17-octadecynoic acid is a lipid of Fatty Acyls (FA) class. 17-octadecynoic acid is associated with abnormalities such as Renal tubular disorder, Hypertensive disease, abnormal fragmented structure, Blood Clot and Subarachnoid Hemorrhage. The involved functions are known as Hypoxia, Pathological Dilatation, Anabolism, Biochemical Pathway and Stimulus. 17-octadecynoic acid often locates in Endothelium, Muscle, Protoplasm, Microsomes and Membrane. The associated genes with 17-octadecynoic acid are P4HTM gene, EDNRA gene, Gene Family, IMPACT gene and PPP1R1A gene. The related lipids are 17-octadecynoic acid, Fatty Acids, 1-oleoyl-2-acetoyl-sn-glycerol and fatty acid analog.
To understand associated biological information of 17-octadecynoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
17-octadecynoic acid is suspected in Hypertensive disease, Renal tubular disorder, Blood Clot, Subarachnoid Hemorrhage, Renal vascular disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 17-octadecynoic acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Hyperthyroidism | D006980 | 12 associated lipids |
| Cicatrix | D002921 | 9 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Corneal Neovascularization | D016510 | 8 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid:28698302 | ||||
| pmid:11556821 | ||||
| pmid:19954757 | ||||
| pmid:17027963 | ||||
| pmid:16120187 | ||||
| pmid:15677873 | ||||
| pmid:14985065 | ||||
| pmid:15464071 | ||||
| pmid: | ||||
| Bełtowski J et al. | Bidirectional regulation of renal cortical Na+,K+-ATPase by protein kinase C. | 2004 | Acta Biochim. Pol. | pmid:15448737 |
| Bełtowski J et al. | Regulation of renal Na(+),K(+)-ATPase and ouabain-sensitive H(+),K(+)-ATPase by the cyclic AMP-protein kinase A signal transduction pathway. | 2003 | Acta Biochim. Pol. | pmid:12673350 |
| Jarus-Dziedzic K et al. | Acute decrease of cerebrocortical microflow and lack of carbon dioxide reactivity following subarachnoid haemorrhage in the rat. | 2003 | Acta Neurochir. Suppl. | pmid:14753489 |
| Kirkebø A et al. | Sustained increase in arterial blood pressure and vascular resistance induced by infusion of arachidonic acid in rats. | 2000 | Acta Physiol. Scand. | pmid:10971217 |
| Evans RG et al. | Effects of intrarenal infusion of 17-octadecynoic acid on renal antihypertensive mechanisms in anesthetized rabbits. | 1998 | Am. J. Hypertens. | pmid:9683041 |
| Lombard JH et al. | Cytochrome P-450 omega-hydroxylase senses O2 in hamster muscle, but not cheek pouch epithelium, microcirculation. | 1999 | Am. J. Physiol. | pmid:9950851 |
| Imig JD and Navar LG | Afferent arteriolar response to arachidonic acid: involvement of metabolic pathways. | 1996 | Am. J. Physiol. | pmid:8760247 |
| Ivey CL et al. | Involvement of cytochrome P-450 enzyme activity in the control of microvascular permeability in canine lung. | 1998 | Am. J. Physiol. | pmid:9755108 |
| Ferreri NR et al. | Angiotensin II induces TNF production by the thick ascending limb: functional implications. | 1998 | Am. J. Physiol. | pmid:9458834 |
| Widmann MD et al. | Cytochrome P-450 pathway in acetylcholine-induced canine coronary microvascular vasodilation in vivo. | 1998 | Am. J. Physiol. | pmid:9458878 |
| de Wit C et al. | Pentobarbital-sensitive EDHF comediates ACh-induced arteriolar dilation in the hamster microcirculation. | 1999 | Am. J. Physiol. | pmid:10330235 |
| Imig JD et al. | Cytochrome P-450 inhibitors alter afferent arteriolar responses to elevations in pressure. | 1994 | Am. J. Physiol. | pmid:8203587 |
| Zou AP et al. | 20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles. | 1996 | Am. J. Physiol. | pmid:8769806 |
| Macica CM et al. | Arachidonic acid inhibits activity of cloned renal K+ channel, ROMK1. | 1996 | Am. J. Physiol. | pmid:8853420 |
| Zou AP et al. | Inhibition of renal vascular 20-HETE production impairs autoregulation of renal blood flow. | 1994 | Am. J. Physiol. | pmid:8141328 |
| Wang WH et al. | Cytochrome P-450 metabolites mediate extracellular Ca(2+)-induced inhibition of apical K+ channels in the TAL. | 1996 | Am. J. Physiol. | pmid:8760035 |
| Kerkhof CJ et al. | Role of cytochrome P-450 4A in oxygen sensing and NO production in rat cremaster resistance arteries. | 1999 | Am. J. Physiol. | pmid:10516194 |
| Kunert MP et al. | Cytochrome P-450 omega-hydroxylase: a potential O(2) sensor in rat arterioles and skeletal muscle cells. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11247799 |
| Chlopicki S et al. | Initial and sustained phases of myogenic response of rat mesenteric small arteries. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11668080 |
| Li F and Malik KU | Angiotensin II-induced Akt activation is mediated by metabolites of arachidonic acid generated by CaMKII-stimulated Ca2(+)-dependent phospholipase A2. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15637121 |
| Mauban JR and Wier WG | Essential role of EDHF in the initiation and maintenance of adrenergic vasomotion in rat mesenteric arteries. | 2004 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15059779 |
| Konduri GG et al. | P2Y purine receptor responses and expression in the pulmonary circulation of juvenile rabbits. | 2004 | Am. J. Physiol. Heart Circ. Physiol. | pmid:14962841 |
| Sun SY et al. | Activation of cardiac afferents by arachidonic acid: relative contributions of metabolic pathways. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11406473 |
| Tanaka M et al. | Cytochrome P-450 metabolites but not NO, PGI2, and H2O2 contribute to ACh-induced hyperpolarization of pressurized canine coronary microvessels. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12881219 |
| Frisbee JC et al. | Oxidant stress-induced increase in myogenic activation of skeletal muscle resistance arteries in obese Zucker rats. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12388303 |
| Hoepfl B et al. | EDHF, but not NO or prostaglandins, is critical to evoke a conducted dilation upon ACh in hamster arterioles. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12181129 |
| Frisbee JC et al. | Contribution of cytochrome P-450 omega-hydroxylase to altered arteriolar reactivity with high-salt diet and hypertension. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10775129 |
| Lamb FS and Barna TJ | Endothelium modulates anion channel-dependent aortic contractions to iodide. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10775130 |
| Campbell WB et al. | Regulation of potassium channels in coronary smooth muscle by adenoviral expression of cytochrome P-450 epoxygenase. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16143653 |
| Welsh DG and Segal SS | Role of EDHF in conduction of vasodilation along hamster cheek pouch arterioles in vivo. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10843879 |
| Kehl F et al. | 20-HETE contributes to the acute fall in cerebral blood flow after subarachnoid hemorrhage in the rat. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11893593 |
| Hatoum OA et al. | Role of hydrogen peroxide in ACh-induced dilation of human submucosal intestinal microvessels. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15345486 |
| Gebremedhin D et al. | Role of 20-HETE in the hypoxia-induced activation of Ca2+-activated K+ channel currents in rat cerebral arterial muscle cells. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17906097 |
| Frisbee JC et al. | 20-HETE modulates myogenic response of skeletal muscle resistance arteries from hypertensive Dahl-SS rats. | 2001 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11179048 |
| Earley S et al. | Cytochrome p-450 epoxygenase products contribute to attenuated vasoconstriction after chronic hypoxia. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12623785 |
| Marvar PJ et al. | High dietary salt reduces the contribution of 20-HETE to arteriolar oxygen responsiveness in skeletal muscle. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17114243 |
| Karamsetty MR et al. | EDHF contributes to strain-related differences in pulmonary arterial relaxation in rats. | 2001 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:11159029 |
| Alvarez DF et al. | Role of EETs in regulation of endothelial permeability in rat lung. | 2004 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:14578116 |
| Lee SJ et al. | Cytochrome P-450 metabolites in endothelin-stimulated cardiac hormone secretion. | 2004 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:14715489 |
| Alonso-Galicia M et al. | Role of 20-hydroxyeicosatetraenoic acid in the renal and vasoconstrictor actions of angiotensin II. | 2002 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12069931 |
| Wang X et al. | Redundant signaling mechanisms contribute to the vasodilatory response of the afferent arteriole to proteinase-activated receptor-2. | 2005 | Am. J. Physiol. Renal Physiol. | pmid:15328067 |