17-octadecynoic acid is a lipid of Fatty Acyls (FA) class. 17-octadecynoic acid is associated with abnormalities such as Renal tubular disorder, Hypertensive disease, abnormal fragmented structure, Blood Clot and Subarachnoid Hemorrhage. The involved functions are known as Hypoxia, Pathological Dilatation, Anabolism, Biochemical Pathway and Stimulus. 17-octadecynoic acid often locates in Endothelium, Muscle, Protoplasm, Microsomes and Membrane. The associated genes with 17-octadecynoic acid are P4HTM gene, EDNRA gene, Gene Family, IMPACT gene and PPP1R1A gene. The related lipids are 17-octadecynoic acid, Fatty Acids, 1-oleoyl-2-acetoyl-sn-glycerol and fatty acid analog.
To understand associated biological information of 17-octadecynoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
17-octadecynoic acid is suspected in Hypertensive disease, Renal tubular disorder, Blood Clot, Subarachnoid Hemorrhage, Renal vascular disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 17-octadecynoic acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Hyperthyroidism | D006980 | 12 associated lipids |
| Cicatrix | D002921 | 9 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Corneal Neovascularization | D016510 | 8 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid:28698302 | ||||
| pmid:11556821 | ||||
| pmid:19954757 | ||||
| pmid:17027963 | ||||
| pmid:16120187 | ||||
| pmid:15677873 | ||||
| pmid:14985065 | ||||
| pmid:15464071 | ||||
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| Knapp FF et al. | Synthesis and evaluation of radioiodinated (E)-18-iodo-17-octadecenoic acid as a model iodoalkenyl fatty acid for myocardial imaging. | 1984 | J. Med. Chem. | pmid:6690690 |
| Shak S et al. | Leukotriene B4 omega-hydroxylase in human polymorphonuclear leukocytes. Suicidal inactivation by acetylenic fatty acids. | 1985 | J. Biol. Chem. | pmid:2997155 |
| Muerhoff AS et al. | Prostaglandin and fatty acid omega- and (omega-1)-oxidation in rabbit lung. Acetylenic fatty acid mechanism-based inactivators as specific inhibitors. | 1989 | J. Biol. Chem. | pmid:2910864 |
| Shirane N et al. | Cytochrome P450BM-3 (CYP102): regiospecificity of oxidation of omega-unsaturated fatty acids and mechanism-based inactivation. | 1993 | Biochemistry | pmid:8257708 |
| Gebremedhin D et al. | Role of cytochrome P-450 in elevating renal vascular tone in spontaneously hypertensive rats. | 1993 Jan-Feb | J. Vasc. Res. | pmid:8435472 |
| Imig JD et al. | Cytochrome P-450 inhibitors alter afferent arteriolar responses to elevations in pressure. | 1994 | Am. J. Physiol. | pmid:8203587 |
| Zou AP et al. | Effects of 17-octadecynoic acid, a suicide-substrate inhibitor of cytochrome P450 fatty acid omega-hydroxylase, on renal function in rats. | 1994 | J. Pharmacol. Exp. Ther. | pmid:8301590 |
| Zou AP et al. | Inhibition of renal vascular 20-HETE production impairs autoregulation of renal blood flow. | 1994 | Am. J. Physiol. | pmid:8141328 |
| Oyekan AO et al. | Relaxant responses of rabbit aorta: influence of cytochrome P450 inhibitors. | 1994 | J. Pharmacol. Exp. Ther. | pmid:8301566 |
| Zou AP et al. | Role of changes in renal hemodynamics and P-450 metabolites of arachidonic acid in the reversal of one-kidney, one clip hypertension. | 1995 | J. Hypertens. | pmid:7561014 |
| Imig JD and Navar LG | Afferent arteriolar response to arachidonic acid: involvement of metabolic pathways. | 1996 | Am. J. Physiol. | pmid:8760247 |
| Zou AP et al. | 20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles. | 1996 | Am. J. Physiol. | pmid:8769806 |
| Macica CM et al. | Arachidonic acid inhibits activity of cloned renal K+ channel, ROMK1. | 1996 | Am. J. Physiol. | pmid:8853420 |
| Wang WH et al. | Cytochrome P-450 metabolites mediate extracellular Ca(2+)-induced inhibition of apical K+ channels in the TAL. | 1996 | Am. J. Physiol. | pmid:8760035 |
| Zygmunt PM et al. | Effects of cytochrome P450 inhibitors on EDHF-mediated relaxation in the rat hepatic artery. | 1996 | Br. J. Pharmacol. | pmid:8818337 |
| Edwards G et al. | Effects of cytochrome P450 inhibitors on potassium currents and mechanical activity in rat portal vein. | 1996 | Br. J. Pharmacol. | pmid:8904643 |
| Harder DR et al. | Identification of a putative microvascular oxygen sensor. | 1996 | Circ. Res. | pmid:8925569 |
| Lu M et al. | Effect of angiotensin II on the apical K+ channel in the thick ascending limb of the rat kidney. | 1996 | J. Gen. Physiol. | pmid:8972391 |
| Carroll MA et al. | Cytochrome P450-derived renal HETEs: storage and release. | 1997 | Kidney Int. | pmid:9186856 |
| Grider JS et al. | P450 arachidonate metabolites mediate bradykinin-dependent inhibition of NaCl transport in the rat thick ascending limb. | 1997 | Can. J. Physiol. Pharmacol. | pmid:9114929 |
| Van de Voorde J and Vanheel B | Influence of cytochrome P-450 inhibitors on endothelium-dependent nitro-L-arginine-resistant relaxation and cromakalim-induced relaxation in rat mesenteric arteries. | 1997 | J. Cardiovasc. Pharmacol. | pmid:9234666 |
| Chataigneau T et al. | Epoxyeicosatrienoic acids, potassium channel blockers and endothelium-dependent hyperpolarization in the guinea-pig carotid artery. | 1998 | Br. J. Pharmacol. | pmid:9504399 |
| Evans RG et al. | Effects of intrarenal infusion of 17-octadecynoic acid on renal antihypertensive mechanisms in anesthetized rabbits. | 1998 | Am. J. Hypertens. | pmid:9683041 |
| Uddin MR et al. | Cytochrome P-450 metabolites mediate norepinephrine-induced mitogenic signaling. | 1998 | Hypertension | pmid:9453310 |
| Ivey CL et al. | Involvement of cytochrome P-450 enzyme activity in the control of microvascular permeability in canine lung. | 1998 | Am. J. Physiol. | pmid:9755108 |
| Ferreri NR et al. | Angiotensin II induces TNF production by the thick ascending limb: functional implications. | 1998 | Am. J. Physiol. | pmid:9458834 |
| Widmann MD et al. | Cytochrome P-450 pathway in acetylcholine-induced canine coronary microvascular vasodilation in vivo. | 1998 | Am. J. Physiol. | pmid:9458878 |
| Popp R et al. | Pulsatile stretch in coronary arteries elicits release of endothelium-derived hyperpolarizing factor: a modulator of arterial compliance. | 1998 | Circ. Res. | pmid:9546378 |
| Yamanaka A et al. | Characterization of endothelium-dependent relaxation independent of NO and prostaglandins in guinea pig coronary artery. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9580587 |
| Lombard JH et al. | Cytochrome P-450 omega-hydroxylase senses O2 in hamster muscle, but not cheek pouch epithelium, microcirculation. | 1999 | Am. J. Physiol. | pmid:9950851 |
| de Wit C et al. | Pentobarbital-sensitive EDHF comediates ACh-induced arteriolar dilation in the hamster microcirculation. | 1999 | Am. J. Physiol. | pmid:10330235 |
| Bakker EN et al. | Signal transduction in spontaneous myogenic tone in isolated arterioles from rat skeletal muscle. | 1999 | Cardiovasc. Res. | pmid:10325970 |
| Faraci FM and Sobey CG | Role of soluble guanylate cyclase in dilator responses of the cerebral microcirculation. | 1999 | Brain Res. | pmid:10064823 |
| Kerkhof CJ et al. | Role of cytochrome P-450 4A in oxygen sensing and NO production in rat cremaster resistance arteries. | 1999 | Am. J. Physiol. | pmid:10516194 |
| Yang Z et al. | Hydrogen peroxide-induced endothelium-dependent relaxation of rat aorta involvement of Ca2+ and other cellular metabolites. | 1999 | Gen. Pharmacol. | pmid:10523071 |
| Messer-Létienne I et al. | 20-Hydroxyeicosatetraenoic acid and renal function in Lyon hypertensive rats. | 1999 | Eur. J. Pharmacol. | pmid:10493105 |
| Ito O and Roman RJ | Role of 20-HETE in elevating chloride transport in the thick ascending limb of Dahl SS/Jr rats. | 1999 | Hypertension | pmid:9931140 |
| Lasker JM et al. | Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of Cyp4F2 and Cyp4A11. | 2000 | J. Biol. Chem. | pmid:10660572 |
| Davidson-Garcia CA et al. | Possible role of P-450-derived metabolites in endothelium-dependent relaxation of rat small mesenteric arteries. | 2000 | Life Sci. | pmid:10737360 |
| Brand-Schieber E et al. | Selective inhibition of arachidonic acid epoxidation in vivo. | 2000 | J. Physiol. Pharmacol. | pmid:11192939 |
| Bruce JI and Elliott AC | Pharmacological evaluation of the role of cytochrome P450 in intracellular calcium signalling in rat pancreatic acinar cells. | 2000 | Br. J. Pharmacol. | pmid:11030726 |