of Novel Genetic Determinants of Erythrocyte Membrane Fatty Acid Composition among Greenlanders. 2016 PLoS Genet. pmid:27341449
Benabdoune H et al. The role of resolvin D1 in the regulation of inflammatory and catabolic mediators in osteoarthritis. 2016 Inflamm. Res. pmid:27056390
Medema S et al. Levels of Red Blood Cell Fatty Acids in Patients With Psychosis, Their Unaffected Siblings, and Healthy Controls. 2016 Schizophr Bull pmid:26385764
Abeywardena MY et al. Rise in DPA Following SDA-Rich Dietary Echium Oil Less Effective in Affording Anti-Arrhythmic Actions Compared to High DHA Levels Achieved with Fish Oil in Sprague-Dawley Rats. 2016 Nutrients pmid:26742064
Khaire A et al. Vitamin B Deficiency Across Three Generations Adversely Influences Long-chain Polyunsaturated Fatty Acid Status and Cardiometabolic Markers in Rats. 2016 Arch. Med. Res. pmid:27986122
Sui YH et al. Dietary saturated fatty acid and polyunsaturated fatty acid oppositely affect hepatic NOD-like receptor protein 3 inflammasome through regulating nuclear factor-kappa B activation. 2016 World J. Gastroenterol. pmid:26937141
Meesawatsom P et al. Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models. 2016 J Neuroinflammation pmid:27589850
Tran DQ et al. Induction of Gnrh mRNA expression by the ω-3 polyunsaturated fatty acid docosahexaenoic acid and the saturated fatty acid palmitate in a GnRH-synthesizing neuronal cell model, mHypoA-GnRH/GFP. 2016 Mol. Cell. Endocrinol. pmid:26923440
Kjær MA et al. Regulation of the Omega-3 Fatty Acid Biosynthetic Pathway in Atlantic Salmon Hepatocytes. 2016 PLoS ONE pmid:27973547
Kondreddy VK and Kamatham AN Celecoxib, a COX-2 inhibitor, synergistically potentiates the anti-inflammatory activity of docosahexaenoic acid in macrophage cell line. 2016 Immunopharmacol Immunotoxicol pmid:26954392
Bernhard W et al. Developmental changes in polyunsaturated fetal plasma phospholipids and feto-maternal plasma phospholipid ratios and their association with bronchopulmonary dysplasia. 2016 Eur J Nutr pmid:26363610
Devassy JG et al. Omega-3 Polyunsaturated Fatty Acids and Oxylipins in Neuroinflammation and Management of Alzheimer Disease. 2016 Adv Nutr pmid:27633106
Nuez-Ortín WG et al. Preliminary Validation of a High Docosahexaenoic Acid (DHA) and -Linolenic Acid (ALA) Dietary Oil Blend: Tissue Fatty Acid Composition and Liver Proteome Response in Atlantic Salmon (Salmo salar) Smolts. 2016 PLoS ONE pmid:27556399
Moeinzadeh F et al. Effects of Omega-3 Fatty Acid Supplementation on Serum Biomarkers, Inflammatory Agents, and Quality of Life of Patients on Hemodialysis. 2016 Iran J Kidney Dis pmid:27903997
Del Gobbo LC et al. ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies. 2016 JAMA Intern Med pmid:27357102
Metherel AH et al. Whole-body DHA synthesis-secretion kinetics from plasma eicosapentaenoic acid and alpha-linolenic acid in the free-living rat. 2016 Biochim. Biophys. Acta pmid:27263420
Khaddaj-Mallat R et al. Pro-Resolving Effects of Resolvin D2 in LTD4 and TNF-α Pre-Treated Human Bronchi. 2016 PLoS ONE pmid:27935998
Arnold WR et al. Asymmetric Binding and Metabolism of Polyunsaturated Fatty Acids (PUFAs) by CYP2J2 Epoxygenase. 2016 Biochemistry pmid:27992998
Minihane AM Impact of Genotype on EPA and DHA Status and Responsiveness to Increased Intakes. 2016 Nutrients pmid:26950146
Heskey CE et al. Adipose tissue α-linolenic acid is inversely associated with insulin resistance in adults. 2016 Am. J. Clin. Nutr. pmid:26912497
Mason RP et al. Eicosapentaenoic acid reduces membrane fluidity, inhibits cholesterol domain formation, and normalizes bilayer width in atherosclerotic-like model membranes. 2016 Biochim. Biophys. Acta pmid:27718370
Taha AY et al. Threshold changes in rat brain docosahexaenoic acid incorporation and concentration following graded reductions in dietary alpha-linolenic acid. 2016 Prostaglandins Leukot. Essent. Fatty Acids pmid:26869088
Moriyama R et al. Long-chain unsaturated fatty acids reduce the transcriptional activity of the rat follicle-stimulating hormone β-subunit gene. 2016 J. Reprod. Dev. pmid:26853521
Lo Van A et al. Mechanisms of DHA transport to the brain and potential therapy to neurodegenerative diseases. 2016 Biochimie pmid:27496085
Cinelli G et al. Influence of Maternal Obesity and Gestational Weight Gain on Maternal and Foetal Lipid Profile. 2016 Nutrients pmid:27314385
Revuelta M et al. Antioxidant Treatments Recover the Alteration of Auditory-Evoked Potentials and Reduce Morphological Damage in the Inferior Colliculus after Perinatal Asphyxia in Rat. 2016 Brain Pathol. pmid:25990815
Kuda O et al. Docosahexaenoic Acid-Derived Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) With Anti-inflammatory Properties. 2016 Diabetes pmid:27313314
Easley JT et al. AT-RvD1 combined with DEX is highly effective in treating TNF-α-mediated disruption of the salivary gland epithelium. 2016 Physiol Rep pmid:27694530
McNamara RK and Welge JA Meta-analysis of erythrocyte polyunsaturated fatty acid biostatus in bipolar disorder. 2016 Bipolar Disord pmid:27087497
Titos E et al. Signaling and Immunoresolving Actions of Resolvin D1 in Inflamed Human Visceral Adipose Tissue. 2016 J. Immunol. pmid:27647830
Wang CS et al. ALX/FPR2 Modulates Anti-Inflammatory Responses in Mouse Submandibular Gland. 2016 Sci Rep pmid:27064029
Luo B et al. Resolvin D1 Programs Inflammation Resolution by Increasing TGF-β Expression Induced by Dying Cell Clearance in Experimental Autoimmune Neuritis. 2016 J. Neurosci. pmid:27629711
Bascoul-Colombo C et al. Dietary DHA supplementation causes selective changes in phospholipids from different brain regions in both wild type mice and the Tg2576 mouse model of Alzheimer's disease. 2016 Biochim. Biophys. Acta pmid:26968097
Kim KH et al. Resolvin D1 prevents smoking-induced emphysema and promotes lung tissue regeneration. 2016 Int J Chron Obstruct Pulmon Dis pmid:27313451
Zhao Q et al. Resolvin D1 Alleviates the Lung Ischemia Reperfusion Injury via Complement, Immunoglobulin, TLR4, and Inflammatory Factors in Rats. 2016 Inflammation pmid:27145782
Shi H et al. VIP protects human retinal microvascular endothelial cells against high glucose-induced increases in TNF-α and enhances RvD1. 2016 Prostaglandins Other Lipid Mediat. pmid:27026343
Barden A et al. n-3 Fatty Acid Supplementation and Leukocyte Telomere Length in Patients with Chronic Kidney Disease. 2016 Nutrients pmid:27007392
Gharekhani A et al. Potential Effects of Omega-3 Fatty Acids on Insulin Resistance and Lipid Profile in Maintenance Hemodialysis Patients: a Randomized Placebo-Controlled Trial. 2016 Iran J Kidney Dis pmid:27721230
Zhao Q et al. Resolvin D1 mitigates energy metabolism disorder after ischemia-reperfusion of the rat lung. 2016 J Transl Med pmid:27009328
Schmid M et al. Resolvin D1 Polarizes Primary Human Macrophages toward a Proresolution Phenotype through GPR32. 2016 J. Immunol. pmid:26969756