| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Pain | D010146 | 64 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fan YY et al. | Chemopreventive n-3 fatty acids activate RXRalpha in colonocytes. | 2003 | Carcinogenesis | pmid:12844485 |
| Crawford MA et al. | The potential role for arachidonic and docosahexaenoic acids in protection against some central nervous system injuries in preterm infants. | 2003 | Lipids | pmid:12848275 |
| Dewailly E et al. | Fish consumption and blood lipids in three ethnic groups of Québec (Canada). | 2003 | Lipids | pmid:12848280 |
| Smuts CM et al. | High-DHA eggs: feasibility as a means to enhance circulating DHA in mother and infant. | 2003 | Lipids | pmid:12848286 |
| Visioli F et al. | Dietary intake of fish vs. formulations leads to higher plasma concentrations of n-3 fatty acids. | 2003 | Lipids | pmid:12848287 |
| Cleland LG et al. | A biomarker of n-3 compliance in patients taking fish oil for rheumatoid arthritis. | 2003 | Lipids | pmid:12848288 |
| Mitchell DC et al. | Enhancement of G protein-coupled signaling by DHA phospholipids. | 2003 | Lipids | pmid:12848291 |
| Gawrisch K et al. | The structure of DHA in phospholipid membranes. | 2003 | Lipids | pmid:12848292 |
| Lagarde M et al. | Pathophysiologic role of redox status in blood platelet activation. Influence of docosahexaenoic acid. | 2003 | Lipids | pmid:12848295 |
| Lee JY et al. | Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids. | 2003 | J. Biol. Chem. | pmid:12865424 |
| Véricel E et al. | Pro- and antioxidant activities of docosahexaenoic acid on human blood platelets. | 2003 | J. Thromb. Haemost. | pmid:12871467 |
| Moriguchi K et al. | Dietary docosahexaenoic acid protects against N-methyl-N-nitrosourea-induced retinal degeneration in rats. | 2003 | Exp. Eye Res. | pmid:12873446 |
| Morris MC et al. | Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. | 2003 | Arch. Neurol. | pmid:12873849 |
| Rodemer C et al. | Inactivation of ether lipid biosynthesis causes male infertility, defects in eye development and optic nerve hypoplasia in mice. | 2003 | Hum. Mol. Genet. | pmid:12874108 |
| Ponder DL et al. | Docosahexaenoic acid status of term infants fed breast milk or infant formula containing soy oil or corn oil. | 1992 | Pediatr. Res. | pmid:1287559 |
| Heard CM et al. | The in vitro delivery of NSAIDs across skin was in proportion to the delivery of essential fatty acids in the vehicle--evidence that solutes permeate skin associated with their solvation cages? | 2003 | Int J Pharm | pmid:12878406 |
| Yuri T et al. | Dietary docosahexaenoic acid suppresses N-methyl-N-nitrosourea-induced mammary carcinogenesis in rats more effectively than eicosapentaenoic acid. | 2003 | Nutr Cancer | pmid:12881016 |
| Malcolm CA et al. | Scotopic electroretinogram in term infants born of mothers supplemented with docosahexaenoic acid during pregnancy. | 2003 | Invest. Ophthalmol. Vis. Sci. | pmid:12882824 |
| Bellamy CM et al. | Can supplementation of diet with omega-3 polyunsaturated fatty acids reduce coronary angioplasty restenosis rate? | 1992 | Eur. Heart J. | pmid:1289091 |
| Ajuyah AO et al. | Maternal diet with diverse omega-6/omega-3 ratio affects the brain docosahexaenoic acid content of growing chickens. | 2003 | Biol. Neonate | pmid:12890936 |
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| Miyazawa D et al. | Dietary alpha-linolenic acid suppresses the formation of lysophosphatidic acid, a lipid mediator, in rat platelets compared with linoleic acid. | 2003 | Life Sci. | pmid:12899931 |
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| Otto SJ et al. | Increased risk of postpartum depressive symptoms is associated with slower normalization after pregnancy of the functional docosahexaenoic acid status. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12907133 |
| Tiangson CL et al. | Docosahexaenoic acid level of the breast milk of some Filipino women. | 2003 | Int J Food Sci Nutr | pmid:12907409 |
| Burdge GC et al. | Effect of altered dietary n-3 fatty acid intake upon plasma lipid fatty acid composition, conversion of [13C]alpha-linolenic acid to longer-chain fatty acids and partitioning towards beta-oxidation in older men. | 2003 | Br. J. Nutr. | pmid:12908891 |
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| Meyer A et al. | Biosynthesis of docosahexaenoic acid in Euglena gracilis: biochemical and molecular evidence for the involvement of a Delta4-fatty acyl group desaturase. | 2003 | Biochemistry | pmid:12911321 |
| Dallongeville J et al. | Fish consumption is associated with lower heart rates. | 2003 | Circulation | pmid:12912821 |
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| Marcheselli VL et al. | Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression. | 2003 | J. Biol. Chem. | pmid:12923200 |
| Heath RB et al. | Selective partitioning of dietary fatty acids into the VLDL TG pool in the early postprandial period. | 2003 | J. Lipid Res. | pmid:12923230 |
| Engler MB | Vascular relaxation to omega-3 fatty acids: comparison to sodium nitroprusside, nitroglycerin, papaverine, and D600. | 1992 | Cardiovasc Drugs Ther | pmid:1292580 |
| Oarada M et al. | Dietary supplementation with docosahexaenoic acid, but not with eicosapentaenoic acid, reduces host resistance to fungal infection in mice. | 2003 | Biochim. Biophys. Acta | pmid:12928111 |
| Bordoni A et al. | [The correlation between the acidic composition of diacylglycerol and protein kinase C activation in cultures of rat cardiomyocytes]. | 1992 | Cardiologia | pmid:1292868 |
| Oikawa D et al. | Dietary CLA and DHA modify skin properties in mice. | 2003 | Lipids | pmid:12934670 |
| Trebble TM et al. | Prostaglandin E2 production and T cell function after fish-oil supplementation: response to antioxidant cosupplementation. | 2003 | Am. J. Clin. Nutr. | pmid:12936918 |
| Malcolm CA et al. | Maternal docosahexaenoic acid supplementation during pregnancy and visual evoked potential development in term infants: a double blind, prospective, randomised trial. | 2003 | Arch. Dis. Child. Fetal Neonatal Ed. | pmid:12937042 |
| Hirafuji M et al. | Cardiovascular protective effects of n-3 polyunsaturated fatty acids with special emphasis on docosahexaenoic acid. | 2003 | J. Pharmacol. Sci. | pmid:12939515 |
| Pilitsis JG et al. | Free fatty acids in cerebrospinal fluids from patients with traumatic brain injury. | 2003 | Neurosci. Lett. | pmid:12946571 |
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| Auestad N et al. | Visual, cognitive, and language assessments at 39 months: a follow-up study of children fed formulas containing long-chain polyunsaturated fatty acids to 1 year of age. | 2003 | Pediatrics | pmid:12949309 |
| Bell JG et al. | Altered fatty acid compositions in atlantic salmon (Salmo salar) fed diets containing linseed and rapeseed oils can be partially restored by a subsequent fish oil finishing diet. | 2003 | J. Nutr. | pmid:12949367 |
| Nishizawa C et al. | Effect of dietary DHA on DHA levels in retinal rod outer segments in young versus mature rats. | 2003 | Int J Vitam Nutr Res | pmid:12951898 |
| Xi ZP and Wang JY | Effect of dietary n-3 fatty acids on the composition of long- and very-long-chain polyenoic fatty acid in rat retina. | 2003 | J. Nutr. Sci. Vitaminol. | pmid:12953800 |
| Palacios A et al. | Antioxidant effect of conjugated linoleic acid and vitamin A during non enzymatic lipid peroxidation of rat liver microsomes and mitochondria. | 2003 | Mol. Cell. Biochem. | pmid:12962148 |
| Kroes R et al. | A review of the safety of DHA45-oil. | 2003 | Food Chem. Toxicol. | pmid:12962995 |
| Wheaton DH et al. | Biological safety assessment of docosahexaenoic acid supplementation in a randomized clinical trial for X-linked retinitis pigmentosa. | 2003 | Arch. Ophthalmol. | pmid:12963609 |
| Salem N and Pawlosky RJ | Docosahexaenoic acid is an essential nutrient in the nervous system. | 1992 | J. Nutr. Sci. Vitaminol. | pmid:1297729 |
| Davis PJ | n-3 and n-6 polyunsaturated fatty acids have different effects on acyl-CoA:cholesterol acyltransferase in J774 macrophages. | 1992 | Biochem. Cell Biol. | pmid:1299268 |
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| Hsu JM and Ding ST | Effect of polyunsaturated fatty acids on the expression of transcription factor adipocyte determination and differentiation-dependent factor 1 and of lipogenic and fatty acid oxidation enzymes in porcine differentiating adipocytes. | 2003 | Br. J. Nutr. | pmid:13129455 |
| Takemoto Y et al. | Gas chromatography/mass spectrometry analysis of very long chain fatty acids, docosahexaenoic acid, phytanic acid and plasmalogen for the screening of peroxisomal disorders. | 2003 | Brain Dev. | pmid:13129591 |
| Langelier B et al. | Docosahexaenoic acid membrane content and mRNA expression of acyl-CoA oxidase and of peroxisome proliferator-activated receptor-delta are modulated in Y79 retinoblastoma cells differently by low and high doses of alpha-linolenic acid. | 2003 | J. Neurosci. Res. | pmid:13130515 |
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| Mori TA et al. | Plasma lipid levels and platelet and neutrophil function in patients with vascular disease following fish oil and olive oil supplementation. | 1992 | Metab. Clin. Exp. | pmid:1328817 |
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| Ramsay B et al. | Erythrocyte membrane docosahexaenoic acid in haemodialysis patients on epoetin. | 1992 | Lancet | pmid:1349964 |
| Arbuckle LD et al. | Formula alpha-linolenic (18:3(n - 3)) and linoleic (18:2(n - 6)) acid influence neonatal piglet liver and brain saturated fatty acids, as well as docosahexaenoic acid (22:6(n - 3)). | 1992 | Biochim. Biophys. Acta | pmid:1350737 |
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| Naval J et al. | Expression of mRNAs for alpha-fetoprotein (AFP) and albumin and incorporation of AFP and docosahexaenoic acid in baboon fetuses. | 1992 | J. Biochem. | pmid:1379224 |
| Aukema HM et al. | Abnormal lipid and fatty acid compositions of kidneys from mice with polycystic kidney disease. | 1992 | Lipids | pmid:1385849 |
| Birch DG et al. | Retinal development in very-low-birth-weight infants fed diets differing in omega-3 fatty acids. | 1992 | Invest. Ophthalmol. Vis. Sci. | pmid:1386065 |
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| Bazan NG et al. | Docosahexaenoic acid uptake and metabolism in photoreceptors: retinal conservation by an efficient retinal pigment epithelial cell-mediated recycling process. | 1992 | Adv. Exp. Med. Biol. | pmid:1386177 |
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| Chen ZY et al. | Gestational hyperlipidemia in the rat is characterized by accumulation of n - 6 and n - 3 fatty acids, especially docosahexaenoic acid. | 1992 | Biochim. Biophys. Acta | pmid:1387324 |
| Parks JS et al. | Inhibition of lecithin:cholesterol acyltransferase activity by synthetic phosphatidylcholine species containing eicosapentaenoic acid or docosahexaenoic acid in the sn-2 position. | 1992 | J. Lipid Res. | pmid:1387413 |
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| pmid:14259461 | ||||
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