17-octadecynoic acid is a lipid of Fatty Acyls (FA) class. 17-octadecynoic acid is associated with abnormalities such as Renal tubular disorder, Hypertensive disease, abnormal fragmented structure, Blood Clot and Subarachnoid Hemorrhage. The involved functions are known as Hypoxia, Pathological Dilatation, Anabolism, Biochemical Pathway and Stimulus. 17-octadecynoic acid often locates in Endothelium, Muscle, Protoplasm, Microsomes and Membrane. The associated genes with 17-octadecynoic acid are P4HTM gene, EDNRA gene, Gene Family, IMPACT gene and PPP1R1A gene. The related lipids are 17-octadecynoic acid, Fatty Acids, 1-oleoyl-2-acetoyl-sn-glycerol and fatty acid analog.
To understand associated biological information of 17-octadecynoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
17-octadecynoic acid is suspected in Hypertensive disease, Renal tubular disorder, Blood Clot, Subarachnoid Hemorrhage, Renal vascular disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 17-octadecynoic acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Hyperthyroidism | D006980 | 12 associated lipids |
| Cicatrix | D002921 | 9 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Corneal Neovascularization | D016510 | 8 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Honda H et al. | Comparison of muscarinic receptor- and beta-adrenoceptor-mediated vasorelaxation between euthyroid and acute hyperthyroid rats. | 2005 | Comp. Biochem. Physiol. C Toxicol. Pharmacol. | pmid:16040281 |
| Randriamboavonjy V et al. | The synthesis of 20-HETE in small porcine coronary arteries antagonizes EDHF-mediated relaxation. | 2005 | Cardiovasc. Res. | pmid:15639488 |
| Bełtowski J et al. | Bidirectional regulation of renal cortical Na+,K+-ATPase by protein kinase C. | 2004 | Acta Biochim. Pol. | pmid:15448737 |
| Mauban JR and Wier WG | Essential role of EDHF in the initiation and maintenance of adrenergic vasomotion in rat mesenteric arteries. | 2004 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15059779 |
| Konduri GG et al. | P2Y purine receptor responses and expression in the pulmonary circulation of juvenile rabbits. | 2004 | Am. J. Physiol. Heart Circ. Physiol. | pmid:14962841 |
| Iwata T and Honda H | Acute hyperthyroidism alters adrenoceptor- and muscarinic receptor-mediated responses in isolated rat renal and femoral arteries. | 2004 | Eur. J. Pharmacol. | pmid:15189782 |
| Lee SJ et al. | Cytochrome P-450 metabolites in endothelin-stimulated cardiac hormone secretion. | 2004 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:14715489 |
| Nakamura T et al. | Design and synthesis of 1-(4-benzoylphenyl)imidazole derivatives as new potent 20-HETE synthase inhibitors. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15454216 |
| Caron N et al. | Changes in renal haemodynamics induced by indomethacin in the rat involve cytochrome P450 arachidonic acid-dependent epoxygenases. | 2004 | Clin. Exp. Pharmacol. Physiol. | pmid:15554908 |
| Ikari A et al. | Activation of Na+-independent Mg2+ efflux by 20-hydroxyeicosatetraenoic acid in rat renal epithelial cells. | 2004 | Jpn. J. Physiol. | pmid:15631697 |
| Gross ER et al. | Cytochrome P450 omega-hydroxylase inhibition reduces infarct size during reperfusion via the sarcolemmal KATP channel. | 2004 | J. Mol. Cell. Cardiol. | pmid:15572055 |
| Nithipatikom K et al. | Inhibition of cytochrome P450omega-hydroxylase: a novel endogenous cardioprotective pathway. | 2004 | Circ. Res. | pmid:15388642 |
| Alvarez DF et al. | Role of EETs in regulation of endothelial permeability in rat lung. | 2004 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:14578116 |
| Ikari A et al. | Arachidonic acid-activated Na+-dependent Mg2+ efflux in rat renal epithelial cells. | 2003 | Biochim. Biophys. Acta | pmid:14643927 |
| Tanaka E et al. | Arachidonic acid metabolites contribute to the irreversible depolarization induced by in vitro ischemia. | 2003 | J. Neurophysiol. | pmid:12917387 |
| Bełtowski J et al. | Regulation of renal Na(+),K(+)-ATPase and ouabain-sensitive H(+),K(+)-ATPase by the cyclic AMP-protein kinase A signal transduction pathway. | 2003 | Acta Biochim. Pol. | pmid:12673350 |
| Wang X et al. | Determinants of renal afferent arteriolar actions of bradykinin: evidence that multiple pathways mediate responses attributed to EDHF. | 2003 | Am. J. Physiol. Renal Physiol. | pmid:12734100 |
| Thapaliya S et al. | An endothelium-derived factor modulates purinergic neurotransmission to mesenteric arterial smooth muscle of hamster. | 2003 | Eur. J. Pharmacol. | pmid:12586208 |
| Grider JS et al. | Dopamine D1 receptor-dependent inhibition of NaCl transport in the rat thick ascending limb: mechanism of action. | 2003 | Eur. J. Pharmacol. | pmid:12892837 |
| Jarus-Dziedzic K et al. | Acute decrease of cerebrocortical microflow and lack of carbon dioxide reactivity following subarachnoid haemorrhage in the rat. | 2003 | Acta Neurochir. Suppl. | pmid:14753489 |