TRIPALMITIN is a lipid of Glycerolipids (GL) class. Tripalmitin is associated with abnormalities such as Atherosclerosis, Hypoalphalipoproteinemias, Cystic Fibrosis, PARKINSON DISEASE, LATE-ONSET and Obesity. The involved functions are known as 5-(carboxyamino)imidazole ribonucleotide mutase activity, Certification, phosphatidylcholine-sterol O-acyltransferase activity, Regulation and Uptake. Tripalmitin often locates in Blood, Hepatic, Body tissue, Gastric mucosa and Biopsy sample. The associated genes with TRIPALMITIN are PON1 gene, very high density lipoproteins, THEMIS gene, HEPATIC PROTEIN and chylomicron remnant. The related lipids are Fatty Acids, Total cholesterol, Nonesterified Fatty Acids, Palmitates and tristearin.
To understand associated biological information of TRIPALMITIN, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
TRIPALMITIN is suspected in Atherosclerosis, Fatty Liver, Cystic Fibrosis, Hypoalphalipoproteinemias, PARKINSON DISEASE, LATE-ONSET, Obesity and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with TRIPALMITIN
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leishmaniasis, Visceral | D007898 | 13 associated lipids |
| Respiratory Distress Syndrome, Newborn | D012127 | 5 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Malabsorption Syndromes | D008286 | 16 associated lipids |
| HIV-Associated Lipodystrophy Syndrome | D039682 | 3 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hart SM et al. | Emulsion droplet crystallinity attenuates early in vitro digestive lipolysis and beta-carotene bioaccessibility. | 2018 | Food Chem | pmid:29699655 |
| Shiota M et al. | Mass spectrometric imaging of localization of fat molecules in water-in-oil emulsions containing semi-solid fat. | 2018 | Food Chem | pmid:29287345 |
| Bayard M et al. | Free fatty acids and their esters modulate isothermal crystallization of anhydrous milk fat. | 2017 | Food Chem | pmid:27719901 |
| Pawlik A et al. | Food-grade Pickering emulsions stabilised with solid lipid particles. | 2016 | Food Funct | pmid:27198879 |
| Ciafardini G et al. | Lipase production by yeasts from extra virgin olive oil. | 2006 | Food Microbiol. | pmid:16942987 |
| Lichtenberger LM et al. | Gastric protective activity of mixtures of saturated polar and neutral lipids in rats. | 1990 | Gastroenterology | pmid:2365185 |
| Newcomer AD et al. | Triolein breath test: a sensitive and specific test for fat malabsorption. | 1979 | Gastroenterology | pmid:758149 |
| Aihara Y et al. | Construction of a taste-blind medaka fish and quantitative assay of its preference-aversion behavior. | 2008 | Genes Brain Behav. | pmid:18700838 |
| Lugea A et al. | Surface hydrophobicity of the rat colonic mucosa is a defensive barrier against macromolecules and toxins. | 2000 | Gut | pmid:10716681 |
| Fujimoto T et al. | Lipid droplets: a classic organelle with new outfits. | 2008 | Histochem. Cell Biol. | pmid:18546013 |
| Holmes AK et al. | Ultrasonic scattering in chocolate and model systems containing sucrose, tripalmitin and olive oil. | 2007 | IEEE Trans Ultrason Ferroelectr Freq Control | pmid:18051170 |
| Mukherjee S et al. | Solid lipid nanoparticles: a modern formulation approach in drug delivery system. | 2009 | Indian J Pharm Sci | pmid:20502539 |
| Solanki GK et al. | Polaron hopping in some biomolecular solids and their charge transfer complexes. | 2008 | Indian J. Biochem. Biophys. | pmid:19239130 |
| Fulda S et al. | Cellular stress responses: cell survival and cell death. | 2010 | Int J Cell Biol | pmid:20182529 |
| Qi C et al. | Preparation and characterization of catalase-loaded solid lipid nanoparticles protecting enzyme against proteolysis. | 2011 | Int J Mol Sci | pmid:21845078 |
| Zarevúcka M and Wimmer Z | Plant products for pharmacology: application of enzymes in their transformations. | 2008 | Int J Mol Sci | pmid:19330086 |
| Kashanian S et al. | New surface-modified solid lipid nanoparticles using N-glutaryl phosphatidylethanolamine as the outer shell. | 2011 | Int J Nanomedicine | pmid:22114489 |
| Mansour HM et al. | Nanomedicine in pulmonary delivery. | 2009 | Int J Nanomedicine | pmid:20054434 |
| Uner M and Yener G | Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives. | 2007 | Int J Nanomedicine | pmid:18019829 |
| Urbán-Morlán Z et al. | Preparation and characterization of solid lipid nanoparticles containing cyclosporine by the emulsification-diffusion method. | 2010 | Int J Nanomedicine | pmid:20856836 |
| Appel B et al. | Lipidic implants for controlled release of bioactive insulin: effects on cartilage engineered in vitro. | 2006 | Int J Pharm | pmid:16569486 |
| Elkharraz K et al. | Paclitaxel-loaded microparticles and implants for the treatment of brain cancer: preparation and physicochemical characterization. | 2006 | Int J Pharm | pmid:16490330 |
| Koennings S et al. | In vitro investigation of lipid implants as a controlled release system for interleukin-18. | 2006 | Int J Pharm | pmid:16513302 |
| Guse C et al. | Biocompatibility and erosion behavior of implants made of triglycerides and blends with cholesterol and phospholipids. | 2006 | Int J Pharm | pmid:16517106 |
| Tsai MJ et al. | Baicalein loaded in tocol nanostructured lipid carriers (tocol NLCs) for enhanced stability and brain targeting. | 2012 | Int J Pharm | pmid:22193056 |
| Garcia-Fuentes M et al. | New surface-modified lipid nanoparticles as delivery vehicles for salmon calcitonin. | 2005 | Int J Pharm | pmid:15885464 |
| Illing A and Unruh T | Investigation on the flow behavior of dispersions of solid triglyceride nanoparticles. | 2004 | Int J Pharm | pmid:15454303 |
| Lopes DG et al. | Microphase separation in solid lipid dosage forms as the cause of drug release instability. | 2017 | Int J Pharm | pmid:28007547 |
| Becker K et al. | Advanced stable lipid-based formulations for a patient-centric product design. | 2016 | Int J Pharm | pmid:26621689 |
| Bondì ML et al. | Lipid nanocarriers containing sorafenib inhibit colonies formation in human hepatocarcinoma cells. | 2015 | Int J Pharm | pmid:26211902 |
| Witzleb R et al. | Dissolution of solid lipid extrudates in biorelevant media. | 2012 | Int J Pharm | pmid:22044538 |
| Kumar VV et al. | Development and evaluation of nitrendipine loaded solid lipid nanoparticles: influence of wax and glyceride lipids on plasma pharmacokinetics. | 2007 | Int J Pharm | pmid:17161566 |
| Fadda P et al. | Solid lipid nanoparticle preparation by a warm microemulsion based process: influence of microemulsion microstructure. | 2013 | Int J Pharm | pmid:23422277 |
| Reithmeier H et al. | Development and characterization of lipid microparticles as a drug carrier for somatostatin. | 2001 | Int J Pharm | pmid:11337157 |
| Olbrich C et al. | Lipase degradation of Dynasan 114 and 116 solid lipid nanoparticles (SLN)--effect of surfactants, storage time and crystallinity. | 2002 | Int J Pharm | pmid:11955810 |
| Ahlin P et al. | Influence of spin probe structure on its distribution in SLN dispersions. | 2000 | Int J Pharm | pmid:10699727 |
| Schwendner SW et al. | Potential organ or tumor imaging agents. 32. A triglyceride ester of p-iodophenyl pentadecanoic acid as a potential hepatic imaging agent. | 1992 | Int J Rad Appl Instrum B | pmid:1522018 |
| Jawahar N et al. | Enhanced oral bioavailability of an antipsychotic drug through nanostructured lipid carriers. | 2018 | Int. J. Biol. Macromol. | pmid:29402457 |
| Schneider M et al. | A new ultrasound contrast agent based on biodegradable polymeric microballoons. | 1991 | Invest Radiol | pmid:1808125 |
| Potta SG et al. | Development of solid lipid nanoparticles for enhanced solubility of poorly soluble drugs. | 2010 | J Biomed Nanotechnol | pmid:21361127 |
| Schmiele M et al. | Formation of liquid crystalline phases in aqueous suspensions of platelet-like tripalmitin nanoparticles. | 2014 | J Chem Phys | pmid:24908039 |
| Hazotte A et al. | High-temperature micro liquid chromatography for lipid molecular species analysis with evaporative light scattering detection. | 2007 | J Chromatogr A | pmid:17161844 |
| Gaudin K et al. | Adaptation of an evaporative light-scattering detector to micro and capillary liquid chromatography and response assessment. | 2004 | J Chromatogr A | pmid:15532554 |
| HolÄapek M et al. | Regioisomeric analysis of triacylglycerols using silver-ion liquid chromatography-atmospheric pressure chemical ionization mass spectrometry: comparison of five different mass analyzers. | 2010 | J Chromatogr A | pmid:21075380 |
| Müller M et al. | Development of solvent systems with room temperature ionic liquids for the countercurrent chromatographic separation of very nonpolar lipid compounds. | 2017 | J Chromatogr A | pmid:28179081 |
| Helgason T et al. | Effect of surfactant surface coverage on formation of solid lipid nanoparticles (SLN). | 2009 | J Colloid Interface Sci | pmid:19380149 |
| Garcia-Fuentes M et al. | Design and characterization of a new drug nanocarrier made from solid-liquid lipid mixtures. | 2005 | J Colloid Interface Sci | pmid:15837476 |
| Tikka HK et al. | Soiling of pure PVC studied by FTIR, optical microscopy, and AFM. | 2004 | J Colloid Interface Sci | pmid:15082372 |
| Windbergs M et al. | Tailor-made dissolution profiles by extruded matrices based on lipid polyethylene glycol mixtures. | 2009 | J Control Release | pmid:19358867 |
| Tosi A et al. | Tripalmitin-based cationic lipospheres: preparation, characterization and in Lab-on-a-chip applications. | 2006 | J Control Release | pmid:17718971 |
| Vitorino C et al. | Co-encapsulating nanostructured lipid carriers for transdermal application: from experimental design to the molecular detail. | 2013 | J Control Release | pmid:23454133 |
| Bunjes H and Koch MH | Saturated phospholipids promote crystallization but slow down polymorphic transitions in triglyceride nanoparticles. | 2005 | J Control Release | pmid:16023752 |
| Manjunath K and Venkateswarlu V | Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration. | 2005 | J Control Release | pmid:16014318 |
| Venkateswarlu V and Manjunath K | Preparation, characterization and in vitro release kinetics of clozapine solid lipid nanoparticles. | 2004 | J Control Release | pmid:15023472 |
| Severino P et al. | Current State-of-Art and New Trends on Lipid Nanoparticles (SLN and NLC) for Oral Drug Delivery. | 2012 | J Drug Deliv | pmid:22175030 |
| Manjunath K and Venkateswarlu V | Pharmacokinetics, tissue distribution and bioavailability of nitrendipine solid lipid nanoparticles after intravenous and intraduodenal administration. | 2006 | J Drug Target | pmid:17090399 |
| Pal A et al. | Development and evaluation of tripalmitin emulsomes for the treatment of experimental visceral leishmaniasis. | 2012 | J Liposome Res | pmid:21740098 |
| Potta SG et al. | Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility. | 2011 | J Microencapsul | pmid:21171818 |
| Ucisik MH et al. | Characterization of CurcuEmulsomes: nanoformulation for enhanced solubility and delivery of curcumin. | 2013 | J Nanobiotechnology | pmid:24314310 |
| Mihara H et al. | [Effect of crystallization temperature of palm oil on its crystallization. IV. The influence of tripalmitoylglycerol (PPP) on the crystallization of 1,3-dipalmitoyl-2-oleoyl-glycerol (POP) and 1,2-dioleoyl-3-palmitoyl-glycerol (POO)]. | 2007 | J Oleo Sci | pmid:17898485 |
| Yoshikawa S et al. | Promotional effects of new types of additives on fat crystallization. | 2014 | J Oleo Sci | pmid:24599107 |
| Aramaki K et al. | Preparation of O/I1-type Emulsions and S/I1-type Dispersions Encapsulating UV-Absorbing Agents. | 2015 | J Oleo Sci | pmid:26178999 |
| Tursilli R et al. | Enhancement of melatonin photostability by encapsulation in lipospheres. | 2006 | J Pharm Biomed Anal | pmid:16242283 |
| Hitzman CJ et al. | Development of a respirable, sustained release microcarrier for 5-fluorouracil II: In vitro and in vivo optimization of lipid coated nanoparticles. | 2006 | J Pharm Sci | pmid:16570303 |
| Windbergs M et al. | Investigating the relationship between drug distribution in solid lipid matrices and dissolution behaviour using Raman spectroscopy and mapping. | 2010 | J Pharm Sci | pmid:19691104 |
| Stocker E et al. | Application of ICH Q9 Quality Risk Management Tools for Advanced Development of Hot Melt Coated Multiparticulate Systems. | 2017 | J Pharm Sci | pmid:27842971 |
| Haaser M et al. | Analysis of matrix dosage forms during dissolution testing using raman microscopy. | 2011 | J Pharm Sci | pmid:21560128 |
| Hall A et al. | Modeling of the triglyceride-rich core in lipoprotein particles. | 2008 | J Phys Chem B | pmid:18844397 |
| Schmiele M et al. | Mesoscopic structures of triglyceride nanosuspensions studied by small-angle X-ray and neutron scattering and computer simulations. | 2014 | J Phys Chem B | pmid:24950992 |
| Srivastava A et al. | Candida rugosa lipase LIP1-catalyzed transesterification to produce human milk fat substitute. | 2006 | J. Agric. Food Chem. | pmid:16819932 |
| Smith KW et al. | Slow recrystallization of tripalmitoylglycerol from MCT oil observed by 2H NMR. | 2007 | J. Agric. Food Chem. | pmid:17880150 |
| Greiner M et al. | Temperature- and pressure-dependent densities, self-diffusion coefficients, and phase behavior of monoacid saturated triacylglycerides: toward molecular-level insights into processing. | 2012 | J. Agric. Food Chem. | pmid:22500590 |
| Qin XL et al. | Lipase-catalyzed incorporation of different Fatty acids into tripalmitin-enriched triacylglycerols: effect of reaction parameters. | 2012 | J. Agric. Food Chem. | pmid:22360498 |
| Helgason T et al. | Impact of surfactant properties on oxidative stability of beta-carotene encapsulated within solid lipid nanoparticles. | 2009 | J. Agric. Food Chem. | pmid:19691283 |
| Boyle-Roden E and Khan MA | Quantitative analysis of surface-located triacylglycerol in intact emulsion particles. | 2001 | J. Agric. Food Chem. | pmid:11308361 |
| Karabulut I et al. | Fatty acid selectivity of lipases during acidolysis reaction between oleic acid and monoacid triacylglycerols. | 2009 | J. Agric. Food Chem. | pmid:19835376 |
| Sahin N et al. | Lipase-catalyzed acidolysis of tripalmitin with hazelnut oil fatty acids and stearic acid to produce human milk fat substitutes. | 2005 | J. Agric. Food Chem. | pmid:15998148 |
| Teichert SA and Akoh CC | Stearidonic acid soybean oil enriched with palmitic acid at the sn-2 position by enzymatic interesterification for use as human milk fat analogues. | 2011 | J. Agric. Food Chem. | pmid:21517012 |
| Teichert SA and Akoh CC | Characterization of stearidonic acid soybean oil enriched with palmitic acid produced by solvent-free enzymatic interesterification. | 2011 | J. Agric. Food Chem. | pmid:21830790 |
| Nagachinta S and Akoh CC | Synthesis of structured lipid enriched with omega fatty acids and sn-2 palmitic acid by enzymatic esterification and its incorporation in powdered infant formula. | 2013 | J. Agric. Food Chem. | pmid:23597247 |
| Teichert SA and Akoh CC | Modifications of stearidonic acid soybean oil by enzymatic acidolysis for the production of human milk fat analogues. | 2011 | J. Agric. Food Chem. | pmid:22097918 |
| Martos I et al. | Identification of flavonoid markers for the botanical origin of Eucalyptus honey. | 2000 | J. Agric. Food Chem. | pmid:10820049 |
| Martos I et al. | Flavonoids in monospecific eucalyptus honeys from Australia. | 2000 | J. Agric. Food Chem. | pmid:11052728 |
| Miyazaki M et al. | The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1. | 2000 | J. Biol. Chem. | pmid:10899171 |
| Huang Y et al. | Expression and characterization of a PNPLA3 protein isoform (I148M) associated with nonalcoholic fatty liver disease. | 2011 | J. Biol. Chem. | pmid:21878620 |
| Hamilton JA et al. | 1H NMR studies of lymph chylomicra and very low density lipoproteins from nonhuman primates. | 1983 | J. Biol. Chem. | pmid:6822495 |
| LOSSOW WJ and CHAIKOFF IL | Secretion of intravenously administered tripalmitin-1-C14 and octanoate-1-C14 into milk by the lactating rat. | 1958 | J. Biol. Chem. | pmid:13502382 |
| Minami M et al. | Suppression of endothelin-3-induced nitric oxide synthesis by triglyceride in human endothelial cells. | 1998 | J. Cardiovasc. Pharmacol. | pmid:9595514 |
| Maduko CO et al. | Enzymatic production of infant milk fat analogs containing palmitic acid: optimization of reactions by response surface methodology. | 2007 | J. Dairy Sci. | pmid:17430912 |
| Maduko CO et al. | Enzymatic interesterification of tripalmitin with vegetable oil blends for formulation of caprine milk infant formula analogs. | 2007 | J. Dairy Sci. | pmid:17235135 |
| Diakogiannaki E et al. | Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic beta-cells. | 2007 | J. Endocrinol. | pmid:17641278 |
| Patel MR and San Martin-Gonzalez MF | Characterization of ergocalciferol loaded solid lipid nanoparticles. | 2012 | J. Food Sci. | pmid:22260120 |
| Li R et al. | Enzymatic Synthesis of Refined Olive Oil-Based Structured Lipid Containing Omega -3 and -6 Fatty Acids for Potential Application in Infant Formula. | 2015 | J. Food Sci. | pmid:26408984 |
| Ingham E et al. | Partial purification and characterization of lipase (EC 3.1.1.3) from Propionibacterium acnes. | 1981 | J. Gen. Microbiol. | pmid:7035615 |
| Emerson B et al. | A rapid separation technique for overcoming suppression of triacylglycerols by phosphatidylcholine using MALDI-TOF MS. | 2010 | J. Lipid Res. | pmid:20447931 |
| Ren J et al. | Composition of adipose tissue and marrow fat in humans by 1H NMR at 7 Tesla. | 2008 | J. Lipid Res. | pmid:18509197 |
| Björkhem I et al. | Effect of different dietary triglycerides on 7alpha-hydroxylation of cholesterol and other mixed-function oxidations. | 1978 | J. Lipid Res. | pmid:650092 |
| Kaplan A and Teng MH | Interaction of beef liver lipase with mixed micelles of tripalmitin and Triton X-100. | 1971 | J. Lipid Res. | pmid:5579262 |
| Clark SB et al. | Fat absorption in essential fatty acid deficiency: a model experimental approach to studies of the mechanism of fat malabsorption of unknown etiology. | 1973 | J. Lipid Res. | pmid:4729974 |
| Kariya M and Kaplan A | Effects of acidic phospholipids, nucleotides, and heparin on the activity of lipase from rat liver lysosomes. | 1973 | J. Lipid Res. | pmid:4698271 |