Stearidonic acid

Stearidonic acid is a lipid of Fatty Acyls (FA) class. The involved functions are known as Sudden Cardiac Death and interleukin-6 secretion. Stearidonic acid often locates in Tissue membrane. The related lipids are Fatty Acids and stearidonic acid.

Cross Reference

Introduction

To understand associated biological information of Stearidonic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Stearidonic acid?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Stearidonic acid

MeSH term MeSH ID Detail
Fatty Liver D005234 48 associated lipids
Body Weight D001835 333 associated lipids
Hyperlipidemias D006949 73 associated lipids
Insulin Resistance D007333 99 associated lipids
Total 4

PubChem Associated disorders and diseases

What pathways are associated with Stearidonic acid

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Stearidonic acid through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Stearidonic acid?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Stearidonic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Stearidonic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Stearidonic acid?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Stearidonic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Stearidonic acid

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Authors Title Published Journal PubMed Link
Lefort N et al. Dietary Buglossoides Arvensis Oil Increases Circulating n-3 Polyunsaturated Fatty Acids in a Dose-Dependent Manner and Enhances Lipopolysaccharide-Stimulated Whole Blood Interleukin-10-A Randomized Placebo-Controlled Trial. 2017 Nutrients pmid:28287415
Park H et al. Towards the development of a sustainable soya bean-based feedstock for aquaculture. 2017 Plant Biotechnol. J. pmid:27496594
Kuhnt K et al. Consumption of echium oil increases EPA and DPA in blood fractions more efficiently compared to linseed oil in humans. 2016 Lipids Health Dis pmid:26892399
Abeywardena MY et al. Rise in DPA Following SDA-Rich Dietary Echium Oil Less Effective in Affording Anti-Arrhythmic Actions Compared to High DHA Levels Achieved with Fish Oil in Sprague-Dawley Rats. 2016 Nutrients pmid:26742064
Kim SH et al. Heterologous Reconstitution of Omega-3 Polyunsaturated Fatty Acids in Arabidopsis. 2015 Biomed Res Int pmid:26339641
Baik JY et al. Preparation of Highly Purified Stearidonic Acid from Echium Oil via an Enzymatic Method Combined with Preparative High Performance Liquid Chromatography. 2015 J Oleo Sci pmid:25994555
Kim SH et al. Functional characterization of polyunsaturated fatty acid delta 6-desaturase and elongase genes from the black seabream (Acanthopagrus schlegelii). 2014 Cell Biochem. Biophys. pmid:24052399
Kimura K et al. Increase in stearidonic acid by increasing the supply of histidine to oleaginous Saccharomyces cerevisiae. 2014 J. Biosci. Bioeng. pmid:23932357
Kitessa SM et al. DHA-containing oilseed: a timely solution for the sustainability issues surrounding fish oil sources of the health-benefitting long-chain omega-3 oils. 2014 Nutrients pmid:24858407
Casey JM et al. Effect of stearidonic acid-enriched soybean oil on fatty acid profile and metabolic parameters in lean and obese Zucker rats. 2013 Lipids Health Dis pmid:24139088
Walker CG et al. Stearidonic acid as a supplemental source of ω-3 polyunsaturated fatty acids to enhance status for improved human health. 2013 Nutrition pmid:23102888
Botelho PB et al. Effect of Echium oil compared with marine oils on lipid profile and inhibition of hepatic steatosis in LDLr knockout mice. 2013 Lipids Health Dis pmid:23510369
Kavanagh K et al. Stearidonic and γ-linolenic acids in echium oil improves glucose disposal in insulin resistant monkeys. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23664597
Kim SH et al. Isolation and functional characterization of a delta 6-desaturase gene from the pike eel (Muraenesox cinereus). 2013 J. Microbiol. pmid:24097133
Arm JP et al. Impact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics. 2013 Lipids Health Dis pmid:24088297
Yan Y et al. Survey of the total fatty acid and triacylglycerol composition and content of 30 duckweed species and cloning of a Δ6-desaturase responsible for the production of γ-linolenic and stearidonic acids in Lemna gibba. 2013 BMC Plant Biol. pmid:24308551
Vaezi R et al. Identification and functional characterization of genes encoding omega-3 polyunsaturated fatty acid biosynthetic activities from unicellular microalgae. 2013 Mar Drugs pmid:24351909
Surette ME Dietary omega-3 PUFA and health: stearidonic acid-containing seed oils as effective and sustainable alternatives to traditional marine oils. 2013 Mol Nutr Food Res pmid:23417895
Lemke SL et al. Consumption of stearidonic acid-rich oil in foods increases red blood cell eicosapentaenoic acid. 2013 J Acad Nutr Diet pmid:23885702
Kawabata T et al. Influences of stearidonic acid-enriched soybean oil on the blood and organ biochemical parameters in rats. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23219237
Matsumoto C et al. Erythrocyte stearidonic acid and other n-3 fatty acids and CHD in the Physicians' Health Study. 2013 Br. J. Nutr. pmid:23098619
Do Nascimento M et al. High lipid productivity of an Ankistrodesmus-Rhizobium artificial consortium. 2013 Bioresour. Technol. pmid:23948276
Rincón Cervera MÁ et al. Acyl migration evaluation in monoacylglycerols from Echium plantagineum seed oil and Marinol. 2013 J. Biosci. Bioeng. pmid:23287502
Krul ES et al. Effects of duration of treatment and dosage of eicosapentaenoic acid and stearidonic acid on red blood cell eicosapentaenoic acid content. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22064208
Maki KC and Rains TM Stearidonic acid raises red blood cell membrane eicosapentaenoic acid. 2012 J. Nutr. pmid:22279138
Whelan J et al. Effects of dietary stearidonic acid on biomarkers of lipid metabolism. 2012 J. Nutr. pmid:22279143
Deckelbaum RJ et al. Conclusions and recommendations from the symposium, Heart Healthy Omega-3s for Food: Stearidonic Acid (SDA) as a Sustainable Choice. 2012 J. Nutr. pmid:22323767
Hennessy AA et al. The production of conjugated α-linolenic, γ-linolenic and stearidonic acids by strains of bifidobacteria and propionibacteria. 2012 Lipids pmid:22160449
Alves SP et al. Identification of C18 intermediates formed during stearidonic acid biohydrogenation by rumen microorganisms in vitro. 2012 Lipids pmid:22038686
Deckelbaum RJ and Torrejon C The omega-3 fatty acid nutritional landscape: health benefits and sources. 2012 J. Nutr. pmid:22323763
Maia MR et al. Technical note: stearidonic acid metabolism by mixed ruminal microorganisms in vitro. 2012 J. Anim. Sci. pmid:22021809
Banz WJ et al. Stearidonic acid: is there a role in the prevention and management of type 2 diabetes mellitus? 2012 J. Nutr. pmid:22279133
Decker EA et al. Incorporation of (n-3) fatty acids in foods: challenges and opportunities. 2012 J. Nutr. pmid:22279141
Harris WS Stearidonic acid-enhanced soybean oil: a plant-based source of (n-3) fatty acids for foods. 2012 J. Nutr. pmid:22279144
Harris WS Stearidonic acid as a 'pro-eicosapentaenoic acid'. 2012 Curr. Opin. Lipidol. pmid:22186661
Thibane VS et al. Stearidonic acid acts in synergism with amphotericin B in inhibiting Candida albicans and Candida dubliniensis biofilms in vitro. 2012 Int. J. Antimicrob. Agents pmid:22817915
Atalar F et al. The role of mediastinal adipose tissue 11β-hydroxysteroid d ehydrogenase type 1 and glucocorticoid expression in the development of coronary atherosclerosis in obese patients with ischemic heart disease. 2012 Cardiovasc Diabetol pmid:23009206
Pande G et al. Production of trans-free margarine with stearidonic acid soybean and high-stearate soybean oils-based structured lipid. 2012 J. Food Sci. pmid:23094958
Teichert SA and Akoh CC Stearidonic acid soybean oil enriched with palmitic acid at the sn-2 position by enzymatic interesterification for use as human milk fat analogues. 2011 J. Agric. Food Chem. pmid:21517012
Tan L et al. Molecular analysis of ∆6 desaturase and ∆6 elongase from Conidiobolus obscurus in the biosynthesis of eicosatetraenoic acid, a ω3 fatty acid with nutraceutical potentials. 2011 Appl. Microbiol. Biotechnol. pmid:21210105
Hsueh HW et al. Stearidonic and eicosapentaenoic acids inhibit interleukin-6 expression in ob/ob mouse adipose stem cells via Toll-like receptor-2-mediated pathways. 2011 J. Nutr. pmid:21562237
Alhazzaa R et al. Up-regulated desaturase and elongase gene expression promoted accumulation of polyunsaturated fatty acid (PUFA) but not long-chain PUFA in Lates calcarifer, a tropical euryhaline fish, fed a stearidonic acid- and γ-linoleic acid-enriched diet. 2011 J. Agric. Food Chem. pmid:21707030
Codabaccus MB et al. Effect of feeding Atlantic salmon (Salmo salar L.) a diet enriched with stearidonic acid from parr to smolt on growth and n-3 long-chain PUFA biosynthesis. 2011 Br. J. Nutr. pmid:21303572
Teichert SA and Akoh CC Characterization of stearidonic acid soybean oil enriched with palmitic acid produced by solvent-free enzymatic interesterification. 2011 J. Agric. Food Chem. pmid:21830790
Teichert SA and Akoh CC Modifications of stearidonic acid soybean oil by enzymatic acidolysis for the production of human milk fat analogues. 2011 J. Agric. Food Chem. pmid:22097918
Lemke SL et al. Dietary intake of stearidonic acid-enriched soybean oil increases the omega-3 index: randomized, double-blind clinical study of efficacy and safety. 2010 Am. J. Clin. Nutr. pmid:20739419
Bernal-Santos G et al. Hot topic: Enhancing omega-3 fatty acids in milk fat of dairy cows by using stearidonic acid-enriched soybean oil from genetically modified soybeans. 2010 J. Dairy Sci. pmid:20059901
Bharadwaj AS et al. Dietary source of stearidonic acid promotes higher muscle DHA concentrations than linolenic acid in hybrid striped bass. 2010 Lipids pmid:20049582
Ruiz-Rodriguez A et al. Recent trends in the advanced analysis of bioactive fatty acids. 2010 J Pharm Biomed Anal pmid:19525080
Ruiz-López N et al. The synthesis and accumulation of stearidonic acid in transgenic plants: a novel source of 'heart-healthy' omega-3 fatty acids. 2009 Plant Biotechnol. J. pmid:19702757
Broughton KS et al. Dietary omega-3 fatty acids differentially influence ova release and ovarian cyclooxygenase-1 and cyclooxygenase-2 expression in rats. 2009 Nutr Res pmid:19358934
Whelan J Dietary stearidonic acid is a long chain (n-3) polyunsaturated fatty acid with potential health benefits. 2009 J. Nutr. pmid:19056654
Kimura K et al. Improvement of Stearidonic acid production in Oleaginous Saccharomyces cerevisiae. 2009 Biosci. Biotechnol. Biochem. pmid:19502753
Hammond BG et al. Safety assessment of SDA soybean oil: results of a 28-day gavage study and a 90-day/one generation reproduction feeding study in rats. 2008 Regul. Toxicol. Pharmacol. pmid:18804141
Khan MN et al. Effects of the brown seaweed Undaria pinnatifida on erythematous inflammation assessed using digital photo analysis. 2008 Phytother Res pmid:18384198
Harris WS et al. Stearidonic acid-enriched soybean oil increased the omega-3 index, an emerging cardiovascular risk marker. 2008 Lipids pmid:18683001
Zhang P et al. Echium oil reduces plasma lipids and hepatic lipogenic gene expression in apoB100-only LDL receptor knockout mice. 2008 J. Nutr. Biochem. pmid:18155507
Nandakumar M and Tan MW Gamma-linolenic and stearidonic acids are required for basal immunity in Caenorhabditis elegans through their effects on p38 MAP kinase activity. 2008 PLoS Genet. pmid:19023415
Chilton FH et al. Mechanisms by which botanical lipids affect inflammatory disorders. 2008 Am. J. Clin. Nutr. pmid:18258646
Miller MR et al. Increased elongase and desaturase gene expression with stearidonic acid enriched diet does not enhance long-chain (n-3) content of seawater Atlantic salmon (Salmo salar L.). 2008 J. Nutr. pmid:18936216
Cui PH et al. Monoepoxy octadecadienoates and monoepoxy octadecatrienoates 1: NMR spectral characterization. 2008 Chem. Phys. Lipids pmid:18339314
Khan MN et al. Isolation of two anti-inflammatory and one pro-inflammatory polyunsaturated fatty acids from the brown seaweed Undaria pinnatifida. 2007 J. Agric. Food Chem. pmid:17665931
Miller MR et al. Replacement of dietary fish oil for Atlantic salmon parr (Salmo salar L.) with a stearidonic acid containing oil has no effect on omega-3 long-chain polyunsaturated fatty acid concentrations. 2007 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:17134928
Harris WS et al. Stearidonic acid increases the red blood cell and heart eicosapentaenoic acid content in dogs. 2007 Lipids pmid:17406927
Stolyhwo A and Mol J Changes in the content of gamma-linolenic C18:3 (n-6) and stearidonic C18:4 (n-3) acids in developing seeds of viper's bugloss Echium vulgare L. 2007 Acta Biochim. Pol. pmid:18066400
Tocher DR et al. Effect of diets enriched in Delta6 desaturated fatty acids (18:3n-6 and 18:4n-3), on growth, fatty acid composition and highly unsaturated fatty acid synthesis in two populations of Arctic charr (Salvelinus alpinus L.). 2006 Comp. Biochem. Physiol. B, Biochem. Mol. Biol. pmid:16630735
Miles EA et al. Self-reported health problems in young male subjects supplementing their diet with oils rich in eicosapentaenoic, gamma-linolenic and stearidonic acids. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16820286
Eckert H et al. Co-expression of the borage Delta 6 desaturase and the Arabidopsis Delta 15 desaturase results in high accumulation of stearidonic acid in the seeds of transgenic soybean. 2006 Planta pmid:16718484
Horia E and Watkins BA Comparison of stearidonic acid and alpha-linolenic acid on PGE2 production and COX-2 protein levels in MDA-MB-231 breast cancer cell cultures. 2005 J. Nutr. Biochem. pmid:15741054
Del Castillo ML et al. Fatty acid content and juice characteristics in black currant (Ribes nigrum L.) genotypes. 2004 J. Agric. Food Chem. pmid:14969555
Miles EA et al. The influence of different combinations of gamma-linolenic acid, stearidonic acid and EPA on immune function in healthy young male subjects. 2004 Br. J. Nutr. pmid:15182393
Miles EA et al. The influence of different combinations of gamma-linolenic, stearidonic and eicosapentaenoic acids on the fatty acid composition of blood lipids and mononuclear cells in human volunteers. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15120716
Surette ME et al. Dietary echium oil increases plasma and neutrophil long-chain (n-3) fatty acids and lowers serum triacylglycerols in hypertriglyceridemic humans. 2004 J. Nutr. pmid:15173404
James MJ et al. Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids. 2003 Am. J. Clin. Nutr. pmid:12716664
Ursin VM Modification of plant lipids for human health: development of functional land-based omega-3 fatty acids. 2003 J. Nutr. pmid:14652387
Parker-Barnes JM et al. Identification and characterization of an enzyme involved in the elongation of n-6 and n-3 polyunsaturated fatty acids. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:10899997
Ishihara K et al. Purification of stearidonic acid (18:4(n-3)) and hexadecatetraenoic acid (16:4(n-3)) from algal fatty acid with lipase and medium pressure liquid chromatography. 2000 Biosci. Biotechnol. Biochem. pmid:11193415
Sperling P et al. A bifunctional delta-fatty acyl acetylenase/desaturase from the moss Ceratodon purpureus. A new member of the cytochrome b5 superfamily. 2000 Eur. J. Biochem. pmid:10848999
Dobson G Leaf lipids of Ribes nigrum: a plant containing 16:3, alpha-18:3, gamma-18:3 and 18:4 fatty acids. 2000 Biochem. Soc. Trans. pmid:11171133
Ghioni C et al. Low C18 to C20 fatty acid elongase activity and limited conversion of stearidonic acid, 18:4(n-3), to eicosapentaenoic acid, 20:5(n-3), in a cell line from the turbot, Scophthalmus maximus. 1999 Biochim. Biophys. Acta pmid:10064900
Yamazaki K et al. Comparison of the conversion rates of alpha-linolenic acid (18:3(n - 3)) and stearidonic acid (18:4(n - 3)) to longer polyunsaturated fatty acids in rats. 1992 Biochim. Biophys. Acta pmid:1346092
Findlay JA and Patil AD Antibacterial constituents of the diatom Navicula delognei. 1984 Sep-Oct J. Nat. Prod. pmid:6512534
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