17-octadecynoic acid is a lipid of Fatty Acyls (FA) class. 17-octadecynoic acid is associated with abnormalities such as Renal tubular disorder, Hypertensive disease, abnormal fragmented structure, Blood Clot and Subarachnoid Hemorrhage. The involved functions are known as Hypoxia, Pathological Dilatation, Anabolism, Biochemical Pathway and Stimulus. 17-octadecynoic acid often locates in Endothelium, Muscle, Protoplasm, Microsomes and Membrane. The associated genes with 17-octadecynoic acid are P4HTM gene, EDNRA gene, Gene Family, IMPACT gene and PPP1R1A gene. The related lipids are 17-octadecynoic acid, Fatty Acids, 1-oleoyl-2-acetoyl-sn-glycerol and fatty acid analog.
To understand associated biological information of 17-octadecynoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
17-octadecynoic acid is suspected in Hypertensive disease, Renal tubular disorder, Blood Clot, Subarachnoid Hemorrhage, Renal vascular disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 17-octadecynoic acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Corneal Neovascularization | D016510 | 8 associated lipids |
| Cicatrix | D002921 | 9 associated lipids |
| Hyperthyroidism | D006980 | 12 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bełtowski J et al. | Regulation of renal Na(+),K(+)-ATPase and ouabain-sensitive H(+),K(+)-ATPase by the cyclic AMP-protein kinase A signal transduction pathway. | 2003 | Acta Biochim. Pol. | pmid:12673350 |
| Wang X et al. | Determinants of renal afferent arteriolar actions of bradykinin: evidence that multiple pathways mediate responses attributed to EDHF. | 2003 | Am. J. Physiol. Renal Physiol. | pmid:12734100 |
| Kalyankrishna S and Malik KU | Norepinephrine-induced stimulation of p38 mitogen-activated protein kinase is mediated by arachidonic acid metabolites generated by activation of cytosolic phospholipase A(2) in vascular smooth muscle cells. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12538832 |
| Thapaliya S et al. | An endothelium-derived factor modulates purinergic neurotransmission to mesenteric arterial smooth muscle of hamster. | 2003 | Eur. J. Pharmacol. | pmid:12586208 |
| Grider JS et al. | Dopamine D1 receptor-dependent inhibition of NaCl transport in the rat thick ascending limb: mechanism of action. | 2003 | Eur. J. Pharmacol. | pmid:12892837 |
| Jarus-Dziedzic K et al. | Acute decrease of cerebrocortical microflow and lack of carbon dioxide reactivity following subarachnoid haemorrhage in the rat. | 2003 | Acta Neurochir. Suppl. | pmid:14753489 |
| Hattori T et al. | Effects of H2O2 on membrane potential of smooth muscle cells in rabbit mesenteric resistance artery. | 2003 | Eur. J. Pharmacol. | pmid:12620501 |
| Archer SL et al. | Endothelium-derived hyperpolarizing factor in human internal mammary artery is 11,12-epoxyeicosatrienoic acid and causes relaxation by activating smooth muscle BK(Ca) channels. | 2003 | Circulation | pmid:12578883 |
| Looft-Wilson RC et al. | 20-HETE pathway antagonists inhibit rat small mesenteric artery tone. | 2002 | Microvasc. Res. | pmid:12204659 |
| Frisbee JC et al. | Oxidant stress-induced increase in myogenic activation of skeletal muscle resistance arteries in obese Zucker rats. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12388303 |
| Hoepfl B et al. | EDHF, but not NO or prostaglandins, is critical to evoke a conducted dilation upon ACh in hamster arterioles. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12181129 |
| McGuire JJ et al. | Multiple mechanisms of vascular smooth muscle relaxation by the activation of proteinase-activated receptor 2 in mouse mesenteric arterioles. | 2002 | Br. J. Pharmacol. | pmid:11786491 |
| Kehl F et al. | 20-HETE contributes to the acute fall in cerebral blood flow after subarachnoid hemorrhage in the rat. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11893593 |
| Alonso-Galicia M et al. | Role of 20-hydroxyeicosatetraenoic acid in the renal and vasoconstrictor actions of angiotensin II. | 2002 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12069931 |
| Yu M et al. | Nitric oxide contributes to 20-HETE-induced relaxation of pulmonary arteries. | 2002 | J. Appl. Physiol. | pmid:12235040 |
| Hashizume T et al. | Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal microsomes. | 2002 | J. Pharmacol. Exp. Ther. | pmid:11752129 |
| Frisbee JC et al. | Relative contributions of cyclooxygenase- and cytochrome P450 omega-hydroxylase-dependent pathways to hypoxic dilation of skeletal muscle resistance arteries. | 2001 Jul-Aug | J. Vasc. Res. | pmid:11455201 |
| Kunert MP et al. | Cytochrome P-450 omega-hydroxylase: a potential O(2) sensor in rat arterioles and skeletal muscle cells. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11247799 |
| Ungvari Z and Koller A | Mediation of EDHF-induced reduction of smooth muscle [Ca(2+)](i) and arteriolar dilation by K(+) channels, 5,6-EET, and gap junctions. | 2001 | Microcirculation | pmid:11528534 |
| Frisbee JC et al. | Role of prostanoids and 20-HETE in mediating oxygen-induced constriction of skeletal muscle resistance arteries. | 2001 | Microvasc. Res. | pmid:11678630 |