DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Sparreboom A et al. Disposition of docosahexaenoic acid-paclitaxel, a novel taxane, in blood: in vitro and clinical pharmacokinetic studies. 2003 Clin. Cancer Res. pmid:12538463
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Lemaitre RN et al. n-3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study. 2003 Am. J. Clin. Nutr. pmid:12540389
Innis SM and Elias SL Intakes of essential n-6 and n-3 polyunsaturated fatty acids among pregnant Canadian women. 2003 Am. J. Clin. Nutr. pmid:12540410
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De Vizia B et al. Effect of an 8-month treatment with omega-3 fatty acids (eicosapentaenoic and docosahexaenoic) in patients with cystic fibrosis. 2003 Jan-Feb JPEN J Parenter Enteral Nutr pmid:12549599
Huang H and Bao S [Studies on production of docosahexaenoic acid by Thraustochytrium aureum]. 2002 Wei Sheng Wu Xue Bao pmid:12557559
Howe PR et al. Tuna fishmeal as a source of DHA for n-3 PUFA enrichment of pork, chicken, and eggs. 2002 Lipids pmid:12558057
Kubo K et al. Docosahexaenoic acid-containing phosphatidylethanolamine in the external layer of liposomes protects docosahexaenoic acid from 2,2'-azobis(2-aminopropane)dihydrochloride-mediated lipid peroxidation. 2003 Arch. Biochem. Biophys. pmid:12559986
Chiu CC et al. Omega-3 fatty acids for depression in pregnancy. 2003 Am J Psychiatry pmid:12562593
Montine TJ et al. Antioxidants significantly affect the formation of different classes of isoprostanes and neuroprostanes in rat cerebral synaptosomes. 2003 Biochem. Pharmacol. pmid:12566089
Saito M and Kubo K Relationship between tissue lipid peroxidation and peroxidizability index after alpha-linolenic, eicosapentaenoic, or docosahexaenoic acid intake in rats. 2003 Br. J. Nutr. pmid:12568661
Ait-Said F et al. Inhibition by eicosapentaenoic acid of IL-1beta-induced PGHS-2 expression in human microvascular endothelial cells: involvement of lipoxygenase-derived metabolites and p38 MAPK pathway. 2003 Biochim. Biophys. Acta pmid:12573452
Takeuchi T et al. Possible regulatory mechanism of DHA-induced anti-stress reaction in rats. 2003 Brain Res. pmid:12573522
Berstad P et al. Supplementation with fish oil affects the association between very long-chain n-3 polyunsaturated fatty acids in serum non-esterified fatty acids and soluble vascular cell adhesion molecule-1. 2003 Clin. Sci. pmid:12589702
Hong S et al. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. 2003 J. Biol. Chem. pmid:12590139
Kurowska EM et al. Bioavailability of omega-3 essential fatty acids from perilla seed oil. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12591004
Usami M et al. Effect of gamma-linolenic acid or docosahexaenoic acid on tight junction permeability in intestinal monolayer cells and their mechanism by protein kinase C activation and/or eicosanoid formation. 2003 Nutrition pmid:12591548
Araseki M et al. Oxidative stability of polyunsaturated fatty acid in phosphatidylcholine liposomes. 2002 Biosci. Biotechnol. Biochem. pmid:12596850
Aoki H et al. Incorporation and accumulation of docosahexaenoic acid from the medium by Pichia methanolica HA-32. 2002 Biosci. Biotechnol. Biochem. pmid:12596859
McFadyen M et al. Maternal and umbilical cord erythrocyte omega-3 and omega-6 fatty acids and haemorheology in singleton and twin pregnancies. 2003 Arch. Dis. Child. Fetal Neonatal Ed. pmid:12598503
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Akimoto M et al. Lipase-catalyzed interesterification of soybean oil with an omega-3 polyunsaturated fatty acid concentrate prepared from sardine oil. 2003 Appl. Biochem. Biotechnol. pmid:12603099
Sturlan S et al. Docosahexaenoic acid enhances arsenic trioxide-mediated apoptosis in arsenic trioxide-resistant HL-60 cells. 2003 Blood pmid:12609832
Hibbeln JR et al. Smoking, gender, and dietary influences on erythrocyte essential fatty acid composition among patients with schizophrenia or schizoaffective disorder. 2003 Biol. Psychiatry pmid:12614996
Mayer K et al. Parenteral nutrition with fish oil modulates cytokine response in patients with sepsis. 2003 Am. J. Respir. Crit. Care Med. pmid:12615625
Narayanan BA et al. Modulation of inducible nitric oxide synthase and related proinflammatory genes by the omega-3 fatty acid docosahexaenoic acid in human colon cancer cells. 2003 Cancer Res. pmid:12615711
[Sudden cardiac death. Targets every 2nd person without warning]. 2003 MMW Fortschr Med pmid:12619216
Suresh Y and Das UN Long-chain polyunsaturated fatty acids and chemically induced diabetes mellitus. Effect of omega-3 fatty acids. 2003 Nutrition pmid:12620523
Chen WJ and Yeh SL Effects of fish oil in parenteral nutrition. 2003 Nutrition pmid:12620534
Engler MM et al. Effects of docosahexaenoic acid on vascular pathology and reactivity in hypertension. 2003 Exp. Biol. Med. (Maywood) pmid:12626775
Itoh Y et al. Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. 2003 Nature pmid:12629551
Smuts CM et al. A randomized trial of docosahexaenoic acid supplementation during the third trimester of pregnancy. 2003 Obstet Gynecol pmid:12636950
Houston KD et al. Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma. 2003 Cancer Res. pmid:12649180
Fischler L et al. Influence of a parenteral fish-oil preparation (Omegaven) on erythrocyte morphology and blood viscosity in vitro. 2003 Clin. Hemorheol. Microcirc. pmid:12652013
Tanaka T et al. Mechanisms of accumulation of arachidonate in phosphatidylinositol in yellowtail. A comparative study of acylation systems of phospholipids in rat and the fish species Seriola quinqueradiata. 2003 Eur. J. Biochem. pmid:12654002
Tully AM et al. Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case-control study. 2003 Br. J. Nutr. pmid:12654166
Okada M et al. How does prolonged caloric restriction ameliorate age-related impairment of long-term potentiation in the hippocampus? 2003 Brain Res. Mol. Brain Res. pmid:12654517
de Swaaf ME et al. Fed-batch cultivation of the docosahexaenoic-acid-producing marine alga Crypthecodinium cohnii on ethanol. 2003 Appl. Microbiol. Biotechnol. pmid:12658513
Nesbitt GH et al. Effect of n-3 fatty acid ratio and dose on clinical manifestations, plasma fatty acids and inflammatory mediators in dogs with pruritus. 2003 Vet. Dermatol. pmid:12662263
Abril R et al. Safety assessment of DHA-rich microalgae from Schizochytrium sp. Part V: target animal safety/toxicity study in growing swine. 2003 Regul. Toxicol. Pharmacol. pmid:12662911
Finnegan YE et al. Plant- and marine-derived n-3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects. 2003 Am. J. Clin. Nutr. pmid:12663273
Djoussé L et al. Dietary linolenic acid and carotid atherosclerosis: the National Heart, Lung, and Blood Institute Family Heart Study. 2003 Am. J. Clin. Nutr. pmid:12663278
Reich EE et al. Formation of novel D-ring and E-ring isoprostane-like compounds (D4/E4-neuroprostanes) in vivo from docosahexaenoic acid. 2002 Adv. Exp. Med. Biol. pmid:12664634
Youssef J et al. Pantothenic acid: an organ-specific pro-oxidant vitamin. Brain and liver neuroprostane levels in rats fed a pantothenic acid-deficient diet. 2002 Adv. Exp. Med. Biol. pmid:12664639
Meireles LA et al. Lipid class composition of the microalga Pavlova lutheri: eicosapentaenoic and docosahexaenoic acids. 2003 J. Agric. Food Chem. pmid:12670163
Koo WW Efficacy and safety of docosahexaenoic acid and arachidonic acid addition to infant formulas: can one buy better vision and intelligence? 2003 J Am Coll Nutr pmid:12672705
Wu FC et al. Dietary docosahexaenoic acid is more optimal than eicosapentaenoic acid affecting the level of cellular defence responses of the juvenile grouper Epinephelus malabaricus. 2003 Fish Shellfish Immunol. pmid:12681278
Komatsu W et al. Docosahexaenoic acid suppresses nitric oxide production and inducible nitric oxide synthase expression in interferon-gamma plus lipopolysaccharide-stimulated murine macrophages by inhibiting the oxidative stress. 2003 Free Radic. Biol. Med. pmid:12684085
[Additional omega-3-fatty acids. Infarct mortality gets reduced]. 2003 MMW Fortschr Med pmid:12688033
Wright TC et al. Effect of combinations of fish meal and feather meal on milk fatty acid content and nitrogen utilization in dairy cows. 2003 J. Dairy Sci. pmid:12703623
Mansour MP et al. The effect of growth phase on the lipid class, fatty acid and sterol composition in the marine dinoflagellate, Gymnodinium sp. in batch culture. 2003 Phytochemistry pmid:12711135
Horrobin D et al. The effects on plasma, red cell and platelet fatty acids of taking 12 g/day of ethyl-eicosapentaenoate for 16 months: dihomogammalinolenic, arachidonic and docosahexaenoic acids and relevance to Inuit metabolism. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12711245
Pass the fish (oil capsules), please. Following the latest recommendations from the American Heart Association may mean reaching for fish oil supplements. 2003 Harv Heart Lett pmid:12711572
Insua MF et al. Cell cycle regulation in retinal progenitors by glia-derived neurotrophic factor and docosahexaenoic acid. 2003 Invest. Ophthalmol. Vis. Sci. pmid:12714666
Rotstein NP et al. Protective effect of docosahexaenoic acid on oxidative stress-induced apoptosis of retina photoreceptors. 2003 Invest. Ophthalmol. Vis. Sci. pmid:12714668
James MJ et al. Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids. 2003 Am. J. Clin. Nutr. pmid:12716664
Kew S et al. Lack of effect of foods enriched with plant- or marine-derived n-3 fatty acids on human immune function. 2003 Am. J. Clin. Nutr. pmid:12716684
Wallace FA et al. Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects. 2003 Br. J. Nutr. pmid:12720588
Mattos R et al. Polyunsaturated fatty acids and bovine interferon-tau modify phorbol ester-induced secretion of prostaglandin F2 alpha and expression of prostaglandin endoperoxide synthase-2 and phospholipase-A2 in bovine endometrial cells. 2003 Biol. Reprod. pmid:12724278
Li H et al. [Effect of fish oil supplementation on fatty acid composition and neurotransmitters of growing rats]. 2000 Wei Sheng Yan Jiu pmid:12725043
Marangell LB et al. A double-blind, placebo-controlled study of the omega-3 fatty acid docosahexaenoic acid in the treatment of major depression. 2003 Am J Psychiatry pmid:12727707
Inagaki K et al. Evidence of isozymes for delta6 fatty acid desaturase in rat hepatocytes. 2003 Biosci. Biotechnol. Biochem. pmid:12729021
Berry CB and McBean GJ An investigation into the role of calcium in the modulation of rat synaptosomal D-[3H]aspartate transport by docosahexaenoic acid. 2003 Brain Res. pmid:12729959
Thorpe M Infant formula supplemented with DHA: are there benefits? 2003 J Am Diet Assoc pmid:12733531
Sumino H et al. Effects of hormone replacement therapy on circulating docosahexaenoic acid and eicosapentaenoic acid levels in postmenopausal women. 2003 Endocr. J. pmid:12733709
Cha MC et al. Dietary docosahexaenoic acid levels influence the outcome of arabinosylcytosine chemotherapy in L1210 leukemic mice. 2002 Nutr Cancer pmid:12734065
Sarkadi-Nagy E et al. The influence of prematurity and long chain polyunsaturate supplementation in 4-week adjusted age baboon neonate brain and related tissues. 2003 Pediatr. Res. pmid:12736388
Gu X et al. Oxidatively truncated docosahexaenoate phospholipids: total synthesis, generation, and Peptide adduction chemistry. 2003 J. Org. Chem. pmid:12737551
Merritt RJ et al. Safety evaluation of sources of docosahexaenoic acid and arachidonic acid for use in infant formulas in newborn piglets. 2003 Food Chem. Toxicol. pmid:12738195
Mashek DG and Grummer RR Short communication: Net uptake of nonesterified long chain fatty acids by the perfused caudate lobe of the caprine liver. 2003 J. Dairy Sci. pmid:12741546
Almansa E et al. Temperature-activity relationship for the intestinal Na+-K+-ATPase of Sparus aurata. A role for the phospholipid microenvironment? 2003 J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. pmid:12743726
Armstrong VT et al. Rapid flip-flop in polyunsaturated (docosahexaenoate) phospholipid membranes. 2003 Arch. Biochem. Biophys. pmid:12745257
Llorente AM et al. Effect of maternal docosahexaenoic acid supplementation on postpartum depression and information processing. 2003 Am. J. Obstet. Gynecol. pmid:12748510
Sano Y et al. A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord. 2003 J. Biol. Chem. pmid:12754259
Yusufi AN et al. Differential effects of low-dose docosahexaenoic acid and eicosapentaenoic acid on the regulation of mitogenic signaling pathways in mesangial cells. 2003 J. Lab. Clin. Med. pmid:12761475
de Swaaf ME et al. Analysis of docosahexaenoic acid biosynthesis in Crypthecodinium cohnii by 13C labelling and desaturase inhibitor experiments. 2003 J. Biotechnol. pmid:12770501
Harel M and Place AR Tissue essential fatty acid composition and competitive response to dietary manipulations in white bass (Morone chrysops), striped bass (M. saxatilis) and hybrid striped bass (M. chrysopsxM. saxatilis). 2003 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:12781976
Barceló-Coblijn G et al. Gene expression and molecular composition of phospholipids in rat brain in relation to dietary n-6 to n-3 fatty acid ratio. 2003 Biochim. Biophys. Acta pmid:12782153
Beck S et al. Potentiation of tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation. 2003 J. Biol. Chem. pmid:12782627
Torres CF et al. Lipase-catalyzed ethanolysis of fish oils: multi-response kinetics. 2003 Biotechnol. Bioeng. pmid:12783483
Eldho NV et al. Polyunsaturated docosahexaenoic vs docosapentaenoic acid-differences in lipid matrix properties from the loss of one double bond. 2003 J. Am. Chem. Soc. pmid:12785780
Youssef JA et al. Age-independent, gray matter-localized, brain-enhanced oxidative stress in male fischer 344 rats: brain levels of F(2)-isoprostanes and F(4)-neuroprostanes. 2003 Free Radic. Biol. Med. pmid:12788483
Del Castillo IC et al. Docosahexaenoic acid selectively augments muscarinic stimulation of epithelial Cl- secretion. 2003 J. Surg. Res. pmid:12788663
Rodriguez A et al. Preterm infant formula supplementation with alpha linolenic acid and docosahexaenoic acid. 2003 Eur J Clin Nutr pmid:12792656
pmid:12794672
Clements KM et al. Spontaneously hypertensive and Wistar Kyoto rats differ in delayed matching-to-place performance and response to dietary long-chain polyunsaturated fatty acids. 2003 Dev Psychobiol pmid:12794779
Hulbert AJ Life, death and membrane bilayers. 2003 J. Exp. Biol. pmid:12796449
Ng R Fish oil therapy in recurrent IgA nephropathy. 2003 Ann. Intern. Med. pmid:12809474
Wang Z Role of redox state in modulation of ion channel function by fatty acids and phospholipids. 2003 Br. J. Pharmacol. pmid:12812990
Judé S et al. Peroxidation of docosahexaenoic acid is responsible for its effects on I TO and I SS in rat ventricular myocytes. 2003 Br. J. Pharmacol. pmid:12813005
Erkkilä AT et al. n-3 Fatty acids and 5-y risks of death and cardiovascular disease events in patients with coronary artery disease. 2003 Am. J. Clin. Nutr. pmid:12816772
Chen H et al. EPA and DHA attenuate ox-LDL-induced expression of adhesion molecules in human coronary artery endothelial cells via protein kinase B pathway. 2003 J. Mol. Cell. Cardiol. pmid:12818567
Rojas CV et al. Gene expression analysis in human fetal retinal explants treated with docosahexaenoic acid. 2003 Invest. Ophthalmol. Vis. Sci. pmid:12824268
Qian SY et al. Identification of spin trapped carbon-centered radicals in soybean lipoxygenase-dependent peroxidations of omega-3 polyunsaturated fatty acids by LC/ESR, LC/MS, and tandem MS. 2003 Free Radic. Biol. Med. pmid:12826254
Speake BK et al. Distribution of lipids from the yolk to the tissues during development of the water python (Liasis fuscus). 2003 J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. pmid:12827419
Högyes E et al. Neuroprotective effect of developmental docosahexaenoic acid supplement against excitotoxic brain damage in infant rats. 2003 Neuroscience pmid:12831859
Hoffman DR et al. Visual function in breast-fed term infants weaned to formula with or without long-chain polyunsaturates at 4 to 6 months: a randomized clinical trial. 2003 J. Pediatr. pmid:12838196
Strokin M et al. Docosahexaenoic acid and arachidonic acid release in rat brain astrocytes is mediated by two separate isoforms of phospholipase A2 and is differently regulated by cyclic AMP and Ca2+. 2003 Br. J. Pharmacol. pmid:12839876
Montgomery C et al. Maternal docosahexaenoic acid supplementation and fetal accretion. 2003 Br. J. Nutr. pmid:12844385