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In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis. |
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Phytoestrogen genistein stimulates the production of osteoprotegerin by human trabecular osteoblasts. |
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Arch. Oral Biol. |
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The alpha(v)beta3 integrin, NF-kappaB, osteoprotegerin endothelial cell survival pathway. Potential role in angiogenesis. |
2002 |
Trends Cardiovasc. Med. |
pmid:11852256
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Cytokine inhibition: a new therapeutic avenue for skeletal diseases. |
2002 |
Drug Discov. Today |
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Bisphosphonates pamidronate and zoledronic acid stimulate osteoprotegerin production by primary human osteoblasts. |
2002 |
Biochem. Biophys. Res. Commun. |
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Involvement of receptor activator of NFkappaB ligand and tumor necrosis factor-alpha in bone destruction in rheumatoid arthritis. |
2002 |
Bone |
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2002 |
Annu. Rev. Immunol. |
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RANK (receptor activator of nuclear factor kappa B) and RANK ligand are expressed in giant cell tumors of bone. |
2002 |
Am. J. Clin. Pathol. |
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Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals. |
2002 |
Immunity |
pmid:11869680
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Nuclear localization of type I parathyroid hormone/parathyroid hormone-related protein receptors in deer antler osteoclasts: evidence for parathyroid hormone-related protein and receptor activator of NF-kappaB-dependent effects on osteoclast formation in regenerating mammalian bone. |
2002 |
J. Bone Miner. Res. |
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Increased circulating levels of osteoclastogenesis inhibitory factor (osteoprotegerin) in patients with chronic renal failure. |
2002 |
Am. J. Kidney Dis. |
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Osteoprotegerin and parathyroid hormone as markers of high-turnover osteodystrophy and decreased bone mineralization in hemodialysis patients. |
2002 |
Am. J. Kidney Dis. |
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Ann. Rheum. Dis. |
pmid:11890662
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Osteoprotegerin (OPG) is a survival factor for human prostate cancer cells. |
2002 |
Cancer Res. |
pmid:11912131
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RANK ligand, RANK, and OPG expression in type II collagen-induced arthritis mouse. |
2002 |
Histochem. Cell Biol. |
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