17-octadecynoic acid is a lipid of Fatty Acyls (FA) class. 17-octadecynoic acid is associated with abnormalities such as Renal tubular disorder, Hypertensive disease, abnormal fragmented structure, Blood Clot and Subarachnoid Hemorrhage. The involved functions are known as Hypoxia, Pathological Dilatation, Anabolism, Biochemical Pathway and Stimulus. 17-octadecynoic acid often locates in Endothelium, Muscle, Protoplasm, Microsomes and Membrane. The associated genes with 17-octadecynoic acid are P4HTM gene, EDNRA gene, Gene Family, IMPACT gene and PPP1R1A gene. The related lipids are 17-octadecynoic acid, Fatty Acids, 1-oleoyl-2-acetoyl-sn-glycerol and fatty acid analog.
To understand associated biological information of 17-octadecynoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
17-octadecynoic acid is suspected in Hypertensive disease, Renal tubular disorder, Blood Clot, Subarachnoid Hemorrhage, Renal vascular disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 17-octadecynoic acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Hyperthyroidism | D006980 | 12 associated lipids |
| Cicatrix | D002921 | 9 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Corneal Neovascularization | D016510 | 8 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhai G et al. | Inhibition of cytochromes P450 and the hydroxylation of 4-monochlorobiphenyl in whole poplar. | 2013 | Environ. Sci. Technol. | pmid:23320482 |
| Jarrar YB et al. | Identification of cytochrome P450s involved in the metabolism of arachidonic acid in human platelets. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23932368 |
| Singh TU et al. | Arachidonic acid inhibits Naâº-Kâº-ATPase via cytochrome P-450, lipoxygenase and protein kinase C-dependent pathways in sheep pulmonary artery. | 2012 Jan-Feb | Vascul. Pharmacol. | pmid:22155164 |
| Li Y et al. | DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells. | 2012 | J. Biol. Chem. | pmid:22081607 |
| Yount JS et al. | Bioorthogonal proteomics of 15-hexadecynyloxyacetic acid chemical reporter reveals preferential targeting of fatty acid modified proteins and biosynthetic enzymes. | 2012 | Bioorg. Med. Chem. | pmid:21524915 |
| Martin BR et al. | Global profiling of dynamic protein palmitoylation. | 2012 | Nat. Methods | pmid:22056678 |
| Jerez S et al. | 17-Octadecynoic acid improves contractile response to angiotensin II by releasing vasocontrictor prostaglandins. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:21839852 |
| Ivaldi C et al. | Proteomic analysis of S-acylated proteins in human B cells reveals palmitoylation of the immune regulators CD20 and CD23. | 2012 | PLoS ONE | pmid:22615937 |
| Zoltewicz SJ et al. | The palmitoylation state of PMP22 modulates epithelial cell morphology and migration. | 2012 | ASN Neuro | pmid:23127255 |
| Calderon LE et al. | iPLA2β overexpression in smooth muscle exacerbates angiotensin II-induced hypertension and vascular remodeling. | 2012 | PLoS ONE | pmid:22363752 |
| Weeks T et al. | Lipid-cell interactions in human monocytes investigated by doubly-resonant coherent anti-Stokes Raman scattering microscopy. | 2011 | J Biomed Opt | pmid:21361680 |
| Ljuca F et al. | Contribution of Ras farnesyl transferase, MAP kinase and cytochrome P-450 metabolites to endothelin-1 induced hypertension. | 2011 | Bosn J Basic Med Sci | pmid:21619553 |
| Nishimuta H et al. | Species differences in intestinal metabolic activities of cytochrome P450 isoforms between cynomolgus monkeys and humans. | 2011 | Drug Metab. Pharmacokinet. | pmid:21383522 |
| Shao J et al. | P-450-dependent epoxygenase pathway of arachidonic acid is involved in myeloma-induced angiogenesis of endothelial cells. | 2011 | J. Huazhong Univ. Sci. Technol. Med. Sci. | pmid:22038346 |
| Adams MN et al. | The role of palmitoylation in signalling, cellular trafficking and plasma membrane localization of protease-activated receptor-2. | 2011 | PLoS ONE | pmid:22140500 |
| Ohata H et al. | Onset of pulmonary ventilation in fetal sheep produces pial arteriolar constriction dependent on cytochrome p450 omega-hydroxylase activity. | 2010 | J. Appl. Physiol. | pmid:20489034 |
| Martin BR and Cravatt BF | Large-scale profiling of protein palmitoylation in mammalian cells. | 2009 | Nat. Methods | pmid:19137006 |
| Gu RM et al. | CYP-omega-hydroxylation-dependent metabolites of arachidonic acid inhibit the basolateral 10 pS chloride channel in the rat thick ascending limb. | 2009 | Kidney Int. | pmid:19641481 |
| Wang Z et al. | 20-Hydroxyeicosatetraenoic acid inhibits the apoptotic responses in pulmonary artery smooth muscle cells. | 2008 | Eur. J. Pharmacol. | pmid:18455723 |
| Jerez S et al. | Endothelial dysfunction and improvement of the angiotensin II-reactivity in hypercholesterolemic rabbits: role of cyclooxygenase metabolites. | 2008 | Eur. J. Pharmacol. | pmid:18053983 |