17-octadecynoic acid is a lipid of Fatty Acyls (FA) class. 17-octadecynoic acid is associated with abnormalities such as Renal tubular disorder, Hypertensive disease, abnormal fragmented structure, Blood Clot and Subarachnoid Hemorrhage. The involved functions are known as Hypoxia, Pathological Dilatation, Anabolism, Biochemical Pathway and Stimulus. 17-octadecynoic acid often locates in Endothelium, Muscle, Protoplasm, Microsomes and Membrane. The associated genes with 17-octadecynoic acid are P4HTM gene, EDNRA gene, Gene Family, IMPACT gene and PPP1R1A gene. The related lipids are 17-octadecynoic acid, Fatty Acids, 1-oleoyl-2-acetoyl-sn-glycerol and fatty acid analog.
To understand associated biological information of 17-octadecynoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
17-octadecynoic acid is suspected in Hypertensive disease, Renal tubular disorder, Blood Clot, Subarachnoid Hemorrhage, Renal vascular disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 17-octadecynoic acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Hyperthyroidism | D006980 | 12 associated lipids |
| Cicatrix | D002921 | 9 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Corneal Neovascularization | D016510 | 8 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
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| Wang X et al. | Determinants of renal afferent arteriolar actions of bradykinin: evidence that multiple pathways mediate responses attributed to EDHF. | 2003 | Am. J. Physiol. Renal Physiol. | pmid:12734100 |
| Li D et al. | Arachidonic acid metabolic pathways regulating activity of renal Na(+)-K(+)-ATPase are age dependent. | 2000 | Am. J. Physiol. Renal Physiol. | pmid:10807595 |
| Wang X et al. | Redundant signaling mechanisms contribute to the vasodilatory response of the afferent arteriole to proteinase-activated receptor-2. | 2005 | Am. J. Physiol. Renal Physiol. | pmid:15328067 |
| Kirchheimer C et al. | Role of 20-HETE in D1/D2 dopamine receptor synergism resulting in the inhibition of Na+-K+-ATPase activity in the proximal tubule. | 2007 | Am. J. Physiol. Renal Physiol. | pmid:17264308 |
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| Matoba T et al. | Electron spin resonance detection of hydrogen peroxide as an endothelium-derived hyperpolarizing factor in porcine coronary microvessels. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12763764 |
| Zoltewicz SJ et al. | The palmitoylation state of PMP22 modulates epithelial cell morphology and migration. | 2012 | ASN Neuro | pmid:23127255 |
| Sánchez-Mendoza A et al. | Angiotensin II modulates ion transport in rat proximal tubules through CYP metabolites. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10833430 |
| Shirane N et al. | Cytochrome P450BM-3 (CYP102): regiospecificity of oxidation of omega-unsaturated fatty acids and mechanism-based inactivation. | 1993 | Biochemistry | pmid:8257708 |
| Ikari A et al. | Arachidonic acid-activated Na+-dependent Mg2+ efflux in rat renal epithelial cells. | 2003 | Biochim. Biophys. Acta | pmid:14643927 |
| Yount JS et al. | Bioorthogonal proteomics of 15-hexadecynyloxyacetic acid chemical reporter reveals preferential targeting of fatty acid modified proteins and biosynthetic enzymes. | 2012 | Bioorg. Med. Chem. | pmid:21524915 |