17-octadecynoic acid is a lipid of Fatty Acyls (FA) class. 17-octadecynoic acid is associated with abnormalities such as Renal tubular disorder, Hypertensive disease, abnormal fragmented structure, Blood Clot and Subarachnoid Hemorrhage. The involved functions are known as Hypoxia, Pathological Dilatation, Anabolism, Biochemical Pathway and Stimulus. 17-octadecynoic acid often locates in Endothelium, Muscle, Protoplasm, Microsomes and Membrane. The associated genes with 17-octadecynoic acid are P4HTM gene, EDNRA gene, Gene Family, IMPACT gene and PPP1R1A gene. The related lipids are 17-octadecynoic acid, Fatty Acids, 1-oleoyl-2-acetoyl-sn-glycerol and fatty acid analog.
To understand associated biological information of 17-octadecynoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
17-octadecynoic acid is suspected in Hypertensive disease, Renal tubular disorder, Blood Clot, Subarachnoid Hemorrhage, Renal vascular disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 17-octadecynoic acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Hyperthyroidism | D006980 | 12 associated lipids |
| Cicatrix | D002921 | 9 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Corneal Neovascularization | D016510 | 8 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Singh TU et al. | Arachidonic acid inhibits Naâº-Kâº-ATPase via cytochrome P-450, lipoxygenase and protein kinase C-dependent pathways in sheep pulmonary artery. | 2012 Jan-Feb | Vascul. Pharmacol. | pmid:22155164 |
| Jerez S et al. | 17-Octadecynoic acid improves contractile response to angiotensin II by releasing vasocontrictor prostaglandins. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:21839852 |
| Jarrar YB et al. | Identification of cytochrome P450s involved in the metabolism of arachidonic acid in human platelets. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23932368 |
| Ivaldi C et al. | Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23. | 2012 | PLoS ONE | pmid:22615937 |
| Calderon LE et al. | iPLA2β overexpression in smooth muscle exacerbates angiotensin II-induced hypertension and vascular remodeling. | 2012 | PLoS ONE | pmid:22363752 |
| Adams MN et al. | The role of palmitoylation in signalling, cellular trafficking and plasma membrane localization of protease-activated receptor-2. | 2011 | PLoS ONE | pmid:22140500 |
| Martin BR and Cravatt BF | Large-scale profiling of protein palmitoylation in mammalian cells. | 2009 | Nat. Methods | pmid:19137006 |
| Martin BR et al. | Global profiling of dynamic protein palmitoylation. | 2012 | Nat. Methods | pmid:22056678 |
| Looft-Wilson RC et al. | 20-HETE pathway antagonists inhibit rat small mesenteric artery tone. | 2002 | Microvasc. Res. | pmid:12204659 |
| Frisbee JC et al. | Role of prostanoids and 20-HETE in mediating oxygen-induced constriction of skeletal muscle resistance arteries. | 2001 | Microvasc. Res. | pmid:11678630 |
| Kunert MP et al. | Differential effect of cytochrome P-450 omega-hydroxylase inhibition on O2-induced constriction of arterioles in SHR with early and established hypertension. | 2001 | Microcirculation | pmid:11781816 |
| Frisbee JC et al. | 20-HETE contributes to myogenic activation of skeletal muscle resistance arteries in Brown Norway and Sprague-Dawley rats. | 2001 | Microcirculation | pmid:11296852 |
| Frisbee JC et al. | Altered mechanisms underlying hypoxic dilation of skeletal muscle resistance arteries of hypertensive versus normotensive Dahl rats. | 2001 | Microcirculation | pmid:11379791 |
| Ungvari Z and Koller A | Mediation of EDHF-induced reduction of smooth muscle [Ca(2+)](i) and arteriolar dilation by K(+) channels, 5,6-EET, and gap junctions. | 2001 | Microcirculation | pmid:11528534 |
| Peterson DA et al. | Triple-bonded unsaturated fatty acids are redox active compounds. | 2001 | Lipids | pmid:11383698 |
| Davidson-Garcia CA et al. | Possible role of P-450-derived metabolites in endothelium-dependent relaxation of rat small mesenteric arteries. | 2000 | Life Sci. | pmid:10737360 |
| Gu RM et al. | CYP-omega-hydroxylation-dependent metabolites of arachidonic acid inhibit the basolateral 10 pS chloride channel in the rat thick ascending limb. | 2009 | Kidney Int. | pmid:19641481 |
| Carroll MA et al. | Cytochrome P450-derived renal HETEs: storage and release. | 1997 | Kidney Int. | pmid:9186856 |
| Alexander LD et al. | Arachidonic acid directly activates members of the mitogen-activated protein kinase superfamily in rabbit proximal tubule cells. | 2001 | Kidney Int. | pmid:11380805 |
| Ikari A et al. | Activation of Na+-independent Mg2+ efflux by 20-hydroxyeicosatetraenoic acid in rat renal epithelial cells. | 2004 | Jpn. J. Physiol. | pmid:15631697 |