| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
| Pain | D010146 | 64 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Engler MB and Engler MM | Docosahexaenoic acid--induced vasorelaxation in hypertensive rats: mechanisms of action. | 2000 | Biol Res Nurs | pmid:11337819 |
| Siddiqui RA et al. | Docosahexaenoic acid induces apoptosis in Jurkat cells by a protein phosphatase-mediated process. | 2001 | Biochim. Biophys. Acta | pmid:11341974 |
| Jørgensen MH et al. | Is there a relation between docosahexaenoic acid concentration in mothers' milk and visual development in term infants? | 2001 | J. Pediatr. Gastroenterol. Nutr. | pmid:11345178 |
| Hammond BG et al. | Safety assessment of DHA-rich microalgae from Schizochytrium sp. | 2001 | Regul. Toxicol. Pharmacol. | pmid:11350202 |
| Hammond BG et al. | Safety assessment of DHA-rich microalgae from Schizochytrium sp. | 2001 | Regul. Toxicol. Pharmacol. | pmid:11350203 |
| Shimakata T | [Polyunsaturated fatty acid]. | 2001 | Nippon Rinsho | pmid:11351628 |
| Wang H et al. | Regulation of apolipoprotein secretion by long-chain polyunsaturated fatty acids in newborn swine enterocytes. | 2001 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11352806 |
| Rapoport SI et al. | Delivery and turnover of plasma-derived essential PUFAs in mammalian brain. | 2001 | J. Lipid Res. | pmid:11352974 |
| Berger A et al. | Anandamide and diet: inclusion of dietary arachidonate and docosahexaenoate leads to increased brain levels of the corresponding N-acylethanolamines in piglets. | 2001 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11353819 |
| Peet M et al. | Two double-blind placebo-controlled pilot studies of eicosapentaenoic acid in the treatment of schizophrenia. | 2001 | Schizophr. Res. | pmid:11356585 |
| Rump P et al. | Leptin and phospholipid-esterified docosahexaenoic acid concentrations in plasma of women: observations during pregnancy and lactation. | 2001 | Eur J Clin Nutr | pmid:11360128 |
| Ksiazyk J | [Influence of feeding long-chain polyunsaturated fatty acids on children's health]. | 2000 | Med Wieku Rozwoj | pmid:11381150 |
| Otto SJ et al. | Comparison of the peripartum and postpartum phospholipid polyunsaturated fatty acid profiles of lactating and nonlactating women. | 2001 | Am. J. Clin. Nutr. | pmid:11382662 |
| Hirano R et al. | Regulation by long-chain fatty acids of the expression of cholesteryl ester transfer protein in HepG2 cells. | 2001 | Lipids | pmid:11383693 |
| Qiu X et al. | Identification of a Delta 4 fatty acid desaturase from Thraustochytrium sp. involved in the biosynthesis of docosahexanoic acid by heterologous expression in Saccharomyces cerevisiae and Brassica juncea. | 2001 | J. Biol. Chem. | pmid:11397798 |
| Marsh DE | Waters-edge evolution. | 2001 | Nutr Health | pmid:11403375 |
| Sweeney B et al. | Polyunsaturated fatty acids influence neonatal monocyte survival. | 2001 | Pediatr. Surg. Int. | pmid:11409157 |
| Bernoud-Hubac N et al. | Formation of highly reactive gamma-ketoaldehydes (neuroketals) as products of the neuroprostane pathway. | 2001 | J. Biol. Chem. | pmid:11413140 |
| Kankaanpää P et al. | Polyunsaturated fatty acids in maternal diet, breast milk, and serum lipid fatty acids of infants in relation to atopy. | 2001 | Allergy | pmid:11421921 |
| Mangels AR and Messina V | Considerations in planning vegan diets: infants. | 2001 | J Am Diet Assoc | pmid:11424546 |
| Anderson RE et al. | Low docosahexaenoic acid levels in rod outer segment membranes of mice with rds/peripherin and P216L peripherin mutations. | 2001 | Invest. Ophthalmol. Vis. Sci. | pmid:11431433 |
| Burke PA et al. | Sites of conditional essential fatty acid deficiency in end stage liver disease. | 2001 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:11434649 |
| Thies F et al. | Dietary supplementation with gamma-linolenic acid or fish oil decreases T lymphocyte proliferation in healthy older humans. | 2001 | J. Nutr. | pmid:11435508 |
| Kinoshita H and Ota Y | Concentration of docosahexaenoic acid from fish oils using Geotrichum sp. FO347-2. | 2001 | Biosci. Biotechnol. Biochem. | pmid:11440112 |
| Hashimoto M et al. | Effects of docosahexaenoic acid on annular lipid fluidity of the rat bile canalicular plasma membrane. | 2001 | J. Lipid Res. | pmid:11441145 |
| López-Ferrer S et al. | n-3 enrichment of chicken meat. 1. Use of very long-chain fatty acids in chicken diets and their influence on meat quality: fish oil. | 2001 | Poult. Sci. | pmid:11441841 |
| Tanaka S et al. | Medium-chain fatty acids stimulate interleukin-8 production in Caco-2 cells with different mechanisms from long-chain fatty acids. | 2001 | J. Gastroenterol. Hepatol. | pmid:11446882 |
| Whitehouse AS and Tisdale MJ | Downregulation of ubiquitin-dependent proteolysis by eicosapentaenoic acid in acute starvation. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11453634 |
| Miyauchi O et al. | Protective effect of docosahexaenoic acid against retinal ischemic injury: an electroretinographic study. | 2001 Jul-Aug | Ophthalmic Res. | pmid:11464070 |
| Green P et al. | Enhanced free radical scavenging and decreased lipid peroxidation in the rat fetal brain after treatment with ethyl docosahexaenoate. | 2001 | Biochim. Biophys. Acta | pmid:11470241 |
| Chung BH et al. | Effects of docosahexaenoic acid and eicosapentaenoic acid on androgen-mediated cell growth and gene expression in LNCaP prostate cancer cells. | 2001 | Carcinogenesis | pmid:11470750 |
| Kachhap SK et al. | Effect of omega-3 fatty acid (docosahexanoic acid) on BRCA1 gene expression and growth in MCF-7 cell line. | 2001 | Cancer Biother. Radiopharm. | pmid:11471489 |
| Kobayashi M et al. | Single measurement of serum phospholipid fatty acid as a biomarker of specific fatty acid intake in middle-aged Japanese men. | 2001 | Eur J Clin Nutr | pmid:11477462 |
| Spector AA | Plasma free fatty acid and lipoproteins as sources of polyunsaturated fatty acid for the brain. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478370 |
| Cunnane SC et al. | NMR and isotope ratio mass spectrometry studies of in vivo uptake and metabolism of polyunsaturates by the developing rat brain. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478372 |
| Moore SA | Polyunsaturated fatty acid synthesis and release by brain-derived cells in vitro. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478374 |
| Lagarde M et al. | Lysophosphatidylcholine as a preferred carrier form of docosahexaenoic acid to the brain. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478375 |
| Li F et al. | Biosynthesis of docosahexaenoate-containing glycerolipid molecular species in the retina. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478376 |
| Kim HY et al. | Inhibition of neuronal apoptosis by polyunsaturated fatty acids. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478377 |
| Yavin E et al. | Docosahexaenoic acid accumulation in the prenatal brain: prooxidant and antioxidant features. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478378 |
| Litman BJ et al. | The role of docosahexaenoic acid containing phospholipids in modulating G protein-coupled signaling pathways: visual transduction. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478379 |
| Farooqui AA and Horrocks LA | Plasmalogens, phospholipase A2, and docosahexaenoic acid turnover in brain tissue. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478381 |
| Faust PL et al. | The peroxisome deficient PEX2 Zellweger mouse: pathologic and biochemical correlates of lipid dysfunction. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478384 |
| Salem N et al. | Alterations in brain function after loss of docosahexaenoate due to dietary restriction of n-3 fatty acids. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478385 |
| Martinez M | Restoring the DHA levels in the brains of Zellweger patients. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478386 |
| Katz R et al. | Brain uptake and utilization of fatty acids: recommendations for future research. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478387 |
| Watkins PA et al. | Brain uptake and utilization of fatty acids: applications to peroxisomal biogenesis diseases. | 2001 Apr-Jun | J. Mol. Neurosci. | pmid:11478388 |
| Le Petit-Thévenin J et al. | Effects of arachidonic and docosahexaenoic acids on secretion and degradation of bile salt-dependent lipase in AR4-2J cells. | 2001 | J. Lipid Res. | pmid:11483623 |
| Pawlosky RJ et al. | Physiological compartmental analysis of alpha-linolenic acid metabolism in adult humans. | 2001 | J. Lipid Res. | pmid:11483627 |
| O'Connor DL et al. | Growth and development in preterm infants fed long-chain polyunsaturated fatty acids: a prospective, randomized controlled trial. | 2001 | Pediatrics | pmid:11483801 |