TRIPALMITIN is a lipid of Glycerolipids (GL) class. Tripalmitin is associated with abnormalities such as Atherosclerosis, Hypoalphalipoproteinemias, Cystic Fibrosis, PARKINSON DISEASE, LATE-ONSET and Obesity. The involved functions are known as 5-(carboxyamino)imidazole ribonucleotide mutase activity, Certification, phosphatidylcholine-sterol O-acyltransferase activity, Regulation and Uptake. Tripalmitin often locates in Blood, Hepatic, Body tissue, Gastric mucosa and Biopsy sample. The associated genes with TRIPALMITIN are PON1 gene, very high density lipoproteins, THEMIS gene, HEPATIC PROTEIN and chylomicron remnant. The related lipids are Fatty Acids, Total cholesterol, Nonesterified Fatty Acids, Palmitates and tristearin.
To understand associated biological information of TRIPALMITIN, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
TRIPALMITIN is suspected in Atherosclerosis, Fatty Liver, Cystic Fibrosis, Hypoalphalipoproteinemias, PARKINSON DISEASE, LATE-ONSET, Obesity and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with TRIPALMITIN
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leishmaniasis, Visceral | D007898 | 13 associated lipids |
| Respiratory Distress Syndrome, Newborn | D012127 | 5 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Malabsorption Syndromes | D008286 | 16 associated lipids |
| HIV-Associated Lipodystrophy Syndrome | D039682 | 3 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kyriakides EC et al. | Alterations in phosphatidylcholine species and their reversal in pulmonary surfactant during essential fatty-acid deficiency. | 1976 | Biochim. Biophys. Acta | pmid:988841 |
| Holleran AL et al. | Effect of tamoxifen on cholesterol synthesis in HepG2 cells and cultured rat hepatocytes. | 1998 | Metab. Clin. Exp. | pmid:9867082 |
| Murphy JL et al. | Metabolic handling of 13C labelled tripalmitin in healthy controls and patients with cystic fibrosis. | 1998 | Arch. Dis. Child. | pmid:9771251 |
| Bennoson J et al. | Influence of lipid content of testmeal on gastrointestinal handling and metabolic partitioning of dietary lipid in young men. | 1998 | Biochem. Soc. Trans. | pmid:9649863 |
| Minami M et al. | Suppression of endothelin-3-induced nitric oxide synthesis by triglyceride in human endothelial cells. | 1998 | J. Cardiovasc. Pharmacol. | pmid:9595514 |
| Costa G et al. | Effects of human and experimental cancer on the conversion of 14C tripalmitin to 14CO2. | 1976 | Cancer | pmid:953967 |
| Salter AM et al. | The effect of different dietary fatty acids on lipoprotein metabolism: concentration-dependent effects of diets enriched in oleic, myristic, palmitic and stearic acids. | 1998 | Br. J. Nutr. | pmid:9536864 |
| Baumeister W et al. | Radiation damage in tripalmitin layers studied by means of infrared spectroscopy and electron microscopy. | 1976 | Biophys. J. | pmid:938719 |
| Erdahl WL and Privett OS | A new system for lipid analysis by liquid chromatography-mass spectrometry. | 1977 | Lipids | pmid:916821 |
| Mitjavila MT et al. | Effect of degree of unsaturation in dietary fatty acids on arachidonic acid mobilization by peritoneal macrophages. | 1996 | Lipids | pmid:8784749 |
| Salter AM et al. | Interactive effects of dietary cholesterol and saturated fat on low density lipoprotein cholesterol. | 1996 | Biochem. Soc. Trans. | pmid:8736838 |
| Sakayama K et al. | Recombinant human tumour necrosis factor-alpha suppresses synthesis, activity and secretion of lipoprotein lipase in cultures of a human osteosarcoma cell line. | 1996 | Biochem. J. | pmid:8670156 |
| Uzawa H et al. | Determination of the lipase stereoselectivities using circular dichroism (CD); lipases produce chiral di-O-acylglycerols from achiral tri-O-acylglycerols. | 1993 | Biochim. Biophys. Acta | pmid:8323964 |
| Ellerbe P et al. | Isotope dilution mass spectrometry as a candidate definitive method for determining total glycerides and triglycerides in serum. | 1995 | Clin. Chem. | pmid:7882515 |
| Isler D et al. | Effect of the lipase inhibitor orlistat and of dietary lipid on the absorption of radiolabelled triolein, tri-gamma-linolenin and tripalmitin in mice. | 1995 | Br. J. Nutr. | pmid:7632666 |
| Bennett AJ et al. | Regulation of hamster hepatic microsomal triglyceride transfer protein mRNA levels by dietary fats. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7626061 |
| Muntané J et al. | Dietary lipid and iron status modulate lipid peroxidation in rats with induced adjuvant arthritis. | 1995 | J. Nutr. | pmid:7616310 |
| Newcomer AD et al. | Triolein breath test: a sensitive and specific test for fat malabsorption. | 1979 | Gastroenterology | pmid:758149 |
| Bennett AJ et al. | Modulation of hepatic apolipoprotein B, 3-hydroxy-3-methylglutaryl-CoA reductase and low-density lipoprotein receptor mRNA and plasma lipoprotein concentrations by defined dietary fats. Comparison of trimyristin, tripalmitin, tristearin and triolein. | 1995 | Biochem. J. | pmid:7575449 |
| Rumjanek FD and Simpson AJ | The incorporation and utilization of radiolabelled lipids by adult Schistosoma mansoni in vitro. | 1980 | Mol. Biochem. Parasitol. | pmid:7442709 |
| Herzberg GR and Janmohamed N | Regulation of hepatic lipogenesis by dietary maize oil or tripalmitin in the meal-fed mouse. | 1980 | Br. J. Nutr. | pmid:7417398 |
| Meeker HE et al. | Clinical Experiences in 14C-tripalmitin breath test for fat malabsorption. | 1980 | Am. J. Gastroenterol. | pmid:7405923 |
| Needs EC and Welch VA | Intermolecular specificity of pancreatic lipase in the lipolysis of triacylglycerols containing phytanic acid. | 1978 | Biochem. J. | pmid:736903 |
| Schnitzer-Polokoff R and Suttie JW | Effect of fluoride on the absorption of dietary fat in rats. | 1981 | J. Nutr. | pmid:7205406 |
| Lo CW et al. | Breath tests: principles, problems, and promise. | 1982 | Adv Pediatr | pmid:7180696 |
| Zimowski J et al. | Enzymatic synthesis of wax esters by cell-free preparations from Sinapis alba L roots. | 1982 | Acta Biochim. Pol. | pmid:7180324 |
| Delaney WE et al. | Fatty acid breath test values in the malabsorption range in cancer patients. | 1982 | Nutr Cancer | pmid:7134008 |
| McNamara JP et al. | Lipoprotein lipase and lipid metabolism in muscle and adipose tissues of Zucker rats. | 1982 | Am. J. Physiol. | pmid:7114287 |
| Ingham E et al. | Partial purification and characterization of lipase (EC 3.1.1.3) from Propionibacterium acnes. | 1981 | J. Gen. Microbiol. | pmid:7035615 |
| Lutton C et al. | Effect of dietary long-chain fatty acids on the rates of cholesterol turnover processes, cholesterol origin and distribution in the rat intestinal lumen. | 1980 | Reprod Nutr Dev | pmid:6897578 |
| Gorrissen H et al. | Deuterium magnetic resonance of triacylglycerols in phospholipid bilayers. | 1982 | Chem. Phys. Lipids | pmid:6890881 |
| Crane RT et al. | Complexities in lipid quantitation using thin layer chromatography for separation and flame ionization for detection. | 1983 | Lipids | pmid:6835038 |
| Hamilton JA et al. | 1H NMR studies of lymph chylomicra and very low density lipoproteins from nonhuman primates. | 1983 | J. Biol. Chem. | pmid:6822495 |
| Halevy O and Sklan D | A low molecular weight zinc-copper lipolytic protein from chick liver. | 1984 | Life Sci. | pmid:6727548 |
| Clifford CK et al. | Effect of dietary triglycerides on lymphocyte transformation in rats. | 1983 | J. Nutr. | pmid:6600786 |
| Balint JA et al. | The effects of essential fatty acid deficiency on pulmonary alveolar macrophage function. | 1985 | Trans. Am. Clin. Climatol. Assoc. | pmid:6537682 |
| Björkhem I et al. | Effect of different dietary triglycerides on 7alpha-hydroxylation of cholesterol and other mixed-function oxidations. | 1978 | J. Lipid Res. | pmid:650092 |
| King RF et al. | Calculation of short-term changes in body fat from measurement of respiratory gas exchange. | 1984 | Metab. Clin. Exp. | pmid:6433148 |
| Banno Y et al. | Targeting of asialofetuin sugar chain-bearing liposomes to liver lysosomes. | 1983 | Biochem. Int. | pmid:6207826 |
| Burnell JM et al. | The relationship of fatty acid composition and surface activity of lung extracts. | 1978 | Respir Physiol | pmid:580481 |
| Kaplan A and Teng MH | Interaction of beef liver lipase with mixed micelles of tripalmitin and Triton X-100. | 1971 | J. Lipid Res. | pmid:5579262 |
| Clark SB et al. | Fat absorption in essential fatty acid deficiency: a model experimental approach to studies of the mechanism of fat malabsorption of unknown etiology. | 1973 | J. Lipid Res. | pmid:4729974 |
| Kariya M and Kaplan A | Effects of acidic phospholipids, nucleotides, and heparin on the activity of lipase from rat liver lysosomes. | 1973 | J. Lipid Res. | pmid:4698271 |
| Griffiths LA and Smith GE | Metabolism of myricetin and related compounds in the rat. Metabolite formation in vivo and by the intestinal microflora in vitro. | 1972 | Biochem. J. | pmid:4655415 |
| Suwalsky M et al. | X-ray studies on phospholipid bilayers. V. Interactions with DDT. | 1985 Jul-Aug | Z. Naturforsch., C, Biosci. | pmid:4050029 |
| Rao GA et al. | Comparison of the thin layer chromatography/flame ionization detection system with other methods for the quantitative analysis of liver lipid contents in alcohol-fed rats and controls. | 1985 | Lipids | pmid:4033371 |
| Gillin JS et al. | Malabsorption and mucosal abnormalities of the small intestine in the acquired immunodeficiency syndrome. | 1985 | Ann. Intern. Med. | pmid:3985513 |
| Trimble ME | Effect of free fatty acids on renal metabolism of very low density lipoprotein triglyceride. | 1985 | Ren Physiol | pmid:3969505 |
| Altura BM and Gebrewold A | Chemical blockade of the reticuloendothelial system results in arteriolar spasms: possible role of endothelial cells. | 1985 | Microcirc Endothelium Lymphatics | pmid:3836339 |
| Rogel AM and Watkins BA | Liver subcellular fatty acid profiles of chicks fed diets containing hydrogenated fats and varying linoleate levels. | 1987 | Lipids | pmid:3669926 |
| Sulpice JC et al. | Diet and sterol biohydrogenation in the rat: occurrence of epicoprostanol. | 1978 | Lipids | pmid:345032 |
| Lohninger A et al. | Determination of triacylglycerols in serum by capillary gas chromatography with trinonadecanoylglycerol as internal standard. | 1988 | Anal. Biochem. | pmid:3407934 |
| Sebastian J and Kolattukudy PE | Purification and characterization of cutinase from a fluorescent Pseudomonas putida bacterial strain isolated from phyllosphere. | 1988 | Arch. Biochem. Biophys. | pmid:3130804 |
| Hamosh M et al. | Fat digestion in the stomach of premature infants. I. Characteristics of lipase activity. | 1978 | J. Pediatr. | pmid:29953 |
| Iima R et al. | Thermal Behavior of F Nuclear Magnetic Resonance Signal of F-Containing Compound in Lipid Nano-Emulsion for Potential Tumor Diagnosis. | 2018 | AAPS PharmSciTech | pmid:29943279 |
| Hart SM et al. | Emulsion droplet crystallinity attenuates early in vitro digestive lipolysis and beta-carotene bioaccessibility. | 2018 | Food Chem | pmid:29699655 |
| Jawahar N et al. | Enhanced oral bioavailability of an antipsychotic drug through nanostructured lipid carriers. | 2018 | Int. J. Biol. Macromol. | pmid:29402457 |
| Shiota M et al. | Mass spectrometric imaging of localization of fat molecules in water-in-oil emulsions containing semi-solid fat. | 2018 | Food Chem | pmid:29287345 |
| Nakasato DY et al. | Evaluation of the effects of polymeric chitosan/tripolyphosphate and solid lipid nanoparticles on germination of Zea mays, Brassica rapa and Pisum sativum. | 2017 | Ecotoxicol. Environ. Saf. | pmid:28437729 |
| Müller M et al. | Development of solvent systems with room temperature ionic liquids for the countercurrent chromatographic separation of very nonpolar lipid compounds. | 2017 | J Chromatogr A | pmid:28179081 |
| Lopes DG et al. | Microphase separation in solid lipid dosage forms as the cause of drug release instability. | 2017 | Int J Pharm | pmid:28007547 |
| Croce A et al. | A Model Study to Unravel the Complexity of Bio-Oil from Organic Wastes. | 2017 | ChemSusChem | pmid:28004532 |
| Kimura W and Endo Y | Decomposition products of glycidyl esters of fatty acids by heating. | 2017 | Biosci. Biotechnol. Biochem. | pmid:27884080 |
| Stocker E et al. | Application of ICH Q9 Quality Risk Management Tools for Advanced Development of Hot Melt Coated Multiparticulate Systems. | 2017 | J Pharm Sci | pmid:27842971 |
| Ganzuka M et al. | [Lung lavage and artificial surfactant replacement therapy--animal experimentation and clinical application]. | 1989 | Masui | pmid:2778950 |
| Bayard M et al. | Free fatty acids and their esters modulate isothermal crystallization of anhydrous milk fat. | 2017 | Food Chem | pmid:27719901 |
| Hathout RM and Metwally AA | Towards better modelling of drug-loading in solid lipid nanoparticles: Molecular dynamics, docking experiments and Gaussian Processes machine learning. | 2016 | Eur J Pharm Biopharm | pmid:27449631 |
| Vijayakumar A et al. | Quercetin-Loaded Solid Lipid Nanoparticle Dispersion with Improved Physicochemical Properties and Cellular Uptake. | 2017 | AAPS PharmSciTech | pmid:27368922 |
| Hamilton JA | Interactions of triglycerides with phospholipids: incorporation into the bilayer structure and formation of emulsions. | 1989 | Biochemistry | pmid:2730879 |
| Pawlik A et al. | Food-grade Pickering emulsions stabilised with solid lipid particles. | 2016 | Food Funct | pmid:27198879 |
| Silva RC et al. | Microscopic approach of the crystallization of tripalmitin and tristearin by microscopy. | 2016 | Chem. Phys. Lipids | pmid:27087282 |
| Pförringer D et al. | Antimicrobial Formulations of Absorbable Bone Substitute Materials as Drug Carriers Based on Calcium Sulfate. | 2016 | Antimicrob. Agents Chemother. | pmid:27067337 |
| Zhang S et al. | Hydrophobic fractal surface from glycerol tripalmitate and the effects on C6 glioma cell growth. | 2016 | Colloids Surf B Biointerfaces | pmid:26970826 |
| Seedat N et al. | Co-encapsulation of multi-lipids and polymers enhances the performance of vancomycin in lipid-polymer hybrid nanoparticles: In vitro and in silico studies. | 2016 | Mater Sci Eng C Mater Biol Appl | pmid:26838890 |
| Liu KM and Liu KJ | Lipase-catalyzed synthesis of palmitanilide: Kinetic model and antimicrobial activity study. | 2016 | Enzyme Microb. Technol. | pmid:26672452 |
| Becker K et al. | Advanced stable lipid-based formulations for a patient-centric product design. | 2016 | Int J Pharm | pmid:26621689 |
| Argilés J and Herrera E | Appearance of circulating and tissue 14C-lipids after oral 14C-tripalmitate administration in the late pregnant rat. | 1989 | Metab. Clin. Exp. | pmid:2643750 |
| Li R et al. | Enzymatic Synthesis of Refined Olive Oil-Based Structured Lipid Containing Omega -3 and -6 Fatty Acids for Potential Application in Infant Formula. | 2015 | J. Food Sci. | pmid:26408984 |
| Bondì ML et al. | Lipid nanocarriers containing sorafenib inhibit colonies formation in human hepatocarcinoma cells. | 2015 | Int J Pharm | pmid:26211902 |
| Aramaki K et al. | Preparation of O/I1-type Emulsions and S/I1-type Dispersions Encapsulating UV-Absorbing Agents. | 2015 | J Oleo Sci | pmid:26178999 |
| Wong PT et al. | Effect of cholesterol on structural and dynamic properties of tripalmitoyl glyceride. A high-pressure infrared spectroscopic study. | 1989 | Biophys. J. | pmid:2605300 |
| Ontko JA et al. | Formation of crystalline tripalmitin-rich spicules in isolated hepatocytes. | 1989 | J. Lipid Res. | pmid:2600542 |
| Ucisik MH et al. | S-layer fusion protein as a tool functionalizing emulsomes and CurcuEmulsomes for antibody binding and targeting. | 2015 | Colloids Surf B Biointerfaces | pmid:25734967 |
| Schmiele M et al. | Mesoscopic structures of triglyceride nanosuspensions studied by small-angle X-ray and neutron scattering and computer simulations. | 2014 | J Phys Chem B | pmid:24950992 |
| Schmiele M et al. | Formation of liquid crystalline phases in aqueous suspensions of platelet-like tripalmitin nanoparticles. | 2014 | J Chem Phys | pmid:24908039 |
| Hu WW et al. | Morphology and functions of astrocytes cultured on water-repellent fractal tripalmitin surfaces. | 2014 | Biomaterials | pmid:24894646 |
| Christophersen PC et al. | Solid lipid particles for oral delivery of peptide and protein drugs II--the digestion of trilaurin protects desmopressin from proteolytic degradation. | 2014 | Pharm. Res. | pmid:24623481 |
| Yoshikawa S et al. | Promotional effects of new types of additives on fat crystallization. | 2014 | J Oleo Sci | pmid:24599107 |
| Jones E et al. | In vitro comparative evaluation of monolayered multipolymeric films embedded with didanosine-loaded solid lipid nanoparticles: a potential buccal drug delivery system for ARV therapy. | 2014 | Drug Dev Ind Pharm | pmid:24576267 |
| Ucisik MH et al. | Characterization of CurcuEmulsomes: nanoformulation for enhanced solubility and delivery of curcumin. | 2013 | J Nanobiotechnology | pmid:24314310 |
| Wasutrasawat P et al. | Drug solubilisation in lipid nanoparticles containing high melting point triglycerides. | 2013 | Eur J Pharm Biopharm | pmid:23688806 |
| Lichtenberger LM et al. | Gastric protective activity of mixtures of saturated polar and neutral lipids in rats. | 1990 | Gastroenterology | pmid:2365185 |
| Nagachinta S and Akoh CC | Synthesis of structured lipid enriched with omega fatty acids and sn-2 palmitic acid by enzymatic esterification and its incorporation in powdered infant formula. | 2013 | J. Agric. Food Chem. | pmid:23597247 |
| Vitorino C et al. | Co-encapsulating nanostructured lipid carriers for transdermal application: from experimental design to the molecular detail. | 2013 | J Control Release | pmid:23454133 |
| Fadda P et al. | Solid lipid nanoparticle preparation by a warm microemulsion based process: influence of microemulsion microstructure. | 2013 | Int J Pharm | pmid:23422277 |
| Kann B and Windbergs M | Chemical imaging of drug delivery systems with structured surfaces-a combined analytical approach of confocal raman microscopy and optical profilometry. | 2013 | AAPS J | pmid:23358922 |
| Clarke SD et al. | Dietary polyunsaturated fats uniquely suppress rat liver fatty acid synthase and S14 mRNA content. | 1990 | J. Nutr. | pmid:2313387 |
| Chen C et al. | Orally delivered salmon calcitonin-loaded solid lipid nanoparticles prepared by micelle-double emulsion method via the combined use of different solid lipids. | 2013 | Nanomedicine (Lond) | pmid:23075315 |
| Yehia SA et al. | Biodegradable donepezil lipospheres for depot injection: optimization and in-vivo evaluation. | 2012 | J. Pharm. Pharmacol. | pmid:22943173 |
| Szakonyi G and Zelkó R | [Taste-masking possibilities in solid dosage forms]. | 2012 | Acta Pharm Hung | pmid:22870781 |