| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Pain | D010146 | 64 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Helge JW et al. | Training affects muscle phospholipid fatty acid composition in humans. | 2001 | J. Appl. Physiol. | pmid:11160068 |
| Lim S and Suzuki H | Changes in maze behavior of mice occur after sufficient accumulation of docosahexaenoic acid in brain. | 2001 | J. Nutr. | pmid:11160553 |
| Tocher DR and Dick JR | Effects of essential fatty acid deficiency and supplementation with docosahexaenoic acid (DHA; 22:6n-3) on cellular fatty acid compositions and fatty acyl desaturation in a cell culture model. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11161581 |
| Chen ZY and Istfan NW | Docosahexaenoic acid, a major constituent of fish oil diets, prevents activation of cyclin-dependent kinases and S-phase entry by serum stimulation in HT-29 cells. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11161587 |
| Infante JP and Huszagh VA | Zellweger syndrome knockout mouse models challenge putative peroxisomal beta-oxidation involvement in docosahexaenoic acid (22:6n-3) biosynthesis. | 2001 | Mol. Genet. Metab. | pmid:11161822 |
| Wiesenfeld PW et al. | Effect of long-chain fatty acids in the culture medium on fatty acid composition of WEHI-3 and J774A.1 cells. | 2001 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:11163311 |
| Ito Y et al. | Effects of polyunsaturated fatty acids on atrophic gastritis in a Japanese population. | 2001 | Cancer Lett. | pmid:11165751 |
| Morita N et al. | Biosynthesis of fatty acids in the docosahexaenoic acid-producing bacterium Moritella marina strain MP-1. | 2000 | Biochem. Soc. Trans. | pmid:11171265 |
| Du M et al. | Effects of dietary conjugated linoleic acid and linoleic:linolenic acid ratio on polyunsaturated fatty acid status in laying hens. | 2000 | Poult. Sci. | pmid:11194037 |
| Conquer JA et al. | Fatty acid analysis of blood plasma of patients with Alzheimer's disease, other types of dementia, and cognitive impairment. | 2000 | Lipids | pmid:11201991 |
| Ashford A et al. | Electron microscopy may reveal structure of docosahexaenoic acid-rich oil within Schizochytrium sp. | 2000 | Lipids | pmid:11202000 |
| al-Awadhi AM and Dunn CD | Effects of fish-oil constituents and plasma lipids on fibrinolysis in vitro. | 2000 | Br. J. Biomed. Sci. | pmid:11204855 |
| Lance VA et al. | Hyperlipidemia and reproductive failure in captive-reared alligators: vitamin E, vitamin A, plasma lipids, fatty acids, and steroid hormones. | 2001 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:11207442 |
| Frenoux JM et al. | A polyunsaturated fatty acid diet lowers blood pressure and improves antioxidant status in spontaneously hypertensive rats. | 2001 | J. Nutr. | pmid:11208936 |
| Hung P et al. | Dietary effects of eicosapentaenoic and docosahexaenoic acid esters on lipid metabolism and immune parameters in Sprague-Dawley rats. | 2000 | Biosci. Biotechnol. Biochem. | pmid:11210121 |
| Song JH and Miyazawa T | Enhanced level of n-3 fatty acid in membrane phospholipids induces lipid peroxidation in rats fed dietary docosahexaenoic acid oil. | 2001 | Atherosclerosis | pmid:11223421 |
| Christophe A and Robberecht E | Directed modification instead of normalization of fatty acid patterns in cystic fibrosis: an emerging concept. | 2001 | Curr Opin Clin Nutr Metab Care | pmid:11224654 |
| Saito M | Dietary docosahexaenoic acid does not promote tissue lipid peroxide formation to the extent expected from the peroxidizability index of the lipids. | 2000 | Biofactors | pmid:11237175 |
| Hamazaki T et al. | Anti-stress effects of DHA. | 2000 | Biofactors | pmid:11237197 |
| Agostoni C et al. | Biochemical effects of supplemented long-chain polyunsaturated fatty acids in hyperphenylalaninemia. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11237478 |
| Thies F et al. | Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 y. | 2001 | Am. J. Clin. Nutr. | pmid:11237929 |
| van den Ham EC et al. | Evaluation of the relation between n-3 and n-6 fatty acid status and parity in nonpregnant women from the Netherlands. | 2001 | Am. J. Clin. Nutr. | pmid:11237941 |
| Infante JP and Huszagh VA | Impaired arachidonic (20:4n-6) and docosahexaenoic (22:6n-3) acid synthesis by phenylalanine metabolites as etiological factors in the neuropathology of phenylketonuria. | 2001 | Mol. Genet. Metab. | pmid:11243724 |
| Xiao YF et al. | Single point mutations affect fatty acid block of human myocardial sodium channel alpha subunit Na+ channels. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11248125 |
| Al MD et al. | Relation between birth order and the maternal and neonatal docosahexaenoic acid status. | 1997 | Eur J Clin Nutr | pmid:11248881 |
| Gamoh S et al. | Chronic administration of docosahexaenoic acid improves the performance of radial arm maze task in aged rats. | 2001 | Clin. Exp. Pharmacol. Physiol. | pmid:11251638 |
| Wood H | An X-orphan. | 2001 | Nat. Rev. Neurosci. | pmid:11252996 |
| Pound EM et al. | Partitioning of polyunsaturated fatty acids, which prevent cardiac arrhythmias, into phospholipid cell membranes. | 2001 | J. Lipid Res. | pmid:11254745 |
| Higdon JV et al. | Supplementation of postmenopausal women with fish oil does not increase overall oxidation of LDL ex vivo compared to dietary oils rich in oleate and linoleate. | 2001 | J. Lipid Res. | pmid:11254753 |
| Moriguchi T et al. | Reversal of docosahexaenoic acid deficiency in the rat brain, retina, liver, and serum. | 2001 | J. Lipid Res. | pmid:11254754 |
| Assies J et al. | Significantly reduced docosahexaenoic and docosapentaenoic acid concentrations in erythrocyte membranes from schizophrenic patients compared with a carefully matched control group. | 2001 | Biol. Psychiatry | pmid:11257236 |
| Fujita S et al. | Docosahexaenoic acid improves long-term potentiation attenuated by phospholipase A(2) inhibitor in rat hippocampal slices. | 2001 | Br. J. Pharmacol. | pmid:11264234 |
| Hayashi M et al. | Uptake and accumulation of exogenous docosahexaenoic acid by Chlorella. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11272831 |
| Rump P et al. | Essential fatty acid composition of plasma phospholipids and birth weight: a study in term neonates. | 2001 | Am. J. Clin. Nutr. | pmid:11273856 |
| Elias SL and Innis SM | Infant plasma trans, n-6, and n-3 fatty acids and conjugated linoleic acids are related to maternal plasma fatty acids, length of gestation, and birth weight and length. | 2001 | Am. J. Clin. Nutr. | pmid:11273857 |
| Donadio JV et al. | A randomized trial of high-dose compared with low-dose omega-3 fatty acids in severe IgA nephropathy. | 2001 | J. Am. Soc. Nephrol. | pmid:11274240 |
| Green P et al. | Ethyl docosahexaenoate-associated decrease in fetal brain lipid peroxide production is mediated by activation of prostanoid and nitric oxide pathways. | 2001 | Biochim. Biophys. Acta | pmid:11278180 |
| Lee JY et al. | Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. | 2001 | J. Biol. Chem. | pmid:11278967 |
| Arrington JL et al. | Docosahexaenoic acid suppresses function of the CD28 costimulatory membrane receptor in primary murine and Jurkat T cells. | 2001 | J. Nutr. | pmid:11285317 |
| Ikeda I et al. | Reduced hepatic triglyceride secretion in rats fed docosahexaenoic acid-rich fish oil suppresses postprandial hypertriglyceridemia. | 2001 | J. Nutr. | pmid:11285319 |
| Collett ED et al. | n-6 and n-3 polyunsaturated fatty acids differentially modulate oncogenic Ras activation in colonocytes. | 2001 | Am. J. Physiol., Cell Physiol. | pmid:11287318 |
| Su HM et al. | Fetal baboons convert 18:3n-3 to 22:6n-3 in vivo. A stable isotope tracer study. | 2001 | J. Lipid Res. | pmid:11290830 |
| Schneider SM et al. | Activity of the leukocyte NADPH oxidase in whole neutrophils and cell-free neutrophil preparations stimulated with long-chain polyunsaturated fatty acids. | 2001 | Inflammation | pmid:11293662 |
| Delton-Vandenbroucke I et al. | Dual regulation of glutathione peroxidase by docosahexaenoic acid in endothelial cells depending on concentration and vascular bed origin. | 2001 | Free Radic. Biol. Med. | pmid:11295532 |
| Rudra PK and Krokan HE | Cell-specific enhancement of doxorubicin toxicity in human tumour cells by docosahexaenoic acid. | 2001 Jan-Feb | Anticancer Res. | pmid:11299749 |
| Durrington PN et al. | An omega-3 polyunsaturated fatty acid concentrate administered for one year decreased triglycerides in simvastatin treated patients with coronary heart disease and persisting hypertriglyceridaemia. | 2001 | Heart | pmid:11303007 |
| Seung Kim HF et al. | Inhibitory effects of omega-3 fatty acids on protein kinase C activity in vitro. | 2001 | Mol. Psychiatry | pmid:11317232 |
| Modeste AB et al. | [Hydroa vacciniforme: dietary fish oil]. | 2001 | Ann Dermatol Venereol | pmid:11319390 |
| Umegaki K et al. | Docosahexaenoic acid supplementation-increased oxidative damage in bone marrow DNA in aged rats and its relation to antioxidant vitamins. | 2001 | Free Radic. Res. | pmid:11328678 |
| Colquhoun A et al. | Eicosapentaenoic acid and docosahexaenoic acid effects on tumour mitochondrial metabolism, acyl CoA metabolism and cell proliferation. | 2001 | Cell Biochem. Funct. | pmid:11335934 |