17-octadecynoic acid is a lipid of Fatty Acyls (FA) class. 17-octadecynoic acid is associated with abnormalities such as Renal tubular disorder, Hypertensive disease, abnormal fragmented structure, Blood Clot and Subarachnoid Hemorrhage. The involved functions are known as Hypoxia, Pathological Dilatation, Anabolism, Biochemical Pathway and Stimulus. 17-octadecynoic acid often locates in Endothelium, Muscle, Protoplasm, Microsomes and Membrane. The associated genes with 17-octadecynoic acid are P4HTM gene, EDNRA gene, Gene Family, IMPACT gene and PPP1R1A gene. The related lipids are 17-octadecynoic acid, Fatty Acids, 1-oleoyl-2-acetoyl-sn-glycerol and fatty acid analog.
To understand associated biological information of 17-octadecynoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
17-octadecynoic acid is suspected in Hypertensive disease, Renal tubular disorder, Blood Clot, Subarachnoid Hemorrhage, Renal vascular disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 17-octadecynoic acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Hyperthyroidism | D006980 | 12 associated lipids |
| Cicatrix | D002921 | 9 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Corneal Neovascularization | D016510 | 8 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Harder DR et al. | Identification of a putative microvascular oxygen sensor. | 1996 | Circ. Res. | pmid:8925569 |
| Popp R et al. | Pulsatile stretch in coronary arteries elicits release of endothelium-derived hyperpolarizing factor: a modulator of arterial compliance. | 1998 | Circ. Res. | pmid:9546378 |
| Miura H et al. | Flow-induced dilation of human coronary arterioles: important role of Ca(2+)-activated K(+) channels. | 2001 | Circulation | pmid:11306529 |
| Archer SL et al. | Endothelium-derived hyperpolarizing factor in human internal mammary artery is 11,12-epoxyeicosatrienoic acid and causes relaxation by activating smooth muscle BK(Ca) channels. | 2003 | Circulation | pmid:12578883 |
| Caron N et al. | Changes in renal haemodynamics induced by indomethacin in the rat involve cytochrome P450 arachidonic acid-dependent epoxygenases. | 2004 | Clin. Exp. Pharmacol. Physiol. | pmid:15554908 |
| Honda H et al. | Comparison of muscarinic receptor- and beta-adrenoceptor-mediated vasorelaxation between euthyroid and acute hyperthyroid rats. | 2005 | Comp. Biochem. Physiol. C Toxicol. Pharmacol. | pmid:16040281 |
| Wang MZ et al. | CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime]. | 2006 | Drug Metab. Dispos. | pmid:16997912 |
| Wang MZ et al. | Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine. | 2007 | Drug Metab. Dispos. | pmid:17709372 |
| Nishimuta H et al. | Species differences in intestinal metabolic activities of cytochrome P450 isoforms between cynomolgus monkeys and humans. | 2011 | Drug Metab. Pharmacokinet. | pmid:21383522 |
| Zhai G et al. | Inhibition of cytochromes P450 and the hydroxylation of 4-monochlorobiphenyl in whole poplar. | 2013 | Environ. Sci. Technol. | pmid:23320482 |
| Thapaliya S et al. | An endothelium-derived factor modulates purinergic neurotransmission to mesenteric arterial smooth muscle of hamster. | 2003 | Eur. J. Pharmacol. | pmid:12586208 |
| Grider JS et al. | Dopamine D1 receptor-dependent inhibition of NaCl transport in the rat thick ascending limb: mechanism of action. | 2003 | Eur. J. Pharmacol. | pmid:12892837 |
| Iwata T and Honda H | Acute hyperthyroidism alters adrenoceptor- and muscarinic receptor-mediated responses in isolated rat renal and femoral arteries. | 2004 | Eur. J. Pharmacol. | pmid:15189782 |
| Wang Z et al. | 20-Hydroxyeicosatetraenoic acid inhibits the apoptotic responses in pulmonary artery smooth muscle cells. | 2008 | Eur. J. Pharmacol. | pmid:18455723 |
| Lv X et al. | Cytochrome P450 omega-hydroxylase inhibition reduces cardiomyocyte apoptosis via activation of ERK1/2 signaling in rat myocardial ischemia-reperfusion. | 2008 | Eur. J. Pharmacol. | pmid:18771665 |
| Jerez S et al. | Endothelial dysfunction and improvement of the angiotensin II-reactivity in hypercholesterolemic rabbits: role of cyclooxygenase metabolites. | 2008 | Eur. J. Pharmacol. | pmid:18053983 |
| Hattori T et al. | Effects of H2O2 on membrane potential of smooth muscle cells in rabbit mesenteric resistance artery. | 2003 | Eur. J. Pharmacol. | pmid:12620501 |
| Messer-Létienne I et al. | 20-Hydroxyeicosatetraenoic acid and renal function in Lyon hypertensive rats. | 1999 | Eur. J. Pharmacol. | pmid:10493105 |
| Hungerford JE et al. | Vasomotor control in arterioles of the mouse cremaster muscle. | 2000 | FASEB J. | pmid:10627294 |
| Komen JC and Wanders RJ | Identification of the cytochrome P450 enzymes responsible for the omega-hydroxylation of phytanic acid. | 2006 | FEBS Lett. | pmid:16782090 |