17-octadecynoic acid is a lipid of Fatty Acyls (FA) class. 17-octadecynoic acid is associated with abnormalities such as Renal tubular disorder, Hypertensive disease, abnormal fragmented structure, Blood Clot and Subarachnoid Hemorrhage. The involved functions are known as Hypoxia, Pathological Dilatation, Anabolism, Biochemical Pathway and Stimulus. 17-octadecynoic acid often locates in Endothelium, Muscle, Protoplasm, Microsomes and Membrane. The associated genes with 17-octadecynoic acid are P4HTM gene, EDNRA gene, Gene Family, IMPACT gene and PPP1R1A gene. The related lipids are 17-octadecynoic acid, Fatty Acids, 1-oleoyl-2-acetoyl-sn-glycerol and fatty acid analog.
To understand associated biological information of 17-octadecynoic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
17-octadecynoic acid is suspected in Hypertensive disease, Renal tubular disorder, Blood Clot, Subarachnoid Hemorrhage, Renal vascular disorder and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with 17-octadecynoic acid
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Hyperthyroidism | D006980 | 12 associated lipids |
| Cicatrix | D002921 | 9 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Corneal Neovascularization | D016510 | 8 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sanders RJ et al. | Evidence for two enzymatic pathways for omega-oxidation of docosanoic acid in rat liver microsomes. | 2005 | J. Lipid Res. | pmid:15716582 |
| Knapp FF et al. | Synthesis and evaluation of radioiodinated (E)-18-iodo-17-octadecenoic acid as a model iodoalkenyl fatty acid for myocardial imaging. | 1984 | J. Med. Chem. | pmid:6690690 |
| Gross ER et al. | Cytochrome P450 omega-hydroxylase inhibition reduces infarct size during reperfusion via the sarcolemmal KATP channel. | 2004 | J. Mol. Cell. Cardiol. | pmid:15572055 |
| Tanaka E et al. | Arachidonic acid metabolites contribute to the irreversible depolarization induced by in vitro ischemia. | 2003 | J. Neurophysiol. | pmid:12917387 |
| Kalyankrishna S and Malik KU | Norepinephrine-induced stimulation of p38 mitogen-activated protein kinase is mediated by arachidonic acid metabolites generated by activation of cytosolic phospholipase A(2) in vascular smooth muscle cells. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12538832 |
| Hercule HC and Oyekan AO | Cytochrome P450 omega/omega-1 hydroxylase-derived eicosanoids contribute to endothelin(A) and endothelin(B) receptor-mediated vasoconstriction to endothelin-1 in the rat preglomerular arteriole. | 2000 | J. Pharmacol. Exp. Ther. | pmid:10688635 |
| Zou AP et al. | Effects of 17-octadecynoic acid, a suicide-substrate inhibitor of cytochrome P450 fatty acid omega-hydroxylase, on renal function in rats. | 1994 | J. Pharmacol. Exp. Ther. | pmid:8301590 |
| Hashizume T et al. | Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal microsomes. | 2002 | J. Pharmacol. Exp. Ther. | pmid:11752129 |
| Oyekan AO et al. | Relaxant responses of rabbit aorta: influence of cytochrome P450 inhibitors. | 1994 | J. Pharmacol. Exp. Ther. | pmid:8301566 |
| Mezentsev A et al. | Transfection of cytochrome P4504B1 into the cornea increases angiogenic activity of the limbal vessels. | 2005 | J. Pharmacol. Exp. Ther. | pmid:16009741 |
| Yamanaka A et al. | Characterization of endothelium-dependent relaxation independent of NO and prostaglandins in guinea pig coronary artery. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9580587 |
| Loyaga-Rendon RY et al. | Mediators involved in decreasing peripheral vascular resistance with carbachol in the rat hind limb perfusion model. | 2005 | J. Pharmacol. Sci. | pmid:16006739 |
| Bełtowski J et al. | Nitric oxide decreases renal medullary Na+, K+-ATPase activity through cyclic GMP-protein kinase G dependent mechanism. | 2003 | J. Physiol. Pharmacol. | pmid:12832721 |
| Brand-Schieber E et al. | Selective inhibition of arachidonic acid epoxidation in vivo. | 2000 | J. Physiol. Pharmacol. | pmid:11192939 |
| Frisbee JC et al. | Relative contributions of cyclooxygenase- and cytochrome P450 omega-hydroxylase-dependent pathways to hypoxic dilation of skeletal muscle resistance arteries. | 2001 Jul-Aug | J. Vasc. Res. | pmid:11455201 |
| Gebremedhin D et al. | Role of cytochrome P-450 in elevating renal vascular tone in spontaneously hypertensive rats. | 1993 Jan-Feb | J. Vasc. Res. | pmid:8435472 |
| Ikari A et al. | Activation of Na+-independent Mg2+ efflux by 20-hydroxyeicosatetraenoic acid in rat renal epithelial cells. | 2004 | Jpn. J. Physiol. | pmid:15631697 |
| Gu RM et al. | CYP-omega-hydroxylation-dependent metabolites of arachidonic acid inhibit the basolateral 10 pS chloride channel in the rat thick ascending limb. | 2009 | Kidney Int. | pmid:19641481 |
| Carroll MA et al. | Cytochrome P450-derived renal HETEs: storage and release. | 1997 | Kidney Int. | pmid:9186856 |
| Alexander LD et al. | Arachidonic acid directly activates members of the mitogen-activated protein kinase superfamily in rabbit proximal tubule cells. | 2001 | Kidney Int. | pmid:11380805 |